thrombin is a serine proteinase that plays a central role in the thrombotic process, acting to cleave fibrinogen into fibrin monomers and to activate factor xiii to factor xiiia, allowing fibrin to develop a covalently cross-linked framework which stabilizes the thrombus; thrombin also activates factors v and viii, promoting further thrombin generation, and activates platelets, stimulating aggregation and granule release.
Parent Term
Biochemical pathway
Parent Definition
A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
Other Metabolites Mapped to 'Bivalirudin Action Pathway'