cytochrome p450 (cyp) enzymes, cyp3a4, cyp3a5, and cyp2c8, have been implicated in this activation step; cyp3a4/5 are responsible for ≥ 80% of simvastatin metabolism while cyp2c8 (not shown in pathway) contributes to ≤ 20% of its metabolism. the simvastatin hydroxy acid inhibits cholesterol synthesis via the mevalonate pathway by competitively inhibiting 3-hydroxy-3-methylglutaryl-coenzyme a (hmg-coa) reductase.
Parent Term
Biochemical pathway
Parent Definition
A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
Other Metabolites Mapped to 'Simvastatin Action Pathway'