Showing metabocard for Choline (HMDB0000097)

General function:

Involved in acyltransferase activity

Specific function:

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.

Gene Name:

CHAT

Uniprot ID:

P28329

Molecular weight:

70425.285

Reactions

General function:

Involved in protein binding

Specific function:

May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity).

Gene Name:

PLD2

Uniprot ID:

O14939

Molecular weight:

104656.485

Reactions

General function:

Involved in protein binding

Specific function:

Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).

Gene Name:

PLD1

Uniprot ID:

Q13393

Molecular weight:

124183.135

Reactions

General function:

Involved in oxidoreductase activity, acting on CH-OH group of donors

Specific function:

Not Available

Gene Name:

CHDH

Uniprot ID:

Q8NE62

Molecular weight:

65358.005

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.

Gene Name:

ACHE

Uniprot ID:

P22303

Molecular weight:

67795.525

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.

Gene Name:

BCHE

Uniprot ID:

P06276

Molecular weight:

68417.575

Reactions

General function:

Involved in catalytic activity

Specific function:

Controls phosphatidylcholine synthesis.

Gene Name:

PCYT1B

Uniprot ID:

Q9Y5K3

Molecular weight:

40228.99

General function:

Involved in catalytic activity

Specific function:

Controls phosphatidylcholine synthesis.

Gene Name:

PCYT1A

Uniprot ID:

P49585

Molecular weight:

41730.67

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.

Gene Name:

CHKB

Uniprot ID:

Q9Y259

Molecular weight:

45270.99

Reactions

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.

Gene Name:

CHKA

Uniprot ID:

P35790

Molecular weight:

52248.53

Reactions