Showing metabocard for Estrone (HMDB0000145)

General function:

Involved in catalytic activity

Specific function:

Not Available

Gene Name:

ARSD

Uniprot ID:

P51689

Molecular weight:

64859.3

General function:

Involved in sulfotransferase activity

Specific function:

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.

Gene Name:

SULT1E1

Uniprot ID:

P49888

Molecular weight:

35126.185

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Responsible for the reduction of the keto group on the C-3 of sterols.

Gene Name:

HSD17B7

Uniprot ID:

P56937

Molecular weight:

38205.77

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.

Gene Name:

HSD17B8

Uniprot ID:

Q92506

Molecular weight:

26973.56

Reactions

General function:

Involved in monooxygenase activity

Specific function:

Not Available

Gene Name:

CYP1A1

Uniprot ID:

A0N0X8

Molecular weight:

58164.8

General function:

Involved in monooxygenase activity

Specific function:

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.

Gene Name:

CYP1A2

Uniprot ID:

P05177

Molecular weight:

58406.915

General function:

Involved in monooxygenase activity

Specific function:

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development.

Gene Name:

CYP1B1

Uniprot ID:

Q16678

Molecular weight:

60845.33

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Gene Name:

CYP2A7

Uniprot ID:

P20853

Molecular weight:

56424.735

General function:

Involved in monooxygenase activity

Specific function:

Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.

Gene Name:

CYP2A13

Uniprot ID:

Q16696

Molecular weight:

56687.095

General function:

Involved in monooxygenase activity

Specific function:

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.

Gene Name:

CYP2B6

Uniprot ID:

P20813

Molecular weight:

56277.81

General function:

Involved in monooxygenase activity

Specific function:

Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.

Gene Name:

CYP2C19

Uniprot ID:

P33261

Molecular weight:

55944.565

General function:

Involved in monooxygenase activity

Specific function:

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).

Gene Name:

CYP2C8

Uniprot ID:

P10632

Molecular weight:

55824.275

General function:

Involved in monooxygenase activity

Specific function:

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.

Gene Name:

CYP2C9

Uniprot ID:

P11712

Molecular weight:

55627.365

General function:

Involved in monooxygenase activity

Specific function:

Not Available

Gene Name:

CYP2D6

Uniprot ID:

Q6NWU0

Molecular weight:

55729.9

General function:

Involved in monooxygenase activity

Specific function:

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.

Gene Name:

CYP2E1

Uniprot ID:

P05181

Molecular weight:

56848.42

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.

Gene Name:

CYP2F1

Uniprot ID:

P24903

Molecular weight:

55500.64

General function:

Involved in monooxygenase activity

Specific function:

This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.

Gene Name:

CYP2J2

Uniprot ID:

P51589

Molecular weight:

57610.165

General function:

Involved in monooxygenase activity

Specific function:

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.

Gene Name:

CYP3A4

Uniprot ID:

P08684

Molecular weight:

57255.585

General function:

Involved in monooxygenase activity

Specific function:

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Gene Name:

CYP4B1

Uniprot ID:

P13584

Molecular weight:

58990.64

General function:

Involved in monooxygenase activity

Specific function:

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Gene Name:

CYP19A1

Uniprot ID:

P11511

Molecular weight:

57882.48

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

Not Available

Gene Name:

CYP4Z1

Uniprot ID:

Q86W10

Molecular weight:

59085.45

General function:

Involved in monooxygenase activity

Specific function:

Has a potential importance for extrahepatic xenobiotic metabolism.

Gene Name:

CYP2S1

Uniprot ID:

Q96SQ9

Molecular weight:

55816.205

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Gene Name:

UGT2B11

Uniprot ID:

O75310

Molecular weight:

61037.8

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.

Gene Name:

UGT2A1

Uniprot ID:

Q9Y4X1

Molecular weight:

60771.605

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.

Gene Name:

UGT2B28

Uniprot ID:

Q9BY64

Molecular weight:

38742.9

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

Not Available

Gene Name:

UGT1A10

Uniprot ID:

Q5DT02

Molecular weight:

59809.1

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

Not Available

Gene Name:

UGT1A8

Uniprot ID:

Q5DSZ6

Molecular weight:

59741.0

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

Not Available

Gene Name:

UGT1A7

Uniprot ID:

Q5DSZ7

Molecular weight:

59818.3

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.

Gene Name:

UGT1A6

Uniprot ID:

P19224

Molecular weight:

60750.215

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Gene Name:

UGT1A5

Uniprot ID:

P35504

Molecular weight:

60070.565

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.

Gene Name:

UGT1A9

Uniprot ID:

O60656

Molecular weight:

59940.495

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.

Gene Name:

UGT1A4

Uniprot ID:

P22310

Molecular weight:

60024.535

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.

Gene Name:

UGT1A1

Uniprot ID:

P22309

Molecular weight:

59590.91

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Gene Name:

UGT1A3

Uniprot ID:

P35503

Molecular weight:

60337.835

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

Gene Name:

UGT2B4

Uniprot ID:

P06133

Molecular weight:

60512.035

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.

Gene Name:

UGT2B15

Uniprot ID:

P54855

Molecular weight:

61035.815

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).

Gene Name:

UGT2B17

Uniprot ID:

O75795

Molecular weight:

61094.915

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

Gene Name:

UGT2A3

Uniprot ID:

Q6UWM9

Molecular weight:

60253.94

Reactions

General function:

Involved in catalytic activity

Specific function:

May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates

Gene Name:

ARSE

Uniprot ID:

P51690

Molecular weight:

65668.4

General function:

Involved in catalytic activity

Specific function:

Conversion of sulfated steroid precursors to estrogens during pregnancy.

Gene Name:

STS

Uniprot ID:

P08842

Molecular weight:

65491.72

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.

Gene Name:

HSD17B12

Uniprot ID:

Q53GQ0

Molecular weight:

34323.875

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.

Gene Name:

HSD17B2

Uniprot ID:

P37059

Molecular weight:

42784.75

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.

Gene Name:

HSD17B6

Uniprot ID:

O14756

Molecular weight:

35965.41

Reactions

General function:

Involved in monooxygenase activity

Specific function:

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Gene Name:

CYP1A1

Uniprot ID:

P04798

Molecular weight:

58164.815

General function:

Involved in estradiol 17-beta-dehydrogenase activity

Specific function:

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

Gene Name:

HSD17B1

Uniprot ID:

P14061

Molecular weight:

34949.715

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.

Gene Name:

HSD17B11

Uniprot ID:

Q8NBQ5

Molecular weight:

32935.525

Reactions

General function:

Involved in transport

Specific function:

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc

Gene Name:

ALB

Uniprot ID:

P02768

Molecular weight:

69365.9

General function:

Involved in sequence-specific DNA binding transcription factor activity

Specific function:

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1

Gene Name:

ESR1

Uniprot ID:

P03372

Molecular weight:

66215.4

General function:

Involved in androgen binding

Specific function:

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration

Gene Name:

SHBG

Uniprot ID:

P04278

Molecular weight:

43778.8

General function:

Involved in monooxygenase activity

Specific function:

Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.

Gene Name:

CYP2A6

Uniprot ID:

P11509

Molecular weight:

56517.005