Showing metabocard for Estrone (HMDB0000145)

General function:

Involved in catalytic activity

Specific function:

Not Available

Gene Name:

ARSD

Uniprot ID:

P51689

Molecular weight:

64859.3

General function:

Involved in catalytic activity

Specific function:

May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates

Gene Name:

ARSE

Uniprot ID:

P51690

Molecular weight:

65668.4

General function:

Involved in sulfotransferase activity

Specific function:

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.

Gene Name:

SULT1E1

Uniprot ID:

P49888

Molecular weight:

35126.185

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.

Gene Name:

HSD17B2

Uniprot ID:

P37059

Molecular weight:

42784.75

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.

Gene Name:

UGT2B28

Uniprot ID:

Q9BY64

Molecular weight:

38742.9

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.

Gene Name:

HSD17B8

Uniprot ID:

Q92506

Molecular weight:

26973.56

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

Gene Name:

UGT2B4

Uniprot ID:

P06133

Molecular weight:

60512.035

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.

Gene Name:

UGT1A4

Uniprot ID:

P22310

Molecular weight:

60024.535

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Gene Name:

UGT2B10

Uniprot ID:

P36537

Molecular weight:

60773.485

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).

Gene Name:

UGT2B7

Uniprot ID:

P16662

Molecular weight:

60720.15

Reactions