HMDBP00302 | Prolyl 4-hydroxylase subunit alpha-2 | O15460 | P4HA2 | 5q31 | Enzyme | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
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HMDBP00303 | Pyrroline-5-carboxylate reductase 1, mitochondrial | P32322 | PYCR1 | 17q25.3 | Unknown | - Huang TC, Huang YW, Hung HJ, Ho CT, Wu ML: Delta1-pyrroline-5-carboxylic acid formed by proline dehydrogenase from the Bacillus subtilis ssp. natto expressed in Escherichia coli as a precursor for 2-acetyl-1-pyrroline. J Agric Food Chem. 2007 Jun 27;55(13):5097-102. Epub 2007 May 31. [PubMed:17536821 ]
- Hu CA, Donald SP, Yu J, Lin WW, Liu Z, Steel G, Obie C, Valle D, Phang JM: Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis. Mol Cell Biochem. 2007 Jan;295(1-2):85-92. Epub 2006 Jul 28. [PubMed:16874462 ]
- Meng Z, Lou Z, Liu Z, Hui D, Bartlam M, Rao Z: Purification, characterization, and crystallization of human pyrroline-5-carboxylate reductase. Protein Expr Purif. 2006 Sep;49(1):83-7. Epub 2006 Mar 20. [PubMed:16600630 ]
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HMDBP00304 | Prolyl 4-hydroxylase subunit alpha-1 | P13674 | P4HA1 | 10q21.3-q23.1 | Enzyme | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
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HMDBP00305 | Pyrroline-5-carboxylate reductase 2 | Q96C36 | PYCR2 | 1q42.12 | Unknown | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
- Murahama M, Yoshida T, Hayashi F, Ichino T, Sanada Y, Wada K: Purification and characterization of Delta(1)-pyrroline-5-carboxylate reductase isoenzymes, indicating differential distribution in spinach (Spinacia oleracea L.) leaves. Plant Cell Physiol. 2001 Jul;42(7):742-50. [PubMed:11479381 ]
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HMDBP00567 | Bifunctional glutamate/proline--tRNA ligase | P07814 | EPRS | 1q41 | Enzyme | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
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HMDBP00865 | Cytosol aminopeptidase | P28838 | LAP3 | | Unknown | Not Available |
HMDBP02042 | Proline dehydrogenase 1, mitochondrial | O43272 | PRODH | 22q11.21 | Unknown | - Huang TC, Huang YW, Hung HJ, Ho CT, Wu ML: Delta1-pyrroline-5-carboxylic acid formed by proline dehydrogenase from the Bacillus subtilis ssp. natto expressed in Escherichia coli as a precursor for 2-acetyl-1-pyrroline. J Agric Food Chem. 2007 Jun 27;55(13):5097-102. Epub 2007 May 31. [PubMed:17536821 ]
- White TA, Krishnan N, Becker DF, Tanner JJ: Structure and kinetics of monofunctional proline dehydrogenase from Thermus thermophilus. J Biol Chem. 2007 May 11;282(19):14316-27. Epub 2007 Mar 7. [PubMed:17344208 ]
- White TA, Tanner JJ: Cloning, purification and crystallization of Thermus thermophilus proline dehydrogenase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Aug 1;61(Pt 8):737-9. Epub 2005 Jul 8. [PubMed:16511143 ]
- Phang JM, Donald SP, Pandhare J, Liu Y: The metabolism of proline, a stress substrate, modulates carcinogenic pathways. Amino Acids. 2008 Nov;35(4):681-90. doi: 10.1007/s00726-008-0063-4. Epub 2008 Apr 10. [PubMed:18401543 ]
- Phang JM, Liu W, Zabirnyk O: Proline metabolism and microenvironmental stress. Annu Rev Nutr. 2010 Aug 21;30:441-63. doi: 10.1146/annurev.nutr.012809.104638. [PubMed:20415579 ]
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HMDBP02972 | Pyrroline-5-carboxylate reductase 3 | Q53H96 | PYCRL | 8q24.3 | Unknown | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
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HMDBP03037 | Proline synthase co-transcribed bacterial homolog protein | O94903 | PROSC | 8p11.2 | Enzyme | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
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HMDBP03153 | Pyrroline-5-carboxylate reductase | Q4W8W1 | P5CR2 | | Enzyme | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
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HMDBP03259 | Sodium-dependent proline transporter | Q99884 | SLC6A7 | 5q32 | Unknown | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
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HMDBP03302 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | Q9UN76 | SLC6A14 | | Unknown | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
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HMDBP05340 | Monocarboxylate transporter 10 | Q8TF71 | SLC16A10 | 6q21-q22 | Transporter | - Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. [PubMed:11278508 ]
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HMDBP05360 | Probable proline dehydrogenase 2 | Q9UF12 | PRODH2 | 19q13.1 | Unknown | Not Available |
HMDBP08080 | Transient receptor potential cation channel subfamily M member 1 | Q7Z4N2 | TRPM1 | 15q13.3 | Unknown | Not Available |
HMDBP08681 | Prolyl 3-hydroxylase 1 | Q32P28 | LEPRE1 | 1p34.1 | Unknown | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
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HMDBP08682 | Prolyl 3-hydroxylase 2 | Q8IVL5 | LEPREL1 | 3q28 | Unknown | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
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HMDBP08683 | Prolyl 3-hydroxylase 3 | Q8IVL6 | LEPREL2 | 12q13 | Unknown | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
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HMDBP09111 | Prolyl 4-hydroxylase subunit alpha-3 | Q7Z4N8 | P4HA3 | 11q13.4 | Enzyme | Not Available |
HMDBP09210 | Egl nine homolog 1 | Q9GZT9 | EGLN1 | 1q42.1 | Enzyme | Not Available |
HMDBP09211 | Egl nine homolog 2 | Q96KS0 | EGLN2 | 19q13.2 | Enzyme | Not Available |
HMDBP09212 | Egl nine homolog 3 | Q9H6Z9 | EGLN3 | 14q13.1 | Enzyme | Not Available |
HMDBP09213 | Transmembrane prolyl 4-hydroxylase | Q9NXG6 | P4HTM | 3p21.3 | Enzyme | Not Available |
HMDBP10688 | Trans-L-3-hydroxyproline dehydratase | Q96EM0 | L3HYPDH | 14q23.1 | Enzyme | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
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HMDBP10690 | Peptidyl-prolyl cis-trans isomerase F, mitochondrial | P30405 | PPIF | 10q22-q23 | Enzyme | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
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