HMDBP00012 | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | P11177 | PDHB | 3p21.1-p14.2 | Enzyme | - Kumar V, Rangaraj N, Shivaji S: Activity of pyruvate dehydrogenase A (PDHA) in hamster spermatozoa correlates positively with hyperactivation and is associated with sperm capacitation. Biol Reprod. 2006 Nov;75(5):767-77. Epub 2006 Jul 19. [PubMed:16855207 ]
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HMDBP00019 | Pyruvate carboxylase, mitochondrial | P11498 | PC | 11q13.4-q13.5 | Unknown | - Jitrapakdee S, Vidal-Puig A, Wallace JC: Anaplerotic roles of pyruvate carboxylase in mammalian tissues. Cell Mol Life Sci. 2006 Apr;63(7-8):843-54. [PubMed:16505973 ]
- Simpson NE, Khokhlova N, Oca-Cossio JA, Constantinidis I: Insights into the role of anaplerosis in insulin secretion: A 13C NMR study. Diabetologia. 2006 Jun;49(6):1338-48. Epub 2006 Mar 31. [PubMed:16575559 ]
- Jensen MV, Joseph JW, Ilkayeva O, Burgess S, Lu D, Ronnebaum SM, Odegaard M, Becker TC, Sherry AD, Newgard CB: Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion. J Biol Chem. 2006 Aug 4;281(31):22342-51. Epub 2006 Jun 1. [PubMed:16740637 ]
- Ikeda K, Yukihiro Hiraoka B, Iwai H, Matsumoto T, Mineki R, Taka H, Takamori K, Ogawa H, Yamakura F: Detection of 6-nitrotryptophan in proteins by Western blot analysis and its application for peroxynitrite-treated PC12 cells. Nitric Oxide. 2007 Feb;16(1):18-28. Epub 2006 May 4. [PubMed:16765071 ]
- Liu L, Li Y, Zhu Y, Du G, Chen J: Redistribution of carbon flux in Torulopsis glabrata by altering vitamin and calcium level. Metab Eng. 2007 Jan;9(1):21-9. Epub 2006 Aug 12. [PubMed:17008113 ]
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HMDBP00046 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | P08559 | PDHA1 | Xp22.1 | Enzyme | Not Available |
HMDBP00050 | Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial | P29803 | PDHA2 | 4q22-q23 | Enzyme | Not Available |
HMDBP00054 | Dihydrolipoyl dehydrogenase, mitochondrial | P09622 | DLD | 7q31-q32 | Unknown | Not Available |
HMDBP00055 | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial | P10515 | DLAT | 11q23.1 | Enzyme | Not Available |
HMDBP00206 | D-amino-acid oxidase | P14920 | DAO | 12q24 | Unknown | Not Available |
HMDBP00248 | 4-aminobutyrate aminotransferase, mitochondrial | P80404 | ABAT | 16p13.2 | Enzyme | - Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
- Andersen G, Andersen B, Dobritzsch D, Schnackerz KD, Piskur J: A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast. FEBS J. 2007 Apr;274(7):1804-17. Epub 2007 Mar 12. [PubMed:17355287 ]
- Schmidt C, Hofmann U, Kohlmuller D, Murdter T, Zanger UM, Schwab M, Hoffmann GF: Comprehensive analysis of pyrimidine metabolism in 450 children with unspecific neurological symptoms using high-pressure liquid chromatography-electrospray ionization tandem mass spectrometry. J Inherit Metab Dis. 2005;28(6):1109-22. [PubMed:16435204 ]
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HMDBP00396 | Alanine--glyoxylate aminotransferase 2, mitochondrial | Q9BYV1 | AGXT2 | 5p13 | Enzyme | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
- Tamaki N, Fujimoto S, Mizota C, Kaneko M, Kikugawa M: Inhibitory effect of 6-azauracil on beta-alanine metabolism in rat. J Nutr Sci Vitaminol (Tokyo). 1989 Oct;35(5):451-61. [PubMed:2632679 ]
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HMDBP00420 | S-adenosylmethionine decarboxylase proenzyme | P17707 | AMD1 | 6q21 | Unknown | Not Available |
HMDBP00464 | Kynurenine--oxoglutarate transaminase 1 | Q16773 | CCBL1 | 9q34.11 | Enzyme | Not Available |
HMDBP00538 | Cystathionine gamma-lyase | P32929 | CTH | 1p31.1 | Enzyme | Not Available |
HMDBP00671 | L-serine dehydratase/L-threonine deaminase | P20132 | SDS | 12q24.13 | Enzyme | Not Available |
HMDBP00704 | Adenylate cyclase type 7 | P51828 | ADCY7 | 16q12.1 | Unknown | Not Available |
HMDBP00705 | Adenylate cyclase type 4 | Q8NFM4 | ADCY4 | 14q12 | Unknown | Not Available |
HMDBP00706 | Adenylate cyclase type 6 | O43306 | ADCY6 | 12q12-q13 | Unknown | Not Available |
HMDBP00707 | Adenylate cyclase type 5 | O95622 | ADCY5 | 3q21.1 | Unknown | Not Available |
HMDBP00708 | Adenylate cyclase type 8 | P40145 | ADCY8 | 8q24 | Unknown | Not Available |
HMDBP00709 | Adenylate cyclase type 9 | O60503 | ADCY9 | 16p13.3 | Unknown | Not Available |
HMDBP00710 | Adenylate cyclase type 3 | O60266 | ADCY3 | 2p23.3 | Unknown | Not Available |
HMDBP00711 | Adenylate cyclase type 1 | Q08828 | ADCY1 | 7p13-p12 | Unknown | Not Available |
HMDBP00763 | Pyruvate kinase isozymes M1/M2 | P14618 | PKM | 15q22 | Unknown | - Stetak A, Veress R, Ovadi J, Csermely P, Keri G, Ullrich A: Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death. Cancer Res. 2007 Feb 15;67(4):1602-8. [PubMed:17308100 ]
- Li Y, Chang Y, Zhang L, Feng Q, Liu Z, Zhang Y, Zuo J, Meng Y, Fang F: High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2). Mol Cell Biochem. 2005 Sep;277(1-2):117-25. [PubMed:16132722 ]
- Vlaeminck-Guillem V, Safi R, Guillem P, Leteurtre E, Duterque-Coquillaud M, Laudet V: Thyroid hormone receptor expression in the obligatory paedomorphic salamander Necturus maculosus. Int J Dev Biol. 2006;50(6):553-60. [PubMed:16741870 ]
- Weinberger R, Appel B, Stein A, Metz Y, Neheman A, Barak M: The pyruvate kinase isoenzyme M2 (Tu M2-PK) as a tumour marker for renal cell carcinoma. Eur J Cancer Care (Engl). 2007 Jul;16(4):333-7. [PubMed:17587357 ]
- Staib P, Hoffmann M, Schinkothe T: Plasma levels of tumor M2-pyruvate kinase should not be used as a tumor marker for hematological malignancies and solid tumors. Clin Chem Lab Med. 2006;44(1):28-31. [PubMed:16375581 ]
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HMDBP00765 | Pyruvate kinase isozymes R/L | P30613 | PKLR | 1q21 | Unknown | - Percy MJ, van Wijk R, Haggan S, Savage GA, Boyd K, Dempsey S, Hamilton J, Kettle P, Kyle A, Shepherd CW, van Solinge WW, Lappin TR, McMullin MF: Pyruvate kinase deficient hemolytic anemia in the Northern Irish population. Blood Cells Mol Dis. 2007 Sep-Oct;39(2):189-94. Epub 2007 Jun 15. [PubMed:17574881 ]
- Meza NW, Quintana-Bustamante O, Puyet A, Rio P, Navarro S, Diez A, Bueren JA, Bautista JM, Segovia JC: In vitro and in vivo expression of human erythrocyte pyruvate kinase in erythroid cells: a gene therapy approach. Hum Gene Ther. 2007 Jun;18(6):502-14. [PubMed:17547515 ]
- Rajaseger G, Lim CL, Lee KW, Arjunan P, Jia L, Moochhala S: Profiling of hepatocellular proteins by 1D PAGE-MALDI/MS/MS in a rat heat stress model. Front Biosci. 2006 Sep 1;11:2924-8. [PubMed:16720364 ]
- Xu J, Christian B, Jump DB: Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist. J Biol Chem. 2006 Jul 7;281(27):18351-62. Epub 2006 Apr 27. [PubMed:16644726 ]
- Suzuki T, Kawamoto M, Murai A, Muramatsu T: Identification of the regulatory region of the L-type pyruvate kinase gene in mouse liver by hydrodynamics-based gene transfection. J Nutr. 2006 Jan;136(1):16-20. [PubMed:16365052 ]
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HMDBP00781 | 3-mercaptopyruvate sulfurtransferase | P25325 | MPST | 22q13.1 | Enzyme | Not Available |
HMDBP00789 | Serine--pyruvate aminotransferase | P21549 | AGXT | 2q37.3 | Unknown | Not Available |