Record Information |
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Version | 5.0 |
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Status | Detected and Quantified |
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Creation Date | 2005-11-16 15:48:42 UTC |
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Update Date | 2022-03-07 02:49:03 UTC |
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HMDB ID | HMDB0000495 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | Androstanediol |
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Description | Androstanediol is a metabolite of dihydrotestosterone, itself a metabolite of testosterone. Androstanediol is implicated in the regulation of gonadotropin secretion. As a metabolite of dihydroxytestosterone formed in the peripheral tissues, androstanediol and androstnediol-glucuronide can be used to estimate peripheral androgen activity. Androstanediol is a potential GABA (A) receptor-modulating neurosteroid with anticonvulsant properties and hence could act as a key neuromodulator in the central nervous system. It is considered that androstanediol has hedonic effects; therefore it is anticipated that androgens that are readily metabolized to androstanediol may have higher abuse potential than androgens that are not as easily metabolized to androstanediol. These results add to the growing literature indicating that athletes and non-athletes may be at considerable risk when they abuse androgens. (PMID: 11500254 , 16040068 , 11744084 ). |
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Structure | [H][C@@]12CCC(O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@H](O)CC[C@]12C InChI=1S/C19H32O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-17,20-21H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,17?,18-,19-/m0/s1 |
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Synonyms | Value | Source |
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Androstane-3,17-diol | KEGG | 3-a-Androstanediol | HMDB | 3-alpha-Androstanediol | HMDB | 3alpha-Androstanediol | HMDB | 5 a-Androstane-3 a, 17 b-diol | HMDB | 5 alpha-Androstane-3 alpha, 17 beta-diol | HMDB | 5-a-Androstane-3-a, 17-b-diol | HMDB | 5-alpha-Androstan-3-alpha,17-beta-diol | HMDB | 5-alpha-Androstane-3-a, 17-beta-diol | HMDB | 5-alpha-Androstane-3-alpha-17-beta-diol | HMDB | 5 Androstane 3,17 diol | MeSH, HMDB | 5 alpha Androstane 3 alpha,17 beta diol | MeSH, HMDB | 5 alpha Androstane 3 beta,17 alpha diol | MeSH, HMDB | 5 alpha Androstane 3 beta,17 beta diol | MeSH, HMDB | 5 alpha Androstane 3alpha,17 beta diol | MeSH, HMDB | 5 alpha-Androstane-3 alpha,17 beta-diol | MeSH, HMDB | 5 alpha-Androstane-3 beta,17 alpha-diol | MeSH, HMDB | 5 alpha-Androstane-3 beta,17 beta-diol | MeSH, HMDB | 5 alpha-Androstane-3alpha,17 beta-diol | MeSH, HMDB | 5 beta Androstane 3 alpha,17 beta diol | MeSH, HMDB | 5 beta-Androstane-3 alpha,17 beta-diol | MeSH, HMDB | 5-Androstane-3,17-diol | MeSH, HMDB | 5alpha Androstane 3beta,17alpha diol | MeSH, HMDB | 5alpha-Androstane-3beta,17alpha-diol | MeSH, HMDB | Androstane 3,17 diol | MeSH, HMDB |
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Chemical Formula | C19H32O2 |
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Average Molecular Weight | 292.4562 |
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Monoisotopic Molecular Weight | 292.240230268 |
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IUPAC Name | (1S,2S,5R,7S,10R,11S,15S)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-5,14-diol |
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Traditional Name | (1S,2S,5R,7S,10R,11S,15S)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-5,14-diol |
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CAS Registry Number | 25126-76-5 |
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SMILES | [H][C@@]12CCC(O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@H](O)CC[C@]12C |
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InChI Identifier | InChI=1S/C19H32O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-17,20-21H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,17?,18-,19-/m0/s1 |
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InChI Key | CBMYJHIOYJEBSB-UNPXRYTGSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as phosphatidylcholines. These are glycerophosphocholines in which the two free -OH are attached to one fatty acid each through an ester linkage. |
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Kingdom | Organic compounds |
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Super Class | Lipids and lipid-like molecules |
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Class | Glycerophospholipids |
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Sub Class | Glycerophosphocholines |
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Direct Parent | Phosphatidylcholines |
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Alternative Parents | |
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Substituents | - Diacylglycero-3-phosphocholine
- Phosphocholine
- Fatty acid ester
- Dialkyl phosphate
- Dicarboxylic acid or derivatives
- Organic phosphoric acid derivative
- Phosphoric acid ester
- Alkyl phosphate
- Fatty acyl
- Quaternary ammonium salt
- Tetraalkylammonium salt
- Carboxylic acid ester
- Carboxylic acid derivative
- Organic oxygen compound
- Organic nitrogen compound
- Carbonyl group
- Organooxygen compound
- Organonitrogen compound
- Organic oxide
- Organopnictogen compound
- Amine
- Organic salt
- Hydrocarbon derivative
- Aliphatic acyclic compound
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Molecular Framework | Aliphatic acyclic compounds |
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External Descriptors | Not Available |
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Ontology |
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Physiological effect | Not Available |
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Disposition | |
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Process | |
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Role | |
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Physical Properties |
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State | Solid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | |
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatizedDerivatizedDerivative Name / Structure | SMILES | Kovats RI Value | Column Type | Reference |
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Androstanediol,1TMS,isomer #1 | C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CCC2O[Si](C)(C)C | 2596.8 | Semi standard non polar | 33892256 | Androstanediol,1TMS,isomer #2 | C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O[Si](C)(C)C)CC[C@@]43C)[C@@H]1CCC2O | 2582.8 | Semi standard non polar | 33892256 | Androstanediol,2TMS,isomer #1 | C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O[Si](C)(C)C)CC[C@@]43C)[C@@H]1CCC2O[Si](C)(C)C | 2601.9 | Semi standard non polar | 33892256 | Androstanediol,1TBDMS,isomer #1 | CC(C)(C)[Si](C)(C)OC1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C | 2876.1 | Semi standard non polar | 33892256 | Androstanediol,1TBDMS,isomer #2 | CC(C)(C)[Si](C)(C)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CCC(O)[C@@]4(C)CC[C@@H]32)C1 | 2839.6 | Semi standard non polar | 33892256 | Androstanediol,2TBDMS,isomer #1 | CC(C)(C)[Si](C)(C)OC1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O[Si](C)(C)C(C)(C)C)CC[C@]4(C)[C@H]3CC[C@]12C | 3155.6 | Semi standard non polar | 33892256 |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - Androstanediol GC-MS (Non-derivatized) - 70eV, Positive | splash10-03gi-0290000000-ef7ce05726cbec3a35bd | 2017-09-01 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Androstanediol GC-MS (2 TMS) - 70eV, Positive | splash10-05fr-2237900000-35be1627cada18777db8 | 2017-10-06 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Androstanediol GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Androstanediol GC-MS (TMS_1_1) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Androstanediol GC-MS (TMS_1_2) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Androstanediol GC-MS (TBDMS_1_1) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Androstanediol GC-MS (TBDMS_1_2) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Androstanediol GC-MS (TBDMS_2_1) - 70eV, Positive | Not Available | 2021-11-05 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Androstanediol 10V, Positive-QTOF | splash10-004l-0090000000-22d60c19836ea8b4c291 | 2016-08-02 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Androstanediol 20V, Positive-QTOF | splash10-056r-0390000000-edb0fb77b27575b4b729 | 2016-08-02 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Androstanediol 40V, Positive-QTOF | splash10-00mk-2980000000-cd6eafa93f3164ed780a | 2016-08-02 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Androstanediol 10V, Negative-QTOF | splash10-0006-0090000000-bc689c3cdfdf044c011e | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Androstanediol 20V, Negative-QTOF | splash10-006x-0090000000-bfbc140857bbdb62bcff | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Androstanediol 40V, Negative-QTOF | splash10-06vm-1290000000-bced1e06a8686f3501af | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Androstanediol 10V, Negative-QTOF | splash10-0006-0090000000-11452f48ce72555f1f28 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Androstanediol 20V, Negative-QTOF | splash10-0006-0090000000-11452f48ce72555f1f28 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Androstanediol 40V, Negative-QTOF | splash10-000l-0090000000-ac9e93370094e8aebfa1 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Androstanediol 10V, Positive-QTOF | splash10-002f-0090000000-36f4d97265b0d994d628 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Androstanediol 20V, Positive-QTOF | splash10-052b-3940000000-b87bad8b672cc5fb32b0 | 2021-09-22 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Androstanediol 40V, Positive-QTOF | splash10-0aos-3900000000-0f8ce10c286f165d6e0f | 2021-09-22 | Wishart Lab | View Spectrum |
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- Klemm W, Liebich HM, Gupta D: Plasma levels of 5alpha-androstane-3alpha,17beta-diol in boys during adolescent growth. J Clin Endocrinol Metab. 1976 Mar;42(3):514-9. [PubMed:1254692 ]
- Frye CA, Park D, Tanaka M, Rosellini R, Svare B: The testosterone metabolite and neurosteroid 3alpha-androstanediol may mediate the effects of testosterone on conditioned place preference. Psychoneuroendocrinology. 2001 Oct;26(7):731-50. [PubMed:11500254 ]
- Reddy DS, Venkatarangan L, Chien B, Ramu K: A high-performance liquid chromatography-tandem mass spectrometry assay of the androgenic neurosteroid 3alpha-androstanediol (5alpha-androstane-3alpha,17beta-diol) in plasma. Steroids. 2005 Dec 1;70(13):879-85. Epub 2005 Jul 22. [PubMed:16040068 ]
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