Showing metabocard for beta-D-Glucose (HMDB0000516)

General function:

Involved in ATP binding

Specific function:

Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.

Gene Name:

GCK

Uniprot ID:

P35557

Molecular weight:

52191.07

Reactions

General function:

Involved in ATP binding

Specific function:

Not Available

Gene Name:

HK3

Uniprot ID:

P52790

Molecular weight:

99024.56

Reactions

General function:

Involved in ATP binding

Specific function:

Not Available

Gene Name:

HK2

Uniprot ID:

P52789

Molecular weight:

102379.06

Reactions

General function:

Involved in ATP binding

Specific function:

Not Available

Gene Name:

HK1

Uniprot ID:

P19367

Molecular weight:

102485.1

Reactions

General function:

Involved in 6-phosphogluconolactonase activity

Specific function:

Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.

Gene Name:

H6PD

Uniprot ID:

O95479

Molecular weight:

88891.99

Reactions

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

LPH splits lactose in the small intestine.

Gene Name:

LCT

Uniprot ID:

P09848

Molecular weight:

218584.77

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).

Gene Name:

ADPGK

Uniprot ID:

Q9BRR6

Molecular weight:

53960.185

Reactions

General function:

Involved in catalytic activity

Specific function:

Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.

Gene Name:

TREH

Uniprot ID:

O43280

Molecular weight:

66567.26

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.

Gene Name:

UGT1A1

Uniprot ID:

P22309

Molecular weight:

59590.91

Reactions

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.

Gene Name:

GLB1

Uniprot ID:

P16278

Molecular weight:

Not Available