Showing metabocard for Flavin Mononucleotide (HMDB0001520)

General function:

Involved in acid phosphatase activity

Specific function:

Not Available

Gene Name:

ACP2

Uniprot ID:

P11117

Molecular weight:

48343.92

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.

Gene Name:

ACP1

Uniprot ID:

P24666

Molecular weight:

18042.315

Reactions

General function:

Involved in hydrolase activity

Specific function:

Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

Gene Name:

ACP5

Uniprot ID:

P13686

Molecular weight:

36598.47

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.

Gene Name:

ACPP

Uniprot ID:

P15309

Molecular weight:

44565.715

Reactions

General function:

Involved in catalytic activity

Specific function:

Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.

Gene Name:

ENPP1

Uniprot ID:

P22413

Molecular weight:

104923.58

Reactions

General function:

Involved in iron ion binding

Specific function:

Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol.

Gene Name:

SC5DL

Uniprot ID:

O75845

Molecular weight:

35300.55

General function:

Involved in oxidoreductase activity

Specific function:

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

Gene Name:

POR

Uniprot ID:

P16435

Molecular weight:

77047.575

References

1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

General function:

Involved in catalytic activity

Specific function:

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Gene Name:

DHODH

Uniprot ID:

Q02127

Molecular weight:

42866.93

References

1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Gene Name:

NDUFV1

Uniprot ID:

P49821

Molecular weight:

49867.66

General function:

Involved in catalytic activity

Specific function:

Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD (By similarity).

Gene Name:

ENPP3

Uniprot ID:

O14638

Molecular weight:

100123.54

Reactions