Human Metabolome Database Version 3.5

Showing metabocard for 3-O-Sulfogalactosylceramide (d18:1/24:0) (HMDB00024)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:07:46 -0700
HMDB ID HMDB00024
Secondary Accession Numbers None
Metabolite Identification
Common Name 3-O-Sulfogalactosylceramide (d18:1/24:0)
Description 3-O-Sulfogalactosylceramide is an acidic, sulfated glycosphingolipid, often known as sulfatide. This lipid occurs in membranes of various cell types, but is found in particularly high concentrations in myelin where it constitutes 3-4% of total membrane lipids. This lipid is synthesized primarily in the oligodendrocytes in the central nervous system. Accumulation of this lipid in the lysosomes is a characteristic of metachromatic leukodystrophy, a lysosomal storage disease caused by the deficiency of arylsulfatase A. Alterations in sulfatide metabolism, trafficking, and homeostasis are present in the earliest clinically recognizable stages of Alzheimer's disease. Cerebrosides are glycosphingolipids. There are four types of glycosphingolipids, the cerebrosides, sulfatides, globosides and gangliosides. Cerebrosides have a single sugar group linked to ceramide. The most common are galactocerebrosides (containing galactose), the least common are glucocerebrosides (containing glucose). Galactocerebrosides are found predominantly in neuronal cell membranes. In contrast glucocerebrosides are not normally found in membranes. Instead, they are typically intermediates in the synthesis or degradation of more complex glycosphingolipids. Galactocerebrosides are synthesized from ceramide and UDP-galactose. Excess lysosomal accumulation of glucocerebrosides is found in Gaucher disease. Sulfatides are glycosphingolipids. There are four types of glycosphingolipids, the cerebrosides, sulfatides, globosides and gangliosides. Sulfatides are the sulfuric acid esters of galactocerebrosides. They are synthesized from galactocerebrosides and activated sulfate, 3'-phosphoadenosine 5'-phosphosulfate (PAPS).
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. 3'-O-Sulphogalactosylceramide
  2. 3-O-Sulfo-beta-D-galactosylceramide
  3. 3-O-Sulfo-beta-delta-galactosylceramide
  4. 3-O-Sulfogalactosylceramide
  5. 3-O-Sulphogalactosylceramide
  6. Cerebroside 3-sulfate
  7. Cerebroside 3-sulphate
  8. Galactosylceramide-sulfate
  9. Galactosylceramide-sulphate
  10. Galactosylceramidesulfate
  11. Galactosylceramidesulphate
  12. N-[(1S,2R,3E)-2-Hydroxy-1-[[(3-O-sulfo-b-D-galactopyranosyl)oxy]methyl]-3-heptadecen-1-yl]-Tetracosanamide
  13. N-[(1S,2R,3E)-2-Hydroxy-1-[[(3-O-sulfo-b-D-galactopyranosyl)oxy]methyl]-3-heptadecenyl]-Tetracosanamide
  14. N-[(1S,2R,3E)-2-Hydroxy-1-[[(3-O-sulfo-beta-delta-galactopyranosyl)oxy]methyl]-3-heptadecen-1-yl]-Tetracosanamide
  15. N-[(1S,2R,3E)-2-Hydroxy-1-[[(3-O-sulfo-beta-delta-galactopyranosyl)oxy]methyl]-3-heptadecenyl]-Tetracosanamide
  16. Sulfatide
  17. Sulfatide (d18:1/24:0)
  18. [R-[R*,S*-(E)]]-N-[2-hydroxy-1-[[(3-O-sulfo-b-D-galactopyranosyl)oxy]methyl]-3-heptadecenyl]-Tetracosanamide
  19. [R-[R*,S*-(E)]]-N-[2-hydroxy-1-[[(3-O-sulfo-beta-delta-galactopyranosyl)oxy]methyl]-3-heptadecenyl]-Tetracosanamide
Chemical Formula C48H93NO11S
Average Molecular Weight 892.317
Monoisotopic Molecular Weight 891.646933513
IUPAC Name [(2R,3R,4S,5S,6R)-3,5-dihydroxy-2-{[(2S,3R,4E)-3-hydroxy-2-tetracosanamidooctadec-4-en-1-yl]oxy}-6-(hydroxymethyl)oxan-4-yl]oxidanesulfonic acid
Traditional IUPAC Name [(2R,3R,4S,5S,6R)-3,5-dihydroxy-2-{[(2S,3R,4E)-3-hydroxy-2-tetracosanamidooctadec-4-en-1-yl]oxy}-6-(hydroxymethyl)oxan-4-yl]oxidanesulfonic acid
CAS Registry Number 151122-71-3
SMILES CCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](OS(O)(=O)=O)[C@H]1O)[C@H](O)\C=C\CCCCCCCCCCCCC
InChI Identifier InChI=1S/C48H93NO11S/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-44(52)49-41(42(51)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2)40-58-48-46(54)47(60-61(55,56)57)45(53)43(39-50)59-48/h35,37,41-43,45-48,50-51,53-54H,3-34,36,38-40H2,1-2H3,(H,49,52)(H,55,56,57)/b37-35+/t41-,42+,43+,45-,46+,47-,48+/m0/s1
InChI Key MEAZTWJVOWHKJM-CIAPRIGGSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Lipids
Class Sphingolipids
Sub Class Sulfatides
Other Descriptors
  • Aliphatic Heteromonocyclic Compounds
Substituents
  • Acetal
  • Alkyl Glycoside
  • Allyl Alcohol
  • Carboxamide Group
  • Ceramide
  • Fatty Acyl Glycoside
  • Glycosyl Compound
  • Hexose Monosaccharide
  • N Acyl Amine
  • O Glycosyl Compound
  • Organic Sulfuric Acid Monoester
  • Oxane
  • Primary Alcohol
  • Saccharide
  • Secondary Alcohol
  • Secondary Carboxylic Acid Amide
  • Sulfate Ester
Direct Parent Sulfatides
Ontology
Status Detected and Quantified
Origin
  • Endogenous
  • Food
Biofunction
  • Cell signaling
  • Component of Glycosphingolipid metabolism
  • Fuel and energy storage
  • Fuel or energy source
  • Membrane integrity/stability
Application
  • Nutrients
  • Stabilizers
  • Surfactants and Emulsifiers
Cellular locations
  • Extracellular
  • Membrane
  • Lysosome
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility 2.090E-04 g/L ALOGPS
LogP 6.01 ALOGPS
LogP 10.65 ChemAxon
LogS -6.63 ALOGPS
pKa (strongest acidic) -1.9 ChemAxon
pKa (strongest basic) 0.025 ChemAxon
Hydrogen Acceptor Count 10 ChemAxon
Hydrogen Donor Count 6 ChemAxon
Polar Surface Area 192.08 A2 ChemAxon
Rotatable Bond Count 43 ChemAxon
Refractivity 244.99 ChemAxon
Polarizability 111.22 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -1 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
  • Lysosome
Biofluid Locations
  • Urine
Tissue Location
  • Kidney
  • Brain
  • Myelin
Pathways
Name SMPDB Link KEGG Link
Sphingolipid Metabolism SMP00034 map00500 Link_out
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Urine Detected and Quantified
0.205 (0.07-0.34) umol/mmol creatinine Adult (>18 years old) Both Normal
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Urine Detected and Quantified 12.7 (1.2-24.2) umol/mmol creatinine Adult (>18 years old) Both Metachromatic Leukodystrophy (MLD)
Associated Disorders and Diseases
Disease References
Metachromatic leukodystrophy
  • Natowicz MR, Prence EM, Chaturvedi P, Newburg DS: Urine sulfatides and the diagnosis of metachromatic leukodystrophy. Clin Chem. 1996 Feb;42(2):232-8. Pubmed: 8595716 Link_out
      Associated OMIM IDs
      • 250100 Link_out (Metachromatic leukodystrophy)
      DrugBank ID Not Available
      DrugBank Metabolite ID Not Available
      Phenol Explorer Compound ID Not Available
      Phenol Explorer Metabolite ID Not Available
      FoodDB ID FDB021878
      KNApSAcK ID Not Available
      Chemspider ID 4953605 Link_out
      KEGG Compound ID C06125 Link_out
      BioCyc ID GALACTOSYLCERAMIDE-SULFATE Link_out
      BiGG ID Not Available
      Wikipedia Link Sulfatide Link_out
      NuGOwiki Link HMDB00024 Link_out
      Metagene Link HMDB00024 Link_out
      METLIN ID 5096 Link_out
      PubChem Compound 6451121 Link_out
      PDB ID Not Available
      ChEBI ID 60361 Link_out
      References
      Synthesis Reference Hakomori, Senichiro; Ishimoda, Taiko; Nakamura, Kiyoshi. Separation and characterization of two sulfatides of brain. Journal of Biochemistry (Tokyo, Japan) (1962), 52 468-9.
      Material Safety Data Sheet (MSDS) Not Available
      General References
      1. Wenger DA, DeGala G, Williams C, Taylor HA, Stevenson RE, Pruitt JR, Miller J, Garen PD, Balentine JD: Clinical, pathological, and biochemical studies on an infantile case of sulfatide/GM1 activator protein deficiency. Am J Med Genet. 1989 Jun;33(2):255-65. Pubmed: 2764035 Link_out
      2. Tamaoki A, Kikkawa Y: [The role of sulfatides in autoimmunity in children with various glomerular disease] Nippon Jinzo Gakkai Shi. 1991 Nov;33(11):1045-54. Pubmed: 1808356 Link_out
      3. Eto Y, Kawame H, Hasegawa Y, Ohashi T, Ida H, Tokoro T: Molecular characteristics in Japanese patients with lipidosis: novel mutations in metachromatic leukodystrophy and Gaucher disease. Mol Cell Biochem. 1993 Feb 17;119(1-2):179-84. Pubmed: 8455580 Link_out
      4. Monti E, Preti A, Novati A, Aleo MF, Clemente ML, Marchesini S: Uptake and metabolism of a fluorescent sulfatide analogue in cultured skin fibroblasts. Biochim Biophys Acta. 1992 Feb 20;1124(1):80-7. Pubmed: 1543730 Link_out
      5. Tsaioun KI: Vitamin K-dependent proteins in the developing and aging nervous system. Nutr Rev. 1999 Aug;57(8):231-40. Pubmed: 10518409 Link_out
      6. Nobile-Orazio E, Manfredini E, Carpo M, Meucci N, Monaco S, Ferrari S, Bonetti B, Cavaletti G, Gemignani F, Durelli L, et al.: Frequency and clinical correlates of anti-neural IgM antibodies in neuropathy associated with IgM monoclonal gammopathy. Ann Neurol. 1994 Sep;36(3):416-24. Pubmed: 8080249 Link_out
      7. Natowicz MR, Prence EM, Chaturvedi P, Newburg DS: Urine sulfatides and the diagnosis of metachromatic leukodystrophy. Clin Chem. 1996 Feb;42(2):232-8. Pubmed: 8595716 Link_out
      8. Hulyalkar AR, Nora R, Manowitz P: Arylsulfatase A variants in patients with alcoholism. Alcohol Clin Exp Res. 1984 May-Jun;8(3):337-41. Pubmed: 6146271 Link_out
      9. Marchesini S, Preti A, Aleo MF, Casella A, Dagan A, Gatt S: Synthesis, spectral properties and enzymatic hydrolysis of fluorescent derivatives of cerebroside sulfate containing long-wavelength-emission probes. Chem Phys Lipids. 1990 Mar;53(2-3):165-75. Pubmed: 1970953 Link_out
      10. Cheng H, Xu J, McKeel DW Jr, Han X: Specificity and potential mechanism of sulfatide deficiency in Alzheimer's disease: an electrospray ionization mass spectrometric study. Cell Mol Biol (Noisy-le-grand). 2003 Jul;49(5):809-18. Pubmed: 14528918 Link_out
      11. Guchhait P, Lopez JA, Thiagarajan P: Characterization of autoantibodies against sulfatide from a V-gene phage-display library derived from patients with systemic lupus erythematosus. J Immunol Methods. 2004 Dec;295(1-2):129-37. Epub 2004 Oct 26. Pubmed: 15627618 Link_out
      12. Eto Y, Tahara T, Koda N, Yamaguchi S, Ito F, Okuno A: Prenatal diagnosis of metachromatic leukodystrophy: a diagnosis by amniotic fluid and its confirmation. Arch Neurol. 1982 Jan;39(1):29-32. Pubmed: 6119972 Link_out
      13. Inui K, Wenger DA: Concentrations of an activator protein for sphingolipid hydrolysis in liver and brain samples from patients with lysosomal storage diseases. J Clin Invest. 1983 Nov;72(5):1622-8. Pubmed: 6415115 Link_out
      14. Li YT, Muhiudeen IA, DeGasperi R, Hirabayashi Y, Li SC: Presence of activator proteins for the enzymic hydrolysis of GM1 and GM2 gangliosides in normal human urine. Am J Hum Genet. 1983 Jul;35(4):629-34. Pubmed: 6881139 Link_out
      15. Matzner U, Herbst E, Hedayati KK, Lullmann-Rauch R, Wessig C, Schroder S, Eistrup C, Moller C, Fogh J, Gieselmann V: Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy. Hum Mol Genet. 2005 May 1;14(9):1139-52. Epub 2005 Mar 16. Pubmed: 15772092 Link_out

      Enzymes

      Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 71 enzymes in total.

      Name: Galactocerebrosidase
      Reactions: Not Available
      Gene Name: GALC
      Uniprot ID: P54803 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Arylsulfatase D
      Reactions: Not Available
      Gene Name: ARSD
      Uniprot ID: P51689 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Galactosylceramide sulfotransferase
      Reactions: Not Available
      Gene Name: GAL3ST1
      Uniprot ID: Q99999 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Arylsulfatase A
      Reactions: Not Available
      Gene Name: ARSA
      Uniprot ID: P15289 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Arylsulfatase E
      Reactions: Not Available
      Gene Name: ARSE
      Uniprot ID: P51690 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
      Reactions: Not Available
      Gene Name: GBGT1
      Uniprot ID: Q8N5D6 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
      Reactions: Not Available
      Gene Name: PIGL
      Uniprot ID: Q9Y2B2 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Sphingomyelin phosphodiesterase
      Reactions: Not Available
      Gene Name: SMPD1
      Uniprot ID: P17405 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Ceramide glucosyltransferase
      Reactions: Not Available
      Gene Name: UGCG
      Uniprot ID: Q16739 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Lactosylceramide 4-alpha-galactosyltransferase
      Reactions: Not Available
      Gene Name: A4GALT
      Uniprot ID: Q9NPC4 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
      Reactions: Not Available
      Gene Name: PIGQ
      Uniprot ID: Q9BRB3 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
      Reactions: Not Available
      Gene Name: PIGA
      Uniprot ID: P37287 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
      Reactions: Not Available
      Gene Name: PIGH
      Uniprot ID: Q14442 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
      Reactions: Not Available
      Gene Name: PIGP
      Uniprot ID: P57054 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
      Reactions: Not Available
      Gene Name: PIGC
      Uniprot ID: Q92535 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Acid ceramidase
      Reactions: Not Available
      Gene Name: ASAH1
      Uniprot ID: Q13510 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
      Reactions: Not Available
      Gene Name: ENPP7
      Uniprot ID: Q6UWV6 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Sphingomyelin phosphodiesterase 2
      Reactions: Not Available
      Gene Name: SMPD2
      Uniprot ID: O60906 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Collagen type IV alpha-3-binding protein
      Reactions: Not Available
      Gene Name: COL4A3BP
      Uniprot ID: Q9Y5P4 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Proactivator polypeptide
      Reactions: Not Available
      Gene Name: PSAP
      Uniprot ID: P07602 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Ganglioside GM2 activator
      Reactions: Not Available
      Gene Name: GM2A
      Uniprot ID: P17900 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Myelin basic protein
      Reactions: Not Available
      Gene Name: MBP
      Uniprot ID: P02686 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Glucosylceramidase
      Reactions: Not Available
      Gene Name: GBA
      Uniprot ID: P04062 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: P-selectin
      Reactions: Not Available
      Gene Name: SELP
      Uniprot ID: P16109 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: L-selectin
      Reactions: Not Available
      Gene Name: SELL
      Uniprot ID: P14151 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: T-cell surface glycoprotein CD1e, membrane-associated
      Reactions: Not Available
      Gene Name: CD1E
      Uniprot ID: P15812 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Epididymal secretory protein E1
      Reactions: Not Available
      Gene Name: NPC2
      Uniprot ID: P61916 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Ceramide synthase 1
      Reactions: Not Available
      Gene Name: CERS1
      Uniprot ID: P27544 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Antigen-presenting glycoprotein CD1d
      Reactions: Not Available
      Gene Name: CD1D
      Uniprot ID: P15813 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: ADAMTS-like protein 1
      Reactions: Not Available
      Gene Name: ADAMTSL1
      Uniprot ID: Q8N6G6 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: GPI mannosyltransferase 1
      Reactions: Not Available
      Gene Name: PIGM
      Uniprot ID: Q9H3S5 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol-glycan biosynthesis class W protein
      Reactions: Not Available
      Gene Name: PIGW
      Uniprot ID: Q7Z7B1 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol-glycan biosynthesis class X protein
      Reactions: Not Available
      Gene Name: PIGX
      Uniprot ID: Q8TBF5 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: GPI mannosyltransferase 4
      Reactions: Not Available
      Gene Name: PIGZ
      Uniprot ID: Q86VD9 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
      Reactions: Not Available
      Gene Name: B3GNT5
      Uniprot ID: Q9BYG0 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Sphingomyelin phosphodiesterase 3
      Reactions: Not Available
      Gene Name: SMPD3
      Uniprot ID: Q9NY59 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Beta-1,3-galactosyltransferase 5
      Reactions: Not Available
      Gene Name: B3GALT5
      Uniprot ID: Q9Y2C3 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Beta-1,4-galactosyltransferase 6
      Reactions: Not Available
      Gene Name: B4GALT6
      Uniprot ID: Q9UBX8 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: GPI mannosyltransferase 3
      Reactions: Not Available
      Gene Name: PIGB
      Uniprot ID: Q92521 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol-glycan biosynthesis class F protein
      Reactions: Not Available
      Gene Name: PIGF
      Uniprot ID: Q07326 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: GPI ethanolamine phosphate transferase 2
      Reactions: Not Available
      Gene Name: PIGG
      Uniprot ID: Q5H8A4 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: GPI ethanolamine phosphate transferase 1
      Reactions: Not Available
      Gene Name: PIGN
      Uniprot ID: O95427 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: GPI ethanolamine phosphate transferase 3
      Reactions: Not Available
      Gene Name: PIGO
      Uniprot ID: Q8TEQ8 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: GPI transamidase component PIG-S
      Reactions: Not Available
      Gene Name: PIGS
      Uniprot ID: Q96S52 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: GPI transamidase component PIG-T
      Reactions: Not Available
      Gene Name: PIGT
      Uniprot ID: Q969N2 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol glycan anchor biosynthesis class U protein
      Reactions: Not Available
      Gene Name: PIGU
      Uniprot ID: Q9H490 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: GPI mannosyltransferase 2
      Reactions: Not Available
      Gene Name: PIGV
      Uniprot ID: Q9NUD9 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
      Reactions: Not Available
      Gene Name: PIGY
      Uniprot ID: Q3MUY2 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Pleckstrin homology domain-containing family A member 8
      Reactions: Not Available
      Gene Name: PLEKHA8
      Uniprot ID: Q96JA3 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Sphingomyelin phosphodiesterase 4
      Reactions: Not Available
      Gene Name: SMPD4
      Uniprot ID: Q9NXE4 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA