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Record Information
StatusDetected and Quantified
Creation Date2006-08-13 12:56:35 UTC
Update Date2019-01-11 19:17:56 UTC
Secondary Accession Numbers
  • HMDB04143
Metabolite Identification
Common NameTantalum
DescriptionTantalum is a transition metal (atomic number 73; atomic weight 180.05) that remains relatively inert in vivo. Dating back to the mid-1900s multiple medical devices have been fabricated that utilize this material, including: pacemaker electrodes, foil and mesh for nerve repair, radiopaque markers, and cranioplasty plates. Tantalum-based implants have displayed an exceptional biocompatibility and safety record in orthopedic, cranio-facial, and dentistry literature. The basic structure of this porous tantalum metal yields a high volumetric porosity, a low modulus of elasticity, and relatively high frictional characteristics. Tantalum is known to be relatively inert in vivo and is now used as plates, sutures, radio-markers, and prostheses covering a wide variety of medical subspecialties and procedures. Dental implants have yielded excellent 8-year follow-up with tantalum-based components used for osseous anchorage. The oxide formed on the surface of tantalum implants (self-passivation) in vivo has been found to be quite stable over a wide range of pH and potential ranges. On high-resolution examination, titanium was found to have no multi-nucleated macrophages in the tissue surrounding the metallic implant, while tantalum implants displayed an occasional peri-implant macrophage. Physiologically, it exists as an ion in the body. Overall porous tantalum is corrosion resistant, may be associated with less peri-implant stress shielding, and has the potential to allow for immediate weight bearing (given its high frictional characteristics). These inherent properties and proven biocompatibility make porous tantalum an intriguing metal for the design and manufacture of: press-fit or cementless components for total joint arthroplasty, bone graft substitute, or a scaffold for potential cartilage resurfacing. (PMID: 16737737 ).
Tantalum elementalHMDB
Tantalum metalHMDB
Tantalum metal and oxide dustHMDB
Chemical FormulaTa
Average Molecular Weight180.9479
Monoisotopic Molecular Weight180.947996346
IUPAC Nametantalum(5+) ion
Traditional Nametantalum(5+) ion
CAS Registry Number7440-25-7
InChI Identifier
Chemical Taxonomy
DescriptionThis compound belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous transition metal compounds
Sub ClassNot Available
Direct ParentHomogeneous transition metal compounds
Alternative ParentsNot Available
  • Homogeneous transition metal
Molecular FrameworkNot Available
External DescriptorsNot Available

Route of exposure:

Biological location:


Physical Properties
Experimental Properties
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
Physiological Charge5ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
SpectraNot Available
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue LocationsNot Available
Normal Concentrations
BloodExpected but not Quantified Not AvailableNot Available
    Cerebrospinal Fluid (CSF)Detected and Quantified0.002 +/- 0.0009 uMAdult (>18 years old)Not SpecifiedNormal details
    Cerebrospinal Fluid (CSF)Detected and Quantified0.0005 +/- 0.0004 uMAdult (>18 years old)BothNormal details
    UrineDetected and Quantified0.00020 (0.00004-0.00074) umol/mmol creatinineAdult (>18 years old)Both
    UrineDetected and Quantified0.00008 ± 0.00006 umol/mmol creatinineAdult (>18 years old)BothNormal details
    Abnormal Concentrations
    Not Available
    Associated Disorders and Diseases
    Disease ReferencesNone
    Associated OMIM IDsNone
    DrugBank IDNot Available
    Phenol Explorer Compound IDNot Available
    FoodDB IDFDB003787
    KNApSAcK IDNot Available
    Chemspider ID3726905
    KEGG Compound IDNot Available
    BioCyc IDNot Available
    BiGG IDNot Available
    Wikipedia LinkTantalum
    METLIN IDNot Available
    PubChem Compound4532223
    PDB IDNot Available
    ChEBI ID33348
    Synthesis ReferenceNot Available
    Material Safety Data Sheet (MSDS)Download (PDF)
    General References
    1. Levine BR, Sporer S, Poggie RA, Della Valle CJ, Jacobs JJ: Experimental and clinical performance of porous tantalum in orthopedic surgery. Biomaterials. 2006 Sep;27(27):4671-81. Epub 2006 Jun 5. [PubMed:16737737 ]