Human Metabolome Database Version 3.5

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Showing metabocard for Adenosine monophosphate (HMDB00045)

enzymes (225)

Blood
Urine

Record Information

Version

3.5

Creation Date

2005-11-16 08:48:42 -0700

Update Date

2013-02-08 17:07:48 -0700

HMDB ID

HMDB00045

Secondary Accession Numbers

None

Metabolite Identification

Common Name

Adenosine monophosphate

Description

Adenosine monophosphate, also known as 5'-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. It is an ester of phosphoric acid with the nucleoside adenosine. AMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase adenine. AMP can be produced during ATP synthesis by the enzyme adenylate kinase. AMP has recently been approved as a 'Bitter Blocker' additive to foodstuffs. When AMP is added to bitter foods or foods with a bitter aftertaste it makes them seem 'sweeter'. This potentially makes lower calorie food products more palatable.

Structure

Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure

Synonyms

5'-Adenosine monophosphate
5'-Adenylate
5'-Adenylic acid
5'-AMP
Adenosine 5'-monophosphate
Adenosine 5'-phosphate
Adenosine 5'-phosphorate
Adenosine 5'-phosphoric acid
Adenosine phosphate
Adenosine-5'-monophosphorate
Adenosine-5'-monophosphoric acid
Adenosine-5-monophosphorate
Adenosine-5-monophosphoric acid
Adenosine-monophosphate
Adenosine-phosphate
Adenovite
Adenylate
Adenylic acid
AMP
Cardiomone
Lycedan
Muscle adenylate
Muscle adenylic acid
My-B-Den
My-beta-Den
Phosaden
Phosphaden
Phosphentaside

Chemical Formula

C₁₀H₁₄N₅O₇P

Average Molecular Weight

347.2212

Monoisotopic Molecular Weight

347.063084339

IUPAC Name

{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

Traditional IUPAC Name

[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxyphosphonic acid

CAS Registry Number

61-19-8

SMILES

NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O

InChI Identifier

InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

InChI Key

UDMBCSSLTHHNCD-KQYNXXCUSA-N

Chemical Taxonomy

Kingdom

Organic Compounds

Super Class

Nucleosides, Nucleotides, and Analogues

Class

Purine Nucleotides

Sub Class

Purine Ribonucleotides

Other Descriptors

Aromatic Heteropolycyclic Compounds
Ribonucleotides(KEGG)
adenosine 5'-phosphate(ChEBI)
purine ribonucleoside 5'-monophosphate(ChEBI)

Substituents

1,2 Diol
1 Phosphoribosyl Imidazole
Aminopyrimidine
Glycosyl Compound
Imidazole
Imidazopyrimidine
Monosaccharide Phosphate
N Glycosyl Compound
Organic Hypophosphite
Organic Phosphite
Oxolane
Pentose Monosaccharide
Phosphoric Acid Ester
Purine
Pyrimidine
Saccharide
Secondary Alcohol

Direct Parent

Purine Ribonucleoside Monophosphates

Ontology

Status

Detected and Quantified

Origin

Endogenous

Biofunction

Component of Alanine and aspartate metabolism
Component of Aminoacyl-tRNA biosynthesis
Component of Arginine and proline metabolism
Component of Biotin metabolism
Component of Fatty acid metabolism
Component of Glutamate metabolism
Component of Glycine, serine and threonine metabolism
Component of Histidine metabolism
Component of Lysine biosynthesis
Component of Methionine metabolism
Component of Nitrogen metabolism
Component of Phenylalanine, tyrosine and tryptophan biosynthesis
Component of Porphyrin and chlorophyll metabolism
Component of Propanoate metabolism
Component of Purine metabolism
Component of Pyrimidine metabolism
Component of Pyruvate metabolism
Component of Selenoamino acid metabolism
Component of Sulfur metabolism
Component of Thiamine metabolism
Component of Tryptophan metabolism
Component of Valine, leucine and isoleucine biosynthesis

Application

Not Available

Cellular locations

Extracellular
Mitochondria
Nucleus
Lysosome
Endoplasmic reticulum
Golgi apparatus
Peroxisome

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	195 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	10 mg/mL at 20 °C	BEILSTEIN
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	3.31 g/L	ALOGPS
LogP	-3.13	ALOGPS
LogP	-4.8	ChemAxon
LogS	-2.02	ALOGPS
pKa (strongest acidic)	1.23	ChemAxon
pKa (strongest basic)	4.97	ChemAxon
Hydrogen Acceptor Count	10	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	186.07 A²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	74.07	ChemAxon
Polarizability	29.65	ChemAxon
Formal Charge	0	ChemAxon
Physiological Charge	-2	ChemAxon

Spectra

1H NMR Spectrum

MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)

[1H,1H] 2D NMR Spectrum

[1H,13C] 2D NMR Spectrum

Biological Properties

Cellular Locations

Extracellular
Mitochondria
Nucleus
Lysosome
Endoplasmic reticulum
Golgi apparatus
Peroxisome

Biofluid Locations

Blood
Cellular Cytoplasm
Cerebrospinal Fluid (CSF)
Urine

Tissue Location

All Tissues

Pathways

Name	SMPDB Link	KEGG Link
Transcription/Translation	SMP00019	Not Available
Purine Metabolism	SMP00050	map00230
Urea Cycle	SMP00059	map00330
Histidine Metabolism	SMP00044	map00340
Ethanol Degradation	SMP00449	Not Available
Ammonia Recycling	SMP00009	map00910
Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids	SMP00480	Not Available
Glycine and Serine Metabolism	SMP00004	map00260
Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids	SMP00482	Not Available
Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids	SMP00481	Not Available

Normal Concentrations

Biofluid	Status	Value	Age	Sex	Condition	Comments
Blood	Detected and Quantified	5.1+/- 1.3 uM	Adult (>18 years old)	Female	Normal	Not Available
Blood	Detected and Quantified	51.0 (10.0-92.0) uM	Adult (>18 years old)	Both	Normal	Not Available
Blood	Detected and Quantified	14.0 +/- 3.0 uM	Adult (>18 years old)	Male	Normal	Not Available
Blood	Detected and Quantified	6.2 +/- 3.1 uM	Adult (>18 years old)	Male	Normal	Not Available
Cellular Cytoplasm	Detected and Quantified	80.0 (71.0-89.0) uM	Children (1-13 year old)	Both	Normal	Not Available
Cellular Cytoplasm	Detected and Quantified	23 uM	Children (1-13 year old)	Both	Normal	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	< 0.2 uM	Adult (>18 years old)	Both	Normal	Not Available
Urine	Detected and not Quantified	Not Applicable	Adult (>18 years old)	Male	Normal	Not Available

Abnormal Concentrations

Not Available

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

Phenol Explorer Metabolite ID

Not Available

FoodDB ID

FDB021806

KNApSAcK ID

Not Available

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

Adenosine monophosphate Link_out

NuGOwiki Link

Metagene Link

METLIN ID

PubChem Compound

PDB ID

ChEBI ID

16027

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Download (PDF)

General References

Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2(1):18. Pubmed: 15882454
BISHOP C, RANKINE DM, TALBOTT JH: The nucleotides in normal human blood. J Biol Chem. 1959 May;234(5):1233-7. Pubmed: 13654353
Lin CY, Ishida M: Elevation of cAMP levels in cerebrospinal fluid of patients with neonatal meningitis. Pediatrics. 1983 Jun;71(6):932-4. Pubmed: 6304612
Pagani R, Tabucchi A, Carlucci F, Leoncini R, Consolmagno E, Molinelli M, Valerio P: Some aspects of purine nucleotide metabolism in human lymphocytes before and after infection with HIV-1 virus: nucleotide content. Adv Exp Med Biol. 1991;309B:43-6. Pubmed: 1781403
Drezner MK, Neelon FA, Curtis HB, Lebovitz HE: Renal cyclic adenosine monophosphate: an accurate index of parathyroid function. Metabolism. 1976 Oct;25(10):1103-12. Pubmed: 184364
Aschenbach WG, Sakamoto K, Goodyear LJ: 5' adenosine monophosphate-activated protein kinase, metabolism and exercise. Sports Med. 2004;34(2):91-103. Pubmed: 14965188
Subramanian GM, Cronin PW, Poley G, Weinstein A, Stoughton SM, Zhong J, Ou Y, Zmuda JF, Osborn BL, Freimuth WW: A phase 1 study of PAmAb, a fully human monoclonal antibody against Bacillus anthracis protective antigen, in healthy volunteers. Clin Infect Dis. 2005 Jul 1;41(1):12-20. Epub 2005 May 24. Pubmed: 15937757
Aurbach GD: Genetic disorders involving parathyroid hormone and calcitonin. Birth Defects Orig Artic Ser. 1971 May;7(6):48-54. Pubmed: 4155962
Eells JT, Spector R: Purine and pyrimidine base and nucleoside concentrations in human cerebrospinal fluid and plasma. Neurochem Res. 1983 Nov;8(11):1451-7. Pubmed: 6656991
Post RM, Cramer H, Goodwin FK: Cyclic AMP in cerebrospinal fluid of manic and depressive patients. Psychol Med. 1977 Nov;7(4):599-605. Pubmed: 201957

Enzymes

Name:	Cytosolic 5'-nucleotidase 1B
Reactions:	a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate [RN:R07297]
Gene Name:	NT5C1B
Uniprot ID:	Q96P26
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytosolic 5'-nucleotidase 1A
Reactions:	a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate [RN:R07297]
Gene Name:	NT5C1A
Uniprot ID:	Q9BXI3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	5'(3')-deoxyribonucleotidase, cytosolic type
Reactions:
Gene Name:	NT5C
Uniprot ID:	Q8TCD5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Deoxycytidine kinase
Reactions:	NTP + deoxycytidine = NDP + dCMP [RN:R02321]
Gene Name:	DCK
Uniprot ID:	P27707
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	5'(3')-deoxyribonucleotidase, mitochondrial
Reactions:
Gene Name:	NT5M
Uniprot ID:	Q9NPB1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acetyl-coenzyme A synthetase 2-like, mitochondrial
Reactions:	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA [RN:R00235]
Gene Name:	ACSS1
Uniprot ID:	Q9NUB1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleoside triphosphate diphosphohydrolase 1
Reactions:	ATP + 2 H2O = AMP + 2 phosphate [RN:R00085]
Gene Name:	ENTPD1
Uniprot ID:	P49961
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Soluble calcium-activated nucleotidase 1
Reactions:	a nucleoside diphosphate + H2O = a nucleotide + phosphate [RN:R00329]
Gene Name:	CANT1
Uniprot ID:	Q8WVQ1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleoside triphosphate diphosphohydrolase 3
Reactions:	ATP + 2 H2O = AMP + 2 phosphate [RN:R00085]
Gene Name:	ENTPD3
Uniprot ID:	O75355
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serum paraoxonase/lactonase 3
Reactions:	an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol [RN:R03979]
Gene Name:	PON3
Uniprot ID:	Q15166
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Reactions:	a dinucleotide + H2O = 2 mononucleotides [RN:R00056]
Gene Name:	ENPP1
Uniprot ID:	P22413
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Reactions:	a dinucleotide + H2O = 2 mononucleotides [RN:R00056]
Gene Name:	ENPP3
Uniprot ID:	O14638
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phenylalanyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe [RN:R03660]
Gene Name:	FARS2
Uniprot ID:	O95363
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	3'(2'),5'-bisphosphate nucleotidase 1
Reactions:	adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate [RN:R00188]
Gene Name:	BPNT1
Uniprot ID:	O95861
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ADP-dependent glucokinase
Reactions:	ADP + D-glucose = AMP + D-glucose 6-phosphate [RN:R05804]
Gene Name:	ADPGK
Uniprot ID:	Q9BRR6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glycogen phosphorylase, liver form
Reactions:	[(1->4)-alpha-D-glucosyl]n + phosphate = [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate [RN:R01821 R06050]
Gene Name:	PYGL
Uniprot ID:	P06737
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glycogen phosphorylase, muscle form
Reactions:	[(1->4)-alpha-D-glucosyl]n + phosphate = [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate [RN:R01821 R06050]
Gene Name:	PYGM
Uniprot ID:	P11217
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glycogen phosphorylase, brain form
Reactions:	[(1->4)-alpha-D-glucosyl]n + phosphate = [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate [RN:R01821 R06050]
Gene Name:	PYGB
Uniprot ID:	P11216
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenine phosphoribosyltransferase
Reactions:	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R00190]
Gene Name:	APRT
Uniprot ID:	P07741
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Hypoxanthine-guanine phosphoribosyltransferase
Reactions:	IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01132]
Gene Name:	HPRT1
Uniprot ID:	P00492
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Biotin--protein ligase
Reactions:	ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)] [RN:R04562]
Gene Name:	HLCS
Uniprot ID:	P50747
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phenylalanyl-tRNA synthetase beta chain
Reactions:	ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe [RN:R03660]
Gene Name:	FARSB
Uniprot ID:	Q9NSD9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 A
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2A
Uniprot ID:	P49459
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE6H
Uniprot ID:	Q13956
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylate kinase isoenzyme 1
Reactions:	ATP + AMP = 2 ADP [RN:R00127]
Gene Name:	AK1
Uniprot ID:	P00568
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NEDD8-conjugating enzyme Ubc12
Reactions:
Gene Name:	UBE2M
Uniprot ID:	P61081
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin/ISG15-conjugating enzyme E2 L6
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2L6
Uniprot ID:	O14933
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glycyl-tRNA synthetase
Reactions:	ATP + glycine + tRNAGly = AMP + diphosphate + glycyl-tRNAGly [RN:R03654]
Gene Name:	GARS
Uniprot ID:	P41250
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ribose-phosphate pyrophosphokinase 3
Reactions:	ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01049]
Gene Name:	PRPS1L1
Uniprot ID:	P21108
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bifunctional aminoacyl-tRNA synthetase
Reactions:	ATP + L-glutamate + tRNAGlu = AMP + diphosphate + L-glutamyl-tRNAGlu [RN:R05578]
Gene Name:	EPRS
Uniprot ID:	P07814
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Long-chain-fatty-acid--CoA ligase 4
Reactions:	ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name:	ACSL4
Uniprot ID:	O60488
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE1A
Uniprot ID:	P54750
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	GTP:AMP phosphotransferase, mitochondrial
Reactions:	nucleoside triphosphate + AMP = nucleoside diphosphate + ADP [RN:R00333]
Gene Name:	AK3
Uniprot ID:	Q9UIJ7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tryptophanyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-tryptophan + tRNATrp = AMP + diphosphate + L-tryptophyl-tRNATrp [RN:R03664]
Gene Name:	WARS
Uniprot ID:	P23381
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE8A
Uniprot ID:	O60658
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE1B
Uniprot ID:	Q01064
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Long-chain-fatty-acid--CoA ligase 1
Reactions:	ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name:	ACSL1
Uniprot ID:	P33121
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE3B
Uniprot ID:	Q13370
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 G1
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2G1
Uniprot ID:	P62253
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutaminyl-tRNA synthetase
Reactions:	ATP + L-glutamine + tRNAGln = AMP + diphosphate + L-glutaminyl-tRNAGln [RN:R03652]
Gene Name:	QARS
Uniprot ID:	P47897
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Threonyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-threonine + tRNAThr = AMP + diphosphate + L-threonyl-tRNAThr [RN:R03663]
Gene Name:	TARS
Uniprot ID:	P26639
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Asparagine synthetase [glutamine-hydrolyzing]
Reactions:	(1) ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate [RN:R00578] (2) (1a) L-glutamine + H2O = L-glutamate + NH3 [RN:R00256] (3) (1b) ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine [RN:R00483]
Gene Name:	ASNS
Uniprot ID:	P08243
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 E2
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2E2
Uniprot ID:	Q96LR5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylosuccinate lyase
Reactions:	(1) N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP [RN:R01083] (2) (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [RN:R04559]
Gene Name:	ADSL
Uniprot ID:	P30566
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylate kinase isoenzyme 4, mitochondrial
Reactions:	ATP + AMP = 2 ADP [RN:R00127]
Gene Name:	AK4
Uniprot ID:	P27144
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 D2
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2D2
Uniprot ID:	P62837
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA ligase 4
Reactions:	ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m [RN:R00381]
Gene Name:	LIG4
Uniprot ID:	P49917
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Arginyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-arginine + tRNAArg = AMP + diphosphate + L-arginyl-tRNAArg [RN:R03646]
Gene Name:	RARS
Uniprot ID:	P54136
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	GMP synthase [glutamine-hydrolyzing]
Reactions:	ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate [RN:R01231]
Gene Name:	GMPS
Uniprot ID:	P49915
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 E3
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2E3
Uniprot ID:	Q969T4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 B
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2B
Uniprot ID:	P63146
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable leucyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-leucine + tRNALeu = AMP + diphosphate + L-leucyl-tRNALeu [RN:R03657]
Gene Name:	LARS2
Uniprot ID:	Q15031
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	AMP deaminase 3
Reactions:	AMP + H2O = IMP + NH3 [RN:R00181]
Gene Name:	AMPD3
Uniprot ID:	Q01432
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 J2
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2J2
Uniprot ID:	Q8N2K1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	AMP deaminase 2
Reactions:	AMP + H2O = IMP + NH3 [RN:R00181]
Gene Name:	AMPD2
Uniprot ID:	Q01433
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cGMP-inhibited 3',5'-cyclic phosphodiesterase A
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE3A
Uniprot ID:	Q14432
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 L3
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2L3
Uniprot ID:	P68036
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	RNA 3'-terminal phosphate cyclase
Reactions:	ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate [RN:R04274]
Gene Name:	RTCD1
Uniprot ID:	O00442
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative adenylate kinase 7
Reactions:	ATP + AMP = 2 ADP [RN:R00127]
Gene Name:	AK7
Uniprot ID:	Q96M32
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Reactions:	guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate [RN:R01234]
Gene Name:	PDE10A
Uniprot ID:	Q9Y233
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE1C
Uniprot ID:	Q14123
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-tyrosine + tRNATyr = AMP + diphosphate + L-tyrosyl-tRNATyr [RN:R02918]
Gene Name:	YARS
Uniprot ID:	P54577
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA ligase 3
Reactions:	ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m [RN:R00381]
Gene Name:	LIG3
Uniprot ID:	P49916
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aspartyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp [RN:R05577]
Gene Name:	DARS
Uniprot ID:	P14868
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE4B
Uniprot ID:	Q07343
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 D3
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2D3
Uniprot ID:	P61077
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Asparaginyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-asparagine + tRNAAsn = AMP + diphosphate + L-asparaginyl-tRNAAsn [RN:R03648]
Gene Name:	NARS
Uniprot ID:	O43776
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE7B
Uniprot ID:	Q9NP56
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lysyl-tRNA synthetase
Reactions:	ATP + L-lysine + tRNALys = AMP + diphosphate + L-lysyl-tRNALys [RN:R03658]
Gene Name:	KARS
Uniprot ID:	Q15046
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Isoleucyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle [RN:R03656]
Gene Name:	IARS
Uniprot ID:	P41252
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bis(5'-adenosyl)-triphosphatase
Reactions:	P1,P3-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP [RN:R00187]
Gene Name:	FHIT
Uniprot ID:	P49789
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Reactions:	guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate [RN:R01234]
Gene Name:	PDE9A
Uniprot ID:	O76083
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cGMP-dependent 3',5'-cyclic phosphodiesterase
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE2A
Uniprot ID:	O00408
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-like modifier-activating enzyme 1
Reactions:
Gene Name:	UBA1
Uniprot ID:	P22314
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-tyrosine + tRNATyr = AMP + diphosphate + L-tyrosyl-tRNATyr [RN:R02918]
Gene Name:	YARS2
Uniprot ID:	Q9Y2Z4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 E1
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2E1
Uniprot ID:	P51965
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
Reactions:	P1,P4-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP [RN:R01232]
Gene Name:	NUDT2
Uniprot ID:	P50583
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Long-chain-fatty-acid--CoA ligase 6
Reactions:	ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name:	ACSL6
Uniprot ID:	Q9UKU0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Methionyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet [RN:R03659]
Gene Name:	MARS
Uniprot ID:	P56192
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alanyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-alanine + tRNAAla = AMP + diphosphate + L-alanyl-tRNAAla [RN:R03038]
Gene Name:	AARS
Uniprot ID:	P49588
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tryptophanyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-tryptophan + tRNATrp = AMP + diphosphate + L-tryptophyl-tRNATrp [RN:R03664]
Gene Name:	WARS2
Uniprot ID:	Q9UGM6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ADP-sugar pyrophosphatase
Reactions:	ADP-ribose + H2O = AMP + D-ribose 5-phosphate [RN:R01054]
Gene Name:	NUDT5
Uniprot ID:	Q9UKK9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ribose-phosphate pyrophosphokinase 1
Reactions:	ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01049]
Gene Name:	PRPS1
Uniprot ID:	P60891
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Seryl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer [RN:R03662]
Gene Name:	SARS2
Uniprot ID:	Q9NP81
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE8B
Uniprot ID:	O95263
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE4C
Uniprot ID:	Q08493
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ribose-phosphate pyrophosphokinase 2
Reactions:	ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01049]
Gene Name:	PRPS2
Uniprot ID:	P11908
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	SUMO-conjugating enzyme UBC9
Reactions:
Gene Name:	UBE2I
Uniprot ID:	P63279
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE4D
Uniprot ID:	Q08499
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE6G
Uniprot ID:	P18545
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenosine kinase
Reactions:	ATP + adenosine = ADP + AMP [RN:R00185]
Gene Name:	ADK
Uniprot ID:	P55263
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Reactions:
Gene Name:	PDE6D
Uniprot ID:	O43924
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable histidyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis [RN:R03655]
Gene Name:	HARS2
Uniprot ID:	P49590
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 J1
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2J1
Uniprot ID:	Q9Y385
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Long-chain-fatty-acid--CoA ligase 5
Reactions:	ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name:	ACSL5
Uniprot ID:	Q9ULC5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Histidyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis [RN:R03655]
Gene Name:	HARS
Uniprot ID:	P12081
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Seryl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer [RN:R03662]
Gene Name:	SARS
Uniprot ID:	P49591
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Long-chain-fatty-acid--CoA ligase 3
Reactions:	ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name:	ACSL3
Uniprot ID:	O95573
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Leucyl-tRNA synthetase, cytoplasmic
Reactions:	ATP + L-leucine + tRNALeu = AMP + diphosphate + L-leucyl-tRNALeu [RN:R03657]
Gene Name:	LARS
Uniprot ID:	Q9P2J5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 C
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2C
Uniprot ID:	O00762
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE4A
Uniprot ID:	P27815
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Valyl-tRNA synthetase
Reactions:	ATP + L-valine + tRNAVal = AMP + diphosphate + L-valyl-tRNAVal [RN:R03665]
Gene Name:	VARS
Uniprot ID:	P26640
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylate kinase isoenzyme 5
Reactions:	ATP + AMP = 2 ADP [RN:R00127]
Gene Name:	AK5
Uniprot ID:	Q9Y6K8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Selenide, water dikinase 1
Reactions:	ATP + selenide + H2O = AMP + selenophosphate + phosphate [RN:R03595]
Gene Name:	SEPHS1
Uniprot ID:	P49903
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 N
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2N
Uniprot ID:	P61088
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cGMP-specific 3',5'-cyclic phosphodiesterase
Reactions:	guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate [RN:R01234]
Gene Name:	PDE5A
Uniprot ID:	O76074
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Argininosuccinate synthase
Reactions:	ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate [RN:R01954]
Gene Name:	ASS1
Uniprot ID:	P00966
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	AMP deaminase 1
Reactions:	AMP + H2O = IMP + NH3 [RN:R00181]
Gene Name:	AMPD1
Uniprot ID:	P23109
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Selenide, water dikinase 2
Reactions:	ATP + selenide + H2O = AMP + selenophosphate + phosphate [RN:R03595]
Gene Name:	SEPHS2
Uniprot ID:	Q99611
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA ligase 1
Reactions:	ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m [RN:R00381]
Gene Name:	LIG1
Uniprot ID:	P18858
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylate cyclase type 1
Reactions:	ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
Gene Name:	ADCY1
Uniprot ID:	Q08828
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Histidine triad nucleotide-binding protein 1
Reactions:
Gene Name:	HINT1
Uniprot ID:	P49773
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cyclic AMP-responsive element-binding protein 1
Reactions:
Gene Name:	CREB1
Uniprot ID:	P16220
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase NEDD4-like
Reactions:
Gene Name:	NEDD4L
Uniprot ID:	Q96PU5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase Mdm2
Reactions:
Gene Name:	MDM2
Uniprot ID:	Q00987
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphopantothenoylcysteine synthetase
Reactions:	--- - CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine [RN:R04231]
Gene Name:	PPCS
Uniprot ID:	Q9HAB8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bile acyl-CoA synthetase
Reactions:	(1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA [RN:R02794] (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA [RN:R04580]
Gene Name:	SLC27A5
Uniprot ID:	Q9Y2P5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytosolic 5'-nucleotidase 3
Reactions:	a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate [RN:R07297]
Gene Name:	NT5C3
Uniprot ID:	Q9H0P0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutamine-dependent NAD(+) synthetase
Reactions:	ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate [RN:R00257]
Gene Name:	NADSYN1
Uniprot ID:	Q6IA69
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acetoacetyl-CoA synthetase
Reactions:	ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA [RN:R01357]
Gene Name:	AACS
Uniprot ID:	Q86V21
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-coenzyme A synthetase ACSM1, mitochondrial
Reactions:	ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
Gene Name:	ACSM1
Uniprot ID:	Q08AH1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Reactions:	guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate [RN:R01234]
Gene Name:	PDE11A
Uniprot ID:	Q9HCR9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable arginyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-arginine + tRNAArg = AMP + diphosphate + L-arginyl-tRNAArg [RN:R03646]
Gene Name:	RARS2
Uniprot ID:	Q5T160
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable cysteinyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-cysteine + tRNACys = AMP + diphosphate + L-cysteinyl-tRNACys [RN:R03650]
Gene Name:	CARS2
Uniprot ID:	Q9HA77
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable glutamyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-glutamate + tRNAGlu = AMP + diphosphate + L-glutamyl-tRNAGlu [RN:R05578]
Gene Name:	EARS2
Uniprot ID:	Q5JPH6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-CoA synthetase family member 4
Reactions:
Gene Name:	AASDH
Uniprot ID:	Q4L235
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal NADH pyrophosphatase NUDT12
Reactions:	NAD+ + H2O = AMP + NMN [RN:R00103]
Gene Name:	NUDT12
Uniprot ID:	Q9BQG2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ACSS2 protein
Reactions:
Gene Name:	ACSS2
Uniprot ID:	Q96FY7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Valyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-valine + tRNAVal = AMP + diphosphate + L-valyl-tRNAVal [RN:R03665]
Gene Name:	VARS2
Uniprot ID:	Q5ST30
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase CBL
Reactions:	--- []
Gene Name:	CBL
Uniprot ID:	P22681
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Signal transduction protein CBL-C
Reactions:
Gene Name:	CBLC
Uniprot ID:	Q9ULV8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleoside triphosphate diphosphohydrolase 8
Reactions:	ATP + 2 H2O = AMP + 2 phosphate [RN:R00085]
Gene Name:	ENTPD8
Uniprot ID:	Q5MY95
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable E3 ubiquitin-protein ligase HERC1
Reactions:
Gene Name:	HERC1
Uniprot ID:	Q15751
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase HERC2
Reactions:
Gene Name:	HERC2
Uniprot ID:	O95714
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nuclear respiratory factor 1
Reactions:
Gene Name:	NRF1
Uniprot ID:	Q16656
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable threonyl-tRNA synthetase 2, cytoplasmic
Reactions:	ATP + L-threonine + tRNAThr = AMP + diphosphate + L-threonyl-tRNAThr [RN:R03663]
Gene Name:	TARSL2
Uniprot ID:	A2RTX5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Threonyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-threonine + tRNAThr = AMP + diphosphate + L-threonyl-tRNAThr [RN:R03663]
Gene Name:	TARS2
Uniprot ID:	Q9BW92
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Methionyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet [RN:R03659]
Gene Name:	MARS2
Uniprot ID:	Q96GW9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aspartyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp [RN:R05577]
Gene Name:	DARS2
Uniprot ID:	Q6PI48
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cysteinyl-tRNA synthetase, isoform CRA_e
Reactions:	--- - ATP + L-cysteine + tRNACys = AMP + diphosphate + L-cysteinyl-tRNACys [RN:R03650]
Gene Name:	DKFZp686F1612
Uniprot ID:	P49589
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	FARSLA protein
Reactions:
Gene Name:	FARSLA
Uniprot ID:	Q6IBR2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable asparaginyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-asparagine + tRNAAsn = AMP + diphosphate + L-asparaginyl-tRNAAsn [RN:R03648]
Gene Name:	NARS2
Uniprot ID:	Q96I59
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	SUMO-activating enzyme subunit 2
Reactions:
Gene Name:	UBA2
Uniprot ID:	Q9UBT2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase HUWE1
Reactions:
Gene Name:	HUWE1
Uniprot ID:	Q7Z6Z7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase Topors
Reactions:
Gene Name:	TOPORS
Uniprot ID:	Q9NS56
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	STIP1 homology and U-box containing protein 1 (STIP1 homology and U- box containing protein 1, isoform CRA_c)
Reactions:
Gene Name:	STUB1
Uniprot ID:	Q9UNE7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin conjugation factor E4 B
Reactions:
Gene Name:	UBE4B
Uniprot ID:	O95155
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Membrane-associated ring finger (C3HC4) 6 (Membrane-associated ring finger (C3HC4) 6, isoform CRA_a)
Reactions:
Gene Name:	MARCH6
Uniprot ID:	O60337
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	TGIF-interacting ubiquitin ligase 1
Reactions:
Gene Name:	Not Available
Uniprot ID:	Q9H0M0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NEDD4-like E3 ubiquitin-protein ligase WWP2
Reactions:
Gene Name:	WWP2
Uniprot ID:	O00308
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH3
Reactions:
Gene Name:	MARCH3
Uniprot ID:	Q86UD3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NEDD8-conjugating enzyme UBE2F
Reactions:
Gene Name:	UBE2F
Uniprot ID:	Q969M7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 U
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2U
Uniprot ID:	Q5VVX9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable E3 ubiquitin-protein ligase MARCH10
Reactions:
Gene Name:	MARCH10
Uniprot ID:	Q8NA82
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase UBR1
Reactions:
Gene Name:	UBR1
Uniprot ID:	Q8IWV7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH8
Reactions:
Gene Name:	MARCH8
Uniprot ID:	Q5T0T0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase ZNRF2
Reactions:
Gene Name:	ZNRF2
Uniprot ID:	Q8NHG8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase TRIM32
Reactions:
Gene Name:	TRIM32
Uniprot ID:	Q13049
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable E3 ubiquitin-protein ligase MYCBP2
Reactions:
Gene Name:	MYCBP2
Uniprot ID:	O75592
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MGRN1
Reactions:
Gene Name:	MGRN1
Uniprot ID:	O60291
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase UBR2
Reactions:
Gene Name:	UBR2
Uniprot ID:	Q8IWV8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase UBR4
Reactions:
Gene Name:	UBR4
Uniprot ID:	Q5T4S7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase AMFR
Reactions:
Gene Name:	AMFR
Uniprot ID:	Q9UKV5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 S
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2S
Uniprot ID:	Q16763
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pre-mRNA-processing factor 19
Reactions:
Gene Name:	PRPF19
Uniprot ID:	Q9UMS4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Myosin regulatory light chain interacting protein (Myosin regulatory light chain interacting protein, isoform CRA_a)
Reactions:
Gene Name:	MYLIP
Uniprot ID:	Q8WY64
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	HNP95
Reactions:
Gene Name:	hNp95
Uniprot ID:	Q96T88
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative ubiquitin-conjugating enzyme E2 N-like
Reactions:
Gene Name:	UBE2NL
Uniprot ID:	Q5JXB2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Midline-1
Reactions:
Gene Name:	MID1
Uniprot ID:	O15344
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase NEDD4
Reactions:
Gene Name:	NEDD4
Uniprot ID:	P46934
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	CCR4-NOT transcription complex subunit 4
Reactions:
Gene Name:	CNOT4
Uniprot ID:	O95628
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH2
Reactions:
Gene Name:	MARCH2
Uniprot ID:	Q9P0N8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase UBR5
Reactions:
Gene Name:	UBR5
Uniprot ID:	O95071
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase TRIM33
Reactions:
Gene Name:	TRIM33
Uniprot ID:	Q9UPN9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH5
Reactions:
Gene Name:	MARCH5
Uniprot ID:	Q9NX47
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 R2
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2R2
Uniprot ID:	Q712K3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH1
Reactions:
Gene Name:	MARCH1
Uniprot ID:	Q8TCQ1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase FANCL
Reactions:
Gene Name:	FANCL
Uniprot ID:	Q9NW38
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-like modifier-activating enzyme 6
Reactions:
Gene Name:	UBA6
Uniprot ID:	A0AVT1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme 16
Reactions:
Gene Name:	UBE2W
Uniprot ID:	Q96B02
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Galactosyl transferase-associated protein
Reactions:
Gene Name:	GTAP
Uniprot ID:	Q29SN7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase CHFR
Reactions:
Gene Name:	CHFR
Uniprot ID:	Q96EP1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ring finger protein 20
Reactions:
Gene Name:	RNF20
Uniprot ID:	Q5VTR2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase RAD18
Reactions:
Gene Name:	RAD18
Uniprot ID:	Q9NS91
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin ligase SMURF1
Reactions:
Gene Name:	SMURF1
Uniprot ID:	Q9HCE7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Baculoviral IAP repeat-containing protein 6
Reactions:
Gene Name:	BIRC6
Uniprot ID:	Q9NR09
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH4
Reactions:
Gene Name:	MARCH4
Uniprot ID:	Q9P2E8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase CCNB1IP1
Reactions:
Gene Name:	CCNB1IP1
Uniprot ID:	Q9NPC3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase RNF5
Reactions:
Gene Name:	RNF5
Uniprot ID:	Q99942
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 O
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2O
Uniprot ID:	Q9C0C9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Praja 1
Reactions:
Gene Name:	PJA1
Uniprot ID:	A2A322
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	RFWD2 protein
Reactions:
Gene Name:	RFWD2
Uniprot ID:	Q05CT6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase SMURF2
Reactions:
Gene Name:	SMURF2
Uniprot ID:	Q9HAU4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase SIAH1
Reactions:
Gene Name:	SIAH1
Uniprot ID:	Q8IUQ4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase SIAH2
Reactions:
Gene Name:	SIAH2
Uniprot ID:	O43255
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH7
Reactions:
Gene Name:	MARCH7
Uniprot ID:	Q9H992
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 Z
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2Z
Uniprot ID:	Q9H832
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-like modifier-activating enzyme 7
Reactions:
Gene Name:	UBA7
Uniprot ID:	P41226
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin carrier protein
Reactions:
Gene Name:	UBE2H
Uniprot ID:	A4D1L5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-protein ligase E3A
Reactions:
Gene Name:	UBE3A
Uniprot ID:	Q05086
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase RNF128
Reactions:
Gene Name:	RNF128
Uniprot ID:	Q8TEB7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase TRIM11
Reactions:
Gene Name:	TRIM11
Uniprot ID:	Q96F44
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	BRCA1 associated protein variant
Reactions:
Gene Name:	Not Available
Uniprot ID:	Q59H81
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase synoviolin
Reactions:
Gene Name:	SYVN1
Uniprot ID:	Q86TM6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase TRIM63
Reactions:
Gene Name:	TRIM63
Uniprot ID:	Q969Q1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase LNX
Reactions:
Gene Name:	LNX1
Uniprot ID:	Q8TBB1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase ZNRF1
Reactions:
Gene Name:	ZNRF1
Uniprot ID:	Q8ND25
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tripartite motif-containing protein 5
Reactions:
Gene Name:	TRIM5
Uniprot ID:	Q9C035
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-protein ligase E3B
Reactions:
Gene Name:	UBE3B
Uniprot ID:	Q7Z3V4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase RNF8
Reactions:
Gene Name:	RNF8
Uniprot ID:	O76064
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase LRSAM1
Reactions:
Gene Name:	LRSAM1
Uniprot ID:	Q6UWE0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 Q2
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2Q2
Uniprot ID:	Q8WVN8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MARCH9
Reactions:
Gene Name:	MARCH9
Uniprot ID:	Q86YJ5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable E3 ubiquitin-protein ligase TRIP12
Reactions:
Gene Name:	TRIP12
Uniprot ID:	Q14669
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase DZIP3
Reactions:
Gene Name:	DZIP3
Uniprot ID:	Q86Y13
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-protein ligase E3C
Reactions:
Gene Name:	UBE3C
Uniprot ID:	Q15386
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Isoleucyl-tRNA synthetase, mitochondrial
Reactions:	ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle [RN:R03656]
Gene Name:	IARS2
Uniprot ID:	Q9NSE4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase MIB1
Reactions:
Gene Name:	MIB1
Uniprot ID:	Q86YT6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase RNF138
Reactions:
Gene Name:	RNF138
Uniprot ID:	Q8WVD3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase RING2
Reactions:
Gene Name:	RNF2
Uniprot ID:	Q99496
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Reactions:
Gene Name:	AASDHPPT
Uniprot ID:	Q9NRN7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	SUMO-activating enzyme subunit 1
Reactions:
Gene Name:	SAE1
Uniprot ID:	Q9UBE0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin-conjugating enzyme E2 D4
Reactions:	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876]
Gene Name:	UBE2D4
Uniprot ID:	Q9Y2X8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquitin conjugation factor E4 A
Reactions:
Gene Name:	UBE4A
Uniprot ID:	Q14139
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	E3 ubiquitin-protein ligase RNF144B
Reactions:
Gene Name:	RNF144B
Uniprot ID:	Q7Z419
Protein Sequence:	FASTA
Gene Sequence:	FASTA