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Record Information
StatusExpected but not Quantified
Creation Date2007-05-23 15:30:42 UTC
Update Date2019-01-11 19:19:24 UTC
Secondary Accession Numbers
  • HMDB06548
Metabolite Identification
Common NameEcgonine
DescriptionEcgonine is an organic chemical and tropane alkaloid found naturally in coca leaves. It is has a close structural relation to cocaine: it is both a metabolite and a precursor, and as such, it is a controlled substance, as are all known substances which can be used as precursors to ecgonine itself. Structurally, ecgonine is a cycloheptane derivative with a nitrogen bridge. It is obtained by hydrolysis of cocaine with acids or alkalis, and crystallizes with one molecule of water, the crystals melting at 198-199oC. It is levorotary, and on warming with alkalis gives iso-ecgonine, which is dextrorotary. It is a tertiary base, and has the properties of an acid and an alcohol. It is the carboxylic acid corresponding to tropine, for it yields the same products on oxidation, and by treatment with phosphorus pentachloride is converted into anhydroecgonine, C9H13NO2, which, when heated to 280oC with hydrochloric acid, eliminates carbon dioxide and yields tropidine, C8H13N.(Wikipedia).
(2R,3S)-3-Hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acidHMDB
3-b-Hydroxy-2-b-tropanecarboxylic acidHMDB
3-beta-Hydroxy-2-beta-tropanecarboxylic acidHMDB
Ecgonine acetate, (1R-(exo,exo))-isomerMeSH
Ecgonine hydrochlorideMeSH
Ecgonine, (1R-(2-endo,3-exo))-isomerMeSH
Chemical FormulaC9H15NO3
Average Molecular Weight185.2203
Monoisotopic Molecular Weight185.105193351
IUPAC Name(2R,3S)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid
Traditional Nameecgonine
CAS Registry Number481-37-8
InChI Identifier
Chemical Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as tropane alkaloids. These are organic compounds containing the nitrogenous bicyclic alkaloid parent N-Methyl-8-azabicyclo[3.2.1]octane.
KingdomOrganic compounds
Super ClassAlkaloids and derivatives
ClassTropane alkaloids
Sub ClassNot Available
Direct ParentTropane alkaloids
Alternative Parents
  • Piperidinecarboxylic acid
  • Tropane alkaloid
  • Beta-hydroxy acid
  • Hydroxy acid
  • Piperidine
  • N-alkylpyrrolidine
  • Cyclic alcohol
  • Pyrrolidine
  • Amino acid or derivatives
  • Amino acid
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary alcohol
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Azacycle
  • Organoheterocyclic compound
  • Amine
  • Organic oxide
  • Organopnictogen compound
  • Alcohol
  • Carbonyl group
  • Organonitrogen compound
  • Organooxygen compound
  • Hydrocarbon derivative
  • Organic nitrogen compound
  • Organic oxygen compound
  • Aliphatic heteropolycyclic compound
Molecular FrameworkAliphatic heteropolycyclic compounds
External Descriptors

Biological location:


Physical Properties
Experimental Properties
Melting Point205 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility178 mg/mLNot Available
LogPNot AvailableNot Available
Predicted Properties
Water Solubility1050 g/LALOGPS
pKa (Strongest Acidic)3.48ChemAxon
pKa (Strongest Basic)9.69ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area60.77 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity46.57 m³·mol⁻¹ChemAxon
Polarizability18.83 ųChemAxon
Number of Rings2ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectrum TypeDescriptionSplash KeyView
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-001j-9200000000-48c3b8ee572b2dc52292JSpectraViewer | MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positivesplash10-006t-9132000000-9a8887ca9dce4b08af81JSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-014r-0900000000-84cf8248e17a8b226247JSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0gb9-0900000000-ada9e3b58a4a68bf34feJSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0fk9-3900000000-4fe8aa09d75ccea8cb33JSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-007o-0900000000-c8352412d369827945bcJSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-00dl-0900000000-143c9c6dc9126fa654dcJSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-00dl-1900000000-cb49be4d17eb1921ff3eJSpectraViewer | MoNA
Biological Properties
Cellular Locations
  • Endoplasmic reticulum
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB023968
KNApSAcK IDC00002291
Chemspider ID391305
KEGG Compound IDC10858
BioCyc IDCPD-9777
BiGG ID2273742
Wikipedia LinkEcgonine
METLIN IDNot Available
PubChem Compound443003
PDB IDNot Available
ChEBI ID708641
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Valente MJ, Henrique R, Vilas-Boas V, Silva R, Bastos Mde L, Carvalho F, Guedes de Pinho P, Carvalho M: Cocaine-induced kidney toxicity: an in vitro study using primary cultured human proximal tubular epithelial cells. Arch Toxicol. 2012 Feb;86(2):249-61. doi: 10.1007/s00204-011-0749-3. Epub 2011 Oct 8. [PubMed:21983858 ]
  2. Yao D, Shi X, Wang L, Gosnell BA, Chen C: Characterization of differential cocaine metabolism in mouse and rat through metabolomics-guided metabolite profiling. Drug Metab Dispos. 2013 Jan;41(1):79-88. doi: 10.1124/dmd.112.048678. Epub 2012 Oct 3. [PubMed:23034697 ]
  3. Hezinova V, Aturki Z, Kleparnik K, D'Orazio G, Foret F, Fanali S: Simultaneous analysis of cocaine and its metabolites in urine by capillary electrophoresis-electrospray mass spectrometry using a pressurized liquid junction nanoflow interface. Electrophoresis. 2012 Feb;33(4):653-60. doi: 10.1002/elps.201100410. [PubMed:22451058 ]
  4. Brim RL, Noon KR, Collins GT, Nichols J, Narasimhan D, Sunahara RK, Woods JH: The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry. Mol Pharmacol. 2011 Dec;80(6):1119-27. doi: 10.1124/mol.111.074534. Epub 2011 Sep 1. [PubMed:21885621 ]
  5. van Nuijs AL, Abdellati K, Bervoets L, Blust R, Jorens PG, Neels H, Covaci A: The stability of illicit drugs and metabolites in wastewater, an important issue for sewage epidemiology? J Hazard Mater. 2012 Nov 15;239-240:19-23. doi: 10.1016/j.jhazmat.2012.04.030. Epub 2012 Apr 21. [PubMed:22572562 ]
  6. Gonzalez-Marino I, Quintana JB, Rodriguez I, Sanchez-Mendez N, Cela R: Transformation of cocaine during water chlorination. Anal Bioanal Chem. 2012 Dec;404(10):3135-44. doi: 10.1007/s00216-012-6428-2. Epub 2012 Sep 30. [PubMed:23052872 ]
  7. Hantson P, Capron A, Wallemacq P: Toxicokinetics of cocaine and metabolites in a body-packer becoming symptomatic. J Forensic Leg Med. 2011 Nov;18(8):385-7. doi: 10.1016/j.jflm.2011.07.004. Epub 2011 Aug 9. [PubMed:22018173 ]
  8. Saussereau E, Lacroix C, Gaulier JM, Goulle JP: On-line liquid chromatography/tandem mass spectrometry simultaneous determination of opiates, cocainics and amphetamines in dried blood spots. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Feb 15;885-886:1-7. doi: 10.1016/j.jchromb.2011.11.035. Epub 2011 Dec 2. [PubMed:22281234 ]


General function:
Involved in hydrolase activity
Specific function:
Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionally causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores.
Gene Name:
Uniprot ID:
Molecular weight: