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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:14:29 UTC
HMDB IDHMDB0000068
Secondary Accession Numbers
  • HMDB0000615
  • HMDB00068
  • HMDB00615
Metabolite Identification
Common NameEpinephrine
DescriptionEpinephrine is a catecholamine, a sympathomimetic monoamine derived from the amino acids phenylalanine and tyrosine. It is the active sympathomimetic hormone secreted from the adrenal medulla in most species. It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. It is used in asthma and cardiac failure and to delay absorption of local anesthetics. Epinephrine also constricts arterioles in the skin and gut while dilating arterioles in leg muscles. It elevates the blood sugar level by increasing hydrolysis of glycogen to glucose in the liver, and at the same time begins the breakdown of lipids in adipocytes. Epinephrine has a suppressive effect on the immune system.
Structure
Data?1676999669
Synonyms
ValueSource
(-)-(R)-EpinephrineChEBI
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcoholChEBI
(-)-AdrenalineChEBI
(R)-(-)-AdrenalineChEBI
(R)-(-)-AdnephrineChEBI
(R)-(-)-EpinephrineChEBI
(R)-(-)-EpirenamineChEBI
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediolChEBI
AdrenalinChEBI
AdrenalineChEBI
EpinefrinaChEBI
EpinephrinChEBI
EpinephrinumChEBI
EpipenChEBI
Epipen JRChEBI
L-AdrenalineChEBI
LevoepinephrineChEBI
PrimateneChEBI
Auvi-QKegg
(-)-3,4-Dihydroxy-a-((methylamino)methyl)benzyl alcoholGenerator
(-)-3,4-Dihydroxy-α-((methylamino)methyl)benzyl alcoholGenerator
(-)-3,4-Dihydroxy-a-[(methylamino)methyl]-benzyl alcoholHMDB
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcoholHMDB
(-)-3,4-Dihydroxy-alpha-[(methylamino)methyl]-benzyl alcoholHMDB
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcoholHMDB
(-)-EpinephrineHMDB
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediolHMDB
(R)-AdrenalineHMDB
(R)-EpinephrineHMDB
AdnephrineHMDB
AdrenalHMDB
AdrenineHMDB
AdrinHMDB
Ana-kitHMDB
BosminHMDB
Bronkaid mistHMDB
ChelafrinHMDB
EpifrinHMDB
EpiglaufrinHMDB
EpinephranHMDB
EpirenanHMDB
EppyHMDB
ExadrinHMDB
GlauposineHMDB
HemisineHMDB
HemostasinHMDB
HemostatinHMDB
HypernephrinHMDB
IsoptoepinalHMDB
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanolHMDB
L-EpinephrineHMDB
L-EpirenamineHMDB
L-MethylaminoethanolcatecholHMDB
LevorenenHMDB
LevoreninHMDB
LevorenineHMDB
LevoreninumHMDB
LyodrinHMDB
MethylarterenolHMDB
MucidrinaHMDB
NephridineHMDB
NieralineHMDB
ParanephrinHMDB
Primatene mistHMDB
R-(-)-EpinephrineHMDB
RenaglandinHMDB
RenaleptineHMDB
RenalinaHMDB
RenoformHMDB
RenostypticinHMDB
RenostyptinHMDB
ScurenalineHMDB
SimpleneHMDB
StyptirenalHMDB
SupracapsulinHMDB
SupranephraneHMDB
SuprarenalineHMDB
SuprareninHMDB
SurrenineHMDB
Sus-phrineHMDB
TakaminaHMDB
VasoconstrictineHMDB
VasotoninHMDB
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediolHMDB
Epinephrine bitartrateHMDB
Epinephrine hydrogen tartrateHMDB
LyophrinHMDB
Adrenaline bitartrateHMDB
Adrenaline hydrochlorideHMDB
Epinephrine acetateHMDB
Allergan brand OF adrenaline hydrochlorideHMDB
EpitrateHMDB
Acetate, epinephrineHMDB
Adrenaline acid tartrateHMDB
Epinephrine hydrochlorideHMDB
Medihaler-epiHMDB
Chemical FormulaC9H13NO3
Average Molecular Weight183.2044
Monoisotopic Molecular Weight183.089543287
IUPAC Name4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
Traditional Nameepinephrine
CAS Registry Number51-43-4
SMILES
CNC[C@H](O)C1=CC(O)=C(O)C=C1
InChI Identifier
InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1
InChI KeyUCTWMZQNUQWSLP-VIFPVBQESA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as catechols. Catechols are compounds containing a 1,2-benzenediol moiety.
KingdomOrganic compounds
Super ClassBenzenoids
ClassPhenols
Sub ClassBenzenediols
Direct ParentCatechols
Alternative Parents
Substituents
  • Catechol
  • 1-hydroxy-4-unsubstituted benzenoid
  • 1-hydroxy-2-unsubstituted benzenoid
  • Aralkylamine
  • Monocyclic benzene moiety
  • 1,2-aminoalcohol
  • Secondary alcohol
  • Secondary amine
  • Secondary aliphatic amine
  • Aromatic alcohol
  • Alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxygen compound
  • Organic nitrogen compound
  • Amine
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Physiological effect
Disposition
Biological locationSource
Process
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point211.5 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.18 mg/mLNot Available
LogP-1.37HANSCH,C & LEO,AJ (1985)
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-Baker144.83330932474
[M-H]-MetCCS_train_neg137.86630932474
[M+H]+Astarita_pos132.730932474
[M-H]-Not Available140.9http://allccs.zhulab.cn/database/detail?ID=AllCCS00000283
Predicted Molecular Properties
PropertyValueSource
Water Solubility18.6 g/LALOGPS
logP-0.82ALOGPS
logP-0.43ChemAxon
logS-0.99ALOGPS
pKa (Strongest Acidic)9.69ChemAxon
pKa (Strongest Basic)8.91ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area72.72 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity49.23 m³·mol⁻¹ChemAxon
Polarizability19.04 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+145.06931661259
DarkChem[M-H]-141.44831661259
AllCCS[M+H]+141.61332859911
AllCCS[M-H]-140.61832859911
DeepCCS[M+H]+144.24430932474
DeepCCS[M-H]-141.84830932474
DeepCCS[M-2H]-175.78730932474
DeepCCS[M+Na]+150.45130932474
AllCCS[M+H]+141.632859911
AllCCS[M+H-H2O]+137.532859911
AllCCS[M+NH4]+145.532859911
AllCCS[M+Na]+146.632859911
AllCCS[M-H]-140.632859911
AllCCS[M+Na-2H]-141.632859911
AllCCS[M+HCOO]-142.832859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
EpinephrineCNC[C@H](O)C1=CC(O)=C(O)C=C13056.2Standard polar33892256
EpinephrineCNC[C@H](O)C1=CC(O)=C(O)C=C11820.5Standard non polar33892256
EpinephrineCNC[C@H](O)C1=CC(O)=C(O)C=C11827.4Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Epinephrine,1TMS,isomer #1CNC[C@H](O[Si](C)(C)C)C1=CC=C(O)C(O)=C11870.7Semi standard non polar33892256
Epinephrine,1TMS,isomer #2CNC[C@H](O)C1=CC=C(O)C(O[Si](C)(C)C)=C11814.9Semi standard non polar33892256
Epinephrine,1TMS,isomer #3CNC[C@H](O)C1=CC=C(O[Si](C)(C)C)C(O)=C11826.5Semi standard non polar33892256
Epinephrine,1TMS,isomer #4CN(C[C@H](O)C1=CC=C(O)C(O)=C1)[Si](C)(C)C1994.8Semi standard non polar33892256
Epinephrine,2TMS,isomer #1CNC[C@H](O[Si](C)(C)C)C1=CC=C(O[Si](C)(C)C)C(O)=C11804.8Semi standard non polar33892256
Epinephrine,2TMS,isomer #2CNC[C@H](O[Si](C)(C)C)C1=CC=C(O)C(O[Si](C)(C)C)=C11804.1Semi standard non polar33892256
Epinephrine,2TMS,isomer #3CN(C[C@H](O[Si](C)(C)C)C1=CC=C(O)C(O)=C1)[Si](C)(C)C1990.1Semi standard non polar33892256
Epinephrine,2TMS,isomer #4CNC[C@H](O)C1=CC=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C11859.5Semi standard non polar33892256
Epinephrine,2TMS,isomer #5CN(C[C@H](O)C1=CC=C(O)C(O[Si](C)(C)C)=C1)[Si](C)(C)C1959.0Semi standard non polar33892256
Epinephrine,2TMS,isomer #6CN(C[C@H](O)C1=CC=C(O[Si](C)(C)C)C(O)=C1)[Si](C)(C)C1985.3Semi standard non polar33892256
Epinephrine,3TMS,isomer #1CNC[C@H](O[Si](C)(C)C)C1=CC=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C11856.3Semi standard non polar33892256
Epinephrine,3TMS,isomer #2CN(C[C@H](O[Si](C)(C)C)C1=CC=C(O[Si](C)(C)C)C(O)=C1)[Si](C)(C)C1955.3Semi standard non polar33892256
Epinephrine,3TMS,isomer #3CN(C[C@H](O[Si](C)(C)C)C1=CC=C(O)C(O[Si](C)(C)C)=C1)[Si](C)(C)C1949.4Semi standard non polar33892256
Epinephrine,3TMS,isomer #4CN(C[C@H](O)C1=CC=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C1)[Si](C)(C)C2004.7Semi standard non polar33892256
Epinephrine,4TMS,isomer #1CN(C[C@H](O[Si](C)(C)C)C1=CC=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C1)[Si](C)(C)C2023.0Semi standard non polar33892256
Epinephrine,4TMS,isomer #1CN(C[C@H](O[Si](C)(C)C)C1=CC=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C1)[Si](C)(C)C1994.6Standard non polar33892256
Epinephrine,4TMS,isomer #1CN(C[C@H](O[Si](C)(C)C)C1=CC=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C1)[Si](C)(C)C1930.9Standard polar33892256
Epinephrine,1TBDMS,isomer #1CNC[C@H](O[Si](C)(C)C(C)(C)C)C1=CC=C(O)C(O)=C12093.7Semi standard non polar33892256
Epinephrine,1TBDMS,isomer #2CNC[C@H](O)C1=CC=C(O)C(O[Si](C)(C)C(C)(C)C)=C12075.5Semi standard non polar33892256
Epinephrine,1TBDMS,isomer #3CNC[C@H](O)C1=CC=C(O[Si](C)(C)C(C)(C)C)C(O)=C12090.6Semi standard non polar33892256
Epinephrine,1TBDMS,isomer #4CN(C[C@H](O)C1=CC=C(O)C(O)=C1)[Si](C)(C)C(C)(C)C2230.5Semi standard non polar33892256
Epinephrine,2TBDMS,isomer #1CNC[C@H](O[Si](C)(C)C(C)(C)C)C1=CC=C(O[Si](C)(C)C(C)(C)C)C(O)=C12288.3Semi standard non polar33892256
Epinephrine,2TBDMS,isomer #2CNC[C@H](O[Si](C)(C)C(C)(C)C)C1=CC=C(O)C(O[Si](C)(C)C(C)(C)C)=C12294.3Semi standard non polar33892256
Epinephrine,2TBDMS,isomer #3CN(C[C@H](O[Si](C)(C)C(C)(C)C)C1=CC=C(O)C(O)=C1)[Si](C)(C)C(C)(C)C2484.2Semi standard non polar33892256
Epinephrine,2TBDMS,isomer #4CNC[C@H](O)C1=CC=C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)=C12361.2Semi standard non polar33892256
Epinephrine,2TBDMS,isomer #5CN(C[C@H](O)C1=CC=C(O)C(O[Si](C)(C)C(C)(C)C)=C1)[Si](C)(C)C(C)(C)C2451.6Semi standard non polar33892256
Epinephrine,2TBDMS,isomer #6CN(C[C@H](O)C1=CC=C(O[Si](C)(C)C(C)(C)C)C(O)=C1)[Si](C)(C)C(C)(C)C2489.7Semi standard non polar33892256
Epinephrine,3TBDMS,isomer #1CNC[C@H](O[Si](C)(C)C(C)(C)C)C1=CC=C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)=C12520.8Semi standard non polar33892256
Epinephrine,3TBDMS,isomer #2CN(C[C@H](O[Si](C)(C)C(C)(C)C)C1=CC=C(O[Si](C)(C)C(C)(C)C)C(O)=C1)[Si](C)(C)C(C)(C)C2698.9Semi standard non polar33892256
Epinephrine,3TBDMS,isomer #3CN(C[C@H](O[Si](C)(C)C(C)(C)C)C1=CC=C(O)C(O[Si](C)(C)C(C)(C)C)=C1)[Si](C)(C)C(C)(C)C2690.3Semi standard non polar33892256
Epinephrine,3TBDMS,isomer #4CN(C[C@H](O)C1=CC=C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)=C1)[Si](C)(C)C(C)(C)C2724.8Semi standard non polar33892256
Epinephrine,4TBDMS,isomer #1CN(C[C@H](O[Si](C)(C)C(C)(C)C)C1=CC=C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)=C1)[Si](C)(C)C(C)(C)C2938.8Semi standard non polar33892256
Epinephrine,4TBDMS,isomer #1CN(C[C@H](O[Si](C)(C)C(C)(C)C)C1=CC=C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)=C1)[Si](C)(C)C(C)(C)C2768.0Standard non polar33892256
Epinephrine,4TBDMS,isomer #1CN(C[C@H](O[Si](C)(C)C(C)(C)C)C1=CC=C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)=C1)[Si](C)(C)C(C)(C)C2420.0Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Epinephrine GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (Non-derivatized)splash10-014i-0900000000-5ca773e378035e522e652014-06-16HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Epinephrine GC-EI-TOF (Non-derivatized)splash10-014i-0900000000-5ca773e378035e522e652017-09-12HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (Non-derivatized) - 70eV, Positivesplash10-0006-9600000000-584d6e44f2be8cb4eeb12017-08-28Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (3 TMS) - 70eV, Positivesplash10-00si-7639000000-5bde61303f7506ecea582017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TMS_1_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TMS_1_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TMS_1_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TMS_1_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TMS_2_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TMS_2_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TMS_2_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TMS_2_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TMS_2_5) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TMS_2_6) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TMS_3_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TMS_3_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TMS_3_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TBDMS_1_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TBDMS_1_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TBDMS_1_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TBDMS_1_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TBDMS_2_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TBDMS_2_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Epinephrine GC-MS (TBDMS_2_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine Quattro_QQQ 10V, Positive-QTOF (Annotated)splash10-014i-0900000000-7718bec49c1a109083e52012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine Quattro_QQQ 25V, Positive-QTOF (Annotated)splash10-0a4i-4900000000-ec5581e838e2a4a661392012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine Quattro_QQQ 40V, Positive-QTOF (Annotated)splash10-004i-9200000000-4572448ba3dadff2d2a62012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative-QTOFsplash10-001i-0900000000-9da12d9c8551de2507be2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative-QTOFsplash10-03di-0900000000-12dd42d00be1feb2ea6f2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative-QTOFsplash10-00di-0900000000-57c9bc614d9bbbfeed6b2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative-QTOFsplash10-00dj-0900000000-375b0df9797eb0a3db5f2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative-QTOFsplash10-0fdk-1900000000-04c230e802b08770ccd42012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive-QTOFsplash10-014i-0900000000-b707acd2982b875d2b8a2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive-QTOFsplash10-014i-0900000000-f35900548228729020322012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive-QTOFsplash10-0a4i-1900000000-7d7916641e9f2b8c2a1d2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive-QTOFsplash10-0adi-8900000000-5bbc248c0ddc66e4fe402012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive-QTOFsplash10-004i-9300000000-af8ce8ce2cdd535404e92012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive-QTOFsplash10-0159-0900000000-f2fafb87963f9f1c69602012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive-QTOFsplash10-0uxr-2900000000-b54ca44315664cba912a2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive-QTOFsplash10-0udi-4900000000-881b25fed45874c66e132012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive-QTOFsplash10-0ugi-9500000000-1fadd0dd0beb4816b39d2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive-QTOFsplash10-004j-9000000000-61011b8f179c08d62b622012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Epinephrine LC-ESI-QFT , negative-QTOFsplash10-03di-0900000000-32c82b77af021d75c50c2017-09-14HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Epinephrine 10V, Positive-QTOFsplash10-0159-0900000000-92937e3a48622f40baed2017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Epinephrine 20V, Positive-QTOFsplash10-014r-0900000000-b00275b1e8611c273f022017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Epinephrine 40V, Positive-QTOFsplash10-0k9l-7900000000-065763dae156017492c92017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Epinephrine 10V, Negative-QTOFsplash10-001i-0900000000-45c50917c3f404f38e712017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Epinephrine 20V, Negative-QTOFsplash10-01q9-1900000000-713b357534dc0f81ae972017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Epinephrine 40V, Negative-QTOFsplash10-0a4i-5900000000-c6b1d16c9e7e368055572017-07-26Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Experimental 1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, experimental)2012-12-04Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Experimental 2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental)2012-12-04Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
Biospecimen Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Locations
  • Adipose Tissue
  • Adrenal Cortex
  • Adrenal Gland
  • Adrenal Medulla
  • Bladder
  • Epidermis
  • Eye Lens
  • Fibroblasts
  • Intestine
  • Kidney
  • Liver
  • Neuron
  • Ovary
  • Pancreas
  • Placenta
  • Platelet
  • Skeletal Muscle
  • Testis
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.00164 +/- 0.00012 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.00029 +/- 0.000021 uMAdult (>18 years old)FemaleNormal details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.00072 (0.00049-0.0013) uMAdult (>18 years old)MaleNormal
    • Geigy Scientific ...
details
BloodDetected and Quantified0.0003 +/- 0.00003 uMAdult (>18 years old)MaleNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.0 (0.0-0.00022) uMAdult (>18 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.000235 +/- 0.00003277 uMNot SpecifiedNot SpecifiedNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.034 (0.0063-0.062) uMAdult (>18 years old)FemaleNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.00024 uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
UrineDetected and Quantified0.0057 +/- 0.00092 umol/mmol creatinineAdult (>18 years old)BothNormal details
UrineDetected and Quantified0.002 +/- 0.00099 umol/mmol creatinineChildren (1-13 years old)BothNormal details
UrineDetected and Quantified0.0052 (0.00043-0.0099) umol/mmol creatinineAdult (>18 years old)BothNormal details
UrineDetected and Quantified0.016 (0.001-0.089) umol/mmol creatinineInfant (0-1 year old)Both
Normal
details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
UrineDetected and Quantified0.0021 (0.00098-0.0052) umol/mmol creatinineAdult (>18 years old)BothNormal
    • Geigy Scientific ...
    • West Cadwell, N.J...
    • Basel, Switzerlan...
details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.00241 +/- 0.00057 uMAdult (>18 years old)BothHead trauma details
BloodDetected and Quantified0.000077 +/- 0.000025 uMAdult (>18 years old)FemaleAddison's disease details
BloodDetected and Quantified0.001 +/- 0.00036 uMAdult (>18 years old)BothSubarachnoid haemorrhage details
BloodDetected and Quantified0.00014 +/- 0.000036 uMAdult (>18 years old)MaleAddison's disease details
BloodDetected and Quantified0.00029 (0.00005-0.00054) uMAdult (>18 years old)Both
Pheochromocytoma
details
BloodDetected and Quantified0.0025 (0.0002-0.0048) uMAdult (>18 years old)Both
Pheochromocytoma
details
Cerebrospinal Fluid (CSF)Detected and Quantified0.000453 +/- 0.00004916 uMAdult (>18 years old)Not Specifiedborderline hypertensives details
Cerebrospinal Fluid (CSF)Detected and Quantified0.000147 +/- 0.000109 uMAdult (>18 years old)Not SpecifiedCerebral infarction, headache, paresthesia and ununconfirmed suspicion of leucemic infaction or brain metastasis with normal CSF value details
Cerebrospinal Fluid (CSF)Detected and Quantified0.000109 uMAdult (>18 years old)Not SpecifiedCerebral infarction, headache, paresthesia and ununconfirmed suspicion of leucemic infaction or brain metastasis with normal CSF value but renal insufficiency details
Cerebrospinal Fluid (CSF)Detected and Quantified0.000251 uMAdult (>18 years old)Not SpecifiedHaemorrhagic infarction details
Cerebrospinal Fluid (CSF)Detected and Quantified0.000300 uMAdult (>18 years old)Not SpecifiedBacterial meningitis details
Cerebrospinal Fluid (CSF)Detected and Quantified0.000481 uMAdult (>18 years old)Not SpecifiedLeucemic meningiosa details
Cerebrospinal Fluid (CSF)Detected and Quantified0.000153 uMAdult (>18 years old)Not SpecifiedEncephalitis details
UrineDetected and Quantified0.011 +/- 0.0022 umol/mmol creatinineAdult (>18 years old)BothExercise details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothSchizophrenia details
Associated Disorders and Diseases
Disease References
Addison's Disease
  1. Bornstein SR, Breidert M, Ehrhart-Bornstein M, Kloos B, Scherbaum WA: Plasma catecholamines in patients with Addison's disease. Clin Endocrinol (Oxf). 1995 Feb;42(2):215-8. [PubMed:7704967 ]
Subarachnoid hemorrhage
  1. Lambert G, Naredi S, Eden E, Rydenhag B, Friberg P: Monoamine metabolism and sympathetic nervous activation following subarachnoid haemorrhage: influence of gender and hydrocephalus. Brain Res Bull. 2002 May;58(1):77-82. [PubMed:12121816 ]
Pheochromocytoma
  1. Eisenhofer G, Keiser H, Friberg P, Mezey E, Huynh TT, Hiremagalur B, Ellingson T, Duddempudi S, Eijsbouts A, Lenders JW: Plasma metanephrines are markers of pheochromocytoma produced by catechol-O-methyltransferase within tumors. J Clin Endocrinol Metab. 1998 Jun;83(6):2175-85. [PubMed:9626157 ]
Head injury
  1. Lambert G, Naredi S, Eden E, Rydenhag B, Friberg P: Monoamine metabolism and sympathetic nervous activation following subarachnoid haemorrhage: influence of gender and hydrocephalus. Brain Res Bull. 2002 May;58(1):77-82. [PubMed:12121816 ]
Cerebral infarction
  1. Ratge D, Bauersfeld W, Wisser H: The relationship of free and conjugated catecholamines in plasma and cerebrospinal fluid in cerebral and meningeal disease. J Neural Transm. 1985;62(3-4):267-84. [PubMed:4031843 ]
Bacterial meningitis
  1. Ratge D, Bauersfeld W, Wisser H: The relationship of free and conjugated catecholamines in plasma and cerebrospinal fluid in cerebral and meningeal disease. J Neural Transm. 1985;62(3-4):267-84. [PubMed:4031843 ]
Encephalitis
  1. Ratge D, Bauersfeld W, Wisser H: The relationship of free and conjugated catecholamines in plasma and cerebrospinal fluid in cerebral and meningeal disease. J Neural Transm. 1985;62(3-4):267-84. [PubMed:4031843 ]
Schizophrenia
  1. Fryar-Williams S, Strobel JE: Biomarkers of a five-domain translational substrate for schizophrenia and schizoaffective psychosis. Biomark Res. 2015 Feb 6;3:3. doi: 10.1186/s40364-015-0028-1. eCollection 2015. [PubMed:25729574 ]
Associated OMIM IDs
DrugBank IDDB00668
Phenol Explorer Compound IDNot Available
FooDB IDFDB021889
KNApSAcK IDC00029643
Chemspider ID5611
KEGG Compound IDC00788
BioCyc IDL-EPINEPHRINE
BiGG ID35997
Wikipedia LinkEpinephrine
METLIN ID5127
PubChem Compound5816
PDB IDNot Available
ChEBI ID28918
Food Biomarker OntologyNot Available
VMH IDADRNL
MarkerDB IDMDB00000035
Good Scents IDNot Available
References
Synthesis ReferenceSinger, Robert A.; Carreira, Erick M. An in situ procedure for catalytic, enantioselective acetate aldol addition. Application to the synthesis of (R)-(-)-epinephrine. Tetrahedron Letters (1997), 38(6), 927-930.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Blagitko N, Schulz U, Schinzel AA, Ropers HH, Kalscheuer VM: gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome. Hum Mol Genet. 1999 Dec;8(13):2387-96. [PubMed:10556286 ]
  2. Goldstein DS, Eisenhofer G, Kopin IJ: Sources and significance of plasma levels of catechols and their metabolites in humans. J Pharmacol Exp Ther. 2003 Jun;305(3):800-11. Epub 2003 Mar 20. [PubMed:12649306 ]
  3. Kurtis JD, Friedman JF, Leenstra T, Langdon GC, Wu HW, Manalo DL, Su L, Jiz M, Jarilla B, Pablo AO, McGarvey ST, Olveda RM, Acosta LP: Pubertal development predicts resistance to infection and reinfection with Schistosoma japonicum. Clin Infect Dis. 2006 Jun 15;42(12):1692-8. Epub 2006 May 12. [PubMed:16705573 ]
  4. Eisenhofer G, Keiser H, Friberg P, Mezey E, Huynh TT, Hiremagalur B, Ellingson T, Duddempudi S, Eijsbouts A, Lenders JW: Plasma metanephrines are markers of pheochromocytoma produced by catechol-O-methyltransferase within tumors. J Clin Endocrinol Metab. 1998 Jun;83(6):2175-85. [PubMed:9626157 ]
  5. Igdoura SA, Gafuik C, Mertineit C, Saberi F, Pshezhetsky AV, Potier M, Trasler JM, Gravel RA: Cloning of the cDNA and gene encoding mouse lysosomal sialidase and correction of sialidase deficiency in human sialidosis and mouse SM/J fibroblasts. Hum Mol Genet. 1998 Jan;7(1):115-21. [PubMed:9384611 ]
  6. Kaufer D, Ogle WO, Pincus ZS, Clark KL, Nicholas AC, Dinkel KM, Dumas TC, Ferguson D, Lee AL, Winters MA, Sapolsky RM: Restructuring the neuronal stress response with anti-glucocorticoid gene delivery. Nat Neurosci. 2004 Sep;7(9):947-53. Epub 2004 Aug 8. [PubMed:15300253 ]
  7. Yasuda G, Umemura S, Ishii M: Characterization of bunazosin-sensitive alpha1-adrenoceptors in human renal medulla. J Cardiovasc Pharmacol. 1997 Aug;30(2):163-8. [PubMed:9269942 ]
  8. Gear AR, Camerini D: Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense. Microcirculation. 2003 Jun;10(3-4):335-50. [PubMed:12851650 ]
  9. Wilson BS, Petrella E, Lowe SR, Lien K, Mackensen DG, Gridley DS, Stickney DR: Radiolocalization of human small cell lung cancer and antigen-positive normal tissues using monoclonal antibody LS2D617. Cancer Res. 1990 May 15;50(10):3124-30. [PubMed:2159374 ]
  10. Blakely RD, Apparsundaram S: Structural diversity in the catecholamine transporter gene family: molecular cloning and characterization of an L-epinephrine transporter from bullfrog sympathetic ganglia. Adv Pharmacol. 1998;42:206-10. [PubMed:9327880 ]
  11. Belloni AS, Albertin G, Forneris ML, Nussdorfer GG: Proadrenomedullin-derived peptides as autocrine-paracrine regulators of cell growth. Histol Histopathol. 2001 Oct;16(4):1263-74. [PubMed:11642745 ]
  12. Contreras LN, Arregger AL, Persi GG, Gonzalez NS, Cardoso EM: A new less-invasive and more informative low-dose ACTH test: salivary steroids in response to intramuscular corticotrophin. Clin Endocrinol (Oxf). 2004 Dec;61(6):675-82. [PubMed:15579180 ]
  13. Kushnir MM, Rockwood AL, Roberts WL, Pattison EG, Owen WE, Bunker AM, Meikle AW: Development and performance evaluation of a tandem mass spectrometry assay for 4 adrenal steroids. Clin Chem. 2006 Aug;52(8):1559-67. Epub 2006 Jun 15. [PubMed:16777916 ]
  14. Krohn K, Uibo R, Aavik E, Peterson P, Savilahti K: Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17 alpha-hydroxylase. Lancet. 1992 Mar 28;339(8796):770-3. [PubMed:1347802 ]
  15. Bornstein SR, Breidert M, Ehrhart-Bornstein M, Kloos B, Scherbaum WA: Plasma catecholamines in patients with Addison's disease. Clin Endocrinol (Oxf). 1995 Feb;42(2):215-8. [PubMed:7704967 ]
  16. Engelborghs S, Marescau B, De Deyn PP: Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. Neurochem Res. 2003 Aug;28(8):1145-50. [PubMed:12834252 ]
  17. Hiroi N, Yanagisawa R, Yoshida-Hiroi M, Endo T, Kawase T, Tsuchida Y, Toyama K, Shibuya K, Nakata K, Yoshino G: Retroperitoneal hemorrhage due to bilateral adrenal metastases from lung adenocarcinoma. J Endocrinol Invest. 2006 Jun;29(6):551-4. [PubMed:16840834 ]
  18. Kennedy B, Bigby TD, Ziegler MG: Nonadrenal epinephrine-forming enzymes in humans. Characteristics, distribution, regulation, and relationship to epinephrine levels. J Clin Invest. 1995 Jun;95(6):2896-902. [PubMed:7769131 ]
  19. Panholzer TJ, Beyer J, Lichtwald K: Coupled-column liquid chromatographic analysis of catecholamines, serotonin, and metabolites in human urine. Clin Chem. 1999 Feb;45(2):262-8. [PubMed:9931050 ]
  20. De Bellis MD, Baum AS, Birmaher B, Keshavan MS, Eccard CH, Boring AM, Jenkins FJ, Ryan ND: A.E. Bennett Research Award. Developmental traumatology. Part I: Biological stress systems. Biol Psychiatry. 1999 May 15;45(10):1259-70. [PubMed:10349032 ]
  21. Brunk E, Sahoo S, Zielinski DC, Altunkaya A, Drager A, Mih N, Gatto F, Nilsson A, Preciat Gonzalez GA, Aurich MK, Prlic A, Sastry A, Danielsdottir AD, Heinken A, Noronha A, Rose PW, Burley SK, Fleming RMT, Nielsen J, Thiele I, Palsson BO: Recon3D enables a three-dimensional view of gene variation in human metabolism. Nat Biotechnol. 2018 Mar;36(3):272-281. doi: 10.1038/nbt.4072. Epub 2018 Feb 19. [PubMed:29457794 ]

Only showing the first 10 proteins. There are 11 proteins in total.

Enzymes

General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
Gene Name:
MAOB
Uniprot ID:
P27338
Molecular weight:
58762.475
Reactions
Epinephrine + Water + Oxygen → 3,4-Dihydroxymandelaldehyde + Methylamine + Hydrogen peroxidedetails
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Gene Name:
MAOA
Uniprot ID:
P21397
Molecular weight:
59681.27
Reactions
Epinephrine + Water + Oxygen → 3,4-Dihydroxymandelaldehyde + Methylamine + Hydrogen peroxidedetails
General function:
Involved in magnesium ion binding
Specific function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Gene Name:
COMT
Uniprot ID:
P21964
Molecular weight:
30036.77
Reactions
S-Adenosylmethionine + Epinephrine → S-Adenosylhomocysteine + Metanephrinedetails
General function:
Involved in amino acid binding
Specific function:
Not Available
Gene Name:
PAH
Uniprot ID:
P00439
Molecular weight:
51861.565
General function:
Involved in methyltransferase activity
Specific function:
Converts noradrenaline to adrenaline.
Gene Name:
PNMT
Uniprot ID:
P11086
Molecular weight:
30854.745
Reactions
S-Adenosylmethionine + Norepinephrine → S-Adenosylhomocysteine + Epinephrinedetails
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol
Gene Name:
ADRA2A
Uniprot ID:
P08913
Molecular weight:
48956.3
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol
Gene Name:
ADRA2B
Uniprot ID:
P18089
Molecular weight:
49953.1
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity
Gene Name:
ADRB1
Uniprot ID:
P08588
Molecular weight:
51322.1
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine
Gene Name:
ADRB2
Uniprot ID:
P07550
Molecular weight:
46458.3
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins
Gene Name:
ADRA1A
Uniprot ID:
P35348
Molecular weight:
51486.0

Only showing the first 10 proteins. There are 11 proteins in total.