Human Metabolome Database Version 3.5

Showing metabocard for Dopamine (HMDB00073)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:07:51 -0700
HMDB ID HMDB00073
Secondary Accession Numbers None
Metabolite Identification
Common Name Dopamine
Description Dopamine is a member of the catecholamine (Neurotransmitters) family in the brain, and is a precursor to epinephrine (adrenaline) and norepinephrine (noradrenaline). Dopamine is synthesized in the body (mainly by nervous tissue and adrenal glands) first by the hydration of the amino acid tyrosine to DOPA by tyrosine hydroxylase and then by the decarboxylation of DOPA by aromatic-L-amino-acid decarboxylase. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (Dopamine receptors) mediates its action. --PubChem.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. 2-(3,4-Dihydroxyphenyl)ethylamine
  2. 3,4-Dihydroxyphenethylamine
  3. 3,4-Dihydroxyphenylethylamine
  4. 3-Hydroxytyramine
  5. 4-(2-Aminoethyl)-1,2-benzenediol
  6. 4-(2-Aminoethyl)-Pyrocatechol
  7. 4-(2-Aminoethyl)catechol
  8. 4-(2-Aminoethyl)pyrocatechol
  9. a-(3,4-Dihydroxyphenyl)-b-aminoethane
  10. alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
  11. Deoxyepinephrine
  12. Dopamin
  13. Dopamine
  14. Dopaminum
  15. Dopastat
  16. Dophamine
  17. Dynatra
  18. Hydroxytyramin
  19. Hydroxytyramine
  20. Intropin
  21. Oxytyramine
  22. Revivan
Chemical Formula C8H11NO2
Average Molecular Weight 153.1784
Monoisotopic Molecular Weight 153.078978601
IUPAC Name 4-(2-aminoethyl)benzene-1,2-diol
Traditional IUPAC Name dopamine
CAS Registry Number 62-31-7
SMILES NCCC1=CC=C(O)C(O)=C1
InChI Identifier InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
InChI Key VYFYYTLLBUKUHU-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Aromatic Homomonocyclic Compounds
Class Phenols and Derivatives
Sub Class Benzenediols
Other Descriptors
  • Aromatic Homomonocyclic Compounds
  • Biogenic amines(KEGG)
  • Dopamine(KEGG)
  • Tyramine derivatives(KEGG)
  • catecholamine(ChEBI)
Substituents
  • 1,2 Diphenol
  • Phenethylamine
  • Primary Aliphatic Amine (Alkylamine)
Direct Parent Catecholamines and Derivatives
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Tyrosine metabolism
Application Not Available
Cellular locations
  • Cytoplasm
  • Extracellular
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point 128 °C Not Available
Boiling Point Not Available Not Available
Water Solubility 535 mg/mL Not Available
LogP -0.98 HANSCH,C ET AL. (1995)
Predicted Properties
Property Value Source
Water Solubility 7.43 g/L ALOGPS
LogP -0.40 ALOGPS
LogP 0.03 ChemAxon
LogS -1.31 ALOGPS
pKa (strongest acidic) 10.01 ChemAxon
pKa (strongest basic) 9.27 ChemAxon
Hydrogen Acceptor Count 3 ChemAxon
Hydrogen Donor Count 3 ChemAxon
Polar Surface Area 66.48 A2 ChemAxon
Rotatable Bond Count 2 ChemAxon
Refractivity 43.25 ChemAxon
Polarizability 16.21 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge 1 ChemAxon
Spectra
Gas-MS Spectrum
1H NMR Spectrum
MS/MS Spectrum Quattro_QQQ 10
MS/MS Spectrum Quattro_QQQ 25
MS/MS Spectrum Quattro_QQQ 40
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 10
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 20
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 30
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 40
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 50
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 10
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 20
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 30
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 40
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 50
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 10
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 20
[1H,13C] 2D NMR Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Location
  • Muscle
  • Skeletal Muscle
  • Bladder
  • Fibroblasts
  • Neuron
  • Pancreas
  • Placenta
  • Testes
  • Kidney
  • Epidermis
  • Brain
  • Myelin
  • Adrenal Gland
  • Adipose Tissue
  • Adrenal Cortex
  • Adrenal Medulla
  • Nerve Cells
  • Platelet
  • Spleen
  • Striatum
Pathways
Name SMPDB Link KEGG Link
Tyrosine Metabolism SMP00006 map00350 Link_out
Catecholamine Biosynthesis SMP00012 map00350 Link_out
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
22.50 +/- 4.50 uM Adult (>18 years old) Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.002+/-0.002 uM Adult (>18 years old) Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.0059 +/- 0.002 uM Elderly (>65 years old) Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.0045 +/- 0.0026 uM Adult (>18 years old) Both Normal
Urine Detected and Quantified
0.107 (0.043-0.172) umol/mmol creatinine Adult (>18 years old) Both Normal
Urine Detected and Quantified
0.22 +/- 0.07 umol/mmol creatinine Adult (>18 years old) Both Normal
Urine Detected and Quantified
0.44 +/- 0.13 umol/mmol creatinine Adolescent (13-18 years old) Both Normal
Urine Detected and Quantified
860 (179-1541) nmol/mmol creatinine Infant (0-1 year old) Not Specified Comment Normal
Urine Detected and Quantified
2626 (30-5221) nmol/mmol creatinine Infant (0-1 year old) Not Specified Comment Normal
Urine Detected and Quantified
0.4 (0.2-0.7) umol/mmol creatinine Adult (>18 years old) Both Comment Normal
Urine Detected and Quantified
0.10 (0.066-0.16) umol/mmol creatinine Adult (>18 years old) Both Normal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified 18.0284 +/- 2.4552 uM Elderly (>65 years old) Both Alzheimer's disease
Cerebrospinal Fluid (CSF) Detected and Quantified 0.000268 +/- 0.000124 uM Adult (>18 years old) Not Specified Cerebral infarction, headache, paresthesia and ununconfirmed suspicion of leucemic infaction or brain metastasis with normal CSF value
Cerebrospinal Fluid (CSF) Detected and Quantified 0.000300 uM Adult (>18 years old) Not Specified Cerebral infarction, headache, paresthesia and ununconfirmed suspicion of leucemic infaction or brain metastasis with normal CSF value but renal insufficiency
Cerebrospinal Fluid (CSF) Detected and Quantified 0.000392 uM Adult (>18 years old) Not Specified Haemorrhagic infraction
Cerebrospinal Fluid (CSF) Detected and Quantified 0.000510 uM Adult (>18 years old) Not Specified Bacterial meningitis
Cerebrospinal Fluid (CSF) Detected and Quantified 0.000810 uM Adult (>18 years old) Not Specified Leucemic meningiosa
Cerebrospinal Fluid (CSF) Detected and Quantified 0.000287 uM Adult (>18 years old) Not Specified Encephalitis
Cerebrospinal Fluid (CSF) Detected and Quantified 0.34 +/- 0.10 uM Adult (>18 years old) Both Alzheimer's disease
Cerebrospinal Fluid (CSF) Detected and Quantified 0.00002 +/- 0.000006 uM Adult (>18 years old) Both Hypothyroidism
Cerebrospinal Fluid (CSF) Detected and Quantified 0.000021 (0.000015-0.000027) uM Adult (>18 years old) Both Hypothyroidism
Cerebrospinal Fluid (CSF) Detected and Quantified 0.000078 (0.0000065-0.00015) uM Adult (>18 years old) Both Alzheimer's disease
Urine Detected and Quantified 0.49 +/- 0.06 umol/mmol creatinine Infant (0-1 year old) Both Vitiligo
Urine Detected and Quantified 0.37 +/- 0.03 umol/mmol creatinine Children (1-13 year old) Both Comment Vitiligo
Urine Detected and Quantified 0.4 +/- 0.05 umol/mmol creatinine Children (1-13 year old) Both Comment Vitiligo
Urine Detected and Quantified 2426 +/- 0 nmol/mmol creatinine Infant (0-1 year old) Male Comment Aromatic L-amino acid decarboxylase deficiency
Urine Detected and Quantified 3119 +/- 0 nmol/mmol creatinine Infant (0-1 year old) Male Comment Aromatic L-amino acid decarboxylase deficiency
Associated Disorders and Diseases
Disease References
Vitiligo
  • Cucchi ML, Frattini P, Santagostino G, Preda S, Orecchia G: Catecholamines increase in the urine of non-segmental vitiligo especially during its active phase. Pigment Cell Res. 2003 Apr;16(2):111-6. Pubmed: 12622787 Link_out
      Hypothyroidism
      • Sjoberg S, Eriksson M, Nordin C: L-thyroxine treatment and neurotransmitter levels in the cerebrospinal fluid of hypothyroid patients: a pilot study. Eur J Endocrinol. 1998 Nov;139(5):493-7. Pubmed: 9849813 Link_out
          Alzheimer's disease
          • Raskind MA, Peskind ER, Holmes C, Goldstein DS: Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer's disease. Biol Psychiatry. 1999 Sep 15;46(6):756-65. Pubmed: 10494443 Link_out
          • Fonteh AN, Harrington RJ, Tsai A, Liao P, Harrington MG: Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects. Amino Acids. 2007 Feb;32(2):213-24. Epub 2006 Oct 10. Pubmed: 17031479 Link_out
              Aromatic L-amino acid decarboxylase deficiency
              • Abdenur JE, Abeling N, Specola N, Jorge L, Schenone AB, van Cruchten AC, Chamoles NA: Aromatic l-aminoacid decarboxylase deficiency: unusual neonatal presentation and additional findings in organic acid analysis. Mol Genet Metab. 2006 Jan;87(1):48-53. Epub 2005 Nov 9. Pubmed: 16288991 Link_out
                  Associated OMIM IDs
                  DrugBank ID DB00988 Link_out
                  DrugBank Metabolite ID Not Available
                  Phenol Explorer Compound ID Not Available
                  Phenol Explorer Metabolite ID Not Available
                  FoodDB ID FDB012163
                  KNApSAcK ID C00001408 Link_out
                  Chemspider ID 661 Link_out
                  KEGG Compound ID C03758 Link_out
                  BioCyc ID DOPAMINE Link_out
                  BiGG ID 42467 Link_out
                  Wikipedia Link Dopamine Link_out
                  NuGOwiki Link HMDB00073 Link_out
                  Metagene Link HMDB00073 Link_out
                  METLIN ID 64 Link_out
                  PubChem Compound 681 Link_out
                  PDB ID LDP Link_out
                  ChEBI ID 18243 Link_out
                  References
                  Synthesis Reference Budnik, Josef. 2-(3,4-Dihydroxyphenyl)ethylamine hydrochloride. Czech. (1986), 2 pp.
                  Material Safety Data Sheet (MSDS) Not Available
                  General References
                  1. Raskind MA, Peskind ER, Holmes C, Goldstein DS: Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer's disease. Biol Psychiatry. 1999 Sep 15;46(6):756-65. Pubmed: 10494443 Link_out
                  2. Mannelli M, Ianni L, Lazzeri C, Castellani W, Pupilli C, La Villa G, Barletta G, Serio M, Franchi F: In vivo evidence that endogenous dopamine modulates sympathetic activity in man. Hypertension. 1999 Sep;34(3):398-402. Pubmed: 10489384 Link_out
                  3. Jiang H, Betancourt L, Smith RG: Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers. Mol Endocrinol. 2006 Aug;20(8):1772-85. Epub 2006 Apr 6. Pubmed: 16601073 Link_out
                  4. Brody AL, Mandelkern MA, Olmstead RE, Scheibal D, Hahn E, Shiraga S, Zamora-Paja E, Farahi J, Saxena S, London ED, McCracken JT: Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens. Arch Gen Psychiatry. 2006 Jul;63(7):808-16. Pubmed: 16818870 Link_out
                  5. Bauman A: Unilateral adrenal catecholamine excess. Pheochromocytoma or possible sporadic medullary hyperplasia. Arch Intern Med. 1982 Feb;142(2):377-8. Pubmed: 7059264 Link_out
                  6. Goldstein DS, Eisenhofer G, Kopin IJ: Sources and significance of plasma levels of catechols and their metabolites in humans. J Pharmacol Exp Ther. 2003 Jun;305(3):800-11. Epub 2003 Mar 20. Pubmed: 12649306 Link_out
                  7. King BM: The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight. Physiol Behav. 2006 Feb 28;87(2):221-44. Epub 2006 Jan 18. Pubmed: 16412483 Link_out
                  8. Cucchi ML, Frattini P, Santagostino G, Preda S, Orecchia G: Catecholamines increase in the urine of non-segmental vitiligo especially during its active phase. Pigment Cell Res. 2003 Apr;16(2):111-6. Pubmed: 12622787 Link_out
                  9. Sjoberg S, Eriksson M, Nordin C: L-thyroxine treatment and neurotransmitter levels in the cerebrospinal fluid of hypothyroid patients: a pilot study. Eur J Endocrinol. 1998 Nov;139(5):493-7. Pubmed: 9849813 Link_out
                  10. Engelborghs S, Marescau B, De Deyn PP: Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. Neurochem Res. 2003 Aug;28(8):1145-50. Pubmed: 12834252 Link_out
                  11. Kobayashi K, Yasuhara T, Agari T, Muraoka K, Kameda M, Ji Yuan W, Hayase H, Matsui T, Miyoshi Y, Shingo T, Date I: Control of dopamine-secretion by Tet-Off system in an in vivo model of parkinsonian rat. Brain Res. 2006 Aug 2;1102(1):1-11. Epub 2006 Jun 27. Pubmed: 16806124 Link_out
                  12. Schenarts PJ, Sagraves SG, Bard MR, Toschlog EA, Goettler CE, Newell MA, Rotondo MF: Low-dose dopamine: a physiologically based review. Curr Surg. 2006 May-Jun;63(3):219-25. Pubmed: 16757377 Link_out
                  13. Piazza O, Zito G, Valente A, Tufano R: Effects of dopamine infusion on forearm blood flow in critical patients. Med Sci Monit. 2006 Feb;12(2):CR90-3. Epub 2006 Jan 26. Pubmed: 16449954 Link_out
                  14. Wang HY, Xiao Y, Han J, Chang XS: Simultaneous determination of dopamine and carvedilol in human serum and urine by first-order derivative fluorometry. Anal Sci. 2005 Nov;21(11):1281-5. Pubmed: 16317894 Link_out
                  15. Elchisak MA, Carlson JH: Assay of free and conjugated catecholamines by high-performance liquid chromatography with electrochemical detection. J Chromatogr. 1982 Dec 10;233:79-88. Pubmed: 7161364 Link_out
                  16. Eklundh T, Eriksson M, Sjoberg S, Nordin C: Monoamine precursors, transmitters and metabolites in cerebrospinal fluid: a prospective study in healthy male subjects. J Psychiatr Res. 1996 May-Jun;30(3):201-8. Pubmed: 8884658 Link_out
                  17. Kopieniak M, Wieczorkiewicz-Plaza A, Maciejewski R: Dopamine activity changes in cerebral cortex in the course of experimental acute pancreatitis. Ann Univ Mariae Curie Sklodowska [Med]. 2004;59(1):382-6. Pubmed: 16146016 Link_out
                  18. Raw I, Schmidt BJ, Merzel J: Catecholamines and congenital pain insensitivity. Braz J Med Biol Res. 1984;17(3-4):271-9. Pubmed: 6085021 Link_out
                  19. Nikolelis DP, Drivelos DA, Simantiraki MG, Koinis S: An optical spot test for the detection of dopamine in human urine using stabilized in air lipid films. Anal Chem. 2004 Apr 15;76(8):2174-80. Pubmed: 15080725 Link_out
                  20. Eisenhofer G, Aneman A, Friberg P, Hooper D, Fandriks L, Lonroth H, Hunyady B, Mezey E: Substantial production of dopamine in the human gastrointestinal tract. J Clin Endocrinol Metab. 1997 Nov;82(11):3864-71. Pubmed: 9360553 Link_out
                  21. Berridge KC, Robinson TE: What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev. 1998 Dec;28(3):309-69. Pubmed: 9858756 Link_out
                  22. Giuliano F, Allard J: Dopamine and sexual function. Int J Impot Res. 2001 Aug;13 Suppl 3:S18-28. Pubmed: 11477488 Link_out
                  23. Giuliano F, Allard J: Dopamine and male sexual function. Eur Urol. 2001 Dec;40(6):601-8. Pubmed: 11805404 Link_out
                  24. Pecina S, Cagniard B, Berridge KC, Aldridge JW, Zhuang X: Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards. J Neurosci. 2003 Oct 15;23(28):9395-402. Pubmed: 14561867 Link_out
                  25. Barron AB, Maleszka R, Vander Meer RK, Robinson GE: Octopamine modulates honey bee dance behavior. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1703-7. Epub 2007 Jan 19. Pubmed: 17237217 Link_out

                  Enzymes
                  Name: Tyrosinase
                  Reactions:
                  Tyramine + Oxygen + NADH + Hydrogen Ion unknown Dopamine + NAD + Water details
                  Gene Name: TYR
                  Uniprot ID: P14679 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Amine oxidase [flavin-containing] B
                  Reactions:
                  Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide details
                  Gene Name: MAOB
                  Uniprot ID: P27338 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Amine oxidase [flavin-containing] A
                  Reactions:
                  Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide details
                  Gene Name: MAOA
                  Uniprot ID: P21397 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Dopamine beta-hydroxylase
                  Reactions:
                  Dopamine + Ascorbic acid + Oxygen unknown xi-Norepinephrine + Dehydroascorbic acid + Water details
                  Dopamine + Ascorbic acid + Oxygen unknown Norepinephrine + Dehydroascorbic acid + Water details
                  Gene Name: DBH
                  Uniprot ID: P09172 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Catechol O-methyltransferase
                  Reactions:
                  S-Adenosylmethionine + Dopamine unknown S-Adenosylhomocysteine + 3-Methoxytyramine details
                  Gene Name: COMT
                  Uniprot ID: P21964 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Aromatic-L-amino-acid decarboxylase
                  Reactions:
                  L-Dopa unknown Dopamine + CO(2) details
                  L-Dopa unknown Dopamine + Carbon dioxide details
                  Gene Name: DDC
                  Uniprot ID: P20711 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Amiloride-sensitive amine oxidase [copper-containing]
                  Reactions: Not Available
                  Gene Name: ABP1
                  Uniprot ID: P19801 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Membrane primary amine oxidase
                  Reactions:
                  Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide details
                  Gene Name: AOC3
                  Uniprot ID: Q16853 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Retina-specific copper amine oxidase
                  Reactions:
                  Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide details
                  Gene Name: AOC2
                  Uniprot ID: O75106 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Cytochrome P450 2C9
                  Reactions: Not Available
                  Gene Name: CYP2C9
                  Uniprot ID: P11712 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Cytochrome P450 2C19
                  Reactions: Not Available
                  Gene Name: CYP2C19
                  Uniprot ID: P33261 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Cytochrome P450 2D6
                  Reactions: Not Available
                  Gene Name: CYP2D6
                  Uniprot ID: P10635 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Cytochrome P450 1A2
                  Reactions: Not Available
                  Gene Name: CYP1A2
                  Uniprot ID: P05177 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: D(2) dopamine receptor
                  Reactions: Not Available
                  Gene Name: DRD2
                  Uniprot ID: P14416 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: D(4) dopamine receptor
                  Reactions: Not Available
                  Gene Name: DRD4
                  Uniprot ID: P21917 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Sodium-dependent dopamine transporter
                  Reactions: Not Available
                  Gene Name: SLC6A3
                  Uniprot ID: Q01959 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Neuron-specific vesicular protein calcyon
                  Reactions: Not Available
                  Gene Name: CALY
                  Uniprot ID: Q9NYX4 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Calcium-dependent secretion activator 1
                  Reactions: Not Available
                  Gene Name: CADPS
                  Uniprot ID: Q9ULU8 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Calcium-dependent secretion activator 2
                  Reactions: Not Available
                  Gene Name: CADPS2
                  Uniprot ID: Q86UW7 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: D(3) dopamine receptor
                  Reactions: Not Available
                  Gene Name: DRD3
                  Uniprot ID: P35462 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: D(1A) dopamine receptor
                  Reactions: Not Available
                  Gene Name: DRD1
                  Uniprot ID: P21728 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: D(1B) dopamine receptor
                  Reactions: Not Available
                  Gene Name: DRD5
                  Uniprot ID: P21918 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Dopamine D4 receptor
                  Reactions: Not Available
                  Gene Name: dopamine D4 receptor
                  Uniprot ID: Q99586 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Dopamine D4 receptor
                  Reactions: Not Available
                  Gene Name: dopamine D4 receptor
                  Uniprot ID: Q99587 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Transporters
                  Name: Solute carrier family 22 member 5
                  Reactions: Not Available
                  Gene Name: SLC22A5
                  Uniprot ID: O76082 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Solute carrier family 22 member 1
                  Reactions: Not Available
                  Gene Name: SLC22A1
                  Uniprot ID: O15245 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Solute carrier family 22 member 2
                  Reactions: Not Available
                  Gene Name: SLC22A2
                  Uniprot ID: O15244 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Solute carrier family 22 member 3
                  Reactions: Not Available
                  Gene Name: SLC22A3
                  Uniprot ID: O75751 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA