Human Metabolome Database Version 3.5

Showing metabocard for Ethanol (HMDB00108)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:07:54 -0700
HMDB ID HMDB00108
Secondary Accession Numbers None
Metabolite Identification
Common Name Ethanol
Description Ethanol is a clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages. Indeed, ethanol has widespread use as a solvent of substances intended for human contact or consumption, including scents, flavorings, colorings, and medicines. Ethanol has a depressive effect on the central nervous system and because of its psychoactive effects, it is considered a drug. Ethanol has a complex mode of action and affects multiple systems in the brain, most notably it acts as an agonist to the GABA receptors. Death from ethanol consumption is possible when blood alcohol level reaches 0.4%. A blood level of 0.5% or more is commonly fatal. Levels of even less than 0.1% can cause intoxication, with unconsciousness often occurring at 0.3-0.4 %. Ethanol is metabolized by the body as an energy-providing carbohydrate nutrient, as it metabolizes into acetyl CoA, an intermediate common with glucose metabolism, that can be used for energy in the citric acid cycle or for biosynthesis. Ethanol within the human body is converted into acetaldehyde by alcohol dehydrogenase and then into acetic acid by acetaldehyde dehydrogenase. The product of the first step of this breakdown, acetaldehyde, is more toxic than ethanol. Acetaldehyde is linked to most of the clinical effects of alcohol. It has been shown to increase the risk of developing cirrhosis of the liver,[77] multiple forms of cancer, and alcoholism. Industrially, ethanol is produced both as a petrochemical, through the hydration of ethylene, and biologically, by fermenting sugars with yeast. Small amounts of ethanol are endogenously produced by gut microflora through anaerobic fermentation. However most ethanol detected in biofluids and tissues likely comes from consumption of alcoholic beverages. Absolute ethanol or anhydrous alcohol generally refers to purified ethanol, containing no more than one percent water. Absolute alcohol is not intended for human consumption. It often contains trace amounts of toxic benzene (used to remove water by azeotropic distillation). Consumption of this form of ethanol can be fatal over a short time period. Generally absolute or pure ethanol is used as a solvent for lab and industrial settings where water will disrupt a desired reaction. Pure ethanol is classed as 200 proof in the USA and Canada, equivalent to 175 degrees proof in the UK system.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. 1-Hydroxyethane
  2. Absolute alcohol
  3. Absolute ethanol
  4. Absolute ethyl alcohol
  5. Aethanol
  6. Aethylalkohol
  7. Alcare Hand Degermer
  8. Alcohol
  9. Alcohols
  10. Alcool ethylique
  11. Alcool etilico
  12. Algrain
  13. Alkohol
  14. Alkoholu etylowego
  15. Anhydrol
  16. Anhydrous alcohol
  17. Cologne spirit
  18. Cologne spirits
  19. Dehydrated alcohol
  20. Dehydrated ethanol
  21. Denatured alcohol
  22. Denatured ethanol
  23. Desinfektol EL
  24. Diluted Alcohol
  25. Distilled spirits
  26. Ethanol 200 proof
  27. Ethanol solution
  28. Ethicap
  29. Ethyl alc
  30. Ethyl alcohol
  31. Ethyl alcohol anhydrous
  32. Ethyl alcohol in alcoholic beverages
  33. Ethyl alcohol usp
  34. Ethyl hydrate
  35. Ethyl hydroxide
  36. Fermentation alcohol
  37. Grain alcohol
  38. Hinetoless
  39. Hydroxyethane
  40. Infinity Pure
  41. Jaysol
  42. Jaysol S
  43. Lux
  44. Methylcarbinol
  45. Molasses alcohol
  46. Potato alcohol
  47. Punctilious ethyl alcohol
  48. Pyro
  49. Silent spirit
  50. Spirit
  51. Spirits of wine
  52. Spirt
  53. Synasol
  54. Tecsol
  55. Tecsol C
  56. Thanol
  57. Undenatured Ethanol
Chemical Formula C2H6O
Average Molecular Weight 46.0684
Monoisotopic Molecular Weight 46.041864814
IUPAC Name ethanol
Traditional IUPAC Name ethyl alcohol
CAS Registry Number 64-17-5
SMILES CCO
InChI Identifier InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3
InChI Key LFQSCWFLJHTTHZ-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Aliphatic Acyclic Compounds
Class Alcohols and Polyols
Sub Class Primary Alcohols
Other Descriptors
  • Aliphatic Acyclic Compounds
  • a primary alcohol(Cyc)
  • a short-chain alcohol(Cyc)
  • alkyl alcohol(ChEBI)
  • ethanols(ChEBI)
  • primary alcohol(ChEBI)
Substituents
  • N/A
Direct Parent Primary Alcohols
Ontology
Status Detected and Quantified
Origin
  • Food
Biofunction
  • Component of Androgen and estrogen metabolism
  • Component of Bile acid biosynthesis
  • Component of C21-Steroid hormone metabolism
  • Component of Fatty acid metabolism
  • Component of Glycerolipid metabolism
  • Component of Sulfur metabolism
  • Component of Tyrosine metabolism
Application Not Available
Cellular locations
  • Cytoplasm
  • Extracellular
  • Peroxisome
Physical Properties
State Liquid
Experimental Properties
Property Value Reference
Melting Point -114.1 °C Not Available
Boiling Point Not Available Not Available
Water Solubility 1000.0 mg/mL Not Available
LogP -0.31 HANSCH,C ET AL. (1995)
Predicted Properties
Property Value Source
Water Solubility 579 g/L ALOGPS
LogP -0.40 ALOGPS
LogP -0.16 ChemAxon
LogS 1.10 ALOGPS
pKa (strongest acidic) 16.47 ChemAxon
pKa (strongest basic) -2.2 ChemAxon
Hydrogen Acceptor Count 1 ChemAxon
Hydrogen Donor Count 1 ChemAxon
Polar Surface Area 20.23 A2 ChemAxon
Rotatable Bond Count 0 ChemAxon
Refractivity 13.01 ChemAxon
Polarizability 5.3 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge 0 ChemAxon
Spectra
1H NMR Spectrum
13C NMR Spectrum
MS/MS Spectrum EI-B (HITACHI RMU-7M)
[1H,1H] 2D NMR Spectrum
[1H,13C] 2D NMR Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Peroxisome
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue Location
  • Muscle
  • Skeletal Muscle
  • Bladder
  • Fibroblasts
  • Intestine
  • Neuron
  • Pancreas
  • Placenta
  • Kidney
  • Liver
  • Epidermis
  • Brain
  • Myelin
  • Prostate
  • Adrenal Gland
  • Fetus
  • Adipose Tissue
  • Adrenal Cortex
  • Adrenal Medulla
  • Lung
  • Nerve Cells
  • Platelet
  • Gonads
  • Gut
  • Heart
  • Mouth
Pathways
Name SMPDB Link KEGG Link
Ethanol Degradation SMP00449 Not Available
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
40.0 (0.0-80.0) uM Adult (>18 years old) Both Normal
Blood Detected and Quantified
15.0 (0.0-33.0) uM Adult (>18 years old) Both Normal
  • Geigy Scient...
Saliva Detected and Quantified
>10 uM Adult (>18 years old) Both Normal
Urine Detected and Quantified
<0.01 umol/mmol creatinine Adult (>18 years old) Both Normal
Urine Detected and Quantified
0.0105 umol/mmol creatinine Adult (>18 years old) Both Normal
Urine Detected and Quantified
5-500 umol/mmol creatinine Adult (>18 years old) Both Comment Normal
Urine Detected and Quantified
3.1 umol/mmol creatinine Adult (>18 years old) Both Normal
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified 40.2 +/- 12.1 uM Adult (>18 years old) Not Specified Heart Transplant
Blood Detected and Quantified 45393.0 (18027.0-74063.0) uM Adult (>18 years old) Both Alcohol intoxication
Blood Detected and Quantified 40615.0 +/- 17158.0 uM Adult (>18 years old) Male Drunk driver
Blood Detected and Quantified 90.0 (10.0-170.0) uM Adult (>18 years old) Both Comment Kidney disease
Cerebrospinal Fluid (CSF) Detected and Quantified 230 +/- 30 uM Adult (>18 years old) Not Specified Cervical myelopathy
Urine Detected and Quantified 54.0 (0.0-661.0) umol/mmol creatinine Not Specified Both Lung cancer
Urine Detected and Quantified 0.0039 - 0.0617 umol/mmol creatinine Adult (>18 years old) Both ADPKD
Urine Detected and Quantified 3543.6 +/- 1414.6 umol/mmol creatinine Adult (>18 years old) Male Drunk driver
Associated Disorders and Diseases
Disease References
Cervical myelopathy
  • Meshitsuka S, Morio Y, Nagashima H, Teshima R: 1H-NMR studies of cerebrospinal fluid: endogenous ethanol in patients with cervical myelopathy. Clin Chim Acta. 2001 Oct;312(1-2):25-30. Pubmed: 11580906 Link_out
      Lung Cancer
      • Wishart DS, Knox C, Guo AC, Eisner R, Young N, Gautam B, Hau DD, Psychogios N, Dong E, Bouatra S, Mandal R, Sinelnikov I, Xia J, Jia L, Cruz JA, Lim E, Sobsey CA, Shrivastava S, Huang P, Liu P, Fang L, Peng J, Fradette R, Cheng D, Tzur D, Clements M, Lewis A, De Souza A, Zuniga A, Dawe M, Xiong Y, Clive D, Greiner R, Nazyrova A, Shaykhutdinov R, Li L, Vogel HJ, Forsythe I: HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2008 Oct 25. Pubmed: 18953024 Link_out
          Kidney disease
          • Liebich HM, Woll J: Volatile substances in blood serum: profile analysis and quantitative determination. J Chromatogr. 1977 Nov 11;142:505-16. Pubmed: 914932 Link_out
              Alcoholism
              • Jones AW, Lund M, Andersson E: Drinking drivers in Sweden who consume denatured alcohol preparations: an analytical-toxicological study. J Anal Toxicol. 1989 Jul-Aug;13(4):199-203. Pubmed: 2779169 Link_out
              • Jones AW, Helander A: Changes in the concentrations of ethanol, methanol and metabolites of serotonin in two successive urinary voids from drinking drivers. Forensic Sci Int. 1998 May 11;93(2-3):127-34. Pubmed: 9717263 Link_out
                  Abnormal
                  • Schneider H, Glatt H: Sulpho-conjugation of ethanol in humans in vivo and by individual sulphotransferase forms in vitro. Biochem J. 2004 Nov 1;383(Pt. 3):543-9. Pubmed: 15281911 Link_out
                      Associated OMIM IDs
                      DrugBank ID DB00898 Link_out
                      DrugBank Metabolite ID Not Available
                      Phenol Explorer Compound ID Not Available
                      Phenol Explorer Metabolite ID Not Available
                      FoodDB ID FDB000753
                      KNApSAcK ID C00019560 Link_out
                      Chemspider ID 682 Link_out
                      KEGG Compound ID C00469 Link_out
                      BioCyc ID ETOH Link_out
                      BiGG ID 35062 Link_out
                      Wikipedia Link Ethanol Link_out
                      NuGOwiki Link HMDB00108 Link_out
                      Metagene Link HMDB00108 Link_out
                      METLIN ID 3203 Link_out
                      PubChem Compound 702 Link_out
                      PDB ID EOH Link_out
                      ChEBI ID 16236 Link_out
                      References
                      Synthesis Reference Lashley, David. Process for producing an alcoholic sugar cane juice beverage. U.S. (1988), 3 pp. CODEN: USXXAM US 4784859 A 19881115 CAN 110:113222 AN 1989:113222
                      Material Safety Data Sheet (MSDS) Download (PDF)
                      General References
                      1. Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7. Pubmed: 12097436 Link_out
                      2. Gordon Z, Parsons CL, Monga M: Intravesical ethanol test: an ineffective measure of bladder hyperpermeability. Urology. 2003 Mar;61(3):555-7. Pubmed: 12639646 Link_out
                      3. Huang JS, She QB, Crilly KS, Kiss Z: Ethanol, Zn2+ and insulin interact as progression factors to enhance DNA synthesis synergistically in the presence of Ca2+ and other cell cycle initiators in fibroblasts. Biochem J. 2000 Feb 15;346 Pt 1:241-7. Pubmed: 10657263 Link_out
                      4. Friedman GD, Klatsky AL, Siegelaub AB: Alcohol, tobacco, and hypertension. Hypertension. 1982 Sep-Oct;4(5 Pt 2):III143-50. Pubmed: 7049929 Link_out
                      5. Uemura M, Lehmann WD, Schneider W, Seitz HK, Benner A, Keppler-Hafkemeyer A, Hafkemeyer P, Kojima H, Fujimoto M, Tsujii T, Fukui H, Keppler D: Enhanced urinary excretion of cysteinyl leukotrienes in patients with acute alcohol intoxication. Gastroenterology. 2000 Jun;118(6):1140-8. Pubmed: 10833489 Link_out
                      6. Hemmingsen R, Barry DI, Hertz MM, Klinken L: Cerebral blood flow and oxygen consumption during ethanol withdrawal in the rat. Brain Res. 1979 Sep 14;173(2):259-69. Pubmed: 573652 Link_out
                      7. Lopez JM, Bombi JA, Valderrama R, Gimenez A, Pares A, Caballeria J, Imperial S, Navarro S: Effects of prolonged ethanol intake and malnutrition on rat pancreas. Gut. 1996 Feb;38(2):285-92. Pubmed: 8801213 Link_out
                      8. Yamashina S, Ikejima K, Enomoto N, Takei Y, Sato N: [Ethanol changes sensitivity of Kupffer cells to endotoxin] Nihon Arukoru Yakubutsu Igakkai Zasshi. 2003 Oct;38(5):415-24. Pubmed: 14639920 Link_out
                      9. Aye MM, Ma C, Lin H, Bower KA, Wiggins RC, Luo J: Ethanol-induced in vitro invasion of breast cancer cells: the contribution of MMP-2 by fibroblasts. Int J Cancer. 2004 Dec 10;112(5):738-46. Pubmed: 15386367 Link_out
                      10. De Martinis BS, de Paula CM, Braga A, Moreira HT, Martin CC: Alcohol distribution in different postmortem body fluids. Hum Exp Toxicol. 2006 Feb;25(2):93-7. Pubmed: 16539214 Link_out
                      11. Pohorecky LA: Influence of alcohol on peripheral neurotransmitter function. Fed Proc. 1982 Jun;41(8):2452-5. Pubmed: 6123447 Link_out
                      12. Dean RA, Zhang J, Brzezinski MR, Bosron WF: Tissue distribution of cocaine methyl esterase and ethyl transferase activities: correlation with carboxylesterase protein. J Pharmacol Exp Ther. 1995 Nov;275(2):965-71. Pubmed: 7473189 Link_out
                      13. Elias AN, Meshkinpour H, Valenta LJ, Grossman MK: Pseudo-Cushing's syndrome: the role of alcohol. J Clin Gastroenterol. 1982 Apr;4(2):137-9. Pubmed: 6282953 Link_out
                      14. Henriksson J, Knol M: A single bout of exercise is followed by a prolonged decrease in the interstitial glucose concentration in skeletal muscle. Acta Physiol Scand. 2005 Dec;185(4):313-20. Pubmed: 16266372 Link_out
                      15. Rosdahl H, Lind L, Millgard J, Lithell H, Ungerstedt U, Henriksson J: Effect of physiological hyperinsulinemia on blood flow and interstitial glucose concentration in human skeletal muscle and adipose tissue studied by microdialysis. Diabetes. 1998 Aug;47(8):1296-301. Pubmed: 9703331 Link_out
                      16. Boschmann M, Adams F, Schaller K, Franke G, Sharma AM, Klaus S, Luft FC, Jordan J: Hemodynamic and metabolic responses to interstitial angiotensin II in normal weight and obese men. J Hypertens. 2006 Jun;24(6):1165-71. Pubmed: 16685217 Link_out
                      17. Igawa Y, Satoh T, Mizusawa H, Seki S, Kato H, Ishizuka O, Nishizawa O: The role of capsaicin-sensitive afferents in autonomic dysreflexia in patients with spinal cord injury. BJU Int. 2003 May;91(7):637-41. Pubmed: 12699475 Link_out
                      18. Enocksson S, Shimizu M, Lonnqvist F, Nordenstrom J, Arner P: Demonstration of an in vivo functional beta 3-adrenoceptor in man. J Clin Invest. 1995 May;95(5):2239-45. Pubmed: 7738189 Link_out
                      19. Collins JW, Macdermott S, Bradbrook RA, Keeley FX Jr, Timoney AG: Is using ethanol-glycine irrigating fluid monitoring and 'good surgical practice' enough to prevent harmful absorption during transurethral resection of the prostate? BJU Int. 2006 Jun;97(6):1247-51. Pubmed: 16686720 Link_out
                      20. Sokolik VV, Chursina VS, Artemchuk AA, Artemchuk AF, Bozhko GKh: [Depression of serum esterase and lipoprotein lipase activities in acute and longitudinal actions of ethanol] Biomed Khim. 2006 Jan-Feb;52(1):95-100. Pubmed: 16739925 Link_out
                      21. Snyder R, Kalf GF: A perspective on benzene leukemogenesis. Crit Rev Toxicol. 1994;24(3):177-209. Pubmed: 7945890 Link_out
                      22. McDonnell G, Russell AD: Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999 Jan;12(1):147-79. Pubmed: 9880479 Link_out
                      23. Barceloux DG, Bond GR, Krenzelok EP, Cooper H, Vale JA: American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. J Toxicol Clin Toxicol. 2002;40(4):415-46. Pubmed: 12216995 Link_out
                      24. Hingson R, Winter M: Epidemiology and consequences of drinking and driving. Alcohol Res Health. 2003;27(1):63-78. Pubmed: 15301401 Link_out
                      25. Chastain G: Alcohol, neurotransmitter systems, and behavior. J Gen Psychol. 2006 Oct;133(4):329-35. Pubmed: 17128954 Link_out

                      Enzymes

                      Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 52 enzymes in total.

                      Name: Serum paraoxonase/lactonase 3
                      Reactions: Not Available
                      Gene Name: PON3
                      Uniprot ID: Q15166 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Serum paraoxonase/arylesterase 1
                      Reactions: Not Available
                      Gene Name: PON1
                      Uniprot ID: P27169 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Serum paraoxonase/arylesterase 2
                      Reactions: Not Available
                      Gene Name: PON2
                      Uniprot ID: Q15165 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Intestinal-type alkaline phosphatase
                      Reactions: Not Available
                      Gene Name: ALPI
                      Uniprot ID: P09923 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Lysosomal acid phosphatase
                      Reactions: Not Available
                      Gene Name: ACP2
                      Uniprot ID: P11117 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Alkaline phosphatase, tissue-nonspecific isozyme
                      Reactions: Not Available
                      Gene Name: ALPL
                      Uniprot ID: P05186 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Tartrate-resistant acid phosphatase type 5
                      Reactions: Not Available
                      Gene Name: ACP5
                      Uniprot ID: P13686 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Alkaline phosphatase, placental-like
                      Reactions: Not Available
                      Gene Name: ALPPL2
                      Uniprot ID: P10696 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Aldehyde dehydrogenase, mitochondrial
                      Reactions: Not Available
                      Gene Name: ALDH2
                      Uniprot ID: P05091 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Aldehyde dehydrogenase X, mitochondrial
                      Reactions: Not Available
                      Gene Name: ALDH1B1
                      Uniprot ID: P30837 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Sulfotransferase family cytosolic 2B member 1
                      Reactions: Not Available
                      Gene Name: SULT2B1
                      Uniprot ID: O00204 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Cytochrome P450 4A11
                      Reactions: Not Available
                      Gene Name: CYP4A11
                      Uniprot ID: Q02928 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Sorbitol dehydrogenase
                      Reactions: Not Available
                      Gene Name: SORD
                      Uniprot ID: Q00796 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Alcohol dehydrogenase [NADP(+)]
                      Reactions:
                      Ethanol + NADP unknown Acetaldehyde + NADPH + Hydrogen Ion details
                      Gene Name: AKR1A1
                      Uniprot ID: P14550 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Alcohol dehydrogenase 4
                      Reactions:
                      Ethanol + NAD unknown Acetaldehyde + NADH + Hydrogen Ion details
                      Gene Name: ADH4
                      Uniprot ID: P08319 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Aldehyde dehydrogenase family 3 member B2
                      Reactions: Not Available
                      Gene Name: ALDH3B2
                      Uniprot ID: P48448 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Aldehyde dehydrogenase family 3 member B1
                      Reactions: Not Available
                      Gene Name: ALDH3B1
                      Uniprot ID: P43353 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Alcohol dehydrogenase class-3
                      Reactions:
                      Ethanol + NAD unknown Acetaldehyde + NADH + Hydrogen Ion details
                      Gene Name: ADH5
                      Uniprot ID: P11766 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: 3-mercaptopyruvate sulfurtransferase
                      Reactions: Not Available
                      Gene Name: MPST
                      Uniprot ID: P25325 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Alcohol dehydrogenase 1B
                      Reactions:
                      Ethanol + NAD unknown Acetaldehyde + NADH + Hydrogen Ion details
                      Gene Name: ADH1B
                      Uniprot ID: P00325 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Alcohol dehydrogenase class 4 mu/sigma chain
                      Reactions:
                      Ethanol + NAD unknown Acetaldehyde + NADH + Hydrogen Ion details
                      Gene Name: ADH7
                      Uniprot ID: P40394 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Alcohol dehydrogenase 1A
                      Reactions:
                      Ethanol + NAD unknown Acetaldehyde + NADH + Hydrogen Ion details
                      Gene Name: ADH1A
                      Uniprot ID: P07327 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Alcohol dehydrogenase 6
                      Reactions:
                      Ethanol + NAD unknown Acetaldehyde + NADH + Hydrogen Ion details
                      Gene Name: ADH6
                      Uniprot ID: P28332 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Alcohol dehydrogenase 1C
                      Reactions:
                      Ethanol + NAD unknown Acetaldehyde + NADH + Hydrogen Ion details
                      Gene Name: ADH1C
                      Uniprot ID: P00326 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Beta-glucuronidase
                      Reactions: Not Available
                      Gene Name: GUSB
                      Uniprot ID: P08236 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Plasma alpha-L-fucosidase
                      Reactions: Not Available
                      Gene Name: FUCA2
                      Uniprot ID: Q9BTY2 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Trans-2-enoyl-CoA reductase, mitochondrial
                      Reactions: Not Available
                      Gene Name: MECR
                      Uniprot ID: Q9BV79 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Cytochrome P450 3A4
                      Reactions: Not Available
                      Gene Name: CYP3A4
                      Uniprot ID: P08684 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Cytochrome P450 2C9
                      Reactions: Not Available
                      Gene Name: CYP2C9
                      Uniprot ID: P11712 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Cytochrome P450 2C19
                      Reactions: Not Available
                      Gene Name: CYP2C19
                      Uniprot ID: P33261 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Cytochrome P450 2E1
                      Reactions: Not Available
                      Gene Name: CYP2E1
                      Uniprot ID: P05181 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Cytochrome P450 2B6
                      Reactions: Not Available
                      Gene Name: CYP2B6
                      Uniprot ID: P20813 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Cytochrome P450 1A1
                      Reactions: Not Available
                      Gene Name: CYP1A1
                      Uniprot ID: P04798 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Cytochrome P450 1A2
                      Reactions: Not Available
                      Gene Name: CYP1A2
                      Uniprot ID: P05177 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Lecithin retinol acyltransferase
                      Reactions: Not Available
                      Gene Name: LRAT
                      Uniprot ID: O95237 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nuclear receptor subfamily 1 group I member 3
                      Reactions: Not Available
                      Gene Name: NR1I3
                      Uniprot ID: Q14994 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Zinc-binding alcohol dehydrogenase domain-containing protein 2
                      Reactions: Not Available
                      Gene Name: ZADH2
                      Uniprot ID: Q8N4Q0 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Hydroxyacid-oxoacid transhydrogenase, mitochondrial
                      Reactions: Not Available
                      Gene Name: ADHFE1
                      Uniprot ID: Q8IWW8 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Fatty acyl-CoA reductase 2
                      Reactions: Not Available
                      Gene Name: FAR2
                      Uniprot ID: Q96K12 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Acyl-CoA wax alcohol acyltransferase 2
                      Reactions: Not Available
                      Gene Name: AWAT2
                      Uniprot ID: Q6E213 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Klotho
                      Reactions: Not Available
                      Gene Name: KL
                      Uniprot ID: Q9UEF7 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Glutamate [NMDA] receptor subunit 3A
                      Reactions: Not Available
                      Gene Name: GRIN3A
                      Uniprot ID: Q8TCU5 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Gamma-aminobutyric acid receptor subunit alpha-1
                      Reactions: Not Available
                      Gene Name: GABRA1
                      Uniprot ID: P14867 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Glycine receptor subunit alpha-1
                      Reactions: Not Available
                      Gene Name: GLRA1
                      Uniprot ID: P23415 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Glycine receptor subunit alpha-2
                      Reactions: Not Available
                      Gene Name: GLRA2
                      Uniprot ID: P23416 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Testicular acid phosphatase
                      Reactions: Not Available
                      Gene Name: ACPT
                      Uniprot ID: Q9BZG2 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Carboxylesterase 5A
                      Reactions: Not Available
                      Gene Name: CES5A
                      Uniprot ID: Q6NT32 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Acid phosphatase-like protein 2
                      Reactions: Not Available
                      Gene Name: ACPL2
                      Uniprot ID: Q8TE99 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Synaptic vesicle membrane protein VAT-1 homolog-like
                      Reactions: Not Available
                      Gene Name: VAT1L
                      Uniprot ID: Q9HCJ6 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Quinone oxidoreductase PIG3
                      Reactions: Not Available
                      Gene Name: TP53I3
                      Uniprot ID: Q53FA7 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA