Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2013-05-29 19:24:47 UTC
HMDB IDHMDB00123
Secondary Accession NumbersNone
Metabolite Identification
Common NameGlycine
DescriptionGlycine is a simple, nonessential amino acid, although experimental animals show reduced growth on low-glycine diets. The average adult ingests 3 to 5 grams of glycine daily. Glycine is involved in the body's production of DNA, phospholipids and collagen, and in release of energy. Glycine levels are effectively measured in plasma in both normal patients and those with inborn errors of glycine metabolism. (http://www.dcnutrition.com/AminoAcids/) Nonketotic hyperglycinaemia (OMIM 606899 ) is an autosomal recessive condition caused by deficient enzyme activity of the glycine cleavage enzyme system (EC 2.1.1.10). The glycine cleavage enzyme system comprises four proteins: P-, T-, H- and L-proteins (EC 1.4.4.2, EC 2.1.2.10 and EC 1.8.1.4 for P-, T- and L-proteins). Mutations have been described in the GLDC (OMIM 238300 ), AMT (OMIM 238310 ), and GCSH (OMIM 238330 ) genes encoding the P-, T-, and H-proteins respectively. The glycine cleavage system catalyses the oxidative conversion of glycine into carbon dioxide and ammonia, with the remaining one-carbon unit transferred to folate as methylenetetrahydrofolate. It is the main catabolic pathway for glycine and it also contributes to one-carbon metabolism. Patients with a deficiency of this enzyme system have increased glycine in plasma, urine and cerebrospinal fluid (CSF) with an increased CSF: plasma glycine ratio. (PMID 16151895 ).
Structure
Thumb
Synonyms
  1. 2-Aminoacetate
  2. 2-Aminoacetic acid
  3. Aciport
  4. Amino-Acetate
  5. Amino-Acetic acid
  6. Aminoacetate
  7. Aminoacetic acid
  8. Aminoethanoate
  9. Aminoethanoic acid
  10. Glicoamin
  11. Glycocoll
  12. Glycolixir
  13. Glycosthene
  14. Gyn-Hydralin
  15. Padil
Chemical FormulaC2H5NO2
Average Molecular Weight75.0666
Monoisotopic Molecular Weight75.032028409
IUPAC Name2-aminoacetic acid
Traditional IUPAC Nameglycine
CAS Registry Number56-40-6
SMILES
NCC(O)=O
InChI Identifier
InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChI KeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
Chemical Taxonomy
KingdomOrganic Compounds
Super ClassAmino Acids, Peptides, and Analogues
ClassAmino Acids and Derivatives
Sub ClassAlpha Amino Acids and Derivatives
Other Descriptors
  • Aliphatic Acyclic Compounds
  • Amino acids(KEGG)
  • Common amino acids(KEGG)
  • amino acid zwitterion(ChEBI)
Substituents
  • Carboxylic Acid
  • Primary Aliphatic Amine (Alkylamine)
Direct ParentAlpha Amino Acids and Derivatives
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
Biofunction
  • Non-essential amino acid
ApplicationNot Available
Cellular locations
  • Extracellular
  • Mitochondria
  • Lysosome
  • Peroxisome
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point262.2 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility249.0 mg/mLNot Available
LogP-3.21HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
water solubility552 g/LALOGPS
logP-3.3ALOGPS
logP-3.4ChemAxon
logS0.87ALOGPS
pKa (strongest acidic)2.31ChemAxon
pKa (strongest basic)9.24ChemAxon
physiological charge0ChemAxon
hydrogen acceptor count3ChemAxon
hydrogen donor count2ChemAxon
polar surface area63.32ChemAxon
rotatable bond count1ChemAxon
refractivity16ChemAxon
polarizability6.65ChemAxon
Spectra
Spectra
Biological Properties
Cellular Locations
  • Extracellular
  • Mitochondria
  • Lysosome
  • Peroxisome
Biofluid Locations
  • Bile
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue Location
  • Bladder
  • Brain
  • Epidermis
  • Fibroblasts
  • Intestine
  • Kidney
  • Myelin
  • Neuron
  • Pancreas
  • Placenta
  • Platelet
  • Prostate
  • Spleen
  • Stratum Corneum
  • Thyroid Gland
Pathways
NameSMPDB LinkKEGG Link
Alanine MetabolismSMP00055map00250
Ammonia RecyclingSMP00009map00910
Bile Acid BiosynthesisSMP00035map00120
Carnitine SynthesisSMP00465Not Available
Glutathione MetabolismSMP00015map00480
Glycine and Serine MetabolismSMP00004map00260
Methionine MetabolismSMP00033map00270
Porphyrin MetabolismSMP00024map00860
Normal Concentrations
BiofluidStatusValueAgeSexConditionReference
BileDetected and Quantified>10 uMAdult (>18 years old)BothNormal
BloodDetected and Quantified242.0 +/- 44.0 uMAdult (>18 years old)MaleNormal
  • Geigy Scient...
BloodDetected and Quantified258.0 +/- 64.0 uMAdult (>18 years old)FemaleNormal
  • Geigy Scient...
BloodDetected and Quantified329.9 +/- 105.6 uMAdult (>18 years old)Not SpecifiedNormal
BloodDetected and Quantified280.0 (140.0-420.0) uMNewborn (0-30 days old)BothNormal
BloodDetected and Quantified486.0 (232.0-740.0) uMAdult (>18 years old)BothNormal
BloodDetected and Quantified212.4 +/- 57.4 uMAdult (>18 years old)MaleNormal
BloodDetected and Quantified230.0 (178.0-282.0) uMAdult (>18 years old)BothNormal
BloodDetected and Quantified325.4 +/- 126.8 uMAdult (>18 years old)Not SpecifiedNormal
BloodDetected and Quantified460.0 +/- 275.0 uMNewborn (0-30 days old)Not SpecifiedNormal
  • Geigy Scient...
BloodDetected and Quantified234.0 +/- 34.0 uMChildren (1-13 year old)MaleNormal
  • Geigy Scient...
Cerebrospinal Fluid (CSF)Detected and Quantified4.7 +/- 1.5 uMAdult (>18 years old)BothNormal
  • Geigy Scient...
Cerebrospinal Fluid (CSF)Detected and Quantified9.0 (3.0-19.0) uMAdult (>18 years old)BothNormal
Cerebrospinal Fluid (CSF)Detected and Quantified9.5 +/- 4.7 uMAdult (>18 years old)Not SpecifiedNormal
Cerebrospinal Fluid (CSF)Detected and Quantified8.2 +/- 3.0 uMAdult (>18 years old)Not SpecifiedNormal
Cerebrospinal Fluid (CSF)Detected and Quantified6.1 +/- 1.4 uMAdult (>18 years old)Not SpecifiedNormal
Cerebrospinal Fluid (CSF)Detected and Quantified4.63 +/- 0.74 uMAdult (>18 years old)BothNormal
Cerebrospinal Fluid (CSF)Detected and Quantified8.30 (5.88-10.7) uMAdult (>18 years old)BothNormal
Cerebrospinal Fluid (CSF)Detected and Quantified11 +/- 4  uMNot SpecifiedNot SpecifiedNormal
SalivaDetected and Quantified1-472 uMAdult (>18 years old)MaleCommentnormal
SalivaDetected and Quantified1-94 uMAdult (>18 years old)MaleCommentnormal
SalivaDetected and Quantified>10 uMAdult (>18 years old)BothNormal
UrineDetected and Quantified75.7 +/- 51.7 umol/mmol creatinineAdult (>18 years old)BothCommentNormal
UrineDetected but not QuantifiedNot ApplicableAdult (>18 years old)MaleNormal
UrineDetected and Quantified165.0 umol/mmol creatinineAdult (>18 years old)BothNormal
UrineDetected and Quantified151(48-233) umol/mmol creatinineAdult (>18 years old)BothNormal
UrineDetected and Quantified119.95-599.74 umol/mmol creatinineAdult (>18 years old)BothNormal
  • David F. Put...
UrineDetected and Quantified151.0 (233-248) umol/mmol creatinineAdult (>18 years old)BothNormal
UrineDetected but not QuantifiedNot ApplicableAdult (>18 years old)BothNormal
UrineDetected and Quantified513.54 +/- 360.61 umol/mmol creatinineInfant (0-1 year old)BothNormal
UrineDetected and Quantified106 (44-300) umol/mmol creatinineAdult (>18 years old)BothCommentNormal
UrineDetected and Quantified0.0027 - 0.0682 umol/mmol creatinineAdult (>18 years old)BothNormal
UrineDetected and Quantified71.23 umol/mmol creatinineAdult (>18 years old)MaleNormal
  • Shaykhutdino...
UrineDetected but not QuantifiedNot ApplicableAdult (>18 years old)BothCommentNormal
UrineDetected and Quantified128.1 +/- 65.5 umol/mmol creatinineAdult (>18 years old)MaleNormal
UrineDetected and Quantified187.6 +/- 92.3 umol/mmol creatinineAdult (>18 years old)FemaleNormal
UrineDetected and Quantified15.0 (10.0-23.0) umol/mmol creatinineNewborn (0-30 days old)BothNormal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
UrineDetected and Quantified30.0 +/- 19.0 umol/mmol creatinineChildren (1-13 year old)BothNormal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
UrineDetected but not QuantifiedNot ApplicableAdult (>18 years old)MaleCommentNormal
UrineDetected and Quantified92.0 +/- 39.0 umol/mmol creatinineAdult (>18 years old)MaleNormal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
UrineDetected but not QuantifiedNot ApplicableAdult (>18 years old)MaleCommentNormal
UrineDetected and Quantified139.0 +/- 86.0 umol/mmol creatinineAdult (>18 years old)FemaleNormal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
UrineDetected and Quantified136.48 +/- 77.27 umol/mmol creatinineAdult (>18 years old)BothNormal
UrineDetected and Quantified101 (37.0-250.6) umol/mmol creatinineAdult (>18 years old)BothCommentNormal
UrineDetected and Quantified118.9 umol/mmol creatinineAdult (>18 years old)BothNormal
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodDetected and Quantified234.9 +/- 181.1 uMAdult (>18 years old)Not SpecifiedHeart Transplant
BloodDetected and Quantified1090.0 (780.0-1400.0) uMNewborn (0-30 days old)BothNon-ketotic hyperglycinemia
BloodDetected and Quantified1000.0 (800.0-1200.0) uMChildren (1-13 year old)BothD-Glyceric acidura
BloodDetected and Quantified210.0 (203.0-217.0) uMAdult (>18 years old)BothRefractory localization-related epilepsy (RLE)
BloodDetected and Quantified354.0 (309.0-399.0) uMChildren (1-13 year old)BothJuvenile myoclonic epilepsy (JME)
BloodDetected and Quantified0.153 +/- 0.012 uMElderly (>65 years old)BothAlzheimer's disease
Cerebrospinal Fluid (CSF)Detected and Quantified9.7 +/- 4.9 uMChildren (1-13 year old)Not SpecifiedLeukemia
Cerebrospinal Fluid (CSF)Detected and Quantified13.4 +/- 6.4 uMChildren (1-13 year old)Not SpecifiedCommentLeukemia
Cerebrospinal Fluid (CSF)Detected and Quantified9.0405 (8.716-9.623) uMNot SpecifiedNot Specifiedcontrol
Cerebrospinal Fluid (CSF)Detected and Quantified4.5 +/- 0.75 uMAdult (>18 years old)BothSchizophrenia
Cerebrospinal Fluid (CSF)Detected and Quantified0.28 +/- 0.12 uMAdult (>18 years old)BothAlzheimer's disease
UrineDetected and Quantified3000.0 (1000.0-5000.0) umol/mmol creatinineChildren (1-13 year old)BothCarbamoyl phosphate synthetase deficiency
UrineDetected and Quantified0.0024 - 0.0339 umol/mmol creatinineAdult (>18 years old)BothADPKD
UrineDetected and Quantified84.0 +/- 67.0 umol/mmol creatinineAdult (>18 years old)BothLung cancer
UrineDetected and Quantified0.010 +/- 0.001 umol/mmol creatinineAdult (>18 years old)BothAlzheimer's disease
UrineDetected and Quantified178.2 +/- 6.4 umol/mmol creatinineAdult (>18 years old)Both3-Hydroxy-3- methylglutaryl-CoA lyase (HL) deficency
UrineDetected and Quantified135.8 +/- 5.8 umol/mmol creatinineAdult (>18 years old)Both3-Hydroxy-3- methylglutaryl-CoA lyase (HL) deficency
UrineDetected and Quantified53.1 +/- 1.8 umol/mmol creatinineAdult (>18 years old)BothArginosuccinic aciduria
UrineDetected and Quantified585.5 +/- 32.1 umol/mmol creatinineAdult (>18 years old)BothPropionic acidemia
UrineDetected and Quantified550.00 (100.00-1000.00) umol/mmol creatinineChildren (1-13 year old)BothIminoglycinuria
UrineDetected and Quantified2040.3 +/- 202.6 umol/mmol creatinineAdult (>18 years old)BothPropionic acidemia
UrineDetected and Quantified49.9 +/- 1.3 umol/mmol creatinineAdult (>18 years old)BothTyrosinemia I
UrineDetected and Quantified176.2 +/- 9.2 umol/mmol creatinineAdult (>18 years old)BothTyrosinemia I
UrineDetected and Quantified82.2 +/- 4.1 umol/mmol creatinineAdult (>18 years old)BothPhenylketonuria
UrineDetected and Quantified304.8 +/- 11.3 umol/mmol creatinineAdult (>18 years old)BothPhenylketonuria
UrineDetected and Quantified233.7 +/- 10.5 umol/mmol creatinineAdult (>18 years old)BothMaple syrup urine disease
UrineDetected and Quantified3205.1 +/- 83.4 umol/mmol creatinineAdult (>18 years old)BothAminoaciduria
Associated Disorders and Diseases
Disease References
Alzheimer's disease
  • Fonteh AN, Harrington RJ, Tsai A, Liao P, Harrington MG: Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects. Amino Acids. 2007 Feb;32(2):213-24. Epub 2006 Oct 10. Pubmed: 17031479
Carbamoyl Phosphate Synthetase Deficiency
D-Glyceric acidemia
  • Boneh A, Degani Y, Harari M: Prognostic clues and outcome of early treatment of nonketotic hyperglycinemia. Pediatr Neurol. 1996 Sep;15(2):137-41. Pubmed: 8888048
Schizophrenia
  • Do KQ, Lauer CJ, Schreiber W, Zollinger M, Gutteck-Amsler U, Cuenod M, Holsboer F: gamma-Glutamylglutamine and taurine concentrations are decreased in the cerebrospinal fluid of drug-naive patients with schizophrenic disorders. J Neurochem. 1995 Dec;65(6):2652-62. Pubmed: 7595563
Juvenile myoclonic epilepsy
  • Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24. Pubmed: 14992292
Leukemia
  • Peng CT, Wu KH, Lan SJ, Tsai JJ, Tsai FJ, Tsai CH: Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy. Eur J Cancer. 2005 May;41(8):1158-63. Epub 2005 Apr 14. Pubmed: 15911239
Lung Cancer
  • Stretch C, Eastman T, Mandal R, Eisner R, Wishart DS, Mourtzakis M, Prado CM, Damaraju S, Ball RO, Greiner R, Baracos VE: Prediction of skeletal muscle and fat mass in patients with advanced cancer using a metabolomic approach. J Nutr. 2012 Jan;142(1):14-21. doi: 10.3945/jn.111.147751. Epub 2011 Dec 7. Pubmed: 22157537
Refractory localization-related epilepsy
  • Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24. Pubmed: 14992292
Iminoglycinuria
Associated OMIM IDs
DrugBank IDDB00145
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite ID1062
FoodDB IDFDB000484
KNApSAcK IDC00001361
Chemspider ID730
KEGG Compound IDC00037
BioCyc IDGLY
BiGG ID33610
Wikipedia LinkGlycine
NuGOwiki LinkHMDB00123
Metagene LinkHMDB00123
METLIN ID20
PubChem Compound750
PDB IDGLY
ChEBI ID15428
References
Synthesis Reference Anslow, Winston K.; King, Harold. Synthesis of glycine. Journal of the Chemical Society (1929), 2163-6.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411
  2. Shoemaker JD, Elliott WH: Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. J Chromatogr. 1991 Jan 2;562(1-2):125-38. Pubmed: 2026685
  3. Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7. Pubmed: 12097436
  4. Nicholson JK, O'Flynn MP, Sadler PJ, Macleod AF, Juul SM, Sonksen PH: Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects. Biochem J. 1984 Jan 15;217(2):365-75. Pubmed: 6696735
  5. Bales JR, Higham DP, Howe I, Nicholson JK, Sadler PJ: Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine. Clin Chem. 1984 Mar;30(3):426-32. Pubmed: 6321058
  6. Engelborghs S, Marescau B, De Deyn PP: Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. Neurochem Res. 2003 Aug;28(8):1145-50. Pubmed: 12834252
  7. Collins JW, Macdermott S, Bradbrook RA, Keeley FX Jr, Timoney AG: Is using ethanol-glycine irrigating fluid monitoring and 'good surgical practice' enough to prevent harmful absorption during transurethral resection of the prostate? BJU Int. 2006 Jun;97(6):1247-51. Pubmed: 16686720
  8. Hagenfeldt L, Bjerkenstedt L, Edman G, Sedvall G, Wiesel FA: Amino acids in plasma and CSF and monoamine metabolites in CSF: interrelationship in healthy subjects. J Neurochem. 1984 Mar;42(3):833-7. Pubmed: 6198473
  9. Christie GR, Ford D, Howard A, Clark MA, Hirst BH: Glycine supply to human enterocytes mediated by high-affinity basolateral GLYT1. Gastroenterology. 2001 Feb;120(2):439-48. Pubmed: 11159884
  10. Jones CM, Smith M, Henderson MJ: Reference data for cerebrospinal fluid and the utility of amino acid measurement for the diagnosis of inborn errors of metabolism. Ann Clin Biochem. 2006 Jan;43(Pt 1):63-6. Pubmed: 16390611
  11. Peng CT, Wu KH, Lan SJ, Tsai JJ, Tsai FJ, Tsai CH: Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy. Eur J Cancer. 2005 May;41(8):1158-63. Epub 2005 Apr 14. Pubmed: 15911239
  12. Cynober LA: Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition. 2002 Sep;18(9):761-6. Pubmed: 12297216
  13. Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24. Pubmed: 14992292
  14. Bennett FI, Jackson AA: Glycine is not formed through the amino transferase reaction in human or rat placenta. Placenta. 1998 May;19(4):329-31. Pubmed: 9639330
  15. Gomeza J, Ohno K, Hulsmann S, Armsen W, Eulenburg V, Richter DW, Laube B, Betz H: Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality. Neuron. 2003 Nov 13;40(4):797-806. Pubmed: 14622583
  16. Boneh A, Degani Y, Harari M: Prognostic clues and outcome of early treatment of nonketotic hyperglycinemia. Pediatr Neurol. 1996 Sep;15(2):137-41. Pubmed: 8888048
  17. Dicke JM, Verges D, Kelley LK, Smith CH: Glycine uptake by microvillous and basal plasma membrane vesicles from term human placentae. Placenta. 1993 Jan-Feb;14(1):85-92. Pubmed: 8456092
  18. Prescot AP, de B Frederick B, Wang L, Brown J, Jensen JE, Kaufman MJ, Renshaw PF: In vivo detection of brain glycine with echo-time-averaged (1)H magnetic resonance spectroscopy at 4.0 T. Magn Reson Med. 2006 Mar;55(3):681-6. Pubmed: 16453318
  19. Byard RW, Harrison R, Wells R, Gilbert JD: Glycine toxicity and unexpected intra-operative death. J Forensic Sci. 2001 Sep;46(5):1244-6. Pubmed: 11569574
  20. Khan SA, Cox IJ, Hamilton G, Thomas HC, Taylor-Robinson SD: In vivo and in vitro nuclear magnetic resonance spectroscopy as a tool for investigating hepatobiliary disease: a review of H and P MRS applications. Liver Int. 2005 Apr;25(2):273-81. Pubmed: 15780050
  21. Van Hove JL, Vande Kerckhove K, Hennermann JB, Mahieu V, Declercq P, Mertens S, De Becker M, Kishnani PS, Jaeken J: Benzoate treatment and the glycine index in nonketotic hyperglycinaemia. J Inherit Metab Dis. 2005;28(5):651-63. Pubmed: 16151895

Enzymes

Gene Name:
ALAS2
Uniprot ID:
P22557
Reactions
Succinyl-CoA + Glycine unknown 5-Aminolevulinic acid + Coenzyme A + CO(2)details
Succinyl-CoA + Glycine unknown 5-Aminolevulinic acid + Coenzyme A + Carbon dioxidedetails
Gene Name:
ALAS1
Uniprot ID:
P13196
Reactions
Succinyl-CoA + Glycine unknown 5-Aminolevulinic acid + Coenzyme A + CO(2)details
Succinyl-CoA + Glycine unknown 5-Aminolevulinic acid + Coenzyme A + Carbon dioxidedetails
Gene Name:
GCAT
Uniprot ID:
O75600
Reactions
Acetyl-CoA + Glycine unknown Coenzyme A + L-2-Amino-3-oxobutanoic aciddetails
Acetyl-CoA + Glycine unknown Coenzyme A + L-2-Amino-3-oxobutanoic aciddetails
Gene Name:
PIPOX
Uniprot ID:
Q9P0Z9
Reactions
Sarcosine + Water + Oxygen unknown Glycine + Formaldehyde + Hydrogen peroxidedetails
Gene Name:
DAO
Uniprot ID:
P14920
Reactions
Glycine + Water + Oxygen unknown Glyoxylic acid + Ammonia + Hydrogen peroxidedetails
Gene Name:
GART
Uniprot ID:
P22102
Reactions
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine unknown ADP + Phosphoric acid + Glycineamideribotidedetails
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine unknown ADP + Phosphoric acid + Glycineamideribotidedetails
Gene Name:
AGXT2
Uniprot ID:
Q9BYV1
Reactions
L-Alanine + Glyoxylic acid unknown Pyruvic acid + Glycinedetails
Glycine + Oxoglutaric acid unknown Glyoxylic acid + L-Glutamic aciddetails
Gene Name:
GNMT
Uniprot ID:
Q14749
Reactions
S-Adenosylmethionine + Glycine unknown S-Adenosylhomocysteine + Sarcosinedetails
Gene Name:
ANPEP
Uniprot ID:
P15144
Reactions
Cysteinylglycine + Water unknown L-Cysteine + Glycinedetails
R-S-Cysteinylglycine + Water unknown S-Substituted L-cysteine + Glycinedetails
Gene Name:
GATM
Uniprot ID:
P50440
Reactions
L-Arginine + Glycine unknown Ornithine + Guanidoacetic aciddetails
Gene Name:
BAAT
Uniprot ID:
Q14032
Reactions
Choloyl-CoA + Glycine unknown Coenzyme A + Glycocholic aciddetails
Chenodeoxycholoyl-CoA + Glycine unknown Chenodeoxycholic acid glycine conjugate + Coenzyme Adetails
Gene Name:
GARS
Uniprot ID:
P41250
Reactions
Adenosine triphosphate + Glycine + tRNA(Gly) unknown Adenosine monophosphate + Pyrophosphate + glycyl-tRNA(Gly)details
Adenosine triphosphate + Glycine + tRNA(Gly) unknown Adenosine monophosphate + Pyrophosphate + Glycyl-tRNA(Gly)details
Gene Name:
AMT
Uniprot ID:
P48728
Reactions
Glycine + Tetrahydrofolic acid + NAD unknown 5,10-Methylene-THF + Ammonia + Carbon dioxide + NADH + Hydrogen Iondetails
Gene Name:
AGXT
Uniprot ID:
P21549
Reactions
L-Alanine + Glyoxylic acid unknown Pyruvic acid + Glycinedetails
Glycine + Oxoglutaric acid unknown Glyoxylic acid + L-Glutamic aciddetails
L-Serine + Glyoxylic acid unknown Hydroxypyruvic acid + Glycinedetails
Gene Name:
GSS
Uniprot ID:
P48637
Reactions
Adenosine triphosphate + Gamma-Glutamylcysteine + Glycine unknown ADP + Phosphoric acid + Glutathionedetails
Gene Name:
SHMT2
Uniprot ID:
P34897
Reactions
5,10-Methylene-THF + Glycine + Water unknown Tetrahydrofolic acid + L-Serinedetails
L-Serine + 5,6,7,8-Tetrahydromethanopterin unknown 5,10-Methylenetetrahydromethanopterin + Glycine + Waterdetails
Gene Name:
SARDH
Uniprot ID:
Q9UL12
Reactions
Sarcosine + Water + electron-transfer flavoprotein unknown Glycine + Formaldehyde + reduced electron-transfer flavoproteindetails
Sarcosine + Electron-transferring flavoprotein + Water unknown Glycine + Formaldehyde + Reduced electron-transferring flavoproteindetails
Gene Name:
SHMT1
Uniprot ID:
P34896
Reactions
5,10-Methylene-THF + Glycine + Water unknown Tetrahydrofolic acid + L-Serinedetails
L-Serine + 5,6,7,8-Tetrahydromethanopterin unknown 5,10-Methylenetetrahydromethanopterin + Glycine + Waterdetails
Gene Name:
GLDC
Uniprot ID:
P23378
Reactions
Glycine + H-protein-lipoyllysine unknown H-protein-S-aminomethyldihydrolipoyllysine + CO(2)details
Glycine + Lipoylprotein unknown S-Aminomethyldihydrolipoylprotein + Carbon dioxidedetails
Gene Name:
LAP3
Uniprot ID:
P28838
Reactions
Cysteinylglycine + Water unknown L-Cysteine + Glycinedetails
R-S-Cysteinylglycine + Water unknown S-Substituted L-cysteine + Glycinedetails
Gene Name:
GRIN3B
Uniprot ID:
O60391
Gene Name:
GCSH
Uniprot ID:
P23434
Reactions
Glycine + Tetrahydrofolic acid + NAD unknown 5,10-Methylene-THF + Ammonia + Carbon dioxide + NADH + Hydrogen Iondetails
Gene Name:
GLYAT
Uniprot ID:
Q6IB77
Reactions
Acyl-CoA + Glycine unknown Coenzyme A + N-acylglycinedetails
Benzoyl-CoA + Glycine unknown Coenzyme A + Hippuric aciddetails
Phenylacetyl-CoA + Glycine unknown Phenylacetylglycine + Coenzyme Adetails
Gene Name:
GLYATL1
Uniprot ID:
Q969I3
Gene Name:
GLYATL2
Uniprot ID:
Q8WU03
Reactions
Acyl-CoA + Glycine unknown Coenzyme A + N-acylglycinedetails
Gene Name:
GLRA1
Uniprot ID:
P23415
Gene Name:
GLRA2
Uniprot ID:
P23416
Gene Name:
GLRA3
Uniprot ID:
O75311
Gene Name:
GLRB
Uniprot ID:
P48167
Gene Name:
CCBL2
Uniprot ID:
Q6YP21
Reactions
L-Kynurenine + Glyoxylic acid unknown 4-(2-Aminophenyl)-2,4-dioxobutanoic acid + Glycinedetails
Gene Name:
Not Available
Uniprot ID:
Q53ET4
Gene Name:
SHMT2
Uniprot ID:
Q5BJF5
Gene Name:
DKFZp686P09201
Uniprot ID:
Q5HYG8
Gene Name:
GPR18
Uniprot ID:
Q14330

Transporters

Gene Name:
SLC36A1
Uniprot ID:
Q7Z2H8
Gene Name:
SLC16A10
Uniprot ID:
Q8TF71