Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2013-05-29 19:24:51 UTC
HMDB IDHMDB00151
Secondary Accession Numbers
  • HMDB04448
  • HMDB04481
Metabolite Identification
Common NameEstradiol
DescriptionEstradiol is the most potent form of mammalian estrogenic steroids. Estradiol is produced in the ovaries. The ovary requires both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to produce sex steroids. LH stimulates the cells surrounding the follicle to produce progesterone and androgens. The androgens diffuse across the basement membrane to the granulosa cell layer, where, under the action of FSH, they are aromatized to estrogens, mainly estradiol. The ovary shows cyclical activity, unlike the testis that is maintained in a more or less constant state of activity. Hormone secretions vary according to the phase of the menstrual cycle. In the developing follicle LH receptors (LH-R) are only located on the thecal cells and FSH receptors (FSHR) on the granulosa cells. The dominant pre-ovulatory follicle develops LH-Rs on the granulosa cells prior to the LH surge. Thecal cells of the preovulatory follicle also develop the capacity to synthesize estradiol and this persists when the thecal cells become incorporated into the corpus luteum. After ovulation, the empty follicle is remodelled and plays an important role in the second half or luteal phase of the menstrual cycle. This phase is dominated by progesterone and, to a lesser extent, estradiol secretion by the corpus luteum. estradiol is also synthesized locally from cholesterol through testosterone in the hippocampus and acts rapidly to modulate neuronal synaptic plasticity. Localization of estrogen receptor alpha (ERalpha) in spines in addition to nuclei of principal neurons implies that synaptic ERalpha is responsible for rapid modulation of synaptic plasticity by endogenous estradiol. estradiol is a potent endogenous antioxidant which suppresses hepatic fibrosis in animal models, and attenuates induction of redox sensitive transcription factors, hepatocyte apoptosis and hepatic stellate cells activation by inhibiting a generation of reactive oxygen species in primary cultures. This suggests that the greater progression of hepatic fibrosis and hepatocellular carcinoma in men and postmenopausal women may be due, at least in part, to lower production of estradiol and a reduced response to the action of estradiol. estradiol has been reported to induce the production of interferon (INF)-gamma in lymphocytes, and augments an antigen-specific primary antibody response in human peripheral blood mononuclear cells. IFN-gamma is a potent cytokine with immunomodulatory and antiproliferative properties. Therefore, female subjects, particularly before menopause, may produce antibodies against hepatitis B virus e antigen and hepatitis B virus surface antigen at a higher frequency than males with chronic hepatitis B virus infection. The estradiol-Dihydrotestosterone model of prostate cancer (PC) proposes that the first step in the development of most PC and breast cancer (BC) occurs when aromatase converts testosterone to estradiol. (PMID: 17708600 , 17678531 , 17644764 ).
Structure
Thumb
Synonyms
  1. (+)-3,17b-Estradiol
  2. (17b)-Estra-1,3,5(10)-triene-3,17-diol
  3. 13b-Methyl-1,3,5(10)-gonatriene-3,17b-ol
  4. 17b-Estradiol
  5. 17b-Oestradiol
  6. 3,17-Epidihydroxyestratriene
  7. 3,17b-Dihydroxyestra-1,3,5(10)-triene
  8. 3,17b-Estradiol
  9. Aerodiol
  10. Agofollin
  11. Altrad
  12. Amnestrogen
  13. Aquadiol
  14. b-Estradiol
  15. Bardiol
  16. beta-Estradiol
  17. Climaderm
  18. Climara
  19. Compudose
  20. Corpagen
  21. D-Estradiol
  22. D-Oestradiol
  23. delta-Estradiol
  24. delta-Oestradiol
  25. Dermestril
  26. Dihydro-Theelin
  27. Dihydrofollicular hormone
  28. Dihydrofolliculin
  29. Dihydromenformon
  30. Dihydrotheelin
  31. Dihydroxyestrin
  32. Dimenformon
  33. Diogyn
  34. Diogynets
  35. Divigel
  36. Encore
  37. Epiestriol 50
  38. Estra-1,3,5(10)-triene-3,17b-diol
  39. Estrace
  40. Estraderm TTS
  41. Estradiol
  42. Estradiol-17-beta
  43. Estradot
  44. Estraldine
  45. Estring Vaginal Ring
  46. Estroclim
  47. Estroclim 50
  48. Estrogel
  49. Estrogel HBF
  50. Estrovite
  51. Evorel
  52. Femestral
  53. Femogen
  54. Follicyclin
  55. Gelestra
  56. Ginosedol
  57. Gynergon
  58. Gynoestryl
  59. Lamdiol
  60. Macrodiol
  61. Menorest
  62. Nordicol
  63. Oesclim
  64. Oestergon
  65. Oestra-1,3,5(10)-triene-3,17b-diol
  66. Oestradiol
  67. Oestrogel
  68. Oestroglandol
  69. Ovahormon
  70. Ovasterol
  71. Ovastevol
  72. Ovocyclin
  73. Ovocylin
  74. Perlatanol
  75. Primofol
  76. Profoliol
  77. Profoliol B
  78. Progynon
  79. Progynon DH
  80. Sandrena 1
  81. Syndiol
  82. Systen
  83. Vivelle
  84. Zumenon
Chemical FormulaC18H24O2
Average Molecular Weight272.382
Monoisotopic Molecular Weight272.177630012
IUPAC Name(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol
Traditional IUPAC Nameestradiol
CAS Registry Number50-28-2
SMILES
[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3
InChI Identifier
InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
InChI KeyVOXZDWNPVJITMN-ZBRFXRBCSA-N
Chemical Taxonomy
KingdomOrganic Compounds
Super ClassLipids
ClassSteroids and Steroid Derivatives
Sub ClassEstrogens and Derivatives
Other Descriptors
  • Aromatic Homomonocyclic Compounds
  • Aromatic Homopolycyclic Compounds
  • Hydroxysteroids
  • a steroid(Cyc)
Substituents
  • Cyclic Alcohol
  • Cyclohexane
  • Cyclohexene
  • Phenanthrene
  • Phenol
  • Phenol Derivative
  • Secondary Alcohol
  • Sesquiterpene Backbone
  • Tetralin
Direct ParentEstrogens and Derivatives
Ontology
StatusDetected and Quantified
Origin
  • Drug
  • Drug metabolite
  • Endogenous
  • Food
Biofunction
  • Anti-menopausal Agents
  • Anticholesteremic Agents
  • Cell signaling
  • Component of Androgen and estrogen metabolism
  • Estrogens
  • Fuel and energy storage
  • Fuel or energy source
  • Membrane integrity/stability
  • Waste products
Application
  • Nutrients
  • Pharmaceutical
  • Stabilizers
  • Surfactants and Emulsifiers
Cellular locations
  • Cytoplasm
  • Extracellular
  • Membrane (predicted from logP)
  • Endoplasmic reticulum
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point178.5 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.0036 mg/mLNot Available
LogP4.01HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
water solubility0.021 g/LALOGPS
logP3.57ALOGPS
logP3.75ChemAxon
logS-4.1ALOGPS
pKa (strongest acidic)10.33ChemAxon
pKa (strongest basic)-0.88ChemAxon
physiological charge0ChemAxon
hydrogen acceptor count2ChemAxon
hydrogen donor count2ChemAxon
polar surface area40.46ChemAxon
rotatable bond count0ChemAxon
refractivity79.9ChemAxon
polarizability32.13ChemAxon
Spectra
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Membrane (predicted from logP)
  • Endoplasmic reticulum
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue Location
  • Adipose Tissue
  • Adrenal Cortex
  • Adrenal Gland
  • Brain
  • Epidermis
  • Fibroblasts
  • Gonads
  • Kidney
  • Liver
  • Muscle
  • Neuron
  • Placenta
  • Platelet
  • Prostate
  • Spleen
  • Stratum Corneum
  • Testes
  • Uterus
Pathways
NameSMPDB LinkKEGG Link
Androgen and Estrogen MetabolismSMP00068map00150
Normal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodDetected and Quantified0.00015 +/- 0.000075 uMAdult (>18 years old)FemaleNormal
BloodDetected and Quantified0.00009 (0.0-0.00018) uMAdult (>18 years old)MaleNormal
  • The Merck Ma...
BloodDetected and Quantified0.00009 (0.0-0.00018) uMAdult (>18 years old)FemaleNormal
  • The Merck Ma...
Cerebrospinal Fluid (CSF)Detected and Quantified0.0000011 +/- 0.0000003 uMAdult (>18 years old)FemaleNormal
Cerebrospinal Fluid (CSF)Detected and Quantified0.0000007 - 0.000011 uMAdult (>18 years old)FemaleNormal
SalivaDetected and Quantified<1.00 uMAdult (>18 years old)BothNormal
UrineDetected and Quantified0.00059 +/- 0.00025 umol/mmol creatinineAdult (>18 years old)FemaleNormal
UrineDetected and Quantified0.0011 +/- 0.00061 umol/mmol creatinineAdult (>18 years old)FemaleNormal
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodDetected and Quantified0.000095 +/- 0.000036 uMAdult (>18 years old)MalePositive coronary arteriograms
BloodDetected and Quantified0.00011 +/- 0.00005 uMAdult (>18 years old)MaleMinor electrocardiongraphic abnormalities and/or arrhythmia with negative coronary arteriograms
BloodDetected and Quantified0.00039 (0.000037-0.00073) uMAdult (>18 years old)FemaleCommentMenstrual cycle
  • The Merck Ma...
BloodDetected and Quantified0.00092 (0.00037-0.0015) uMAdult (>18 years old)FemaleCommentMenstrual cycle
  • The Merck Ma...
BloodDetected and Quantified0.00050 (0.000055-0.00095) uMAdult (>18 years old)FemaleCommentMenstrual cycle
  • The Merck Ma...
Cerebrospinal Fluid (CSF)Detected and Quantified0.000006 (0.0000007-0.000011) uMAdult (>18 years old)FemaleGynecological diseases (benign)
UrineDetected and Quantified0.0016 +/- 0.0011 umol/mmol creatinineAdult (>18 years old)FemaleStress urinary incontinence
Associated Disorders and Diseases
Disease References
Benign gynecological diseases
  • Murakami K, Nakagawa T, Shozu M, Uchide K, Koike K, Inoue M: Changes with aging of steroidal levels in the cerebrospinal fluid of women. Maturitas. 1999 Sep 24;33(1):71-80. Pubmed: 10585175
Menstrual cycle
  • The Merck Manual, 17th ed. Mark H. Beers, MD, Robert Berkow, MD, eds. Whitehouse Station, NJ: Merck Research Labs, 1999.
Associated OMIM IDsNone
DrugBank IDDB00783
DrugBank Metabolite IDDBMET00491
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB000362
KNApSAcK IDNot Available
Chemspider ID5554
KEGG Compound IDC00951
BioCyc IDCPD-352
BiGG ID36456
Wikipedia LinkEstradiol
NuGOwiki LinkHMDB00151
Metagene LinkHMDB00151
METLIN ID263
PubChem Compound5757
PDB IDEST
ChEBI ID16469
References
Synthesis ReferenceVasiljeva, L. L.; Demin, P. M.; Kochev, D. M.; Lapitskaya, M. A.; Pivnitskya, K. K. New synthesis of estradiol from androsta-1,4-diene-3,17-dione. Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) (1999), 48(3), 593-595.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Carani C, Qin K, Simoni M, Faustini-Fustini M, Serpente S, Boyd J, Korach KS, Simpson ER: Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med. 1997 Jul 10;337(2):91-5. Pubmed: 9211678
  2. Raman JD, Schlegel PN: Aromatase inhibitors for male infertility. J Urol. 2002 Feb;167(2 Pt 1):624-9. Pubmed: 11792932
  3. Garcia-Segura LM, Sanz A, Mendez P: Cross-Talk between IGF-I and Estradiol in the Brain: Focus on Neuroprotection. Neuroendocrinology. 2006 Nov 23;. Pubmed: 17124377
  4. Martina V, Benso A, Gigliardi VR, Masha A, Origlia C, Granata R, Ghigo E: Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects. Clin Endocrinol (Oxf). 2006 Mar;64(3):260-4. Pubmed: 16487434
  5. Schaap LA, Pluijm SM, Smit JH, van Schoor NM, Visser M, Gooren LJ, Lips P: The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women. Clin Endocrinol (Oxf). 2005 Aug;63(2):152-60. Pubmed: 16060908
  6. Evagelatou M, Webster AD, Farrant J: Effects of 17 beta-oestradiol on function of lymphocytes from normal donors and patients with common variable immunodeficiency (CVID). Clin Exp Immunol. 1994 Nov;98(2):203-9. Pubmed: 7955523
  7. Gibney MJ, Walsh M, Brennan L, Roche HM, German B, van Ommen B: Metabolomics in human nutrition: opportunities and challenges. Am J Clin Nutr. 2005 Sep;82(3):497-503. Pubmed: 16155259
  8. Carnevale V, Scillitani A, Vecci E, D'Erasmo E, Romagnoli E, Paglia F, Pepe J, Baldini V, Santori C, De Geronimo S, Minisola S: Dehydroepiandrosterone sulfate and bone resorption rates as reflected by serum levels of C-terminal telopeptide of type I collagen: a study in healthy men. J Endocrinol Invest. 2005 Feb;28(2):102-5. Pubmed: 15887853
  9. Jojua T, Sumbadze TS, Papava M: Secretion of sex hormones in patients with open angle glaucoma. Georgian Med News. 2005 Jul-Aug;(124-125):33-7. Pubmed: 16148373
  10. Hamden KE, Ford PW, Whitman AG, Dyson OF, Cheng SY, McCubrey JA, Akula SM: Raf-induced vascular endothelial growth factor augments Kaposi's sarcoma-associated herpesvirus infection. J Virol. 2004 Dec;78(23):13381-90. Pubmed: 15542692
  11. Lahdes-Vasama TT, Koskimaki JE, Streng TK, Fisch RD, Nilson EA, Santti RS, Tammela TL: Urodynamic findings in men operated on for an undescended testicle. BJU Int. 2003 Dec;92(9):972-6. Pubmed: 14632858
  12. Iranmanesh A, Veldhuis JD: Combined inhibition of types I and II 5 alpha-reductase selectively augments the basal (nonpulsatile) mode of testosterone secretion in young men. J Clin Endocrinol Metab. 2005 Jul;90(7):4232-7. Epub 2005 Apr 5. Pubmed: 15811930
  13. Stabile LP, Davis AL, Gubish CT, Hopkins TM, Luketich JD, Christie N, Finkelstein S, Siegfried JM: Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen. Cancer Res. 2002 Apr 1;62(7):2141-50. Pubmed: 11929836
  14. Chabbert-Buffet N, Bouchard P: [Physiology and exploration of the gonadotropic axis] Rev Prat. 1999 Jun 15;49(12):1270-6. Pubmed: 10488657
  15. Schonknecht P, Henze M, Hunt A, Klinga K, Haberkorn U, Schroder J: Hippocampal glucose metabolism is associated with cerebrospinal fluid estrogen levels in postmenopausal women with Alzheimer's disease. Psychiatry Res. 2003 Oct 30;124(2):125-7. Pubmed: 14561431
  16. Elliott KJ, Cable NT, Reilly T: Does oral contraceptive use affect maximum force production in women? Br J Sports Med. 2005 Jan;39(1):15-9. Pubmed: 15618333
  17. Blomquist CH, D'Ascoli PT: Gestational development of human placental 17 beta-hydroxysteroid oxidoreductase types 1 and 2. Hum Reprod. 1995 Oct;10(10):2685-9. Pubmed: 8567793
  18. Fraser D, Padwick ML, Whitehead M, Coffer A, King RJ: Presence of an oestradiol receptor-related protein in the skin: changes during the normal menstrual cycle. Br J Obstet Gynaecol. 1991 Dec;98(12):1277-82. Pubmed: 1777462
  19. Greb RR, Grieshaber K, Gromoll J, Sonntag B, Nieschlag E, Kiesel L, Simoni M: A common single nucleotide polymorphism in exon 10 of the human follicle stimulating hormone receptor is a major determinant of length and hormonal dynamics of the menstrual cycle. J Clin Endocrinol Metab. 2005 Aug;90(8):4866-72. Epub 2005 May 10. Pubmed: 15886248
  20. Archer JS, Love-Geffen TE, Herbst-Damm KL, Swinney DA, Chang JR: Effect of estradiol versus estradiol and testosterone on brain-activation patterns in postmenopausal women. Menopause. 2006 May-Jun;13(3):528-37. Pubmed: 16735951
  21. Anwar A, McTernan PG, Anderson LA, Askaa J, Moody CG, Barnett AH, Eggo MC, Kumar S: Site-specific regulation of oestrogen receptor-alpha and -beta by oestradiol in human adipose tissue. Diabetes Obes Metab. 2001 Oct;3(5):338-49. Pubmed: 11703424
  22. Tanko LB, Christiansen C: Effects of 17beta-oestradiol plus different doses of drospirenone on adipose tissue, adiponectin and atherogenic metabolites in postmenopausal women. J Intern Med. 2005 Dec;258(6):544-53. Pubmed: 16313478
  23. Sulcova J, Hampl R, Hill M, Starka L, Novacek A: Delayed effects of short-term transdermal application of 7-oxo-dehydroepiandrosterone on its metabolites, some hormonal steroids and relevant proteohormones in healthy male volunteers. Clin Chem Lab Med. 2005;43(2):221-7. Pubmed: 15843221
  24. Shimizu I, Kohno N, Tamaki K, Shono M, Huang HW, He JH, Yao DF: Female hepatology: favorable role of estrogen in chronic liver disease with hepatitis B virus infection. World J Gastroenterol. 2007 Aug 28;13(32):4295-305. Pubmed: 17708600
  25. Friedman AE: Can a single model explain both breast cancer and prostate cancer? Theor Biol Med Model. 2007 Aug 1;4:28. Pubmed: 17678531
  26. Ishii H, Tsurugizawa T, Ogiue-Ikeda M, Asashima M, Mukai H, Murakami G, Hojo Y, Kimoto T, Kawato S: Local production of sex hormones and their modulation of hippocampal synaptic plasticity. Neuroscientist. 2007 Aug;13(4):323-34. Pubmed: 17644764
  27. Behl C, Widmann M, Trapp T, Holsboer F: 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem Biophys Res Commun. 1995 Nov 13;216(2):473-82. Pubmed: 7488136
  28. Sharpe RM, Skakkebaek NE: Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet. 1993 May 29;341(8857):1392-5. Pubmed: 8098802
  29. Pentikainen V, Erkkila K, Suomalainen L, Parvinen M, Dunkel L: Estradiol acts as a germ cell survival factor in the human testis in vitro. J Clin Endocrinol Metab. 2000 May;85(5):2057-67. Pubmed: 10843196
  30. Schmidt JW, Wollner D, Curcio J, Riedlinger J, Kim LS: Hormone replacement therapy in menopausal women: Past problems and future possibilities. Gynecol Endocrinol. 2006 Oct;22(10):564-77. Pubmed: 17135036
  31. Foresta C, Zuccarello D, Biagioli A, De Toni L, Prana E, Nicoletti V, Ambrosini G, Ferlin A: Oestrogen stimulates endothelial progenitor cells via oestrogen receptor-alpha. Clin Endocrinol (Oxf). 2007 Oct;67(4):520-5. Epub 2007 Jun 15. Pubmed: 17573901

Only showing the first 50 proteins. There are 66 proteins in total.

Enzymes

Gene Name:
HSD17B2
Uniprot ID:
P37059
Reactions
Estradiol + NAD(P)(+) unknown Estrone + NAD(P)Hdetails
Estradiol + NAD unknown Estrone + NADH + Hydrogen Iondetails
Estradiol + NADP unknown Estrone + NADPH + Hydrogen Iondetails
Gene Name:
UGT2B28
Uniprot ID:
Q9BY64
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
ESR2
Uniprot ID:
Q92731
Gene Name:
HSD17B8
Uniprot ID:
Q92506
Reactions
Estradiol + NAD(P)(+) unknown Estrone + NAD(P)Hdetails
Estradiol + NAD unknown Estrone + NADH + Hydrogen Iondetails
Estradiol + NADP unknown Estrone + NADPH + Hydrogen Iondetails
Gene Name:
UGT2B4
Uniprot ID:
P06133
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT1A4
Uniprot ID:
P22310
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT2B10
Uniprot ID:
P36537
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT2B7
Uniprot ID:
P16662
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT2B15
Uniprot ID:
P54855
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT2A1
Uniprot ID:
Q9Y4X1
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT1A1
Uniprot ID:
P22309
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT1A9
Uniprot ID:
O60656
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT1A8
Uniprot ID:
Q9HAW9
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT1A3
Uniprot ID:
P35503
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT1A10
Uniprot ID:
Q9HAW8
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT2B17
Uniprot ID:
O75795
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT1A6
Uniprot ID:
P19224
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT1A5
Uniprot ID:
P35504
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT2B11
Uniprot ID:
O75310
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
UGT1A7
Uniprot ID:
Q9HAW7
Reactions
Estradiol + Uridine diphosphate glucuronic acid unknown 17-beta-Estradiol-3-glucuronide + Uridine 5'-diphosphatedetails
Gene Name:
HSD17B11
Uniprot ID:
Q8NBQ5
Reactions
Estradiol + NAD(P)(+) unknown Estrone + NAD(P)Hdetails
Gene Name:
HSD17B1
Uniprot ID:
P14061
Reactions
Estradiol + NAD(P)(+) unknown Estrone + NAD(P)Hdetails
Estradiol + NAD unknown Estrone + NADH + Hydrogen Iondetails
Estradiol + NADP unknown Estrone + NADPH + Hydrogen Iondetails
Gene Name:
HSD17B7
Uniprot ID:
P56937
Reactions
Estradiol + NAD(P)(+) unknown Estrone + NAD(P)Hdetails
Estradiol + NAD unknown Estrone + NADH + Hydrogen Iondetails
Estradiol + NADP unknown Estrone + NADPH + Hydrogen Iondetails
Gene Name:
CYP3A4
Uniprot ID:
P08684
Gene Name:
CYP2C9
Uniprot ID:
P11712
Gene Name:
CYP2C19
Uniprot ID:
P33261
Gene Name:
CYP2E1
Uniprot ID:
P05181
Gene Name:
CYP3A43
Uniprot ID:
Q9HB55
Gene Name:
CYP1B1
Uniprot ID:
Q16678
Gene Name:
CYP2C18
Uniprot ID:
P33260
Gene Name:
CYP2F1
Uniprot ID:
P24903
Gene Name:
CYP4X1
Uniprot ID:
Q8N118
Gene Name:
CYP2B6
Uniprot ID:
P20813
Gene Name:
CYP3A5
Uniprot ID:
P20815
Gene Name:
CYP1A1
Uniprot ID:
P04798
Gene Name:
CYP2A13
Uniprot ID:
Q16696
Gene Name:
CYP3A7
Uniprot ID:
P24462
Gene Name:
CYP4B1
Uniprot ID:
P13584
Gene Name:
CYP4Z1
Uniprot ID:
Q86W10
Gene Name:
CYP1A2
Uniprot ID:
P05177
Gene Name:
CYP19A1
Uniprot ID:
P11511
Gene Name:
CYP2C8
Uniprot ID:
P10632
Gene Name:
CYP2S1
Uniprot ID:
Q96SQ9
Gene Name:
CYP2J2
Uniprot ID:
P51589
Gene Name:
CYP2A7
Uniprot ID:
P20853
Gene Name:
CYP2A6
Uniprot ID:
P11509
Gene Name:
SHBG
Uniprot ID:
P04278
Gene Name:
ESR1
Uniprot ID:
P03372
Gene Name:
HSD17B6
Uniprot ID:
O14756
Reactions
Estradiol + NAD(P)(+) unknown Estrone + NAD(P)Hdetails
Estradiol + NAD unknown Estrone + NADH + Hydrogen Iondetails
Estradiol + NADP unknown Estrone + NADPH + Hydrogen Iondetails

Transporters

Gene Name:
ABCB1
Uniprot ID:
P08183
Gene Name:
SLC22A11
Uniprot ID:
Q9NSA0
Gene Name:
SLC22A1
Uniprot ID:
O15245
Gene Name:
SLC22A2
Uniprot ID:
O15244
Gene Name:
SLC22A3
Uniprot ID:
O75751

Only showing the first 50 proteins. There are 66 proteins in total.