Human Metabolome Database Version 3.5

Showing metabocard for L-Proline (HMDB00162)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:08:00 -0700
HMDB ID HMDB00162
Secondary Accession Numbers None
Metabolite Identification
Common Name L-Proline
Description L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. Proline is sometimes called an imino acid, although the IUPAC definition of an imine requires a carbon-nitrogen double bond. Proline is a non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. (-)-(S)-Proline
  2. (-)-2-Pyrrolidinecarboxylate
  3. (-)-2-Pyrrolidinecarboxylic acid
  4. (-)-Proline
  5. (S)-(-)-Proline
  6. (S)-(-)-Pyrrolidine-2-carboxylate
  7. (S)-(-)-Pyrrolidine-2-carboxylic acid
  8. (S)-2-Carboxypyrrolidine
  9. (S)-2-Pyrralidinecarboxylate
  10. (S)-2-Pyrralidinecarboxylic acid
  11. (S)-2-Pyrrolidinecarboxylate
  12. (S)-2-Pyrrolidinecarboxylic acid
  13. (S)-Proline
  14. 2-Pyrrolidinecarboxylate
  15. 2-Pyrrolidinecarboxylic acid
  16. Proline
Chemical Formula C5H9NO2
Average Molecular Weight 115.1305
Monoisotopic Molecular Weight 115.063328537
IUPAC Name (2S)-pyrrolidine-2-carboxylic acid
Traditional IUPAC Name L-proline
CAS Registry Number 147-85-3
SMILES OC(=O)[C@@H]1CCCN1
InChI Identifier InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1
InChI Key ONIBWKKTOPOVIA-BYPYZUCNSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Amino Acids, Peptides, and Analogues
Class Amino Acids and Derivatives
Sub Class Alpha Amino Acids and Derivatives
Other Descriptors
  • Aliphatic Heteromonocyclic Compounds
  • Common amino acids(KEGG)
  • amino acid zwitterion(ChEBI)
Substituents
  • Carboxylic Acid
  • Pyrrolidine
  • Pyrrolidine Carboxylic Acid
  • Secondary Aliphatic Amine (Dialkylamine)
Direct Parent Alpha Amino Acids and Derivatives
Ontology
Status Detected and Quantified
Origin
  • Drug metabolite
  • Endogenous
Biofunction
  • Component of Arginine and proline metabolism
  • Waste products
Application Not Available
Cellular locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Lysosome
  • Endoplasmic reticulum
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point 221 °C Not Available
Boiling Point Not Available Not Available
Water Solubility 162.0 mg/mL Not Available
LogP -2.54 HANSCH,C ET AL. (1995)
Predicted Properties
Property Value Source
Water Solubility 365 g/L ALOGPS
LogP -2.71 ALOGPS
LogP -2.6 ChemAxon
LogS 0.50 ALOGPS
pKa (strongest acidic) 1.94 ChemAxon
pKa (strongest basic) 11.33 ChemAxon
Hydrogen Acceptor Count 3 ChemAxon
Hydrogen Donor Count 2 ChemAxon
Polar Surface Area 49.33 A2 ChemAxon
Rotatable Bond Count 1 ChemAxon
Refractivity 28.06 ChemAxon
Polarizability 11.53 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge 0 ChemAxon
Spectra
Gas-MS Spectrum
1H NMR Spectrum
13C NMR Spectrum
MS/MS Spectrum Quattro_QQQ 10
MS/MS Spectrum Quattro_QQQ 25
MS/MS Spectrum Quattro_QQQ 40
MS/MS Spectrum EI-B (HITACHI M-80)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 10
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 20
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 30
[1H,1H] 2D NMR Spectrum
[1H,13C] 2D NMR Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Lysosome
  • Endoplasmic reticulum
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue Location
  • All Tissues
  • Prostate
Pathways
Name SMPDB Link KEGG Link
Transcription/Translation SMP00019 Not Available
Arginine and Proline Metabolism SMP00020 map00330 Link_out
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
198.3 +/- 64.8 uM Adult (>18 years old) Not Specified Normal
Blood Detected and Quantified
168.0 (108.0-228.0) uM Adult (>18 years old) Both Normal
Blood Detected and Quantified
177.5 +/- 38.6 uM Adult (>18 years old) Not Specified Normal
Blood Detected and Quantified
198.0 +/- 63.0 uM Children (1-13 year old) Male Normal
  • Geigy Scient...
Blood Detected and Quantified
239.0 +/- 70.0 uM Adult (>18 years old) Male Normal
  • Geigy Scient...
Blood Detected and Quantified
168.0 +/- 49.0 uM Adult (>18 years old) Female Normal
  • Geigy Scient...
Blood Detected and Quantified
230.0 +/- 75.0 uM Newborn (0-30 days old) Not Specified Normal
  • Geigy Scient...
Cerebrospinal Fluid (CSF) Detected and Quantified
4.0 (0 - 8.0) uM Adult (>18 years old) Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
1.9 +/- 1.0 uM Adult (>18 years old) Not Specified Normal
Saliva Detected and Quantified
>10 uM Adult (>18 years old) Both Normal
Urine Detected and Quantified
0.86 umol/mmol creatinine Adult (>18 years old) Both Normal
Urine Detected and Quantified
<6.08-34.76 umol/mmol creatinine Adult (>18 years old) Both Normal
  • David F. Put...
Urine Detected and Quantified
3.06 /- 1.87 umol/mmol creatinine Adult (>18 years old) Both Normal
Urine Detected and Quantified
2.171 (0.0658-4.276) umol/mmol creatinine Adult (>18 years old) Both Normal
Urine Detected and Quantified
1.1 (0.1-2.5) umol/mmol creatinine Adult (>18 years old) Both Comment Normal
Urine Detected and Quantified
1.0 (0.5-2.0) umol/mmol creatinine Newborn (0-30 days old) Both Normal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
Urine Detected and Quantified
4.14 +/- 2.85 umol/mmol creatinine Infant (0-1 year old) Both Normal
Urine Detected and Quantified
0.5 umol/mmol creatinine Adult (>18 years old) Both Normal
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified 159.9 +/- 86.3 uM Adult (>18 years old) Not Specified Heart Transplant
Blood Detected and Quantified 201.0 +/- 149.5 uM Adult (>18 years old) Both Comment Hemodialysis
Blood Detected and Quantified 227.2 +/- 108.4 uM Adult (>18 years old) Both Comment Hemodialysis
Blood Detected and Quantified 650.00 (300.00-1000.00) uM Children (1-13 year old) Both Glutathione synthetase deficiency
Cerebrospinal Fluid (CSF) Detected and Quantified 0.68 +/- 0.35 uM Adult (>18 years old) Both Alzheimer's disease
Urine Detected and Quantified 0.0068 - 0.0549 umol/mmol creatinine Adult (>18 years old) Both ADPKD
Urine Detected and Quantified 29.6 (19.7-39.47) umol/mmol creatinine Children (1-13 year old) Both Iminoglycinuria
Associated Disorders and Diseases
Disease References
Hemodialysis
  • Raj DS, Ouwendyk M, Francoeur R, Pierratos A: Plasma amino acid profile on nocturnal hemodialysis. Blood Purif. 2000;18(2):97-102. Pubmed: 10838467 Link_out
      Alzheimer's disease
      • Fonteh AN, Harrington RJ, Tsai A, Liao P, Harrington MG: Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects. Amino Acids. 2007 Feb;32(2):213-24. Epub 2006 Oct 10. Pubmed: 17031479 Link_out
          Glutathione synthetase deficiency
              Iminoglycinuria
                  Associated OMIM IDs
                  DrugBank ID DB00172 Link_out
                  DrugBank Metabolite ID DBMET00494 Link_out
                  Phenol Explorer Compound ID Not Available
                  Phenol Explorer Metabolite ID Not Available
                  FoodDB ID FDB000570
                  KNApSAcK ID C00001388 Link_out
                  Chemspider ID 128566 Link_out
                  KEGG Compound ID C00148 Link_out
                  BioCyc ID PRO Link_out
                  BiGG ID 34042 Link_out
                  Wikipedia Link L-Proline Link_out
                  NuGOwiki Link HMDB00162 Link_out
                  Metagene Link HMDB00162 Link_out
                  METLIN ID 29 Link_out
                  PubChem Compound 145742 Link_out
                  PDB ID PRO Link_out
                  ChEBI ID 17203 Link_out
                  References
                  Synthesis Reference Itoh, Tamio. Synthesis of L-proline from L-glutamine. Bulletin of the Chemical Society of Japan (1963), 36(1), 25-9
                  Material Safety Data Sheet (MSDS) Download (PDF)
                  General References
                  1. Deng C, Shang C, Hu Y, Zhang X: Rapid diagnosis of phenylketonuria and other aminoacidemias by quantitative analysis of amino acids in neonatal blood spots by gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Jul 25;775(1):115-20. Pubmed: 12101068 Link_out
                  2. Azizi M, Junot C, Ezan E, Menard J: Angiotensin I-converting enzyme and metabolism of the haematological peptide N-acetyl-seryl-aspartyl-lysyl-proline. Clin Exp Pharmacol Physiol. 2001 Dec;28(12):1066-9. Pubmed: 11903317 Link_out
                  3. Roesel RA, Blankenship PR, Mobley EB, Coryell ME: Increased excretion of histidyl-L-proline diketopiperazine by infants receiving Pregestimil and Nutramigen formulas. Clin Chem. 1986 May;32(5):865-7. Pubmed: 3698278 Link_out
                  4. Chambers ST, Kunin CM: Osmoprotective activity for Escherichia coli in mammalian renal inner medulla and urine. Correlation of glycine and proline betaines and sorbitol with response to osmotic loads. J Clin Invest. 1987 Nov;80(5):1255-60. Pubmed: 3316273 Link_out
                  5. Cynober LA: Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition. 2002 Sep;18(9):761-6. Pubmed: 12297216 Link_out
                  6. Azizi M, Ezan E, Reny JL, Wdzieczak-Bakala J, Gerineau V, Menard J: Renal and metabolic clearance of N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) during angiotensin-converting enzyme inhibition in humans. Hypertension. 1999 Mar;33(3):879-86. Pubmed: 10082503 Link_out
                  7. Hart W, van den Hamer CJ, van der Sluys Veer J: The use of hydroxy-DL-proline-2-(14)C in the investigation of hydroxyproline metabolism in normal subjects and in patients with renal insufficiency. Clin Nephrol. 1976 Sep;6(3):379-87. Pubmed: 991465 Link_out
                  8. Kanwar YS, Krakower CA, Manaligod JR, Justice P, Wong PW: Biochemical, morphological and hybrid studies in hyperprolinemic mice. Biomedicine. 1975 May;22(3):209-16. Pubmed: 240452 Link_out
                  9. Simila S: Hydroxyproline metabolism in type II hyperprolinaemia. Ann Clin Biochem. 1979 Jul;16(4):177-81. Pubmed: 533224 Link_out
                  10. Lu SH, Ohshima H, Fu HM, Tian Y, Li FM, Blettner M, Wahrendorf J, Bartsch H: Urinary excretion of N-nitrosamino acids and nitrate by inhabitants of high- and low-risk areas for esophageal cancer in Northern China: endogenous formation of nitrosoproline and its inhibition by vitamin C. Cancer Res. 1986 Mar;46(3):1485-91. Pubmed: 3943105 Link_out
                  11. Hausmann D: [Post-traumatic imbalances of plasma amino acids--interference factors or defense mechanisms? A study of protein metabolism in severe craniocerebral trauma] Anasth Intensivther Notfallmed. 1988 Feb;23(1):14-21. Pubmed: 3364629 Link_out
                  12. Scriver CR, McInnes RR, Mohyuddin F: Role of epithelial architecture and intracellular metabolism in proline uptake and transtubular reclamation in PRO/re mouse kidney. Proc Natl Acad Sci U S A. 1975 Apr;72(4):1431-5. Pubmed: 1055415 Link_out
                  13. Boden G, Rezvani I, Owen OE: Effects of glucagon on plasma amino acids. J Clin Invest. 1984 Mar;73(3):785-93. Pubmed: 6142902 Link_out
                  14. Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7. Pubmed: 12097436 Link_out
                  15. Feldman JM, Plonk JW, Admiraal J, Sidbury, JB: Plasma amino acids in patients with the carcinoid syndrome. Cancer. 1976 Nov;38(5):2127-31. Pubmed: 136295 Link_out
                  16. Humbertclaude V, Rivier F, Roubertie A, Echenne B, Bellet H, Vallat C, Morin D: Is hyperprolinemia type I actually a benign trait? Report of a case with severe neurologic involvement and vigabatrin intolerance. J Child Neurol. 2001 Aug;16(8):622-3. Pubmed: 11510941 Link_out
                  17. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411 Link_out

                  Enzymes
                  Name: Prolyl 4-hydroxylase subunit alpha-2
                  Reactions:
                  L-Proline + Oxoglutaric acid + Oxygen unknown 4-Hydroxyproline + Succinic acid + Carbon dioxide details
                  Gene Name: P4HA2
                  Uniprot ID: O15460 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Pyrroline-5-carboxylate reductase 1, mitochondrial
                  Reactions:
                  L-Proline + NAD(P)(+) unknown 1-Pyrroline-5-carboxylic acid + NAD(P)H details
                  L-Proline + NAD unknown 1-Pyrroline-5-carboxylic acid + NADH + Hydrogen Ion details
                  L-Proline + NADP unknown 1-Pyrroline-5-carboxylic acid + NADPH + Hydrogen Ion details
                  Gene Name: PYCR1
                  Uniprot ID: P32322 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Prolyl 4-hydroxylase subunit alpha-1
                  Reactions:
                  L-Proline + Oxoglutaric acid + Oxygen unknown 4-Hydroxyproline + Succinic acid + Carbon dioxide details
                  Gene Name: P4HA1
                  Uniprot ID: P13674 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Pyrroline-5-carboxylate reductase 2
                  Reactions:
                  L-Proline + NAD(P)(+) unknown 1-Pyrroline-5-carboxylic acid + NAD(P)H details
                  L-Proline + NAD unknown 1-Pyrroline-5-carboxylic acid + NADH + Hydrogen Ion details
                  L-Proline + NADP unknown 1-Pyrroline-5-carboxylic acid + NADPH + Hydrogen Ion details
                  Gene Name: PYCR2
                  Uniprot ID: Q96C36 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Bifunctional glutamate/proline--tRNA ligase
                  Reactions:
                  Adenosine triphosphate + L-Proline + tRNA(Pro) unknown Adenosine monophosphate + Pyrophosphate + L-prolyl-tRNA(Pro) details
                  Adenosine triphosphate + L-Proline + tRNA(Pro) unknown Adenosine monophosphate + Pyrophosphate + L-Prolyl-tRNA(Pro) details
                  Gene Name: EPRS
                  Uniprot ID: P07814 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Cytosol aminopeptidase
                  Reactions:
                  Peptide + Water unknown L-Proline + Peptide details
                  Gene Name: LAP3
                  Uniprot ID: P28838 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Proline dehydrogenase 1, mitochondrial
                  Reactions:
                  L-Proline + acceptor unknown 1-Pyrroline-5-carboxylic acid + reduced acceptor details
                  L-Proline + Acceptor unknown 1-Pyrroline-5-carboxylic acid + Reduced acceptor details
                  Gene Name: PRODH
                  Uniprot ID: O43272 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Pyrroline-5-carboxylate reductase 3
                  Reactions:
                  L-Proline + NAD(P)(+) unknown 1-Pyrroline-5-carboxylic acid + NAD(P)H details
                  L-Proline + NAD unknown 1-Pyrroline-5-carboxylic acid + NADH + Hydrogen Ion details
                  L-Proline + NADP unknown 1-Pyrroline-5-carboxylic acid + NADPH + Hydrogen Ion details
                  Gene Name: PYCRL
                  Uniprot ID: Q53H96 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Proline synthase co-transcribed bacterial homolog protein
                  Reactions: Not Available
                  Gene Name: PROSC
                  Uniprot ID: O94903 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Pyrroline-5-carboxylate reductase
                  Reactions: Not Available
                  Gene Name: P5CR2
                  Uniprot ID: Q4W8W1 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Sodium-dependent proline transporter
                  Reactions: Not Available
                  Gene Name: SLC6A7
                  Uniprot ID: Q99884 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
                  Reactions: Not Available
                  Gene Name: SLC6A14
                  Uniprot ID: Q9UN76 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Probable proline dehydrogenase 2
                  Reactions:
                  L-Proline + acceptor unknown 1-Pyrroline-5-carboxylic acid + reduced acceptor details
                  Gene Name: PRODH2
                  Uniprot ID: Q9UF12 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Transient receptor potential cation channel subfamily M member 1
                  Reactions: Not Available
                  Gene Name: TRPM1
                  Uniprot ID: Q7Z4N2 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Prolyl 3-hydroxylase 1
                  Reactions: Not Available
                  Gene Name: LEPRE1
                  Uniprot ID: Q32P28 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Prolyl 3-hydroxylase 2
                  Reactions: Not Available
                  Gene Name: LEPREL1
                  Uniprot ID: Q8IVL5 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Prolyl 3-hydroxylase 3
                  Reactions: Not Available
                  Gene Name: LEPREL2
                  Uniprot ID: Q8IVL6 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Prolyl 4-hydroxylase subunit alpha-3
                  Reactions:
                  L-Proline + Oxoglutaric acid + Oxygen unknown 4-Hydroxyproline + Succinic acid + Carbon dioxide details
                  Gene Name: P4HA3
                  Uniprot ID: Q7Z4N8 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Egl nine homolog 1
                  Reactions: Not Available
                  Gene Name: EGLN1
                  Uniprot ID: Q9GZT9 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Egl nine homolog 2
                  Reactions: Not Available
                  Gene Name: EGLN2
                  Uniprot ID: Q96KS0 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Egl nine homolog 3
                  Reactions: Not Available
                  Gene Name: EGLN3
                  Uniprot ID: Q9H6Z9 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Transmembrane prolyl 4-hydroxylase
                  Reactions: Not Available
                  Gene Name: P4HTM
                  Uniprot ID: Q9NXG6 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Trans-L-3-hydroxyproline dehydratase
                  Reactions: Not Available
                  Gene Name: L3HYPDH
                  Uniprot ID: Q96EM0 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Peptidyl-prolyl cis-trans isomerase F, mitochondrial
                  Reactions: Not Available
                  Gene Name: PPIF
                  Uniprot ID: P30405 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Peptidyl-prolyl cis-trans isomerase A
                  Reactions: Not Available
                  Gene Name: PPIA
                  Uniprot ID: P62937 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Peptidyl-prolyl cis-trans isomerase B
                  Reactions: Not Available
                  Gene Name: PPIB
                  Uniprot ID: P23284 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Peptidyl-prolyl cis-trans isomerase G
                  Reactions: Not Available
                  Gene Name: PPIG
                  Uniprot ID: Q13427 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Probable proline--tRNA ligase, mitochondrial
                  Reactions:
                  Adenosine triphosphate + L-Proline + tRNA(Pro) unknown Adenosine monophosphate + Pyrophosphate + L-prolyl-tRNA(Pro) details
                  Adenosine triphosphate + L-Proline + tRNA(Pro) unknown Adenosine monophosphate + Pyrophosphate + L-Prolyl-tRNA(Pro) details
                  Gene Name: PARS2
                  Uniprot ID: Q7L3T8 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Peptidyl-prolyl cis-trans isomerase H
                  Reactions: Not Available
                  Gene Name: PPIH
                  Uniprot ID: O43447 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Transporters
                  Name: Monocarboxylate transporter 10
                  Reactions: Not Available
                  Gene Name: SLC16A10
                  Uniprot ID: Q8TF71 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA