Human Metabolome Database Version 3.5

Showing metabocard for L-Threonine (HMDB00167)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-05-29 13:24:55 -0600
HMDB ID HMDB00167
Secondary Accession Numbers None
Metabolite Identification
Common Name L-Threonine
Description Threonine is an essential amino acid in humans. It is abundant in human plasma, particularly in newborns. Severe deficiency of threonine causes neurological dysfunction and lameness in experimental animals. Threonine is an immunostimulant which promotes the growth of thymus gland. It also can probably promote cell immune defense function. This amino acid has been useful in the treatment of genetic spasticity disorders and multiple sclerosis at a dose of 1 gram daily. It is highly concentrated in meat products, cottage cheese and wheat germ. (http://www.dcnutrition.com/AminoAcids/) The threonine content of most of the infant formulas currently on the market is approximately 20% higher than the threonine concentration in human milk. Due to this high threonine content the plasma threonine concentrations are up to twice as high in premature infants fed these formulas than in infants fed human milk. The whey proteins which are used for infant formulas are sweet whey proteins. Sweet whey results from cheese production. Threonine catabolism in mammals appears to be due primarily (70-80%) to the activity of threonine dehydrogenase (EC 1.1.1.103) that oxidizes threonine to 2-amino-3-oxobutyrate, which forms glycine and acetyl CoA, whereas threonine dehydratase (EC 4.2.1.16) that catabolizes threonine into 2-oxobutyrate and ammonia, is significantly less active. Increasing the threonine plasma concentrations leads to accumulation of threonine and glycine in the brain. Such accumulation affects the neurotransmitter balance which may have consequences for the brain development during early postnatal life. Thus, excessive threonine intake during infant feeding should be avoided. (PMID 9853925 Link_out).
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. (2S,3R)-(-)-Threonine
  2. (2S,3R)-2-Amino-3-hydroxybutyrate
  3. (2S,3R)-2-Amino-3-hydroxybutyric acid
  4. (R-(R*,S*))-2-Amino-3-hydroxybutanoate
  5. (R-(R*,S*))-2-Amino-3-hydroxybutanoic acid
  6. (S)-Threonine
  7. 2-Amino-3-hydroxybutanoate
  8. 2-Amino-3-hydroxybutanoic acid
  9. 2-Amino-3-hydroxybutyrate
  10. 2-Amino-3-hydroxybutyric acid
  11. L-(-)-Threonine
  12. L-2-Amino-3-hydroxybutyrate
  13. L-2-Amino-3-hydroxybutyric acid
  14. L-alpha-Amino-beta-hydroxybutyrate
  15. L-alpha-Amino-beta-hydroxybutyric acid
  16. Threonin
  17. Threonine
  18. [R-(R*,S*)]-2-amino-3-hydroxy-Butanoate
  19. [R-(R*,S*)]-2-amino-3-hydroxy-Butanoic acid
  20. [R-(R*,S*)]-2-Amino-3-hydroxybutanoate
  21. [R-(R*,S*)]-2-Amino-3-hydroxybutanoic acid
Chemical Formula C4H9NO3
Average Molecular Weight 119.1192
Monoisotopic Molecular Weight 119.058243159
IUPAC Name (2S,3R)-2-amino-3-hydroxybutanoic acid
Traditional IUPAC Name L-threonine
CAS Registry Number 72-19-5
SMILES C[C@@H](O)[C@H](N)C(O)=O
InChI Identifier InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1
InChI Key AYFVYJQAPQTCCC-GBXIJSLDSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Amino Acids, Peptides, and Analogues
Class Amino Acids and Derivatives
Sub Class Alpha Amino Acids and Derivatives
Other Descriptors
  • Aliphatic Acyclic Compounds
  • Common amino acids(KEGG)
  • amino acid zwitterion(ChEBI)
Substituents
  • 1,2 Aminoalcohol
  • Beta Hydroxy Acid
  • Carboxylic Acid
  • Primary Aliphatic Amine (Alkylamine)
  • Secondary Alcohol
Direct Parent Alpha Amino Acids and Derivatives
Ontology
Status Detected and Quantified
Origin
  • Drug
  • Food
  • Plant
Biofunction
  • Component of Aminoacyl-tRNA biosynthesis
  • Component of Glycine, serine and threonine metabolism
  • Essential amino acids
Application Not Available
Cellular locations
  • Cytoplasm
  • Extracellular
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point 256 °C Not Available
Boiling Point Not Available Not Available
Water Solubility 97.0 mg/mL Not Available
LogP -2.94 HANSCH,C ET AL. (1995)
Predicted Properties
Property Value Source
Water Solubility 477 g/L ALOGPS
LogP -3.01 ALOGPS
LogP -3.5 ChemAxon
LogS 0.60 ALOGPS
pKa (strongest acidic) 2.21 ChemAxon
pKa (strongest basic) 9 ChemAxon
Hydrogen Acceptor Count 4 ChemAxon
Hydrogen Donor Count 3 ChemAxon
Polar Surface Area 83.55 A2 ChemAxon
Rotatable Bond Count 2 ChemAxon
Refractivity 26.46 ChemAxon
Polarizability 11.25 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge 0 ChemAxon
Spectra
Gas-MS Spectrum
1H NMR Spectrum
13C NMR Spectrum
MS/MS Spectrum Quattro_QQQ 10
MS/MS Spectrum Quattro_QQQ 25
MS/MS Spectrum Quattro_QQQ 40
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)
[1H,1H] 2D NMR Spectrum
[1H,13C] 2D NMR Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue Location
  • All Tissues
  • Prostate
Pathways
Name SMPDB Link KEGG Link
Transcription/Translation SMP00019 Not Available
Glycine and Serine Metabolism SMP00004 map00260 Link_out
Threonine and 2-Oxobutanoate Degradation SMP00452 Not Available
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
127.7 +/- 41 uM Adult (>18 years old) Not Specified Normal
Blood Detected and Quantified
102.3 +/- 24.6 uM Adult (>18 years old) Not Specified Normal
Blood Detected and Quantified
140.0 (107.0-173.0) uM Adult (>18 years old) Both Normal
Blood Detected and Quantified
215.0 +/- 60.0 uM Newborn (0-30 days old) Not Specified Normal
  • Geigy Scient...
Blood Detected and Quantified
140.0 +/- 28.0 uM Children (1-13 year old) Male Normal
  • Geigy Scient...
Blood Detected and Quantified
146.0 +/- 22.0 uM Adult (>18 years old) Male Normal
  • Geigy Scient...
Blood Detected and Quantified
154.0 +/- 40.0 uM Adult (>18 years old) Female Normal
  • Geigy Scient...
Blood Detected and Quantified
260.0 +/- 10.0 uM Adult (>18 years old) Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
32.0 (4.00-60.0) uM Adult (>18 years old) Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
30 +/- 12 uM Not Specified Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
27.7 +/- 4.7 umol/mmol creatinine Adult (>18 years old) Both Normal
  • Geigy Scient...
Cerebrospinal Fluid (CSF) Detected and Quantified
45.9 +/- 12.3 uM Adult (>18 years old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
37.4 +/- 7.6 uM Adult (>18 years old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
34.7 +/- 6.2 uM Adult (>18 years old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
26.5 +/- 4.2 uM Adult (>18 years old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
10.35 +/- 0.88 uM Adult (>18 years old) Both Normal
Saliva Detected and Quantified
>10 uM Adult (>18 years old) Both Normal
Urine Detected and Quantified
10.3 umol/mmol creatinine Adult (>18 years old) Both Normal
Urine Detected and Quantified
8.40-100.79 umol/mmol creatinine Adult (>18 years old) Both Normal
  • David F. Put...
Urine Detected and Quantified
36.20 +/- 25.38 umol/mmol creatinine Infant (0-1 year old) Both Normal
Urine Detected but not Quantified
Not Applicable Adult (>18 years old) Both Normal
Urine Detected and Quantified
13.3 (6.4-25.2) umol/mmol creatinine Adult (>18 years old) Both Comment Normal
Urine Detected but not Quantified
Not Applicable Adult (>18 years old) Both Comment Normal
Urine Detected and Quantified
5.17-24.59 umol/mmol creatinine Adult (>18 years old) Both Normal
Urine Detected and Quantified
14.6 (6.6-29.3) umol/mmol creatinine Adult (>18 years old) Both Comment Normal
Urine Detected and Quantified
1.0 (0.16-2.4) umol/mmol creatinine Newborn (0-30 days old) Both Normal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
Urine Detected and Quantified
4.9 +/- 2.5 umol/mmol creatinine Children (1-13 year old) Female Normal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
Urine Detected and Quantified
18.0 +/- 9.6 umol/mmol creatinine Adult (>18 years old) Male Normal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
Urine Detected and Quantified
16.0 +/- 9.0 umol/mmol creatinine Adult (>18 years old) Female Normal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
Urine Detected and Quantified
12.7 (4.934-20.4) umol/mmol creatinine Adult (>18 years old) Both Normal
Urine Detected and Quantified
13.4 umol/mmol creatinine Adult (>18 years old) Both Normal
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified 83.4 +/- 47.8 uM Adult (>18 years old) Not Specified Heart Transplant
Blood Detected and Quantified 114.0 +/- 9.2 uM Adult (>18 years old) Both Comment Epilepsy
Blood Detected and Quantified 118.0 +/- 3.8 uM Adult (>18 years old) Both Comment Epilepsy
Blood Detected and Quantified 227.0 +/- 10.0 uM Adult (>18 years old) Both Comment Heart failure
Cerebrospinal Fluid (CSF) Detected and Quantified 41.0 +/- 15.9 uM Children (1-13 year old) Not Specified Leukemia
Cerebrospinal Fluid (CSF) Detected and Quantified 30.2 +/- 9.8 uM Children (1-13 year old) Not Specified Comment Leukemia
Cerebrospinal Fluid (CSF) Detected and Quantified 9.68 +/- 2.22 uM Adult (>18 years old) Both Schizophrenia
Urine Detected but not Quantified Not Applicable Adult (>18 years old) Both Autosomal dominant polycystic kidney disease
Urine Detected and Quantified 0.03 +/- 0.003 umol/mmol creatinine Adult (>18 years old) Both Alzheimer's disease
Associated Disorders and Diseases
Disease References
Epilepsy
  • Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24. Pubmed: 14992292 Link_out
      Leukemia
      • Peng CT, Wu KH, Lan SJ, Tsai JJ, Tsai FJ, Tsai CH: Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy. Eur J Cancer. 2005 May;41(8):1158-63. Epub 2005 Apr 14. Pubmed: 15911239 Link_out
          Heart failure
          • Norrelund H, Wiggers H, Halbirk M, Frystyk J, Flyvbjerg A, Botker HE, Schmitz O, Jorgensen JO, Christiansen JS, Moller N: Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure. J Intern Med. 2006 Jul;260(1):11-21. Pubmed: 16789974 Link_out
              Schizophrenia
              • Do KQ, Lauer CJ, Schreiber W, Zollinger M, Gutteck-Amsler U, Cuenod M, Holsboer F: gamma-Glutamylglutamine and taurine concentrations are decreased in the cerebrospinal fluid of drug-naive patients with schizophrenic disorders. J Neurochem. 1995 Dec;65(6):2652-62. Pubmed: 7595563 Link_out
                  Alzheimer's disease
                  • Fonteh AN, Harrington RJ, Tsai A, Liao P, Harrington MG: Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects. Amino Acids. 2007 Feb;32(2):213-24. Epub 2006 Oct 10. Pubmed: 17031479 Link_out
                      Associated OMIM IDs
                      DrugBank ID DB00156 Link_out
                      DrugBank Metabolite ID Not Available
                      Phenol Explorer Compound ID Not Available
                      Phenol Explorer Metabolite ID Not Available
                      FoodDB ID FDB011999
                      KNApSAcK ID C00001394 Link_out
                      Chemspider ID 6051 Link_out
                      KEGG Compound ID C00188 Link_out
                      BioCyc ID THR Link_out
                      BiGG ID 34186 Link_out
                      Wikipedia Link L-Threonine Link_out
                      NuGOwiki Link HMDB00167 Link_out
                      Metagene Link HMDB00167 Link_out
                      METLIN ID 32 Link_out
                      PubChem Compound 6288 Link_out
                      PDB ID THR Link_out
                      ChEBI ID 16857 Link_out
                      References
                      Synthesis Reference Fujita, Chuzo; Nara, Takashi; Samejima, Hirotoshi; Kinoshita, Shukuo. L-Threonine fermentation. I. Microbial conversion of L-homoserine to L-threonine. Nippon Nogei Kagaku Kaishi (1965), 39(6), 2
                      Material Safety Data Sheet (MSDS) Download (PDF)
                      General References
                      1. Vold BS, Keith DE Jr, Slavik M: Urine levels of N-[9-(beta-D-ribofuranosyl)purin-6-ylcarbamoyl]-L-threonine, N6-(delta 2-isopentenyl)adenosine, and 2'-O-methylguanosine as determined by radioimmunoassay for normal subjects and cancer patients. Cancer Res. 1982 Dec;42(12):5265-9. Pubmed: 7139629 Link_out
                      2. Peng CT, Wu KH, Lan SJ, Tsai JJ, Tsai FJ, Tsai CH: Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy. Eur J Cancer. 2005 May;41(8):1158-63. Epub 2005 Apr 14. Pubmed: 15911239 Link_out
                      3. Hallgren P, Lundblad A, Svensson S: A new type of carbohydrate-protein linkage in a glycopeptide from normal human urine. J Biol Chem. 1975 Jul 25;250(14):5312-4. Pubmed: 1141232 Link_out
                      4. Cynober LA: Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition. 2002 Sep;18(9):761-6. Pubmed: 12297216 Link_out
                      5. Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24. Pubmed: 14992292 Link_out
                      6. Wevers RA, Engelke U, Wendel U, de Jong JG, Gabreels FJ, Heerschap A: Standardized method for high-resolution 1H-NMR of cerebrospinal fluid. Clin Chem. 1995 May;41(5):744-51. Pubmed: 7729054 Link_out
                      7. Wulf G, Finn G, Suizu F, Lu KP: Phosphorylation-specific prolyl isomerization: is there an underlying theme? Nat Cell Biol. 2005 May;7(5):435-41. Pubmed: 15867923 Link_out
                      8. Takeda DY, Parvin JD, Dutta A: Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase. J Biol Chem. 2005 Jun 17;280(24):23416-23. Epub 2005 Apr 25. Pubmed: 15855168 Link_out
                      9. Nanda N, Bao M, Lin H, Clauser K, Komuves L, Quertermous T, Conley PB, Phillips DR, Hart MJ: Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. J Biol Chem. 2005 Jul 1;280(26):24680-9. Epub 2005 Apr 25. Pubmed: 15851471 Link_out
                      10. Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7. Pubmed: 12097436 Link_out
                      11. Boneh A, Korman SH, Sato K, Kanno J, Matsubara Y, Lerer I, Ben-Neriah Z, Kure S: A single nucleotide substitution that abolishes the initiator methionine codon of the GLDC gene is prevalent among patients with glycine encephalopathy in Jerusalem. J Hum Genet. 2005;50(5):230-4. Epub 2005 Apr 29. Pubmed: 15864413 Link_out
                      12. Elzinga M, Maron BJ, Adelstein RS: Human heart and platelet actins are products of different genes. Science. 1976 Jan 9;191(4222):94-5. Pubmed: 1246600 Link_out
                      13. Nicholson JK, O'Flynn MP, Sadler PJ, Macleod AF, Juul SM, Sonksen PH: Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects. Biochem J. 1984 Jan 15;217(2):365-75. Pubmed: 6696735 Link_out
                      14. Rodriguez-Soriano J, Vallo A, Perez de Nanclares G, Bilbao JR, Castano L: A founder mutation in the CLCNKB gene causes Bartter syndrome type III in Spain. Pediatr Nephrol. 2005 Jul;20(7):891-6. Epub 2005 May 5. Pubmed: 15875219 Link_out
                      15. Hagenfeldt L, Bjerkenstedt L, Edman G, Sedvall G, Wiesel FA: Amino acids in plasma and CSF and monoamine metabolites in CSF: interrelationship in healthy subjects. J Neurochem. 1984 Mar;42(3):833-7. Pubmed: 6198473 Link_out
                      16. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411 Link_out
                      17. Boehm G, Cervantes H, Georgi G, Jelinek J, Sawatzki G, Wermuth B, Colombo JP: Effect of increasing dietary threonine intakes on amino acid metabolism of the central nervous system and peripheral tissues in growing rats. Pediatr Res. 1998 Dec;44(6):900-6. Pubmed: 9853925 Link_out

                      Enzymes
                      Name: Threonine--tRNA ligase, cytoplasmic
                      Reactions:
                      Adenosine triphosphate + L-Threonine + tRNA(Thr) unknown Adenosine monophosphate + Pyrophosphate + L-threonyl-tRNA(Thr) details
                      Adenosine triphosphate + L-Threonine + tRNA(Thr) unknown Adenosine monophosphate + Pyrophosphate + L-Threonyl-tRNA(Thr) details
                      Gene Name: TARS
                      Uniprot ID: P26639 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: L-serine dehydratase/L-threonine deaminase
                      Reactions:
                      L-Threonine unknown 2-Ketobutyric acid + Ammonia details
                      Gene Name: SDS
                      Uniprot ID: P20132 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Neutral amino acid transporter A
                      Reactions: Not Available
                      Gene Name: SLC1A4
                      Uniprot ID: P43007 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Threonine synthase-like 1
                      Reactions: Not Available
                      Gene Name: THNSL1
                      Uniprot ID: Q8IYQ7 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Acetolactate synthase-like protein
                      Reactions: Not Available
                      Gene Name: ILVBL
                      Uniprot ID: A1L0T0 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Serine dehydratase-like
                      Reactions:
                      L-Threonine unknown 2-Ketobutyric acid + Ammonia details
                      Gene Name: SDSL
                      Uniprot ID: Q96GA7 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Probable threonine--tRNA ligase 2, cytoplasmic
                      Reactions:
                      Adenosine triphosphate + L-Threonine + tRNA(Thr) unknown Adenosine monophosphate + Pyrophosphate + L-threonyl-tRNA(Thr) details
                      Adenosine triphosphate + L-Threonine + tRNA(Thr) unknown Adenosine monophosphate + Pyrophosphate + L-Threonyl-tRNA(Thr) details
                      Gene Name: TARSL2
                      Uniprot ID: A2RTX5 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Threonine--tRNA ligase, mitochondrial
                      Reactions:
                      Adenosine triphosphate + L-Threonine + tRNA(Thr) unknown Adenosine monophosphate + Pyrophosphate + L-threonyl-tRNA(Thr) details
                      Adenosine triphosphate + L-Threonine + tRNA(Thr) unknown Adenosine monophosphate + Pyrophosphate + L-Threonyl-tRNA(Thr) details
                      Gene Name: TARS2
                      Uniprot ID: Q9BW92 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Transporters
                      Name: Monocarboxylate transporter 10
                      Reactions: Not Available
                      Gene Name: SLC16A10
                      Uniprot ID: Q8TF71 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA