Human Metabolome Database Version 3.5

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Showing metabocard for NADP (HMDB00217)

enzymes (175)

Blood
Urine

Record Information

Version

3.5

Creation Date

2005-11-16 08:48:42 -0700

Update Date

2013-02-08 17:08:06 -0700

HMDB ID

HMDB00217

Secondary Accession Numbers

None

Metabolite Identification

Common Name

NADP

Description

Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5-phosphate (NMN) coupled by pyrophosphate linkage to the 5-phosphate adenosine 2,5-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed.) Hydrogen carrier in biochemical redox systems. In the hexose monophosphoric acid system it is reduced to Dihydrocoenzyme II and reoxidation in the presence of flavoproteins (Dictionary of Organic Compounds).

Structure

Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure

Synonyms

Adenine-nicotinamide dinucleotide phosphate
b-NADP
b-Nicotinamide adenine dinucleotide phosphate
b-TPN
beta-NADP
beta-Nicotinamide adenine dinucleotide phosphate
beta-TPN
Codehydrase II
Codehydrogenase II
Coenzyme II
Cozymase II
NAD phosphate
NADP
NADP+
Nicotinamide adenine dinucleotide phosphate
Nicotinamide-adenine dinucleotide phosphate
TPN
Triphosphopyridine nucleotide

Chemical Formula

C₂₁H₂₉N₇O₁₇P₃

Average Molecular Weight

744.4129

Monoisotopic Molecular Weight

744.083277073

IUPAC Name

1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1$l^{5}-pyridin-1-ylium

Traditional IUPAC Name

1-[(2R,3R,4S,5R)-5-{[({[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxy]methyl}-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1$l^{5}-pyridin-1-ylium

CAS Registry Number

53-59-8

SMILES

NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O

InChI Identifier

InChI=1S/C21H28N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39)/p+1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

InChI Key

XJLXINKUBYWONI-NNYOXOHSSA-O

Chemical Taxonomy

Kingdom

Organic Compounds

Super Class

Nucleosides, Nucleotides, and Analogues

Class

Purine Nucleotides

Sub Class

Purine Ribonucleotides

Other Descriptors

Aromatic Heteropolycyclic Compounds
NAD(P)(+)(ChEBI)
NADP(ChEBI)

Substituents

1,2 Diol
1 Phosphoribosyl Imidazole
Aminopyrimidine
Carboxamide Group
Disaccharide Phosphate
Glycosyl Compound
Imidazole
Imidazopyrimidine
N Glycosyl Compound
Nicotinamide Nucleotide
Organic Hypophosphite
Organic Phosphite
Organic Pyrophosphate
Oxolane
Pentose Disaccharide
Phosphoric Acid Ester
Primary Carboxylic Acid Amide
Purine
Pyridine
Pyridine Nucleotide
Pyridinium
Pyrimidine
Saccharide
Secondary Alcohol

Direct Parent

Purine Ribonucleoside 2',5'-Bisphosphates

Ontology

Status

Expected and Not Quantified

Origin

Endogenous

Biofunction

Component of Androgen and estrogen metabolism
Component of Arginine and proline metabolism
Component of Bile acid biosynthesis
Component of C21-Steroid hormone metabolism
Component of Folate biosynthesis
Component of Glutamate metabolism
Component of Glutathione metabolism
Component of Glycerolipid metabolism
Component of Glyoxylate and dicarboxylate metabolism
Component of Monoterpenoid biosynthesis
Component of Nicotinate and nicotinamide metabolism
Component of Pantothenate and CoA biosynthesis
Component of Porphyrin and chlorophyll metabolism
Component of Prostaglandin and leukotriene metabolism
Component of Purine metabolism
Component of Pyrimidine metabolism
Component of Pyruvate metabolism
Component of beta-Alanine metabolism

Application

Not Available

Cellular locations

Extracellular
Mitochondria
Nucleus
Endoplasmic reticulum
Peroxisome

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	4.15 g/L	ALOGPS
LogP	-0.78	ALOGPS
LogP	-11	ChemAxon
LogS	-2.27	ALOGPS
pKa (strongest acidic)	0.66	ChemAxon
pKa (strongest basic)	4.92	ChemAxon
Hydrogen Acceptor Count	17	ChemAxon
Hydrogen Donor Count	9	ChemAxon
Polar Surface Area	364.79 A²	ChemAxon
Rotatable Bond Count	13	ChemAxon
Refractivity	152.87	ChemAxon
Polarizability	61.01	ChemAxon
Formal Charge	1	ChemAxon
Physiological Charge	-3	ChemAxon

Spectra

13C NMR Spectrum

1H NMR Spectrum

MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)

[1H,1H] 2D NMR Spectrum

[1H,13C] 2D NMR Spectrum

Biological Properties

Cellular Locations

Extracellular
Mitochondria
Nucleus
Endoplasmic reticulum
Peroxisome

Biofluid Locations

Not Available

Tissue Location

All Tissues

Pathways

Name	SMPDB Link	KEGG Link
Glucose-Alanine Cycle	SMP00127	Not Available
Nicotinate and Nicotinamide Metabolism	SMP00048	map00760
Glutathione Metabolism	SMP00015	map00480
Histidine Metabolism	SMP00044	map00340
Glycerolipid Metabolism	SMP00039	map00561
Phytanic Acid Peroxisomal Oxidation	SMP00450	Not Available
Ethanol Degradation	SMP00449	Not Available
Vitamin K Metabolism	SMP00464	Not Available
Transfer of Acetyl Groups into Mitochondria	SMP00466	Not Available
Plasmalogen Synthesis	SMP00479	Not Available
Arachidonic Acid Metabolism	SMP00075	map00590
Pterine Biosynthesis	SMP00005	map00790
Folate Metabolism	SMP00053	map00670

Normal Concentrations

Not Available

Abnormal Concentrations

Not Available

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

Phenol Explorer Metabolite ID

Not Available

FoodDB ID

FDB021908

KNApSAcK ID

Not Available

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

NuGOwiki Link

Metagene Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

18009

References

Synthesis Reference

Simon, L. M.; Kotorman, M.; Szajani, B. Coenzyme production using immobilized enzymes. I. Preparation, characterization, and laboratory-scale application of an immobilized NAD+ kinase. Enzyme and Microbial Technology (1992), 14(12), 997-1000.

Material Safety Data Sheet (MSDS)

Download (PDF)

General References

Siddique YH, Beg T, Afzal M: Genotoxic potential of ethinylestradiol in cultured mammalian cells. Chem Biol Interact. 2005 Jan 15;151(2):133-41. Pubmed: 15698584
Himmelstein MW, Carpenter SC, Hinderliter PM, Snow TA, Valentine R: The metabolism of beta-chloroprene: preliminary in-vitro studies using liver microsomes. Chem Biol Interact. 2001 Jun 1;135-136:267-84. Pubmed: 11397396

Enzymes

Name:	Fatty acid synthase
Reactions:	a (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = a hexadec-2-enoyl-[acyl-carrier protein] + H2O [RN:R04462]
Gene Name:	FASN
Uniprot ID:	P49327
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldo-keto reductase family 1 member C4
Reactions:	chlordecone alcohol + NADP+ = chlordecone + NADPH + H+ [RN:R03716]
Gene Name:	AKR1C4
Uniprot ID:	P17516
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbonyl reductase [NADPH] 1
Reactions:	(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+ [RN:R04552]
Gene Name:	CBR1
Uniprot ID:	P16152
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dehydrogenase/reductase SDR family member 4
Reactions:	R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+ [RN:R03557]
Gene Name:	DHRS4
Uniprot ID:	Q9BTZ2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carbonyl reductase [NADPH] 3
Reactions:	R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+ [RN:R03557]
Gene Name:	CBR3
Uniprot ID:	O75828
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldose reductase
Reactions:	alditol + NAD(P)+ = aldose + NAD(P)H + H+ [RN:R02819 R02820]
Gene Name:	AKR1B1
Uniprot ID:	P15121
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Thioredoxin reductase 1, cytoplasmic
Reactions:	thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ [RN:R02016]
Gene Name:	TXNRD1
Uniprot ID:	Q16881
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lathosterol oxidase
Reactions:	5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O [RN:R03310 R07215]
Gene Name:	SC5DL
Uniprot ID:	O75845
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylaniline monooxygenase [N-oxide-forming] 5
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO5
Uniprot ID:	P49326
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylaniline monooxygenase [N-oxide-forming] 2
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO2
Uniprot ID:	Q99518
Protein Sequence:	FASTA

Name:	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Reactions:	(S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H + H+ [RN:R00707 R00708]
Gene Name:	ALDH4A1
Uniprot ID:	P30038
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Thioredoxin reductase 2, mitochondrial
Reactions:	thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ [RN:R02016]
Gene Name:	TXNRD2
Uniprot ID:	Q9NNW7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylaniline monooxygenase [N-oxide-forming] 4
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO4
Uniprot ID:	P31512
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylaniline monooxygenase [N-oxide-forming] 3
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO3
Uniprot ID:	P31513
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH--cytochrome P450 reductase
Reactions:	NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein
Gene Name:	POR
Uniprot ID:	P16435
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylaniline monooxygenase [N-oxide-forming] 1
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO1
Uniprot ID:	Q01740
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Methylenetetrahydrofolate reductase
Reactions:	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+ [RN:R01224 R07168]
Gene Name:	MTHFR
Uniprot ID:	P42898
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione reductase, mitochondrial
Reactions:	2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ [RN:R00115]
Gene Name:	GSR
Uniprot ID:	P00390
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH:adrenodoxin oxidoreductase, mitochondrial
Reactions:	2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH [RN:R01195]
Gene Name:	FDXR
Uniprot ID:	P22570
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Squalene synthase
Reactions:	(1) (1a) 2 farnesyl diphosphate = diphosphate + presqualene diphosphate [RN:R00702] (2) (1b) presqualene diphosphate + NAD(P)H + H+ = squalene + diphosphate + NAD(P)+ [RN:R02872]
Gene Name:	FDFT1
Uniprot ID:	P37268
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Delta(14)-sterol reductase
Reactions:	4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+ [RN:R05639]
Gene Name:	TM7SF2
Uniprot ID:	O76062
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	C-4 methylsterol oxidase
Reactions:	(1) (1a) 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NAD(P)+ + H2O [RN:R04501 R05736] (2) (1b) 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + NAD(P)+ + 2 H2O [RN:R05733 R05737] (3) (1c) 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + NAD(P)H + H+ + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(P)+ + H2O [RN:R05734 R05738]
Gene Name:	SC4MOL
Uniprot ID:	Q15800
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
Reactions:	3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(P)+ = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NAD(P)H [RN:R04483 R07149]
Gene Name:	NSDHL
Uniprot ID:	Q15738
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lanosterol 14-alpha demethylase
Reactions:	obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 3 NADP+ + 4 H2O [RN:R05731]
Gene Name:	CYP51A1
Uniprot ID:	Q16850
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	4-trimethylaminobutyraldehyde dehydrogenase
Reactions:	4-trimethylammoniobutanal + NAD+ + H2O = 4-trimethylammoniobutanoate + NADH + 2 H+ [RN:R03283]
Gene Name:	ALDH9A1
Uniprot ID:	P49189
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde dehydrogenase, dimeric NADP-preferring
Reactions:	an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+ [RN:R00538 R00634]
Gene Name:	ALDH3A1
Uniprot ID:	P30838
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alpha-aminoadipic semialdehyde dehydrogenase
Reactions:	L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+ [RN:R03102 R03103]
Gene Name:	ALDH7A1
Uniprot ID:	P49419
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde dehydrogenase family 1 member A3
Reactions:	an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+ [RN:R00538 R00634]
Gene Name:	ALDH1A3
Uniprot ID:	P47895
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde dehydrogenase, mitochondrial
Reactions:	an aldehyde + NAD+ + H2O = an acid + NADH + H+ [RN:R00538]
Gene Name:	ALDH2
Uniprot ID:	P05091
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Fatty aldehyde dehydrogenase
Reactions:	an aldehyde + NAD+ + H2O = an acid + NADH + H+ [RN:R00538]
Gene Name:	ALDH3A2
Uniprot ID:	P51648
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde dehydrogenase X, mitochondrial
Reactions:	an aldehyde + NAD+ + H2O = an acid + NADH + H+ [RN:R00538]
Gene Name:	ALDH1B1
Uniprot ID:	P30837
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pyrroline-5-carboxylate reductase 1, mitochondrial
Reactions:	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H + H+ [RN:R01248 R01251]
Gene Name:	PYCR1
Uniprot ID:	P32322
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pyrroline-5-carboxylate reductase 2
Reactions:	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H + H+ [RN:R01248 R01251]
Gene Name:	PYCR2
Uniprot ID:	Q96C36
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	L-xylulose reductase
Reactions:	xylitol + NADP+ = L-xylulose + NADPH + H+ [RN:R01904]
Gene Name:	DCXR
Uniprot ID:	Q7Z4W1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glucose-6-phosphate 1-dehydrogenase
Reactions:	D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+ [RN:R00835]
Gene Name:	G6PD
Uniprot ID:	P11413
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	GDH/6PGL endoplasmic bifunctional protein
Reactions:	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate [RN:R02035]
Gene Name:	H6PD
Uniprot ID:	O95479
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldo-keto reductase family 1 member C3
Reactions:	trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ [RN:R00814]
Gene Name:	AKR1C3
Uniprot ID:	P42330
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	GDP-mannose 4,6 dehydratase
Reactions:	GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O [RN:R00888]
Gene Name:	GMDS
Uniprot ID:	O60547
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldo-keto reductase family 1 member C1
Reactions:	trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ [RN:R00814]
Gene Name:	AKR1C1
Uniprot ID:	Q04828
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldo-keto reductase family 1 member C2
Reactions:	trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ [RN:R00814]
Gene Name:	AKR1C2
Uniprot ID:	P52895
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glyoxylate reductase/hydroxypyruvate reductase
Reactions:	D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H + H+ [RN:R01388 R01392]
Gene Name:	GRHPR
Uniprot ID:	Q9UBQ7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4A11
Reactions:	octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O [RN:R02879]
Gene Name:	CYP4A11
Uniprot ID:	Q02928
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Methionine synthase reductase
Reactions:	2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP+ = 2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine [RN:R05182]
Gene Name:	MTRR
Uniprot ID:	Q9UBK8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sepiapterin reductase
Reactions:	(1) 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ [RN:R02975] (2) tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H+ [RN:R08208]
Gene Name:	SPR
Uniprot ID:	P35270
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Estradiol 17-beta-dehydrogenase 2
Reactions:	testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+ [RN:R01836]
Gene Name:	HSD17B2
Uniprot ID:	P37059
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Estradiol 17-beta-dehydrogenase 8
Reactions:	testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+ [RN:R01836]
Gene Name:	HSD17B8
Uniprot ID:	Q92506
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Reactions:	trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ [RN:R00814]
Gene Name:	DHDH
Uniprot ID:	Q9UQ10
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	11-cis retinol dehydrogenase
Reactions:	retinol + NAD+ = retinal + NADH + H+ [RN:R02124]
Gene Name:	RDH5
Uniprot ID:	Q92781
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cholesterol 7-alpha-monooxygenase
Reactions:	cholesterol + NADPH + H+ + O2 = 7alpha-hydroxycholesterol + NADP+ + H2O [RN:R01463]
Gene Name:	CYP7A1
Uniprot ID:	P22680
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alcohol dehydrogenase [NADP+]
Reactions:	an alcohol + NADP+ = an aldehyde + NADPH + H+ [RN:R07328]
Gene Name:	AKR1A1
Uniprot ID:	P14550
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde dehydrogenase family 3 member B2
Reactions:	an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+ [RN:R00538 R00634]
Gene Name:	ALDH3B2
Uniprot ID:	P48448
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde dehydrogenase family 3 member B1
Reactions:	an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+ [RN:R00538 R00634]
Gene Name:	ALDH3B1
Uniprot ID:	P43353
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	7-dehydrocholesterol reductase
Reactions:	cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ [RN:R01456]
Gene Name:	DHCR7
Uniprot ID:	Q9UBM7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	3-oxo-5-beta-steroid 4-dehydrogenase
Reactions:	(1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ [RN:R02609] (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+ [RN:R02893]
Gene Name:	AKR1D1
Uniprot ID:	P51857
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutamate dehydrogenase 2, mitochondrial
Reactions:	L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+ [RN:R00243 R00248]
Gene Name:	GLUD2
Uniprot ID:	P49448
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	GMP reductase 2
Reactions:	inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH + H+ [RN:R01134]
Gene Name:	GMPR2
Uniprot ID:	Q9P2T1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	GMP reductase 1
Reactions:	inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH + H+ [RN:R01134]
Gene Name:	GMPR
Uniprot ID:	P36959
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Reactions:	D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+ [RN:R01061]
Gene Name:	GAPDHS
Uniprot ID:	O14556
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutamate dehydrogenase 1, mitochondrial
Reactions:	L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+ [RN:R00243 R00248]
Gene Name:	GLUD1
Uniprot ID:	P00367
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glyceraldehyde-3-phosphate dehydrogenase
Reactions:	D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+ [RN:R01061]
Gene Name:	GAPDH
Uniprot ID:	P04406
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Biliverdin reductase A
Reactions:	bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+ [RN:R02391 R02393]
Gene Name:	BLVRA
Uniprot ID:	P53004
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Flavin reductase
Reactions:	reduced riboflavin + NADP+ = riboflavin + NADPH + H+ [RN:R05707]
Gene Name:	BLVRB
Uniprot ID:	P30043
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Corticosteroid 11-beta-dehydrogenase isozyme 2
Reactions:	--- []
Gene Name:	HSD11B2
Uniprot ID:	P80365
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Corticosteroid 11-beta-dehydrogenase isozyme 1
Reactions:	an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ [RN:R03203]
Gene Name:	HSD11B1
Uniprot ID:	P28845
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dihydropyrimidine dehydrogenase [NADP+]
Reactions:	5,6-dihydrouracil + NADP+ = uracil + NADPH + H+ [RN:R00978]
Gene Name:	DPYD
Uniprot ID:	Q12882
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alcohol dehydrogenase class-3
Reactions:	S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+ [RN:R06983 R07140]
Gene Name:	ADH5
Uniprot ID:	P11766
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alcohol dehydrogenase 1B
Reactions:	an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
Gene Name:	ADH1B
Uniprot ID:	P00325
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alcohol dehydrogenase class 4 mu/sigma chain
Reactions:	an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
Gene Name:	ADH7
Uniprot ID:	P40394
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alcohol dehydrogenase 1A
Reactions:	an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
Gene Name:	ADH1A
Uniprot ID:	P07327
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alcohol dehydrogenase 6
Reactions:	an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
Gene Name:	ADH6
Uniprot ID:	P28332
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alcohol dehydrogenase 1C
Reactions:	an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ [RN:R07326 R07327]
Gene Name:	ADH1C
Uniprot ID:	P00326
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dihydrofolate reductase
Reactions:	5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ [RN:R00939]
Gene Name:	DHFR
Uniprot ID:	P00374
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Testosterone 17-beta-dehydrogenase 3
Reactions:	testosterone + NADP+ = androst-4-ene-3,17-dione + NADPH + H+ [RN:R01838]
Gene Name:	HSD17B3
Uniprot ID:	P37058
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Estradiol 17-beta-dehydrogenase 1
Reactions:	estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+ [RN:R02352 R02353]
Gene Name:	HSD17B1
Uniprot ID:	P14061
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	3-keto-steroid reductase
Reactions:	4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP+ = 4alpha-methyl-5alpha-cholest-7-en-3-one + NADPH + H+ [RN:R05691]
Gene Name:	HSD17B7
Uniprot ID:	P56937
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alpha-aminoadipic semialdehyde synthase, mitochondrial
Reactions:	N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+ [RN:R02313]
Gene Name:	AASS
Uniprot ID:	Q9UDR5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Delta-1-pyrroline-5-carboxylate synthase
Reactions:	ATP + L-glutamate = ADP + L-glutamate 5-phosphate [RN:R00239]
Gene Name:	ALDH18A1
Uniprot ID:	P54886
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADP-dependent malic enzyme
Reactions:	(S)-malate + NADP+ = pyruvate + CO2 + NADPH [RN:R00216]
Gene Name:	ME1
Uniprot ID:	P48163
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADP-dependent malic enzyme, mitochondrial
Reactions:	(S)-malate + NADP+ = pyruvate + CO2 + NADPH [RN:R00216]
Gene Name:	ME3
Uniprot ID:	Q16798
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NAD-dependent malic enzyme, mitochondrial
Reactions:	(S)-malate + NAD+ = pyruvate + CO2 + NADH [RN:R00214]
Gene Name:	ME2
Uniprot ID:	P23368
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Isocitrate dehydrogenase [NADP], mitochondrial
Reactions:	(1) isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+ (overall reaction) [RN:R00267] (2) (1a) isocitrate + NADP+ = oxalosuccinate + NADPH + H+ [RN:R01899] (3) (1b) oxalosuccinate = 2-oxoglutarate + CO2 [RN:R00268]
Gene Name:	IDH2
Uniprot ID:	P48735
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Isocitrate dehydrogenase [NADP] cytoplasmic
Reactions:	(1) isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+ (overall reaction) [RN:R00267] (2) (1a) isocitrate + NADP+ = oxalosuccinate + NADPH + H+ [RN:R01899] (3) (1b) oxalosuccinate = 2-oxoglutarate + CO2 [RN:R00268]
Gene Name:	IDH1
Uniprot ID:	O75874
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NAD-dependent deacetylase sirtuin-6
Reactions:
Gene Name:	SIRT6
Uniprot ID:	Q8N6T7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ecto-ADP-ribosyltransferase 3
Reactions:	NAD+ + protein L-arginine = nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine [RN:R00555]
Gene Name:	ART3
Uniprot ID:	Q13508
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ecto-ADP-ribosyltransferase 5
Reactions:	NAD+ + protein L-arginine = nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine [RN:R00555]
Gene Name:	ART5
Uniprot ID:	Q96L15
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
Reactions:	NAD+ + protein L-arginine = nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine [RN:R00555]
Gene Name:	ART1
Uniprot ID:	P52961
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	3-hydroxy-3-methylglutaryl-coenzyme A reductase
Reactions:	(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ [RN:R02082]
Gene Name:	HMGCR
Uniprot ID:	P04035
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NAD(P) transhydrogenase, mitochondrial
Reactions:	NADPH + NAD+ = NADP+ + NADH [RN:R00112]
Gene Name:	NNT
Uniprot ID:	Q13423
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ADP-ribosyl cyclase 2
Reactions:	NAD+ + H2O = ADP-ribose + nicotinamide [RN:R00102]
Gene Name:	BST1
Uniprot ID:	Q10588
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NAD kinase
Reactions:	ATP + NAD+ = ADP + NADP+ [RN:R00104]
Gene Name:	NADK
Uniprot ID:	O95544
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ADP-ribosyl cyclase 1
Reactions:	NAD+ + H2O = ADP-ribose + nicotinamide [RN:R00102]
Gene Name:	CD38
Uniprot ID:	P28907
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ecto-ADP-ribosyltransferase 4
Reactions:	NAD+ + protein L-arginine = nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine [RN:R00555]
Gene Name:	ART4
Uniprot ID:	Q93070
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Reactions:	5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate [RN:R01655]
Gene Name:	MTHFD2
Uniprot ID:	P13995
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	C-1-tetrahydrofolate synthase, cytoplasmic
Reactions:	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate [RN:R00943]
Gene Name:	MTHFD1
Uniprot ID:	P11586
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	GDP-L-fucose synthase
Reactions:	GDP-L-fucose + NADP+ = GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+ [RN:R05692]
Gene Name:	TSTA3
Uniprot ID:	Q13630
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nitric oxide synthase, inducible
Reactions:	L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+ [RN:R00557]
Gene Name:	NOS2
Uniprot ID:	P35228
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nitric oxide synthase, brain
Reactions:	L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+ [RN:R00557]
Gene Name:	NOS1
Uniprot ID:	P29475
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nitric oxide synthase, endothelial
Reactions:	L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+ [RN:R00557]
Gene Name:	NOS3
Uniprot ID:	P29474
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	10-formyltetrahydrofolate dehydrogenase
Reactions:	10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH + H+ [RN:R00941]
Gene Name:	ALDH1L1
Uniprot ID:	O75891
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Trans-2-enoyl-CoA reductase, mitochondrial
Reactions:	acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+ [RN:R07162]
Gene Name:	MECR
Uniprot ID:	Q9BV79
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal trans-2-enoyl-CoA reductase
Reactions:	acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+ [RN:R07162]
Gene Name:	PECR
Uniprot ID:	Q9BY49
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Leukotriene-B(4) omega-hydroxylase 1
Reactions:	(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14- tetraenoate + NADP+ + H2O [RN:R03866]
Gene Name:	CYP4F2
Uniprot ID:	P78329
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Leukotriene-B(4) omega-hydroxylase 2
Reactions:	(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14- tetraenoate + NADP+ + H2O [RN:R03866]
Gene Name:	CYP4F3
Uniprot ID:	Q08477
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 3A4
Reactions:	(1) taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O [RN:R07205] (2) lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O [RN:R07206]
Gene Name:	CYP3A4
Uniprot ID:	P08684
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2C9
Reactions:	(R)-limonene + NADPH + H+ + O2 = (+)-trans-carveol + NADP+ + H2O [RN:R06119]
Gene Name:	CYP2C9
Uniprot ID:	P11712
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sterol 26-hydroxylase, mitochondrial
Reactions:	5beta-cholestane-3alpha,7alpha,12alpha-triol + NADPH + H+ + O2 = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + NADP+ + H2O [RN:R04807]
Gene Name:	CYP27A1
Uniprot ID:	Q02318
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2C19
Reactions:	(R)-limonene + NADPH + H+ + O2 = (+)-trans-carveol + NADP+ + H2O [RN:R06119]
Gene Name:	CYP2C19
Uniprot ID:	P33261
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	6-phosphogluconate dehydrogenase, decarboxylating
Reactions:	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH [RN:R01528]
Gene Name:	PGD
Uniprot ID:	P52209
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	2,4-dienoyl-CoA reductase, mitochondrial
Reactions:	trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+ [RN:R04319]
Gene Name:	DECR1
Uniprot ID:	Q16698
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Quinone oxidoreductase
Reactions:	NADPH + H+ + 2 quinone = NADP+ + 2 semiquinone [RN:R02364]
Gene Name:	CRYZ
Uniprot ID:	Q08257
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Reactions:	calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O [RN:R03610]
Gene Name:	CYP27B1
Uniprot ID:	O15528
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Steroid 17-alpha-hydroxylase/17,20 lyase
Reactions:	a steroid + AH2 + O2 = a 17alpha-hydroxysteroid + A + H2O [RN:R02131]
Gene Name:	CYP17A1
Uniprot ID:	P05093
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal 2,4-dienoyl-CoA reductase
Reactions:	trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+ [RN:R04319]
Gene Name:	DECR2
Uniprot ID:	Q9NUI1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2E1
Reactions:	--- []
Gene Name:	CYP2E1
Uniprot ID:	P05181
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 3A43
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP3A43
Uniprot ID:	Q9HB55
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 1B1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP1B1
Uniprot ID:	Q16678
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2C18
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2C18
Uniprot ID:	P33260
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2F1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2F1
Uniprot ID:	P24903
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4X1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP4X1
Uniprot ID:	Q8N118
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2B6
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2B6
Uniprot ID:	P20813
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 3A5
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP3A5
Uniprot ID:	P20815
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2A13
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2A13
Uniprot ID:	Q16696
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 3A7
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP3A7
Uniprot ID:	P24462
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4B1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP4B1
Uniprot ID:	P13584
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4Z1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP4Z1
Uniprot ID:	Q86W10
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 1A2
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP1A2
Uniprot ID:	P05177
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 19A1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP19A1
Uniprot ID:	P11511
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2C8
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2C8
Uniprot ID:	P10632
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2S1
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2S1
Uniprot ID:	Q96SQ9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2J2
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2J2
Uniprot ID:	P51589
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2A7
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2A7
Uniprot ID:	P20853
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2A6
Reactions:	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name:	CYP2A6
Uniprot ID:	P11509
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Catalase
Reactions:	2 H2O2 = O2 + 2 H2O [RN:R00009]
Gene Name:	CAT
Uniprot ID:	P04040
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Prostaglandin reductase 1
Reactions:	n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+ [RN:R07349 R07350]
Gene Name:	PTGR1
Uniprot ID:	Q14914
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	25-hydroxycholesterol 7-alpha-hydroxylase
Reactions:	(1) cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O [RN:R07209] (2) cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O [RN:R07372]
Gene Name:	CYP7B1
Uniprot ID:	O75881
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NAD(P)H dehydrogenase [quinone] 1
Reactions:	NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone [RN:R07358 R07359]
Gene Name:	NQO1
Uniprot ID:	P15559
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Reactions:	--- []
Gene Name:	CYP24A1
Uniprot ID:	Q07973
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative dimethylaniline monooxygenase [N-oxide-forming] 6
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO6P
Uniprot ID:	O60774
Protein Sequence:	FASTA

Name:	24-dehydrocholesterol reductase
Reactions:
Gene Name:	DHCR24
Uniprot ID:	Q15392
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Kynurenine 3-monooxygenase
Reactions:	L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O [RN:R01960]
Gene Name:	KMO
Uniprot ID:	O15229
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dehydrogenase/reductase SDR family member 9
Reactions:
Gene Name:	DHRS9
Uniprot ID:	Q9BPW9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Vitamin D 25-hydroxylase
Reactions:	5beta-cholestane-3alpha,7alpha,12alpha-triol + NADPH + H+ + O2 = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + NADP+ + H2O [RN:R04807]
Gene Name:	CYP2R1
Uniprot ID:	Q6VVX0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	3-ketodihydrosphingosine reductase
Reactions:	sphinganine + NADP+ = 3-dehydrosphinganine + NADPH + H+ [RN:R02978]
Gene Name:	KDSR
Uniprot ID:	Q06136
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
Reactions:	a 3-oxo-Delta5-steroid = a 3-oxo-Delta4-steroid [RN:R02644]
Gene Name:	HSD3B2
Uniprot ID:	P26439
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cholesterol 24-hydroxylase
Reactions:	cholesterol + NADPH + H+ + O2 = (24S)-24-hydroxycholesterol + NADP+ + H2O [RN:R07207]
Gene Name:	CYP46A1
Uniprot ID:	Q9Y6A2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retinol dehydrogenase 8
Reactions:	retinol + NADP+ = retinal + NADPH + H+
Gene Name:	RDH8
Uniprot ID:	Q9NYR8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	24-hydroxycholesterol 7-alpha-hydroxylase
Reactions:	(24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2 = (24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O [RN:R07208]
Gene Name:	CYP39A1
Uniprot ID:	Q9NYL5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Reactions:	7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O [RN:R04826]
Gene Name:	CYP8B1
Uniprot ID:	Q9UNU6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retinol dehydrogenase 10
Reactions:	retinol + NADP+ = retinal + NADPH + H+
Gene Name:	RDH10
Uniprot ID:	Q8IZV5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Thioredoxin reductase 3
Reactions:	thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ [RN:R02016]
Gene Name:	TXNRD3
Uniprot ID:	Q86VQ6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2
Reactions:	10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH + H+ [RN:R00941]
Gene Name:	ALDH1L2
Uniprot ID:	Q3SY69
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Fatty acyl-CoA reductase 1
Reactions:
Gene Name:	FAR1
Uniprot ID:	Q8WVX9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Fatty acyl-CoA reductase 2
Reactions:
Gene Name:	FAR2
Uniprot ID:	Q96K12
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 4A22
Reactions:	octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O [RN:R02879]
Gene Name:	CYP4A22
Uniprot ID:	Q5TCH4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative uncharacterized protein DKFZp686B0215
Reactions:
Gene Name:	DKFZp686B0215
Uniprot ID:	Q5HYI4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dihydrofolate reductase
Reactions:
Gene Name:	DYR
Uniprot ID:	B0YJ76
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Monofunctional C1-tetrahydrofolate synthase, mitochondrial
Reactions:	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate [RN:R00943]
Gene Name:	MTHFD1L
Uniprot ID:	Q6UB35
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable arylformamidase
Reactions:	N-formyl-L-kynurenine + H2O = formate + L-kynurenine [RN:R01959]
Gene Name:	AFMID
Uniprot ID:	Q63HM1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-CoA synthetase family member 4
Reactions:
Gene Name:	AASDH
Uniprot ID:	Q4L235
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aminoadipate-semialdehyde synthase
Reactions:
Gene Name:	AASS
Uniprot ID:	A4D0W4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative uncharacterized protein PGD
Reactions:
Gene Name:	PGD
Uniprot ID:	A9Z1X1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450, family 1, subfamily A, polypeptide 1
Reactions:
Gene Name:	CYP1A1
Uniprot ID:	A0N0X8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH-dependent diflavin oxidoreductase 1
Reactions:
Gene Name:	NDOR1
Uniprot ID:	Q9UHB4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH oxidase 1
Reactions:
Gene Name:	NOX1
Uniprot ID:	Q9Y5S8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	All-trans-retinol 13,14-reductase
Reactions:	all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor [RN:R07163]
Gene Name:	RETSAT
Uniprot ID:	Q6NUM9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal coenzyme A diphosphatase NUDT7
Reactions:
Gene Name:	NUDT7
Uniprot ID:	P0C024
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde dehydrogenase family 8 member A1
Reactions:
Gene Name:	ALDH8A1
Uniprot ID:	Q9H2A2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative L-aspartate dehydrogenase
Reactions:	L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+ [RN:R07164 R07165]
Gene Name:	ASPDH
Uniprot ID:	A6ND91
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Prostaglandin reductase 2
Reactions:	11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NAD(P)H + H+ [RN:R04556 R04557]
Gene Name:	PTGR2
Uniprot ID:	Q8N8N7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Thioredoxin domain-containing protein 2
Reactions:
Gene Name:	TXNDC2
Uniprot ID:	Q86VQ3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450, family 21, subfamily A, polypeptide 2
Reactions:
Gene Name:	CYP21A2
Uniprot ID:	Q08AG9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome P450 2D6
Reactions:
Gene Name:	CYP2D6
Uniprot ID:	Q6NWU0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NOS1 mutant
Reactions:
Gene Name:	NOS1
Uniprot ID:	B3VK56
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Voltage-gated potassium channel subunit beta-2
Reactions:
Gene Name:	KCNAB2
Uniprot ID:	Q13303
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Reactions:
Gene Name:	AASDHPPT
Uniprot ID:	Q9NRN7
Protein Sequence:	FASTA
Gene Sequence:	FASTA