Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2013-02-09 00:08:06 UTC
HMDB IDHMDB00217
Secondary Accession NumbersNone
Metabolite Identification
Common NameNADP
DescriptionNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5-phosphate (NMN) coupled by pyrophosphate linkage to the 5-phosphate adenosine 2,5-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed.) Hydrogen carrier in biochemical redox systems. In the hexose monophosphoric acid system it is reduced to Dihydrocoenzyme II and reoxidation in the presence of flavoproteins (Dictionary of Organic Compounds).
Structure
Thumb
Synonyms
  1. Adenine-nicotinamide dinucleotide phosphate
  2. b-NADP
  3. b-Nicotinamide adenine dinucleotide phosphate
  4. b-TPN
  5. beta-NADP
  6. beta-Nicotinamide adenine dinucleotide phosphate
  7. beta-TPN
  8. Codehydrase II
  9. Codehydrogenase II
  10. Coenzyme II
  11. Cozymase II
  12. NAD phosphate
  13. NADP
  14. NADP+
  15. Nicotinamide adenine dinucleotide phosphate
  16. Nicotinamide-adenine dinucleotide phosphate
  17. TPN
  18. Triphosphopyridine nucleotide
Chemical FormulaC21H29N7O17P3
Average Molecular Weight744.4129
Monoisotopic Molecular Weight744.083277073
IUPAC Name1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1$l^{5}-pyridin-1-ylium
Traditional IUPAC Name1-[(2R,3R,4S,5R)-5-{[({[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxy]methyl}-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1$l^{5}-pyridin-1-ylium
CAS Registry Number53-59-8
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
InChI Identifier
InChI=1S/C21H28N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39)/p+1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChI KeyXJLXINKUBYWONI-NNYOXOHSSA-O
Chemical Taxonomy
KingdomOrganic Compounds
Super ClassNucleosides, Nucleotides, and Analogues
ClassPurine Nucleotides
Sub ClassPurine Ribonucleotides
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
  • NAD(P)(+)(ChEBI)
  • NADP(ChEBI)
Substituents
  • 1,2 Diol
  • 1 Phosphoribosyl Imidazole
  • Aminopyrimidine
  • Carboxamide Group
  • Disaccharide Phosphate
  • Glycosyl Compound
  • Imidazole
  • Imidazopyrimidine
  • N Glycosyl Compound
  • Nicotinamide Nucleotide
  • Organic Hypophosphite
  • Organic Phosphite
  • Organic Pyrophosphate
  • Oxolane
  • Pentose Disaccharide
  • Phosphoric Acid Ester
  • Primary Carboxylic Acid Amide
  • Purine
  • Pyridine
  • Pyridine Nucleotide
  • Pyridinium
  • Pyrimidine
  • Saccharide
  • Secondary Alcohol
Direct ParentPurine Ribonucleoside 2',5'-Bisphosphates
Ontology
StatusExpected and Not Quantified
Origin
  • Endogenous
Biofunction
  • Component of Androgen and estrogen metabolism
  • Component of Arginine and proline metabolism
  • Component of Bile acid biosynthesis
  • Component of C21-Steroid hormone metabolism
  • Component of Folate biosynthesis
  • Component of Glutamate metabolism
  • Component of Glutathione metabolism
  • Component of Glycerolipid metabolism
  • Component of Glyoxylate and dicarboxylate metabolism
  • Component of Monoterpenoid biosynthesis
  • Component of Nicotinate and nicotinamide metabolism
  • Component of Pantothenate and CoA biosynthesis
  • Component of Porphyrin and chlorophyll metabolism
  • Component of Prostaglandin and leukotriene metabolism
  • Component of Purine metabolism
  • Component of Pyrimidine metabolism
  • Component of Pyruvate metabolism
  • Component of beta-Alanine metabolism
ApplicationNot Available
Cellular locations
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
water solubility4.15 g/LALOGPS
logP-0.78ALOGPS
logP-11ChemAxon
logS-2.3ALOGPS
pKa (strongest acidic)0.66ChemAxon
pKa (strongest basic)4.92ChemAxon
physiological charge-3ChemAxon
hydrogen acceptor count17ChemAxon
hydrogen donor count9ChemAxon
polar surface area364.79ChemAxon
rotatable bond count13ChemAxon
refractivity152.87ChemAxon
polarizability61.01ChemAxon
Spectra
Spectra
Biological Properties
Cellular Locations
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Biofluid LocationsNot Available
Tissue Location
  • All Tissues
Pathways
NameSMPDB LinkKEGG Link
Arachidonic Acid MetabolismSMP00075map00590
Ethanol DegradationSMP00449Not Available
Folate MetabolismSMP00053map00670
Glucose-Alanine CycleSMP00127Not Available
Glutathione MetabolismSMP00015map00480
Glycerolipid MetabolismSMP00039map00561
Histidine MetabolismSMP00044map00340
Nicotinate and Nicotinamide MetabolismSMP00048map00760
Phytanic Acid Peroxisomal OxidationSMP00450Not Available
Plasmalogen SynthesisSMP00479Not Available
Pterine BiosynthesisSMP00005map00790
Transfer of Acetyl Groups into MitochondriaSMP00466Not Available
Vitamin K MetabolismSMP00464Not Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB021908
KNApSAcK IDNot Available
Chemspider ID5675
KEGG Compound IDC00006
BioCyc IDNAD(P)
BiGG ID33488
Wikipedia LinkNADP
NuGOwiki LinkHMDB00217
Metagene LinkHMDB00217
METLIN ID5227
PubChem Compound5886
PDB IDNot Available
ChEBI ID18009
References
Synthesis ReferenceSimon, L. M.; Kotorman, M.; Szajani, B. Coenzyme production using immobilized enzymes. I. Preparation, characterization, and laboratory-scale application of an immobilized NAD+ kinase. Enzyme and Microbial Technology (1992), 14(12), 997-1000.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Siddique YH, Beg T, Afzal M: Genotoxic potential of ethinylestradiol in cultured mammalian cells. Chem Biol Interact. 2005 Jan 15;151(2):133-41. Pubmed: 15698584
  2. Himmelstein MW, Carpenter SC, Hinderliter PM, Snow TA, Valentine R: The metabolism of beta-chloroprene: preliminary in-vitro studies using liver microsomes. Chem Biol Interact. 2001 Jun 1;135-136:267-84. Pubmed: 11397396

Only showing the first 50 proteins. There are 207 proteins in total.

Enzymes

Gene Name:
FASN
Uniprot ID:
P49327
Reactions
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP unknown 3-oxoacyl-[acyl-carrier-protein] + NADPHdetails
Acyl-[acyl-carrier-protein] + NADP unknown trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADPHdetails
Butyryl-[acp] + NADP unknown But-2-enoyl-[acyl-carrier protein] + NADPH + Hydrogen Iondetails
(3R)-3-Hydroxybutanoyl-[acyl-carrier protein] + NADP unknown Acetoacetyl-[acp] + NADPH + Hydrogen Iondetails
(3R)-3-Hydroxydecanoyl-[acyl-carrier protein] + NADP unknown 3-Oxodecanoyl-[acp] + NADPHdetails
(3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] + NADP unknown 3-Oxooctanoyl-[acp] + NADPH + Hydrogen Iondetails
(3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] + NADP unknown 3-Oxohexadecanoyl-[acp] + NADPH + Hydrogen Iondetails
(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] + NADP unknown 3-Oxotetradecanoyl-[acp] + NADPH + Hydrogen Iondetails
Dodecanoyl-[acyl-carrier protein] + NADP unknown trans-Dodec-2-enoyl-[acp] + NADPH + Hydrogen Iondetails
(R)-3-Hydroxyhexanoyl-[acp] + NADP unknown 3-Oxohexanoyl-[acp] + NADPH + Hydrogen Iondetails
Hexanoyl-[acp] + NADP unknown trans-Hex-2-enoyl-[acp] + NADPH + Hydrogen Iondetails
Octanoyl-[acp] + NADP unknown trans-Oct-2-enoyl-[acp] + NADPH + Hydrogen Iondetails
Decanoyl-[acp] + NADP unknown trans-Dec-2-enoyl-[acp] + NADPH + Hydrogen Iondetails
Tetradecanoyl-[acp] + NADP unknown trans-Tetradec-2-enoyl-[acp] + NADPH + Hydrogen Iondetails
Hexadecanoyl-[acp] + NADP unknown trans-Hexadec-2-enoyl-[acp] + NADPH + Hydrogen Iondetails
Gene Name:
ALDH6A1
Uniprot ID:
Q02252
Reactions
Malonic semialdehyde + Coenzyme A + NADP unknown Acetyl-CoA + Carbon dioxide + NADPH + Hydrogen Iondetails
Malonic semialdehyde + Coenzyme A + NADP unknown Malonyl-CoA + NADPH + Hydrogen Iondetails
Gene Name:
AKR1C4
Uniprot ID:
P17516
Reactions
Chlordecone alcohol + NADP unknown Chlordecone + NADPHdetails
Androsterone + NADP unknown Androstanedione + NADPH + Hydrogen Iondetails
Etiocholanolone + NADP unknown Etiocholanedione + NADPH + Hydrogen Iondetails
3a,7a-Dihydroxy-5b-cholestane + NADP unknown 7a-Hydroxy-5b-cholestan-3-one + NADPH + Hydrogen Iondetails
5-b-Cholestane-3a ,7a ,12a-triol + NADP unknown 7a,12a-Dihydroxy-5b-cholestan-3-one + NADPH + Hydrogen Iondetails
17a,21-Dihydroxy-5b-pregnane-3,11,20-trione + Hydrogen Ion + NADPH unknown Tetrahydrocortisone + NADPdetails
Tetrahydrocortisol + NADP unknown Dihydrocortisol + NADPH + Hydrogen Iondetails
3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al + NADP unknown 11b,21-Dihydroxy-3,20-oxo-5b-pregnan-18-al + NADPH + Hydrogen Iondetails
Tetrahydrocorticosterone + NADP unknown 11b,21-Dihydroxy-5b-pregnane-3,20-dione + NADPH + Hydrogen Iondetails
3a,21-Dihydroxy-5b-pregnane-11,20-dione + NADP unknown 21-Hydroxy-5b-pregnane-3,11,20-trione + NADPH + Hydrogen Iondetails
3a-Hydroxy-5b-pregnane-20-one + NADP unknown 5a-Pregnane-3,20-dione + NADPH + Hydrogen Iondetails
Dihydrotestosterone + NADPH + Hydrogen Ion unknown Androstan-3alpha,17beta-diol + NADPdetails
Gene Name:
CBR1
Uniprot ID:
P16152
Reactions
R-CHOH-R' + NADP unknown R-CO-R' + NADPHdetails
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP unknown (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPHdetails
(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP unknown (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPHdetails
Prostaglandin F2a + NADP unknown Prostaglandin E2 + NADPH + Hydrogen Iondetails
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone + NADPH + Hydrogen Ion unknown 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol + NADPdetails
Gene Name:
DHRS4
Uniprot ID:
Q9BTZ2
Reactions
R-CHOH-R' + NADP unknown R-CO-R' + NADPHdetails
Gene Name:
CBR3
Uniprot ID:
O75828
Reactions
R-CHOH-R' + NADP unknown R-CO-R' + NADPHdetails
Prostaglandin F2a + NADP unknown Prostaglandin E2 + NADPH + Hydrogen Iondetails
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone + NADPH + Hydrogen Ion unknown 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol + NADPdetails
Gene Name:
AKR1B1
Uniprot ID:
P15121
Reactions
Glycerol + NADP unknown Glyceraldehyde + NADPH + Hydrogen Iondetails
Beta-D-Galactose + NADPH + Hydrogen Ion unknown Galactitol + NADPdetails
D-Xylitol + NADP unknown D-Xylose + NADPH + Hydrogen Iondetails
L-Arabitol + NADP unknown L-Arabinose + NADPH + Hydrogen Iondetails
Sorbitol + NADP unknown Alpha-D-Glucose + NADPH + Hydrogen Iondetails
Propylene glycol + NADP unknown Lactaldehyde + NADPH + Hydrogen Iondetails
Gene Name:
TXNRD1
Uniprot ID:
Q16881
Reactions
Thioredoxin + NADP unknown thioredoxin disulfide + NADPHdetails
Thioredoxin + NADP unknown Thioredoxin disulfide + NADPH + Hydrogen Iondetails
Hydrogen selenide + NADP + Water unknown Selenite + NADPH + Hydrogen Iondetails
NADPH + Hydrogen Ion + Methylselenic acid unknown NADP + Water + Methaneselenoldetails
Gene Name:
SC5DL
Uniprot ID:
O75845
Reactions
Lathosterol + NADPH + Hydrogen Ion + Oxygen unknown 7-Dehydrocholesterol + NADP + Waterdetails
Episterol + NADP unknown 5,7,24(28)-Ergostatrienol + NADPH + Hydrogen Iondetails
Gene Name:
FMO5
Uniprot ID:
P49326
Reactions
N,N-Dimethylaniline + NADPH + Oxygen unknown Dimethylaniline-N-oxide + NADP + Waterdetails
Trimethylamine + NADPH + Hydrogen Ion + Oxygen unknown Trimethylamine N-oxide + NADP + Waterdetails
Tamoxifen + Oxygen + NADPH + Hydrogen Ion unknown Tamoxifen N-oxide + NADP + Waterdetails
Gene Name:
SQLE
Uniprot ID:
Q14534
Reactions
Squalene + NADPH + Oxygen unknown (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP + Waterdetails
Squalene + Oxygen + NADPH + Hydrogen Ion unknown (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP + Waterdetails
Gene Name:
FMO2
Uniprot ID:
Q99518
Reactions
N,N-Dimethylaniline + NADPH + Oxygen unknown Dimethylaniline-N-oxide + NADP + Waterdetails
Trimethylamine + NADPH + Hydrogen Ion + Oxygen unknown Trimethylamine N-oxide + NADP + Waterdetails
Tamoxifen + Oxygen + NADPH + Hydrogen Ion unknown Tamoxifen N-oxide + NADP + Waterdetails
Gene Name:
ALDH4A1
Uniprot ID:
P30038
Reactions
1-Pyrroline-5-carboxylic acid + NADP + Water unknown L-Glutamic acid + NADPH + Hydrogen Iondetails
Pyrroline hydroxycarboxylic acid + NADP + Water unknown 4-Hydroxy-L-glutamic acid + NADPH + Hydrogen Iondetails
Gene Name:
TXNRD2
Uniprot ID:
Q9NNW7
Reactions
Thioredoxin + NADP unknown thioredoxin disulfide + NADPHdetails
Thioredoxin + NADP unknown Thioredoxin disulfide + NADPH + Hydrogen Iondetails
Hydrogen selenide + NADP + Water unknown Selenite + NADPH + Hydrogen Iondetails
NADPH + Hydrogen Ion + Methylselenic acid unknown NADP + Water + Methaneselenoldetails
Gene Name:
FMO4
Uniprot ID:
P31512
Reactions
N,N-Dimethylaniline + NADPH + Oxygen unknown Dimethylaniline-N-oxide + NADP + Waterdetails
Trimethylamine + NADPH + Hydrogen Ion + Oxygen unknown Trimethylamine N-oxide + NADP + Waterdetails
Tamoxifen + Oxygen + NADPH + Hydrogen Ion unknown Tamoxifen N-oxide + NADP + Waterdetails
Gene Name:
FMO3
Uniprot ID:
P31513
Reactions
N,N-Dimethylaniline + NADPH + Oxygen unknown Dimethylaniline-N-oxide + NADP + Waterdetails
Trimethylamine + NADPH + Oxygen unknown Trimethylamine N-oxide + NADP + Waterdetails
Trimethylamine + NADPH + Hydrogen Ion + Oxygen unknown Trimethylamine N-oxide + NADP + Waterdetails
Tamoxifen + Oxygen + NADPH + Hydrogen Ion unknown Tamoxifen N-oxide + NADP + Waterdetails
Gene Name:
POR
Uniprot ID:
P16435
Reactions
NADPH + n oxidized hemoprotein unknown NADP + n reduced hemoproteindetails
Gene Name:
FMO1
Uniprot ID:
Q01740
Reactions
N,N-Dimethylaniline + NADPH + Oxygen unknown Dimethylaniline-N-oxide + NADP + Waterdetails
Trimethylamine + NADPH + Hydrogen Ion + Oxygen unknown Trimethylamine N-oxide + NADP + Waterdetails
Tamoxifen + Oxygen + NADPH + Hydrogen Ion unknown Tamoxifen N-oxide + NADP + Waterdetails
Gene Name:
MTHFR
Uniprot ID:
P42898
Reactions
5-Methyltetrahydrofolic acid + NADP unknown 5,10-Methylene-THF + NADPH + Hydrogen Iondetails
Gene Name:
GSR
Uniprot ID:
P00390
Reactions
Glutathione + NADP unknown Oxidized glutathione + NADPHdetails
Glutathione + NADP unknown Oxidized glutathione + NADPH + Hydrogen Iondetails
Gene Name:
FDXR
Uniprot ID:
P22570
Reactions
reduced adrenodoxin + NADP unknown oxidized adrenodoxin + NADPHdetails
Reduced adrenal ferredoxin + NADP + Hydrogen Ion unknown Oxidized adrenal ferredoxin + NADPHdetails
Gene Name:
FDFT1
Uniprot ID:
P37268
Reactions
Presqualene diphosphate + NADPH + Hydrogen Ion unknown Pyrophosphate + Squalene + NADPdetails
Farnesyl pyrophosphate + NADPH + Hydrogen Ion unknown Squalene + Pyrophosphate + NADPdetails
Gene Name:
TM7SF2
Uniprot ID:
O76062
Reactions
4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol + NADP unknown 4,4-Dimethylcholesta-8,14,24-trienol + NADPHdetails
4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol + NADP unknown 4,4-Dimethylcholesta-8,14,24-trienol + NADPH + Hydrogen Iondetails
Delta 8,14 -Sterol + NADPH + Hydrogen Ion unknown 4a-Methylfecosterol + NADPdetails
Gene Name:
MSMO1
Uniprot ID:
Q15800
Reactions
4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol + NADPH + Hydrogen Ion + Oxygen unknown 4a-Carboxy-4b-methyl-5a-cholesta-8,24-dien-3b-ol + NADP + Waterdetails
4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol + NADPH + Hydrogen Ion + Oxygen unknown 3-beta-Hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NADP + Waterdetails
Gene Name:
NSDHL
Uniprot ID:
Q15738
Reactions
4a-Carboxy-4b-methyl-5a-cholesta-8,24-dien-3b-ol + NADP unknown 3-Keto-4-methylzymosterol + NADPH + Hydrogen Ion + Carbon dioxidedetails
Gene Name:
CYP51A1
Uniprot ID:
Q16850
Reactions
Obtusifoliol + Oxygen + NADPH unknown Delta 8,14 -Sterol + Formic acid + NADP + Waterdetails
Lanosterin + Oxygen + NADPH + Hydrogen Ion unknown 4,4-Dimethylcholesta-8,14,24-trienol + Formic acid + NADP + Waterdetails
Obtusifoliol + Oxygen + NADPH + Hydrogen Ion unknown Delta 8,14 -Sterol + Formic acid + NADP + Waterdetails
Gene Name:
ALDH9A1
Uniprot ID:
P49189
Reactions
4-Aminobutyraldehyde + NADP + Water unknown Gamma-Aminobutyric acid + NADPH + Hydrogen Iondetails
Gene Name:
ALDH3A1
Uniprot ID:
P30838
Reactions
Acetaldehyde + NADP + Water unknown Acetic acid + NADPH + Hydrogen Iondetails
Phenylacetaldehyde + NADP + Water unknown Phenylacetic acid + NADPH + Hydrogen Iondetails
4-Hydroxyphenylacetaldehyde + NADP + Water unknown p-Hydroxyphenylacetic acid + NADPH + Hydrogen Iondetails
3,4-Dihydroxyphenylacetaldehyde + NADP + Water unknown 3,4-Dihydroxybenzeneacetic acid + NADPH + Hydrogen Iondetails
3,4-Dihydroxymandelaldehyde + NADP + Water unknown 3,4-Dihydroxymandelic acid + NADPH + Hydrogen Iondetails
Homovanillin + NADP + Water unknown Homovanillic acid + NADPH + Hydrogen Iondetails
3-Methoxy-4-hydroxyphenylglycolaldehyde + NADP + Water unknown Vanillylmandelic acid + NADPH + Hydrogen Iondetails
Aldophosphamide + NADP + Water unknown Carboxyphosphamide + NADPH + Hydrogen Iondetails
Gene Name:
ALDH7A1
Uniprot ID:
P49419
Reactions
4-Aminobutyraldehyde + NADP + Water unknown Gamma-Aminobutyric acid + NADPH + Hydrogen Iondetails
Betaine aldehyde + NADP + Water unknown Trimethylammonioacetate + NADPH + Hydrogen Iondetails
(S)-2-amino-6-oxohexanoate + NADP + Water unknown Aminoadipic acid + NADPH + Hydrogen Iondetails
alpha-Aminoadipoyl-S-acyl enzyme + NADPH + Hydrogen Ion unknown (S)-2-amino-6-oxohexanoate + Holo-Lys2 + NADPdetails
Gene Name:
ALDH1A3
Uniprot ID:
P47895
Reactions
Acetaldehyde + NADP + Water unknown Acetic acid + NADPH + Hydrogen Iondetails
Phenylacetaldehyde + NADP + Water unknown Phenylacetic acid + NADPH + Hydrogen Iondetails
4-Hydroxyphenylacetaldehyde + NADP + Water unknown p-Hydroxyphenylacetic acid + NADPH + Hydrogen Iondetails
3,4-Dihydroxyphenylacetaldehyde + NADP + Water unknown 3,4-Dihydroxybenzeneacetic acid + NADPH + Hydrogen Iondetails
3,4-Dihydroxymandelaldehyde + NADP + Water unknown 3,4-Dihydroxymandelic acid + NADPH + Hydrogen Iondetails
Homovanillin + NADP + Water unknown Homovanillic acid + NADPH + Hydrogen Iondetails
3-Methoxy-4-hydroxyphenylglycolaldehyde + NADP + Water unknown Vanillylmandelic acid + NADPH + Hydrogen Iondetails
Aldophosphamide + NADP + Water unknown Carboxyphosphamide + NADPH + Hydrogen Iondetails
Gene Name:
ALDH2
Uniprot ID:
P05091
Reactions
2,5-Dioxopentanoate + NADP + Water unknown Oxoglutaric acid + NADPH + Hydrogen Iondetails
Acetaldehyde + NADP + Water unknown Acetic acid + NADPH + Hydrogen Iondetails
4-Aminobutyraldehyde + NADP + Water unknown Gamma-Aminobutyric acid + NADPH + Hydrogen Iondetails
Gene Name:
ALDH3A2
Uniprot ID:
P51648
Reactions
2,5-Dioxopentanoate + NADP + Water unknown Oxoglutaric acid + NADPH + Hydrogen Iondetails
Acetaldehyde + NADP + Water unknown Acetic acid + NADPH + Hydrogen Iondetails
4-Aminobutyraldehyde + NADP + Water unknown Gamma-Aminobutyric acid + NADPH + Hydrogen Iondetails
Gene Name:
ALDH1B1
Uniprot ID:
P30837
Reactions
2,5-Dioxopentanoate + NADP + Water unknown Oxoglutaric acid + NADPH + Hydrogen Iondetails
Acetaldehyde + NADP + Water unknown Acetic acid + NADPH + Hydrogen Iondetails
4-Aminobutyraldehyde + NADP + Water unknown Gamma-Aminobutyric acid + NADPH + Hydrogen Iondetails
Gene Name:
PYCR1
Uniprot ID:
P32322
Reactions
L-Proline + NADP unknown 1-Pyrroline-5-carboxylic acid + NADPH + Hydrogen Iondetails
4-Hydroxyproline + NADP unknown Pyrroline hydroxycarboxylic acid + NADPH + Hydrogen Iondetails
Gene Name:
PYCR2
Uniprot ID:
Q96C36
Reactions
L-Proline + NADP unknown 1-Pyrroline-5-carboxylic acid + NADPH + Hydrogen Iondetails
4-Hydroxyproline + NADP unknown Pyrroline hydroxycarboxylic acid + NADPH + Hydrogen Iondetails
Gene Name:
DCXR
Uniprot ID:
Q7Z4W1
Reactions
D-Xylitol + NADP unknown L-Threo-2-pentulose + NADPHdetails
D-Xylitol + NADP unknown L-Threo-2-pentulose + NADPH + Hydrogen Iondetails
Gene Name:
G6PD
Uniprot ID:
P11413
Reactions
Glucose 6-phosphate + NADP unknown 6-phospho-D-glucono-1,5-lactone + NADPHdetails
Beta-D-Glucose 6-phosphate + NADP unknown 6-Phosphonoglucono-D-lactone + NADPH + Hydrogen Iondetails
Gene Name:
H6PD
Uniprot ID:
O95479
Reactions
Beta-D-Glucose 6-phosphate + NADP unknown 6-Phosphonoglucono-D-lactone + NADPH + Hydrogen Iondetails
Gene Name:
AKR1C3
Uniprot ID:
P42330
Reactions
trans-1,2-Dihydrobenzene-1,2-diol + NADP unknown Pyrocatechol + NADPHdetails
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP unknown (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPHdetails
Testosterone + NADP unknown Androstenedione + NADPHdetails
5alpha-Dihydrodeoxycorticosterone + NADPH + Hydrogen Ion unknown Tetrahydrodeoxycorticosterone + NADPdetails
5a-Pregnane-3,20-dione + NADPH + Hydrogen Ion unknown Allopregnanolone + NADPdetails
5alpha-Pregnan-20alpha-ol-3-one + NADPH + Hydrogen Ion unknown 5alpha-Pregnane-3alpha,20alpha-diol + NADPdetails
Gene Name:
GMDS
Uniprot ID:
O60547
Gene Name:
AKR1C1
Uniprot ID:
Q04828
Reactions
trans-1,2-Dihydrobenzene-1,2-diol + NADP unknown Pyrocatechol + NADPHdetails
5alpha-Dihydrodeoxycorticosterone + NADPH + Hydrogen Ion unknown Tetrahydrodeoxycorticosterone + NADPdetails
5a-Pregnane-3,20-dione + NADPH + Hydrogen Ion unknown Allopregnanolone + NADPdetails
5alpha-Pregnan-20alpha-ol-3-one + NADPH + Hydrogen Ion unknown 5alpha-Pregnane-3alpha,20alpha-diol + NADPdetails
Gene Name:
AKR1C2
Uniprot ID:
P52895
Reactions
trans-1,2-Dihydrobenzene-1,2-diol + NADP unknown Pyrocatechol + NADPHdetails
5alpha-Dihydrodeoxycorticosterone + NADPH + Hydrogen Ion unknown Tetrahydrodeoxycorticosterone + NADPdetails
5a-Pregnane-3,20-dione + NADPH + Hydrogen Ion unknown Allopregnanolone + NADPdetails
5alpha-Pregnan-20alpha-ol-3-one + NADPH + Hydrogen Ion unknown 5alpha-Pregnane-3alpha,20alpha-diol + NADPdetails
Gene Name:
GRHPR
Uniprot ID:
Q9UBQ7
Reactions
Glycolic acid + NADP unknown Glyoxylic acid + NADPHdetails
Glycolic acid + NADP unknown Glyoxylic acid + NADPH + Hydrogen Iondetails
Glyceric acid + NADP unknown Hydroxypyruvic acid + NADPH + Hydrogen Iondetails
Gene Name:
CYP4A11
Uniprot ID:
Q02928
Reactions
Arachidonic acid + Oxygen + NADPH + Hydrogen Ion unknown 20-Hydroxyeicosatetraenoic acid + NADP + Waterdetails
Arachidonic acid + Oxygen + NADPH + Hydrogen Ion unknown 11,12-EpETrE + NADP + Waterdetails
All-trans-retinoic acid + NADPH + Hydrogen Ion + Oxygen unknown all-trans-18-Hydroxyretinoic acid + NADP + Waterdetails
Gene Name:
MTRR
Uniprot ID:
Q9UBK8
Reactions
[methionine synthase]-methylcob(I)alamin + S-Adenosylhomocysteine + NADP unknown [methionine synthase]-cob(II)alamin + NADPH + S-Adenosylmethioninedetails
Gene Name:
SPR
Uniprot ID:
P35270
Reactions
Dihydrobiopterin + NADP unknown Sepiapterin + NADPHdetails
L-erythro-tetrahydrobiopterin + NADP unknown Dyspropterin + NADPHdetails
L-erythro-tetrahydrobiopterin + NADP unknown 6-Lactoyltetrahydropterin + NADPH + Hydrogen Iondetails
6-Lactoyltetrahydropterin + NADP unknown Dyspropterin + NADPH + Hydrogen Iondetails
Gene Name:
HSD17B2
Uniprot ID:
P37059
Reactions
Estradiol + NADP unknown Estrone + NADPH + Hydrogen Iondetails
Estriol + NADP unknown 16b-Hydroxyestrone + NADPH + Hydrogen Iondetails
11beta,17beta-Dihydroxy-4-androsten-3-one + NADP unknown 11b-Hydroxyandrost-4-ene-3,17-dione + NADPH + Hydrogen Iondetails
Gene Name:
HSD17B8
Uniprot ID:
Q92506
Reactions
Estradiol + NADP unknown Estrone + NADPH + Hydrogen Iondetails
Estriol + NADP unknown 16b-Hydroxyestrone + NADPH + Hydrogen Iondetails
11beta,17beta-Dihydroxy-4-androsten-3-one + NADP unknown 11b-Hydroxyandrost-4-ene-3,17-dione + NADPH + Hydrogen Iondetails
Gene Name:
DHDH
Uniprot ID:
Q9UQ10
Reactions
trans-1,2-Dihydrobenzene-1,2-diol + NADP unknown Pyrocatechol + NADPHdetails
D-Xylose + NADP unknown D-Xylono-1,5-lactone + NADPHdetails
D-Xylose + NADP unknown D-Xylono-1,5-lactone + NADPH + Hydrogen Iondetails
1,2-Dihydronaphthalene-1,2-diol + NADP unknown Naphthalene-1,2-diol + NADPH + Hydrogen Iondetails
Gene Name:
RDH5
Uniprot ID:
Q92781

Only showing the first 50 proteins. There are 207 proteins in total.