Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2013-05-29 19:25:16 UTC
HMDB IDHMDB00254
Secondary Accession NumbersNone
Metabolite Identification
Common NameSuccinic acid
DescriptionSuccinic acid is a dicarboxylic acid. The anion, succinate, is a component of the citric acid cycle capable of donating electrons to the electron transfer chain. Succinate dehydrogenase (SDH) plays an important role in the mitochondria, being both part of the respiratory chain and the Krebs cycle. SDH with a covalently attached FAD prosthetic group, binds enzyme substrates (succinate and fumarate) and physiological regulators (oxaloacetate and ATP). Oxidizing succinate links SDH to the fast-cycling Krebs cycle portion where it participates in the breakdown of acetyl-CoA throughout the whole Krebs cycle. The succinate can readily be imported into the mitochondrial matrix by the n-butylmalonate- (or phenylsuccinate-) sensitive dicarboxylate carrier in exchange with inorganic phosphate or another organic acid, e. g. malate. (PMID 16143825 ) Mutations in the four genes encoding the subunits of the mitochondrial respiratory chain succinate dehydrogenase are associated with a wide spectrum of clinical presentations (i.e.: Huntington's disease. (PMID 11803021 ).
Structure
Thumb
Synonyms
  1. 1,2-Ethanedicarboxylate
  2. 1,2-Ethanedicarboxylic acid
  3. 1,4-Butanedioate
  4. 1,4-Butanedioic acid
  5. Amber acid
  6. Asuccin
  7. Dihydrofumarate
  8. Dihydrofumaric acid
  9. Katasuccin
  10. Succinate
  11. Wormwood acid
Chemical FormulaC4H6O4
Average Molecular Weight118.088
Monoisotopic Molecular Weight118.02660868
IUPAC Namebutanedioic acid
Traditional IUPAC Namesuccinic acid
CAS Registry Number110-15-6
SMILES
OC(=O)CCC(O)=O
InChI Identifier
InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
InChI KeyKDYFGRWQOYBRFD-UHFFFAOYSA-N
Chemical Taxonomy
KingdomOrganic Compounds
Super ClassOrganic Acids and Derivatives
ClassCarboxylic Acids and Derivatives
Sub ClassDicarboxylic Acids and Derivatives
Other Descriptors
  • Aliphatic Acyclic Compounds
  • Dicarboxylic acids(Lipidmaps)
  • Fatty Acids and Conjugates
  • alpha,omega-dicarboxylic acid(ChEBI)
Substituents
  • Carboxylic Acid
Direct ParentDicarboxylic Acids and Derivatives
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
  • Microbial
Biofunction
  • Component of Arginine and proline metabolism
  • Component of Butanoate metabolism
  • Component of C5-Branched dibasic acid metabolism
  • Component of Glutamate metabolism
  • Component of Propanoate metabolism
  • DNA component
ApplicationNot Available
Cellular locations
  • Extracellular
  • Mitochondria
  • Endoplasmic reticulum
  • Peroxisome
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point185 - 188 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility83.2 mg/mLNot Available
LogP-0.59HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
water solubility211 g/LALOGPS
logP-0.53ALOGPS
logP-0.4ChemAxon
logS0.25ALOGPS
pKa (strongest acidic)3.55ChemAxon
physiological charge-2ChemAxon
hydrogen acceptor count4ChemAxon
hydrogen donor count2ChemAxon
polar surface area74.6ChemAxon
rotatable bond count3ChemAxon
refractivity23.54ChemAxon
polarizability10.16ChemAxon
Spectra
Spectra
Biological Properties
Cellular Locations
  • Extracellular
  • Mitochondria
  • Endoplasmic reticulum
  • Peroxisome
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue Location
  • Adipose Tissue
  • Brain
  • Fibroblasts
  • Kidney
  • Liver
  • Muscle
  • Pancreas
  • Placenta
  • Prostate
  • Skeletal Muscle
  • Spleen
Pathways
NameSMPDB LinkKEGG Link
Carnitine SynthesisSMP00465Not Available
Citric Acid CycleSMP00057map00020
Glutamate MetabolismSMP00072map00250
Mitochondrial Electron Transport ChainSMP00355map00190
Phytanic Acid Peroxisomal OxidationSMP00450Not Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodDetected and Quantified16.0 (0.00-32.0) uMAdult (>18 years old)BothNormal
BloodDetected and Quantified23.5 uMAdult (>18 years old)Not SpecifiedNormal
BloodDetected and Quantified8.8 +/- 2.7 uMAdult (>18 years old)BothNormal
  • Geigy Scient...
Cerebrospinal Fluid (CSF)Detected and Quantified47.2 uMAdult (>18 years old)BothNormal
Cerebrospinal Fluid (CSF)Detected and Quantified19 uMAdult (>18 years old)BothNormal
Cerebrospinal Fluid (CSF)Detected and Quantified150.0 +/- 110.0 uMElderly (>65 years old)BothNormal
Cerebrospinal Fluid (CSF)Detected and Quantified3 +/- 2 uMNot SpecifiedBothNormal
Cerebrospinal Fluid (CSF)Detected and Quantified28.5 (24-33) uMAdult (>18 years old)BothNormal
  • Geigy Scient...
Cerebrospinal Fluid (CSF)Detected and Quantified3.0 +/- 2.0 uMAdult (>18 years old)BothNormal
SalivaDetected and Quantified2260 (60.0-4460) uMAdult (>18 years old)BothNormal
SalivaDetected and Quantified4-145 uMAdult (>18 years old)MaleCommentnormal
SalivaDetected and Quantified1-33 uMAdult (>18 years old)MaleCommentnormal
UrineDetected but not QuantifiedNot ApplicableAdult (>18 years old)MaleNormal
UrineDetected and Quantified4.7 (1.1-14.5) umol/mmol creatinineAdult (>18 years old)BothCommentNormal
UrineDetected and Quantified12.60 +/- 12.13 umol/mmol creatinineInfant (0-1 year old)BothNormal
UrineDetected and Quantified14.48 +/- 3.20 umol/mmol creatinineChildren (1-13 year old)BothNormal
UrineDetected but not QuantifiedNot ApplicableAdult (>18 years old)BothCommentNormal
UrineDetected and Quantified7.7 (1.9-20.0) umol/mmol creatinineAdolescent (13-18 years old)BothNormal
UrineDetected and Quantified3.8 (1.25-6.7) umol/mmol creatinineAdult (>18 years old)BothNormal
  • Geigy Scient...
UrineDetected but not QuantifiedNot ApplicableAdult (>18 years old)BothNormal
UrineDetected and Quantified2.10 umol/mmol creatinineAdult (>18 years old)BothNormal
  • Shaykhutdino...
UrineDetected and Quantified9.9 +/- 5.0 umol/mmol creatinineAdult (>18 years old)MaleNormal
UrineDetected and Quantified14.4 +/- 4.9 umol/mmol creatinineAdult (>18 years old)FemaleNormal
UrineDetected and Quantified7.5 (0.5-16) umol/mmol creatinineAdult (>18 years old)BothNormal
UrineDetected and Quantified6.0 (0.3-33.3) umol/mmol creatinineAdult (>18 years old)BothCommentNormal
UrineDetected but not QuantifiedNot ApplicableAdult (>18 years old)MaleCommentNormal
UrineDetected but not QuantifiedNot ApplicableAdult (>18 years old)MaleCommentNormal
UrineDetected and Quantified5.6 +/- 3.8 umol/mmol creatinineAdult (>18 years old)BothNormal
UrineDetected and Quantified197.2 (29.4-486.2) umol/mmol creatinineNewborn (0-30 days old)BothNormal
UrineDetected and Quantified185.4 (6.0-342.6) umol/mmol creatinineInfant (0-1 year old)BothNormal
UrineDetected and Quantified11.6 (4.0-27.3) umol/mmol creatinineChildren (1-13 year old)BothNormal
UrineDetected and Quantified8.25 (0.5-16.0) umol/mmol creatinineAdult (>18 years old)BothNormal
UrineDetected and Quantified1.3 umol/mmol creatinineAdult (>18 years old)BothNormal
UrineDetected and Quantified6.2 (2.5-13.5) umol/mmol creatinineAdult (>18 years old)BothCommentNormal
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReference
Cerebrospinal Fluid (CSF)Detected and Quantified19.0 (0.0-38.0) uMAdult (>18 years old)BothCanavan Disease
Cerebrospinal Fluid (CSF)Detected and Quantified55.0 (19.0-91.0) uMAdult (>18 years old)BothAlzheimer's disease
UrineDetected and Quantified43.35 +/- 25.08 umol/mmol creatinineChildren (1-13 year old)BothSeverely malnourished children
UrineDetected and Quantified9.0 +/- 6.0 umol/mmol creatinineAdult (>18 years old)BothLung cancer
Associated Disorders and Diseases
Disease References
Alzheimer's disease
  • Redjems-Bennani N, Jeandel C, Lefebvre E, Blain H, Vidailhet M, Gueant JL: Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients. Gerontology. 1998;44(5):300-4. Pubmed: 9693263
Canavan disease
  • Wevers RA, Engelke U, Wendel U, de Jong JG, Gabreels FJ, Heerschap A: Standardized method for high-resolution 1H-NMR of cerebrospinal fluid. Clin Chem. 1995 May;41(5):744-51. Pubmed: 7729054
Lung Cancer
  • Wishart DS, Knox C, Guo AC, Eisner R, Young N, Gautam B, Hau DD, Psychogios N, Dong E, Bouatra S, Mandal R, Sinelnikov I, Xia J, Jia L, Cruz JA, Lim E, Sobsey CA, Shrivastava S, Huang P, Liu P, Fang L, Peng J, Fradette R, Cheng D, Tzur D, Clements M, Lewis A, De Souza A, Zuniga A, Dawe M, Xiong Y, Clive D, Greiner R, Nazyrova A, Shaykhutdinov R, Li L, Vogel HJ, Forsythe I: HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2008 Oct 25. Pubmed: 18953024
Associated OMIM IDs
DrugBank IDDB00139
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB001931
KNApSAcK IDC00001205
Chemspider ID1078
KEGG Compound IDC00042
BioCyc IDSUC
BiGG ID33633
Wikipedia LinkSuccinic acid
NuGOwiki LinkHMDB00254
Metagene LinkHMDB00254
METLIN ID114
PubChem Compound1110
PDB IDSIN
ChEBI ID15741
References
Synthesis ReferenceBerglund, Kris Arvid; Andersson, Christian; Rova, Ulrika. Process for the production of succinic acid. PCT Int. Appl. (2007), 30pp.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411
  2. Guneral F, Bachmann C: Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. Clin Chem. 1994 Jun;40(6):862-6. Pubmed: 8087979
  3. Hoffmann GF, Meier-Augenstein W, Stockler S, Surtees R, Rating D, Nyhan WL: Physiology and pathophysiology of organic acids in cerebrospinal fluid. J Inherit Metab Dis. 1993;16(4):648-69. Pubmed: 8412012
  4. Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7. Pubmed: 12097436
  5. Redjems-Bennani N, Jeandel C, Lefebvre E, Blain H, Vidailhet M, Gueant JL: Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients. Gerontology. 1998;44(5):300-4. Pubmed: 9693263
  6. Wevers RA, Engelke U, Wendel U, de Jong JG, Gabreels FJ, Heerschap A: Standardized method for high-resolution 1H-NMR of cerebrospinal fluid. Clin Chem. 1995 May;41(5):744-51. Pubmed: 7729054
  7. Magera MJ, Helgeson JK, Matern D, Rinaldo P: Methylmalonic acid measured in plasma and urine by stable-isotope dilution and electrospray tandem mass spectrometry. Clin Chem. 2000 Nov;46(11):1804-10. Pubmed: 11067816
  8. Zhang TM, Sener A, Malaisse WJ: Hydrolysis of succinic acid dimethyl ester in rat pancreatic islets. Biochem Mol Med. 1995 Aug;55(2):131-7. Pubmed: 7582870
  9. Groenen PM, Engelke UF, Wevers RA, Hendriks JC, Eskes TK, Merkus HM, Steegers-Theunissen RP: High-resolution 1H NMR spectroscopy of amniotic fluids from spina bifida fetuses and controls. Eur J Obstet Gynecol Reprod Biol. 2004 Jan 15;112(1):16-23. Pubmed: 14687733
  10. Meijer-Severs GJ, van Santen E: Short-chain fatty acids and succinate in feces of healthy human volunteers and their correlation with anaerobe cultural counts. Scand J Gastroenterol. 1987 Aug;22(6):672-6. Pubmed: 3659829
  11. Ren LC, Huang XY, Long JH: [Effects of succinic acid on the function of in vitro cultured human fibroblasts] Zhonghua Shao Shang Za Zhi. 2004 Feb;20(1):34-6. Pubmed: 15059451
  12. Wevers RA, Engelke U, Heerschap A: High-resolution 1H-NMR spectroscopy of blood plasma for metabolic studies. Clin Chem. 1994 Jul;40(7 Pt 1):1245-50. Pubmed: 8013094
  13. Borenstein DG, Gibbs CA, Jacobs RP: Gas-liquid chromatographic analysis of synovial fluid: volatile short-chain fatty acids in septic arthritis. Ann Rheum Dis. 1983 Aug;42(4):362-7. Pubmed: 6882030
  14. Frenkel G, Peterson RN, Freund M: Oxidative and glycolytic metabolism of semen components by washed guinea pig spermatozoa. Fertil Steril. 1975 Feb;26(2):144-7. Pubmed: 1126459
  15. Briere JJ, Favier J, El Ghouzzi V, Djouadi F, Benit P, Gimenez AP, Rustin P: Succinate dehydrogenase deficiency in human. Cell Mol Life Sci. 2005 Oct;62(19-20):2317-24. Pubmed: 16143825
  16. Rustin P, Rotig A: Inborn errors of complex II--unusual human mitochondrial diseases. Biochim Biophys Acta. 2002 Jan 17;1553(1-2):117-22. Pubmed: 11803021

Enzymes

Gene Name:
SDHC
Uniprot ID:
Q99643
Reactions
Ubiquinone-2 + Succinic acid unknown QH2 + Fumaric aciddetails
Gene Name:
SDHA
Uniprot ID:
P31040
Reactions
Succinic acid + Coenzyme Q10 unknown Fumaric acid + QH(2)details
Ubiquinone-2 + Succinic acid unknown QH2 + Fumaric aciddetails
Gene Name:
SDHD
Uniprot ID:
O14521
Reactions
Ubiquinone-2 + Succinic acid unknown QH2 + Fumaric aciddetails
Gene Name:
SDHB
Uniprot ID:
P21912
Reactions
Succinic acid + Coenzyme Q10 unknown Fumaric acid + QH(2)details
Ubiquinone-2 + Succinic acid unknown QH2 + Fumaric aciddetails
Gene Name:
ALDH5A1
Uniprot ID:
P51649
Reactions
Succinic acid semialdehyde + NAD + Water unknown Succinic acid + NADHdetails
Succinic acid semialdehyde + NAD + Water unknown Succinic acid + NADH + Hydrogen Iondetails
Gene Name:
PHYH
Uniprot ID:
O14832
Reactions
Phytanoyl-CoA + Oxoglutaric acid + Oxygen unknown 2-Hydroxyphytanoyl-CoA + Succinic acid + CO(2)details
Gene Name:
P4HA2
Uniprot ID:
O15460
Reactions
L-proline-[procollagen] + Oxoglutaric acid + Oxygen unknown trans-4-hydroxy-L-proline-[procollagen] + Succinic acid + CO(2)details
L-Proline + Oxoglutaric acid + Oxygen unknown 4-Hydroxyproline + Succinic acid + Carbon dioxidedetails
Gene Name:
P4HA1
Uniprot ID:
P13674
Reactions
L-proline-[procollagen] + Oxoglutaric acid + Oxygen unknown trans-4-hydroxy-L-proline-[procollagen] + Succinic acid + CO(2)details
L-Proline + Oxoglutaric acid + Oxygen unknown 4-Hydroxyproline + Succinic acid + Carbon dioxidedetails
Gene Name:
BBOX1
Uniprot ID:
O75936
Reactions
4-Trimethylammoniobutanoic acid + Oxoglutaric acid + Oxygen unknown L-Carnitine + Succinic acid + CO(2)details
4-Trimethylammoniobutanoic acid + Oxoglutaric acid + Oxygen unknown L-Carnitine + Succinic acid + Carbon dioxidedetails
Gene Name:
PLOD1
Uniprot ID:
Q02809
Reactions
L-lysine-[procollagen] + Oxoglutaric acid + Oxygen unknown (2S,5R)-5-hydroxy-L-lysine-[procollagen] + Succinic acid + CO(2)details
Protein lysine + Oxoglutaric acid + Oxygen unknown Procollagen 5-hydroxy-L-lysine + Succinic acid + Carbon dioxide + Waterdetails
Gene Name:
PLOD2
Uniprot ID:
O00469
Reactions
L-lysine-[procollagen] + Oxoglutaric acid + Oxygen unknown (2S,5R)-5-hydroxy-L-lysine-[procollagen] + Succinic acid + CO(2)details
Protein lysine + Oxoglutaric acid + Oxygen unknown Procollagen 5-hydroxy-L-lysine + Succinic acid + Carbon dioxide + Waterdetails
Gene Name:
PLOD3
Uniprot ID:
O60568
Reactions
L-lysine-[procollagen] + Oxoglutaric acid + Oxygen unknown (2S,5R)-5-hydroxy-L-lysine-[procollagen] + Succinic acid + CO(2)details
Protein lysine + Oxoglutaric acid + Oxygen unknown Procollagen 5-hydroxy-L-lysine + Succinic acid + Carbon dioxide + Waterdetails
Gene Name:
OXCT1
Uniprot ID:
P55809
Reactions
Succinyl-CoA + a 3-oxo acid unknown Succinic acid + a 3-oxoacyl-CoAdetails
Succinyl-CoA + Acetoacetic acid unknown Succinic acid + Acetoacetyl-CoAdetails
Gene Name:
OXCT2
Uniprot ID:
Q9BYC2
Reactions
Succinyl-CoA + a 3-oxo acid unknown Succinic acid + a 3-oxoacyl-CoAdetails
Succinyl-CoA + Acetoacetic acid unknown Succinic acid + Acetoacetyl-CoAdetails
Gene Name:
SUCLG1
Uniprot ID:
P53597
Reactions
Guanosine triphosphate + Succinic acid + Coenzyme A unknown Guanosine diphosphate + Phosphoric acid + Succinyl-CoAdetails
Adenosine triphosphate + Succinic acid + Coenzyme A unknown ADP + Phosphoric acid + Succinyl-CoAdetails
Inosine triphosphate + Succinic acid + Coenzyme A unknown IDP + Phosphoric acid + Succinyl-CoAdetails
Gene Name:
SUCLG2
Uniprot ID:
Q96I99
Reactions
Guanosine triphosphate + Succinic acid + Coenzyme A unknown Guanosine diphosphate + Phosphoric acid + Succinyl-CoAdetails
Inosine triphosphate + Succinic acid + Coenzyme A unknown IDP + Phosphoric acid + Succinyl-CoAdetails
Gene Name:
SUCLA2
Uniprot ID:
Q9P2R7
Reactions
Adenosine triphosphate + Succinic acid + Coenzyme A unknown ADP + Phosphoric acid + Succinyl-CoAdetails
Guanosine triphosphate + Succinic acid + Coenzyme A unknown Guanosine diphosphate + Phosphoric acid + Succinyl-CoAdetails
Inosine triphosphate + Succinic acid + Coenzyme A unknown IDP + Phosphoric acid + Succinyl-CoAdetails
Gene Name:
ASPH
Uniprot ID:
Q12797
Reactions
Peptide L-aspartate + Oxoglutaric acid + Oxygen unknown peptide 3-hydroxy-L-aspartate + Succinic acid + CO(2)details
Gene Name:
HIF1AN
Uniprot ID:
Q9NWT6
Reactions
Hypoxia-inducible factor-L-asparagine + Oxoglutaric acid + Oxygen unknown hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + Succinic acid + CO(2)details
Ankyrin-repeat-L-histidine + Oxoglutaric acid + Oxygen unknown ankyrin-repeat-(3S)-3-hydroxy-L-histidine + Succinic acid + CO(2)details
Gene Name:
SLC25A10
Uniprot ID:
Q9UBX3
Gene Name:
SLC13A3
Uniprot ID:
Q8WWT9
Gene Name:
SLC13A1
Uniprot ID:
Q9BZW2
Gene Name:
SLC13A2
Uniprot ID:
Q13183
Gene Name:
TMLHE
Uniprot ID:
Q9NVH6
Reactions
N6,N6,N6-Trimethyl-L-lysine + Oxoglutaric acid + Oxygen unknown 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + Succinic acid + CO(2)details
N6,N6,N6-Trimethyl-L-lysine + Oxoglutaric acid + Oxygen unknown 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine + Succinic acid + Carbon dioxidedetails
Gene Name:
ALKBH2
Uniprot ID:
Q6NS38
Reactions
DNA-base-CH(3) + Oxoglutaric acid + Oxygen unknown DNA-base + Formaldehyde + Succinic acid + CO(2)details
Gene Name:
LEPRE1
Uniprot ID:
Q32P28
Reactions
L-proline-[procollagen] + Oxoglutaric acid + Oxygen unknown trans-3-hydroxy-L-proline-[procollagen] + Succinic acid + CO(2)details
Gene Name:
LEPREL1
Uniprot ID:
Q8IVL5
Reactions
L-proline-[procollagen] + Oxoglutaric acid + Oxygen unknown trans-3-hydroxy-L-proline-[procollagen] + Succinic acid + CO(2)details
Gene Name:
LEPREL2
Uniprot ID:
Q8IVL6
Reactions
L-proline-[procollagen] + Oxoglutaric acid + Oxygen unknown trans-3-hydroxy-L-proline-[procollagen] + Succinic acid + CO(2)details
Gene Name:
P4HA3
Uniprot ID:
Q7Z4N8
Reactions
L-proline-[procollagen] + Oxoglutaric acid + Oxygen unknown trans-4-hydroxy-L-proline-[procollagen] + Succinic acid + CO(2)details
L-Proline + Oxoglutaric acid + Oxygen unknown 4-Hydroxyproline + Succinic acid + Carbon dioxidedetails
Gene Name:
KDM2A
Uniprot ID:
Q9Y2K7
Reactions
Protein N(6),N(6)-dimethyl-L-lysine + Oxoglutaric acid + Oxygen unknown protein N(6)-methyl-L-lysine + Succinic acid + Formaldehyde + CO(2)details
Protein N(6)-methyl-L-lysine + Oxoglutaric acid + Oxygen unknown protein L-lysine + Succinic acid + Formaldehyde + CO(2)details
Protein N6,N6-dimethyl-L-lysine + Oxoglutaric acid + Oxygen unknown Protein lysine + Succinic acid + Formaldehyde + Carbon dioxidedetails
Gene Name:
KDM2B
Uniprot ID:
Q8NHM5
Reactions
Protein N(6),N(6)-dimethyl-L-lysine + Oxoglutaric acid + Oxygen unknown protein N(6)-methyl-L-lysine + Succinic acid + Formaldehyde + CO(2)details
Protein N(6)-methyl-L-lysine + Oxoglutaric acid + Oxygen unknown protein L-lysine + Succinic acid + Formaldehyde + CO(2)details
Protein N6,N6-dimethyl-L-lysine + Oxoglutaric acid + Oxygen unknown Protein lysine + Succinic acid + Formaldehyde + Carbon dioxidedetails
Gene Name:
EGLN1
Uniprot ID:
Q9GZT9
Reactions
Hypoxia-inducible factor-L-proline + Oxoglutaric acid + Oxygen unknown hypoxia-inducible factor-trans-4-hydroxy-L-proline + Succinic acid + CO(2)details
Gene Name:
EGLN2
Uniprot ID:
Q96KS0
Reactions
Hypoxia-inducible factor-L-proline + Oxoglutaric acid + Oxygen unknown hypoxia-inducible factor-trans-4-hydroxy-L-proline + Succinic acid + CO(2)details
Gene Name:
EGLN3
Uniprot ID:
Q9H6Z9
Reactions
Hypoxia-inducible factor-L-proline + Oxoglutaric acid + Oxygen unknown hypoxia-inducible factor-trans-4-hydroxy-L-proline + Succinic acid + CO(2)details
Gene Name:
P4HTM
Uniprot ID:
Q9NXG6
Reactions
An HIF alpha chain L-proline + Oxoglutaric acid + Oxygen unknown An HIF alpha chain trans-4-hydroxy-L-proline + Succinic acid + CO(2)details
Gene Name:
ALKBH1
Uniprot ID:
Q13686
Reactions
DNA-base-CH(3) + Oxoglutaric acid + Oxygen unknown DNA-base + Formaldehyde + Succinic acid + CO(2)details
Gene Name:
KDM8
Uniprot ID:
Q8N371
Reactions
Protein N(6),N(6)-dimethyl-L-lysine + Oxoglutaric acid + Oxygen unknown protein N(6)-methyl-L-lysine + Succinic acid + Formaldehyde + CO(2)details
Protein N(6)-methyl-L-lysine + Oxoglutaric acid + Oxygen unknown protein L-lysine + Succinic acid + Formaldehyde + CO(2)details
Gene Name:
MINA
Uniprot ID:
Q8IUF8
Reactions
L-histidine-[60S ribosomal protein L27a] + Oxoglutaric acid + Oxygen unknown (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L27a] + Succinic acid + CO(2)details
Gene Name:
NO66
Uniprot ID:
Q9H6W3
Reactions
Protein N(6),N(6)-dimethyl-L-lysine + Oxoglutaric acid + Oxygen unknown protein N(6)-methyl-L-lysine + Succinic acid + Formaldehyde + CO(2)details
Protein N(6)-methyl-L-lysine + Oxoglutaric acid + Oxygen unknown protein L-lysine + Succinic acid + Formaldehyde + CO(2)details
L-histidine-[60S ribosomal protein L8] + Oxoglutaric acid + Oxygen unknown (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L8] + Succinic acid + CO(2)details
Gene Name:
PHF8
Uniprot ID:
Q9UPP1
Reactions
Protein N(6),N(6)-dimethyl-L-lysine + Oxoglutaric acid + Oxygen unknown protein N(6)-methyl-L-lysine + Succinic acid + Formaldehyde + CO(2)details
Protein N(6)-methyl-L-lysine + Oxoglutaric acid + Oxygen unknown protein L-lysine + Succinic acid + Formaldehyde + CO(2)details
Gene Name:
TET1
Uniprot ID:
Q8NFU7
Reactions
DNA 5-methylcytosine + Oxoglutaric acid + Oxygen unknown DNA 5-hydroxymethylcytosine + Succinic acid + CO(2)details
Gene Name:
TET2
Uniprot ID:
Q6N021
Reactions
DNA 5-methylcytosine + Oxoglutaric acid + Oxygen unknown DNA 5-hydroxymethylcytosine + Succinic acid + CO(2)details
Gene Name:
TET3
Uniprot ID:
O43151
Reactions
DNA 5-methylcytosine + Oxoglutaric acid + Oxygen unknown DNA 5-hydroxymethylcytosine + Succinic acid + CO(2)details