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Human Metabolome Database Version 3.5

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Showing metabocard for Sphinganine (HMDB00269)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:08:13 -0700
HMDB ID HMDB00269
Secondary Accession Numbers None
Metabolite Identification
Common Name Sphinganine
Description Sphinganine is a blocker postlysosomal cholesterol transport by inhibition of low-density lipoprotein-induced esterification of cholesterol and cause unesterified cholesterol to accumulate in perinuclear vesicles. It has been suggested the possibility that endogenous sphinganine may inhibit cholesterol transport in Niemann-Pick Type C (NPC) disease. (PMID 1817037 Link_out).
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. 2-Amino-D-erythro-1,3-Octadecanediol
  2. C18-dihydro-Sphingosine
  3. C18-Dihydrosphingosine
  4. D-Erythro-1,3-Dihydroxy-2-aminooctadecane
  5. D-Erythro-2-Amino-1,3-octadecanediol
  6. D-Erythro-C18-Dihydrosphingosine
  7. D-Erythro-Sphinganine
  8. Dihydro-C18-sphingosine
  9. Dihydrosphingosine
  10. Erythro-Sphinganine
  11. Octadecasphinganine
  12. Sphinganine
  13. [R-(R*,S*)]-2-amino-1,3-Octadecanediol
Chemical Formula C18H39NO2
Average Molecular Weight 301.5078
Monoisotopic Molecular Weight 301.298079497
IUPAC Name (2S,3R)-2-aminooctadecane-1,3-diol
Traditional IUPAC Name sphinganine
CAS Registry Number 764-22-7
SMILES CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO
InChI Identifier InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1
InChI Key OTKJDMGTUTTYMP-ZWKOTPCHSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Lipids
Class Sphingolipids
Sub Class N/A
Other Descriptors
  • 2-aminooctadecane-1,3-diol(ChEBI)
  • Aliphatic Acyclic Compounds
  • Sphinganines(KEGG)
  • Sphinganines(Lipidmaps)
Substituents
  • 1,2 Aminoalcohol
  • Primary Alcohol
  • Primary Aliphatic Amine (Alkylamine)
  • Secondary Alcohol
Direct Parent Sphingolipids
Ontology
Status Detected and Quantified
Origin
  • Endogenous
  • Food
Biofunction
  • Cell signaling
  • Fuel and energy storage
  • Fuel or energy source
  • Membrane integrity/stability
Application
  • Nutrients
  • Stabilizers
  • Surfactants and Emulsifiers
Cellular locations
  • Cytoplasm
  • Extracellular
  • Membrane (predicted from logP)
  • Endoplasmic reticulum
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility 0.0045 g/L ALOGPS
LogP 5.20 ALOGPS
LogP 4.77 ChemAxon
LogS -4.82 ALOGPS
pKa (strongest acidic) 14.42 ChemAxon
pKa (strongest basic) 9.29 ChemAxon
Hydrogen Acceptor Count 3 ChemAxon
Hydrogen Donor Count 3 ChemAxon
Polar Surface Area 66.48 A2 ChemAxon
Rotatable Bond Count 16 ChemAxon
Refractivity 90.93 ChemAxon
Polarizability 40.49 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge 1 ChemAxon
Spectra
1H NMR Spectrum
MS/MS Spectrum Quattro_QQQ 10
MS/MS Spectrum Quattro_QQQ 25
MS/MS Spectrum Quattro_QQQ 40
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 10
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 20
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 30
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 40
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 50
MS/MS Spectrum GC-MS
MS/MS Spectrum GC-MS
[1H,13C] 2D NMR Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Membrane (predicted from logP)
  • Endoplasmic reticulum
Biofluid Locations
  • Blood
  • Urine
Tissue Location
  • Fibroblasts
  • Intestine
  • Kidney
  • Liver
  • Thyroid Gland
  • Platelet
  • Spleen
  • Stratum Corneum
Pathways
Name SMPDB Link KEGG Link
Sphingolipid Metabolism SMP00034 map00500 Link_out
Normal Concentrations
Biofluid Status Value Age Sex Condition Comments
Blood Detected and Quantified
Article_icon
0.011 +/- 0.00033 uM Adult (>18 years old) Both Normal Not Available
Urine Detected and Quantified
Article_icon
0.00023 +/- 0.00020 umol/mmol creatinine Adult (>18 years old) Both Normal Not Available
Urine Detected and Quantified
Article_icon
0.000013 +/- 0.0000059 umol/mmol creatinine Adult (>18 years old) Female Normal Not Available
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Comments
Urine Detected and Quantified
Article_icon
0.00011 +/- 0.00015 umol/mmol creatinine Adult (>18 years old) Female Pregnancy Not Available
Associated Disorders and Diseases
Disease References
Pregnancy
  • Ribar S, Mesaric M, Sedic M: Sphingoid bases as possible diagnostic parameters. Croat Med J. 2003 Apr;44(2):165-70. Pubmed: 12698507 Link_out
    Associated OMIM IDs None
    DrugBank ID Not Available
    Phenol Explorer Compound ID Not Available
    Phenol Explorer Metabolite ID Not Available
    FoodDB ID FDB021924
    KNApSAcK ID Not Available
    Chemspider ID 82609 Link_out
    KEGG Compound ID C00836 Link_out
    BioCyc ID Not Available
    BiGG ID 36159 Link_out
    Wikipedia Link Not Available
    NuGOwiki Link HMDB00269 Link_out
    Metagene Link HMDB00269 Link_out
    METLIN ID 5268 Link_out
    PubChem Compound 91486 Link_out
    PDB ID Not Available
    ChEBI ID 16566 Link_out
    References
    Synthesis Reference Roush, William R.; Adam, Michael A. Directed openings of 2,3-epoxy alcohols via reactions with isocyanates: synthesis of (+)-erythro-dihydrosphingosine. Journal of Organic Chemistry (1985), 50(20), 3752-7.
    Material Safety Data Sheet (MSDS) Download (PDF)
    General References
    1. Deguchi H, Yegneswaran S, Griffin JH: Sphingolipids as bioactive regulators of thrombin generation. J Biol Chem. 2004 Mar 26;279(13):12036-42. Epub 2004 Jan 13. Pubmed: 14722105 Link_out
    2. Flamand N, Justine P, Bernaud F, Rougier A, Gaetani Q: In vivo distribution of free long-chain sphingoid bases in the human stratum corneum by high-performance liquid chromatographic analysis of strippings. J Chromatogr B Biomed Appl. 1994 Jun 3;656(1):65-71. Pubmed: 7952048 Link_out
    3. Martinez G, Jimenez-Sanchez G, Divry P, Vianey-Saban C, Riudor E, Rodes M, Briones P, Ribes A: Plasma free fatty acids in mitochondrial fatty acid oxidation defects. Clin Chim Acta. 1997 Nov 28;267(2):143-54. Pubmed: 9469249 Link_out
    4. Berg C, Trofast C, Bengtsson T: Platelets induce reactive oxygen species-dependent growth of human skin fibroblasts. Eur J Cell Biol. 2003 Nov;82(11):565-71. Pubmed: 14703013 Link_out
    5. Voss KA, Plattner RD, Riley RT, Meredith FI, Norred WP: In vivo effects of fumonisin B1-producing and fumonisin B1-nonproducing Fusarium moniliforme isolates are similar: fumonisins B2 and B3 cause Mycopathologia. 1998;141(1):45-58. Pubmed: 9725030 Link_out
    6. Ribar S, Mesaric M, Bauman M: High-performance liquid chromatographic determination of sphinganine and sphingosine in serum and urine of subjects from an endemic nephropathy area in Croatia. J Chromatogr B Biomed Sci Appl. 2001 Apr 25;754(2):511-9. Pubmed: 11339295 Link_out
    7. Bouchon B, Portoukalian J, Orgiazzi J, Bornet H: Selective enrichment of phytosphingosine in glycosphingolipids of isolated human thyrocytes as compared to the whole thyroid. Biochem Biophys Res Commun. 1987 Mar 30;143(3):827-31. Pubmed: 3566758 Link_out
    8. Dragusin M, Gurgui C, Schwarzmann G, Hoernschemeyer J, van Echten-Deckert G: Metabolism of the unnatural anticancer lipid safingol, L-threo-dihydrosphingosine, in cultured cells. J Lipid Res. 2003 Sep;44(9):1772-9. Epub 2003 Jun 1. Pubmed: 12777464 Link_out
    9. Sharma N, He Q, Sharma RP: Sphingosine kinase activity confers resistance to apoptosis by fumonisin B1 in human embryonic kidney (HEK-293) cells. Chem Biol Interact. 2004 Dec 30;151(1):33-42. Pubmed: 15607760 Link_out
    10. Bibel DJ, Aly R, Shinefield HR: Topical sphingolipids in antisepsis and antifungal therapy. Clin Exp Dermatol. 1995 Sep;20(5):395-400. Pubmed: 8593716 Link_out
    11. Dyatlovitskaya EV, Kandyba AG, Kozlov AM, Somova OG: Sphinganine in sphingomyelins of tumors and mouse regenerating liver. Biochemistry (Mosc). 2001 May;66(5):502-4. Pubmed: 11405884 Link_out
    12. van der Westhuizen L, Shephard GS, van Schalkwyk DJ: The effect of repeated gavage doses of fumonisin B1 on the sphinganine and sphingosine levels in vervet monkeys. Toxicon. 2001 Jul;39(7):969-72. Pubmed: 11223085 Link_out
    13. van der Westhuizen L, Brown NL, Marasas WF, Swanevelder S, Shephard GS: Sphinganine/sphingosine ratio in plasma and urine as a possible biomarker for fumonisin exposure in humans in rural areas of Africa. Food Chem Toxicol. 1999 Dec;37(12):1153-8. Pubmed: 10654591 Link_out
    14. Zimber A, Chedeville A, Gespach C, Abita JP: Inhibition of proliferation and induction of monocytic differentiation on HL60 human promyelocytic leukemia cells treated with bile acids in vitro. Int J Cancer. 1994 Oct 1;59(1):71-7. Pubmed: 7927907 Link_out
    15. Rodriguez-Lafrasse C, Rousson R, Pentchev PG, Louisot P, Vanier MT: Free sphingoid bases in tissues from patients with type C Niemann-Pick disease and other lysosomal storage disorders. Biochim Biophys Acta. 1994 May 25;1226(2):138-44. Pubmed: 8204660 Link_out
    Enzymes
    Name: Lipid phosphate phosphohydrolase 2
    Reactions:
    • a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate [RN:R02239]
    Gene Name: PPAP2C
    Uniprot ID: O43688 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Lipid phosphate phosphohydrolase 1
    Reactions:
    • a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate [RN:R02239]
    Gene Name: PPAP2A
    Uniprot ID: O14494 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Lipid phosphate phosphohydrolase 3
    Reactions:
    • a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate [RN:R02239]
    Gene Name: PPAP2B
    Uniprot ID: O14495 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
    Reactions:
      Gene Name: GBGT1
      Uniprot ID: Q8N5D6 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
      Reactions:
      • 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate [RN:R03482 R05917]
      Gene Name: PIGL
      Uniprot ID: Q9Y2B2 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
      Reactions:
      • UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [RN:R02654 R05916]
      Gene Name: PIGQ
      Uniprot ID: Q9BRB3 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
      Reactions:
      • UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [RN:R02654 R05916]
      Gene Name: PIGA
      Uniprot ID: P37287 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
      Reactions:
      • UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [RN:R02654 R05916]
      Gene Name: PIGH
      Uniprot ID: Q14442 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
      Reactions:
      • UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [RN:R02654 R05916]
      Gene Name: PIGP
      Uniprot ID: P57054 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
      Reactions:
      • UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [RN:R02654 R05916]
      Gene Name: PIGC
      Uniprot ID: Q92535 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Sphingosine kinase 1
      Reactions:
      • ATP + sphinganine = ADP + sphinganine 1-phosphate [RN:R02976]
      Gene Name: SPHK1
      Uniprot ID: Q9NYA1 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Sphingosine kinase 2
      Reactions:
      • ATP + sphinganine = ADP + sphinganine 1-phosphate [RN:R02976]
      Gene Name: SPHK2
      Uniprot ID: Q9NRA0 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Acid ceramidase
      Reactions:
      • N-acylsphingosine + H2O = a carboxylate + sphingosine [RN:R01493]
      Gene Name: ASAH1
      Uniprot ID: Q13510 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Ganglioside GM2 activator
      Reactions:
        Gene Name: GM2A
        Uniprot ID: P17900 Link_out
        Protein Sequence: FASTA
        Gene Sequence: FASTA
        Name: T-cell surface glycoprotein CD1e, membrane-associated
        Reactions:
          Gene Name: CD1E
          Uniprot ID: P15812 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Epididymal secretory protein E1
          Reactions:
            Gene Name: NPC2
            Uniprot ID: P61916 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: Antigen-presenting glycoprotein CD1d
            Reactions:
              Gene Name: CD1D
              Uniprot ID: P15813 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: GPI mannosyltransferase 1
              Reactions:
                Gene Name: PIGM
                Uniprot ID: Q9H3S5 Link_out
                Protein Sequence: FASTA
                Gene Sequence: FASTA
                Name: Phosphatidylinositol-glycan biosynthesis class W protein
                Reactions:
                  Gene Name: PIGW
                  Uniprot ID: Q7Z7B1 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: 3-ketodihydrosphingosine reductase
                  Reactions:
                  • sphinganine + NADP+ = 3-dehydrosphinganine + NADPH + H+ [RN:R02978]
                  Gene Name: KDSR
                  Uniprot ID: Q06136 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Phosphatidylinositol-glycan biosynthesis class X protein
                  Reactions:
                    Gene Name: PIGX
                    Uniprot ID: Q8TBF5 Link_out
                    Protein Sequence: FASTA
                    Gene Sequence: FASTA
                    Name: GPI mannosyltransferase 4
                    Reactions:
                      Gene Name: PIGZ
                      Uniprot ID: Q86VD9 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
                      Reactions:
                        Gene Name: B3GNT5
                        Uniprot ID: Q9BYG0 Link_out
                        Protein Sequence: FASTA
                        Gene Sequence: FASTA
                        Name: Beta-1,3-galactosyltransferase 5
                        Reactions:
                          Gene Name: B3GALT5
                          Uniprot ID: Q9Y2C3 Link_out
                          Protein Sequence: FASTA
                          Gene Sequence: FASTA
                          Name: GPI mannosyltransferase 3
                          Reactions:
                            Gene Name: PIGB
                            Uniprot ID: Q92521 Link_out
                            Protein Sequence: FASTA
                            Gene Sequence: FASTA
                            Name: Phosphatidylinositol-glycan biosynthesis class F protein
                            Reactions:
                              Gene Name: PIGF
                              Uniprot ID: Q07326 Link_out
                              Protein Sequence: FASTA
                              Gene Sequence: FASTA
                              Name: GPI ethanolamine phosphate transferase 2
                              Reactions:
                                Gene Name: PIGG
                                Uniprot ID: Q5H8A4 Link_out
                                Protein Sequence: FASTA
                                Gene Sequence: FASTA
                                Name: GPI ethanolamine phosphate transferase 1
                                Reactions:
                                  Gene Name: PIGN
                                  Uniprot ID: O95427 Link_out
                                  Protein Sequence: FASTA
                                  Gene Sequence: FASTA
                                  Name: GPI ethanolamine phosphate transferase 3
                                  Reactions:
                                    Gene Name: PIGO
                                    Uniprot ID: Q8TEQ8 Link_out
                                    Protein Sequence: FASTA
                                    Gene Sequence: FASTA
                                    Name: GPI transamidase component PIG-S
                                    Reactions:
                                      Gene Name: PIGS
                                      Uniprot ID: Q96S52 Link_out
                                      Protein Sequence: FASTA
                                      Gene Sequence: FASTA
                                      Name: GPI transamidase component PIG-T
                                      Reactions:
                                        Gene Name: PIGT
                                        Uniprot ID: Q969N2 Link_out
                                        Protein Sequence: FASTA
                                        Gene Sequence: FASTA
                                        Name: Phosphatidylinositol glycan anchor biosynthesis class U protein
                                        Reactions:
                                          Gene Name: PIGU
                                          Uniprot ID: Q9H490 Link_out
                                          Protein Sequence: FASTA
                                          Gene Sequence: FASTA
                                          Name: GPI mannosyltransferase 2
                                          Reactions:
                                            Gene Name: PIGV
                                            Uniprot ID: Q9NUD9 Link_out
                                            Protein Sequence: FASTA
                                            Gene Sequence: FASTA
                                            Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
                                            Reactions:
                                              Gene Name: PIGY
                                              Uniprot ID: Q3MUY2 Link_out
                                              Protein Sequence: FASTA
                                              Gene Sequence: FASTA
                                              Name: Pleckstrin homology domain-containing family A member 8
                                              Reactions:
                                                Gene Name: PLEKHA8
                                                Uniprot ID: Q96JA3 Link_out
                                                Protein Sequence: FASTA
                                                Gene Sequence: FASTA
                                                Name: Alkaline ceramidase 3
                                                Reactions:
                                                  Gene Name: ACER3
                                                  Uniprot ID: Q9NUN7 Link_out
                                                  Protein Sequence: FASTA
                                                  Gene Sequence: FASTA
                                                  Name: Alkaline ceramidase 2
                                                  Reactions:
                                                  • N-acylsphingosine + H2O = a carboxylate + sphingosine [RN:R01493]
                                                  Gene Name: ACER2
                                                  Uniprot ID: Q5QJU3 Link_out
                                                  Protein Sequence: FASTA
                                                  Gene Sequence: FASTA
                                                  Name: Non-lysosomal glucosylceramidase
                                                  Reactions:
                                                  • D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine [RN:R01498]
                                                  Gene Name: GBA2
                                                  Uniprot ID: Q9HCG7 Link_out
                                                  Protein Sequence: FASTA
                                                  Gene Sequence: FASTA
                                                  Name: Sphingosine kinase 1
                                                  Reactions:
                                                    Gene Name: SPHK1
                                                    Uniprot ID: Q96GK1 Link_out
                                                    Protein Sequence: FASTA
                                                    Gene Sequence: FASTA
                                                    Name: GPI-anchor transamidase
                                                    Reactions:
                                                      Gene Name: PIGK
                                                      Uniprot ID: Q92643 Link_out
                                                      Protein Sequence: FASTA
                                                      Gene Sequence: FASTA
                                                      Name: Glycosylphosphatidylinositol anchor attachment 1 protein
                                                      Reactions:
                                                        Gene Name: GPAA1
                                                        Uniprot ID: O43292 Link_out
                                                        Protein Sequence: FASTA
                                                        Gene Sequence: FASTA
                                                        Name: Protein PLEKHA9
                                                        Reactions:
                                                          Gene Name: PLEKHA9
                                                          Uniprot ID: O95397 Link_out
                                                          Protein Sequence: FASTA
                                                          Gene Sequence: FASTA
                                                          Name: Glycolipid transfer protein domain-containing protein 2
                                                          Reactions:
                                                            Gene Name: GLTPD2
                                                            Uniprot ID: A6NH11 Link_out
                                                            Protein Sequence: FASTA
                                                            Gene Sequence: FASTA
                                                            Name: Putative uncharacterized protein PLEKHA8
                                                            Reactions:
                                                              Gene Name: PLEKHA8
                                                              Uniprot ID: B5MDU3 Link_out
                                                              Protein Sequence: FASTA
                                                              Gene Sequence: FASTA
                                                              Name: T-cell surface glycoprotein CD1a
                                                              Reactions:
                                                                Gene Name: CD1A
                                                                Uniprot ID: P06126 Link_out
                                                                Protein Sequence: FASTA
                                                                Gene Sequence: FASTA
                                                                Name: Glycolipid transfer protein domain-containing protein 1
                                                                Reactions:
                                                                  Gene Name: GLTPD1
                                                                  Uniprot ID: Q5TA50 Link_out
                                                                  Protein Sequence: FASTA
                                                                  Gene Sequence: FASTA
                                                                  Name: T-cell surface glycoprotein CD1c
                                                                  Reactions:
                                                                    Gene Name: CD1C
                                                                    Uniprot ID: P29017 Link_out
                                                                    Protein Sequence: FASTA
                                                                    Gene Sequence: FASTA
                                                                    Name: Lipopolysaccharide-binding protein
                                                                    Reactions:
                                                                      Gene Name: LBP
                                                                      Uniprot ID: P18428 Link_out
                                                                      Protein Sequence: FASTA
                                                                      Gene Sequence: FASTA
                                                                      Name: Putative uncharacterized protein DKFZp434L0435
                                                                      Reactions:
                                                                        Gene Name: DKFZp434L0435
                                                                        Uniprot ID: Q9UFH6 Link_out
                                                                        Protein Sequence: FASTA
                                                                        Gene Sequence: FASTA
                                                                        Name: T-cell surface glycoprotein CD1b
                                                                        Reactions:
                                                                          Gene Name: CD1B
                                                                          Uniprot ID: P29016 Link_out
                                                                          Protein Sequence: FASTA
                                                                          Gene Sequence: FASTA
                                                                          Name: Glycolipid transfer protein
                                                                          Reactions:
                                                                            Gene Name: GLTP
                                                                            Uniprot ID: Q9NZD2 Link_out
                                                                            Protein Sequence: FASTA
                                                                            Gene Sequence: FASTA
                                                                            Name: Sphingosine-1-phosphate phosphatase 2
                                                                            Reactions:
                                                                              Gene Name: SGPP2
                                                                              Uniprot ID: Q8IWX5 Link_out
                                                                              Protein Sequence: FASTA
                                                                              Gene Sequence: FASTA