Record Information
Creation Date2005-11-16 15:48:42 UTC
Update Date2013-02-09 00:08:15 UTC
Secondary Accession NumbersNone
Metabolite Identification
Common NameUrea
DescriptionUrea is a highly soluble organic compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. Urea is formed in a cyclic pathway known simply as the urea cycle. In this cycle, amino groups donated by ammonia and L-aspartate are converted to urea. Urea is essentially a waste product; it has no physiological function. It is dissolved in blood (in humans in a concentration of 2.5 - 7.5 mmol/liter) and excreted by the kidney in the urine. In addition, a small amount of urea is excreted (along with sodium chloride and water) in human sweat.
  1. Alphadrate
  2. ARF
  3. B-I-k
  4. beta-I-k
  5. Bromisovalum
  6. Bubber shet
  7. Calmurid
  8. Calmurid HC
  9. Carbaderm
  10. Carbamide
  11. Carbamide resin
  12. Carbonyl diamide
  13. Carbonyl diamine
  14. Carbonyldiamide
  15. Carbonyldiamine
  16. Carmol
  17. Helicosol
  18. Hyanit
  19. Isourea
  20. Keratinamin
  21. Keratinamin kowa
  22. Mocovina
  23. Onychomal
  24. Panafil
  25. URE
  26. Urea
  27. Ureaphil
  28. Ureophil
Chemical FormulaCH4N2O
Average Molecular Weight60.0553
Monoisotopic Molecular Weight60.03236276
IUPAC Nameurea
Traditional IUPAC Nameurea
CAS Registry Number57-13-6
InChI Identifier
Chemical Taxonomy
KingdomOrganic Compounds
Super ClassAliphatic Acyclic Compounds
Sub ClassN/A
Other Descriptors
  • a small molecule(Cyc)
  • isourea(ChEBI)
  • N/A
Direct ParentUreas
StatusDetected and Quantified
  • Endogenous
  • Component of Arginine and proline metabolism
ApplicationNot Available
Cellular locations
  • Extracellular
  • Mitochondria
Physical Properties
Experimental Properties
Melting Point132 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility545.0 mg/mLNot Available
LogP-2.11HANSCH,C ET AL. (1995)
Predicted Properties
water solubility412 g/LALOGPS
pKa (strongest acidic)15.73ChemAxon
pKa (strongest basic)-2.4ChemAxon
physiological charge0ChemAxon
hydrogen acceptor count1ChemAxon
hydrogen donor count2ChemAxon
polar surface area69.11ChemAxon
rotatable bond count0ChemAxon
Biological Properties
Cellular Locations
  • Extracellular
  • Mitochondria
Biofluid Locations
  • Blood
  • Cellular Cytoplasm
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue Location
  • Kidney
  • Liver
  • Prostate
  • Skin
Arginine and Proline MetabolismSMP00020map00330
Urea CycleSMP00059map00330
Normal Concentrations
BloodDetected and Quantified6074.6 +/- 2154.2 uMAdult (>18 years old)Not SpecifiedNormal
BloodDetected and Quantified4530.0 (2590.0 - 6470.0) uMAdult (>18 years old)MaleNormal
  • Geigy Scient...
BloodDetected and Quantified4010.0 +/- 920.0 uMAdult (>18 years old)FemaleNormal
  • Geigy Scient...
BloodDetected and Quantified3600.0 (2680.0 - 4780.0) uMNewborn (0-30 days old)BothNormal
  • Geigy Scient...
BloodDetected and Quantified5210.0 (4310.0 - 6780.0) uMChildren (1-13 year old)Not SpecifiedCommentNormal
  • Geigy Scient...
BloodDetected and Quantified6500.0 (4000.0-9000.0) uMAdult (>18 years old)BothNormal
Cellular CytoplasmDetected and Quantified2960 +/- 1000 uMAdult (>18 years old)FemaleNormal
  • Geigy Scient...
Cerebrospinal Fluid (CSF)Detected and Quantified3820.0 (0.0-7640.0) uMAdult (>18 years old)BothNormal
Cerebrospinal Fluid (CSF)Detected and Quantified4160.0 (2300.0-6060.0) uMAdult (>18 years old)BothNormal
  • Geigy Scient...
SalivaDetected and Quantified1-6985 uMAdult (>18 years old)MaleCommentnormal
SalivaDetected and Quantified1-9528 uMAdult (>18 years old)MaleCommentnormal
UrineDetected and Quantified15491.64-38812.40 umol/mmol creatinineAdult (>18 years old)BothNormal
  • David F. Put...
UrineDetected and Quantified22566.0 +/- 4407.0 umol/mmol creatinineAdult (>18 years old)BothNormal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
UrineDetected and Quantified6286.43 umol/mmol creatinineAdult (>18 years old)MaleNormal
  • Shaykhutdino...
UrineDetected and Quantified12285 (174-49097) umol/mmol creatinineAdult (>18 years old)BothCommentNormal
UrineDetected but not QuantifiedNot ApplicableAdult (>18 years old)BothCommentNormal
UrineDetected and Quantified29.6 (6.579-52.6) umol/mmol creatinineAdult (>18 years old)BothNormal
    Abnormal Concentrations
    BloodDetected and Quantified3500.0 +/- 1500.0 uMAdult (>18 years old)BothCirrhosis
    BloodDetected and Quantified3309.9 +/- 1844 uMAdult (>18 years old)Not SpecifiedHeart Transplant
    Cerebrospinal Fluid (CSF)Detected and Quantified1800.0 (1500.0-2100.0) uMAdult (>18 years old)BothTuberculosis Meningitis
    Cerebrospinal Fluid (CSF)Detected and Quantified2150.0 (1850.0-2450.0) uMAdult (>18 years old)BothCommentMeningitis
    Associated Disorders and Diseases
    Disease References
    • Marescau B, De Deyn PP, Holvoet J, Possemiers I, Nagels G, Saxena V, Mahler C: Guanidino compounds in serum and urine of cirrhotic patients. Metabolism. 1995 May;44(5):584-8. Pubmed: 7752905
    • Subramanian A, Gupta A, Saxena S, Gupta A, Kumar R, Nigam A, Kumar R, Mandal SK, Roy R: Proton MR CSF analysis and a new software as predictors for the differentiation of meningitis in children. NMR Biomed. 2005 Jun;18(4):213-25. Pubmed: 15627241
    Tuberculous meningitis
    • Subramanian A, Gupta A, Saxena S, Gupta A, Kumar R, Nigam A, Kumar R, Mandal SK, Roy R: Proton MR CSF analysis and a new software as predictors for the differentiation of meningitis in children. NMR Biomed. 2005 Jun;18(4):213-25. Pubmed: 15627241
    Associated OMIM IDsNone
    DrugBank IDDB03904
    DrugBank Metabolite IDNot Available
    Phenol Explorer Compound IDNot Available
    Phenol Explorer Metabolite IDNot Available
    FoodDB IDFDB012174
    KNApSAcK IDC00007314
    Chemspider ID1143
    KEGG Compound IDC00086
    BioCyc IDUREA
    BiGG ID33799
    Wikipedia LinkUrea
    NuGOwiki LinkHMDB00294
    Metagene LinkHMDB00294
    PubChem Compound1176
    ChEBI ID16199
    Synthesis ReferenceLeuthardt, F.; Glasson, B. Biological synthesis of urea. Verhandl. Ver. schweiz. Physiol. (1942), 21 25-7.
    Material Safety Data Sheet (MSDS)Not Available
    General References
    1. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411
    2. Subramanian A, Gupta A, Saxena S, Gupta A, Kumar R, Nigam A, Kumar R, Mandal SK, Roy R: Proton MR CSF analysis and a new software as predictors for the differentiation of meningitis in children. NMR Biomed. 2005 Jun;18(4):213-25. Pubmed: 15627241
    3. Deja M, Hildebrandt B, Ahlers O, Riess H, Wust P, Gerlach H, Kerner T: Goal-directed therapy of cardiac preload in induced whole-body hyperthermia. Chest. 2005 Aug;128(2):580-6. Pubmed: 16100141
    4. Klassen P, Furst P, Schulz C, Mazariegos M, Solomons NW: Plasma free amino acid concentrations in healthy Guatemalan adults and in patients with classic dengue. Am J Clin Nutr. 2001 Mar;73(3):647-52. Pubmed: 11237944
    5. Georges J: Determination of ammonia and urea in urine and of urea in blood by use of an ammonia-selective electrode. Clin Chem. 1979 Nov;25(11):1888-90. Pubmed: 498498
    6. Vaidya VS, Bonventre JV: Mechanistic biomarkers for cytotoxic acute kidney injury. Expert Opin Drug Metab Toxicol. 2006 Oct;2(5):697-713. Pubmed: 17014390
    7. Nandan RK, Sivapathasundharam B, Sivakumar G: Oral manifestations and analysis of salivary and blood urea levels of patients under going haemo dialysis and kidney transplant. Indian J Dent Res. 2005 Jul-Sep;16(3):77-82. Pubmed: 16454320
    8. Zocco MA, Di Campli C, Gaspari R, Candelli M, Nista EC, Zileri Dal Verme L, Di Gioacchino G, Santoliquido A, Flore R, Tondi P, Proietti R, Pola P, Gasbarrini G, Gasbarrini A: Improvement of mitochondrial function evaluated by ketoisocaproic acid breath test in patients with HCV infection undergoing albumin dialysis. Transplant Proc. 2005 Jul-Aug;37(6):2554-6. Pubmed: 16182741
    9. Kohnle M, Pietruck F, Kribben A, Philipp T, Heemann U, Witzke O: Ezetimibe for the treatment of uncontrolled hypercholesterolemia in patients with high-dose statin therapy after renal transplantation. Am J Transplant. 2006 Jan;6(1):205-8. Pubmed: 16433776
    10. Malyszko J, Malyszko J, Wolczynski S, Mysliwiec M: Adiponectin, leptin and thyroid hormones in patients with chronic renal failure and on renal replacement therapy: are they related? Nephrol Dial Transplant. 2006 Jan;21(1):145-52. Epub 2005 Sep 2. Pubmed: 16141459
    11. Miller TR, Anderson RJ, Linas SL, Henrich WL, Berns AS, Gabow PA, Schrier RW: Urinary diagnostic indices in acute renal failure: a prospective study. Ann Intern Med. 1978 Jul;89(1):47-50. Pubmed: 666184
    12. Final report of the safety assessment of Urea. Int J Toxicol. 2005;24 Suppl 3:1-56. Pubmed: 16422263
    13. Miles L, Heubi JE, Bove KE: Hepatocyte glycogen accumulation in patients undergoing dietary management of urea cycle defects mimics storage disease. J Pediatr Gastroenterol Nutr. 2005 Apr;40(4):471-6. Pubmed: 15795597
    14. Hobbs JR: Monitoring myelomatosis. Arch Intern Med. 1975 Jan;135(1):125-30. Pubmed: 1111461
    15. Racz I, Soos G, Jakab E: [Water content of the skin following salicylic acid and urea treatment] Hautarzt. 1989;40 Suppl 9:61-2. Pubmed: 2807925
    16. Younes H, Alphonse JC, Deteix R: [Role of dietary fibers in the nutritional management of chronic renal failure] Nephrologie. 2004;25(7):283-5. Pubmed: 15584637
    17. Roszczenko A, Galazyn-Sidorczuk M, Brzoska MM, Moniuszko-Jakoniuk J, Zwierz K: [Select parameters of renal function in smokers in correlation with the exposure to cadmium] Przegl Lek. 2004;61(4):348-50. Pubmed: 15521599
    18. Gowda GA, Somashekar BS, Ijare OB, Sharma A, Kapoor VK, Khetrapal CL: One-step analysis of major bile components in human bile using 1H NMR spectroscopy. Lipids. 2006 Jun;41(6):577-89. Pubmed: 16981436
    19. Kurekci AE, Atay AA, Sarici SU, Yesilkaya E, Senses Z, Okutan V, Ozcan O: Is there a relationship between childhood Helicobacter pylori infection and iron deficiency anemia? J Trop Pediatr. 2005 Jun;51(3):166-9. Epub 2005 Apr 26. Pubmed: 15855306
    20. Fostel J, Boneva R, Lloyd A: Exploration of the gene expression correlates of chronic unexplained fatigue using factor analysis. Pharmacogenomics. 2006 Apr;7(3):441-54. Pubmed: 16610954


    Gene Name:
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    L-Arginine + Water unknown Ornithine + Ureadetails
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    L-Arginine + Water unknown Ornithine + Ureadetails
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    Agmatine + Water unknown Putrescine + Ureadetails
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    Allantoic acid + Water unknown (S)-Ureidoglycolic acid + Ureadetails
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    Not Available
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