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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2022-03-07 02:49:00 UTC
HMDB IDHMDB0000319
Secondary Accession Numbers
  • HMDB00319
Metabolite Identification
Common Name18-Hydroxycorticosterone
Description18-Hydroxycorticosterone is a corticosteroid and a derivative of corticosterone. If it is present in sufficiently high concentrations, it can lead to serious electrolyte imbalances (an electrolyte toxin). 18-Hydroxycorticosterone serves as an intermediate in the synthesis of aldosterone by the enzyme aldosterone synthase in the zona glomerulosa. Chronically high levels of 18-hydroxycorticosterone are associated with at least three inborn errors of metabolism including adrenal hyperplasia type V, corticosterone methyl oxidase I deficiency, and corticosterone methyl oxidase II deficiency. Each of these conditions is characterized by excessive amounts of sodium being released in the urine (salt wasting), along with insufficient release of potassium in the urine, usually beginning in the first few weeks of life. This imbalance leads to low levels of sodium and high levels of potassium in the blood (hyponatremia and hyperkalemia, respectively). Individuals with corticosterone methyloxidase deficiency can also have high levels of acid in the blood (metabolic acidosis). Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). The hyponatremia, hyperkalemia, and metabolic acidosis associated with corticosterone methyloxidase deficiency can cause nausea, vomiting, dehydration, low blood pressure, extreme tiredness (fatigue), and muscle weakness.
Structure
Data?1582752123
Synonyms
ValueSource
11b,18,21-Trihydroxy-pregn-4-ene-3,20-dioneHMDB
18 HydrocorticosteroneMeSH, HMDB
18 HydroxycorticosteroneMeSH, HMDB
18-HydrocorticosteroneMeSH, HMDB
Hydroxycorticosterone, 18MeSH, HMDB
(11β)-11,18,21-Trihydroxypregn-4-ene-3,20-dioneHMDB
(11beta)-11,18,21-Trihydroxypregn-4-ene-3,20-dioneHMDB
Chemical FormulaC21H30O5
Average Molecular Weight362.4599
Monoisotopic Molecular Weight362.20932407
IUPAC Name(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-15-(hydroxymethyl)-2-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
Traditional Name(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-15-(hydroxymethyl)-2-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
CAS Registry Number561-65-9
SMILES
[H][C@@]12CC[C@H](C(=O)CO)[C@@]1(CO)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
InChI Identifier
InChI=1S/C21H30O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,14-17,19,22-23,25H,2-7,9-11H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
InChI KeyHFSXHZZDNDGLQN-ZVIOFETBSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassHydroxysteroids
Direct Parent21-hydroxysteroids
Alternative Parents
Substituents
  • Progestogin-skeleton
  • 21-hydroxysteroid
  • Pregnane-skeleton
  • 20-oxosteroid
  • 18-hydroxysteroid
  • 3-oxo-delta-4-steroid
  • 3-oxosteroid
  • 11-hydroxysteroid
  • 11-beta-hydroxysteroid
  • Oxosteroid
  • Delta-4-steroid
  • Cyclohexenone
  • Alpha-hydroxy ketone
  • Cyclic alcohol
  • Ketone
  • Secondary alcohol
  • Cyclic ketone
  • Hydrocarbon derivative
  • Organic oxide
  • Carbonyl group
  • Organic oxygen compound
  • Alcohol
  • Organooxygen compound
  • Primary alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Ontology
Physiological effect
Disposition
Biological locationRoute of exposureSource
Process
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.15 g/LALOGPS
logP1.28ALOGPS
logP0.74ChemAxon
logS-3.4ALOGPS
pKa (Strongest Acidic)13.8ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area94.83 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity97.77 m³·mol⁻¹ChemAxon
Polarizability39.77 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+184.98431661259
DarkChem[M-H]-181.80231661259
AllCCS[M+H]+188.77232859911
AllCCS[M-H]-191.89732859911
DeepCCS[M-2H]-223.32330932474
DeepCCS[M+Na]+198.53330932474
AllCCS[M+H]+188.832859911
AllCCS[M+H-H2O]+186.232859911
AllCCS[M+NH4]+191.232859911
AllCCS[M+Na]+191.832859911
AllCCS[M-H]-191.932859911
AllCCS[M+Na-2H]-192.332859911
AllCCS[M+HCOO]-192.832859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
18-Hydroxycorticosterone[H][C@@]12CC[C@H](C(=O)CO)[C@@]1(CO)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C3689.9Standard polar33892256
18-Hydroxycorticosterone[H][C@@]12CC[C@H](C(=O)CO)[C@@]1(CO)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C3189.5Standard non polar33892256
18-Hydroxycorticosterone[H][C@@]12CC[C@H](C(=O)CO)[C@@]1(CO)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C3625.7Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
18-Hydroxycorticosterone,1TMS,isomer #1C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO)[C@@H](C(=O)CO[Si](C)(C)C)CC[C@@H]123405.3Semi standard non polar33892256
18-Hydroxycorticosterone,1TMS,isomer #2C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=O)CO)CC[C@@H]123348.0Semi standard non polar33892256
18-Hydroxycorticosterone,1TMS,isomer #3C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)[C@@H](C(=O)CO)CC[C@@H]123371.9Semi standard non polar33892256
18-Hydroxycorticosterone,1TMS,isomer #4C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123361.8Semi standard non polar33892256
18-Hydroxycorticosterone,1TMS,isomer #5C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO)[C@@H](C(=CO)O[Si](C)(C)C)CC[C@@H]123355.5Semi standard non polar33892256
18-Hydroxycorticosterone,1TMS,isomer #6C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO)[C@@H](C(=O)CO)CC[C@@H]123308.5Semi standard non polar33892256
18-Hydroxycorticosterone,2TMS,isomer #1C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)[C@@H](C(=O)CO[Si](C)(C)C)CC[C@@H]123348.7Semi standard non polar33892256
18-Hydroxycorticosterone,2TMS,isomer #10C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123273.3Semi standard non polar33892256
18-Hydroxycorticosterone,2TMS,isomer #11C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)[C@@H](C(=O)CO)CC[C@@H]123240.5Semi standard non polar33892256
18-Hydroxycorticosterone,2TMS,isomer #12C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)[C@@H](C(=CO)O[Si](C)(C)C)CC[C@@H]123255.3Semi standard non polar33892256
18-Hydroxycorticosterone,2TMS,isomer #13C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123289.6Semi standard non polar33892256
18-Hydroxycorticosterone,2TMS,isomer #14C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO)[C@@H](C(=CO)O[Si](C)(C)C)CC[C@@H]123250.8Semi standard non polar33892256
18-Hydroxycorticosterone,2TMS,isomer #2C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=O)CO[Si](C)(C)C)CC[C@@H]123335.9Semi standard non polar33892256
18-Hydroxycorticosterone,2TMS,isomer #3C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123369.4Semi standard non polar33892256
18-Hydroxycorticosterone,2TMS,isomer #4C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO)[C@@H](C(=O)CO[Si](C)(C)C)CC[C@@H]123302.2Semi standard non polar33892256
18-Hydroxycorticosterone,2TMS,isomer #5C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123391.1Semi standard non polar33892256
18-Hydroxycorticosterone,2TMS,isomer #6C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=O)CO)CC[C@@H]123279.0Semi standard non polar33892256
18-Hydroxycorticosterone,2TMS,isomer #7C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123334.7Semi standard non polar33892256
18-Hydroxycorticosterone,2TMS,isomer #8C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=O)CO)CC[C@@H]123274.7Semi standard non polar33892256
18-Hydroxycorticosterone,2TMS,isomer #9C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO)O[Si](C)(C)C)CC[C@@H]123289.5Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #1C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=O)CO[Si](C)(C)C)CC[C@@H]123278.9Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #10C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123230.9Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #11C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=O)CO)CC[C@@H]123183.5Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #12C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO)O[Si](C)(C)C)CC[C@@H]123173.4Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #13C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123264.8Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #14C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO)O[Si](C)(C)C)CC[C@@H]123197.0Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #15C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123194.0Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #16C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)[C@@H](C(=CO)O[Si](C)(C)C)CC[C@@H]123134.2Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #2C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123268.5Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #3C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)[C@@H](C(=O)CO[Si](C)(C)C)CC[C@@H]123216.5Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #4C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123295.3Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #5C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123316.8Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #6C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=O)CO[Si](C)(C)C)CC[C@@H]123248.8Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #7C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123352.7Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #8C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123267.6Semi standard non polar33892256
18-Hydroxycorticosterone,3TMS,isomer #9C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123271.3Semi standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #1C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123252.7Semi standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #1C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123342.4Standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #1C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123653.1Standard polar33892256
18-Hydroxycorticosterone,4TMS,isomer #2C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=O)CO[Si](C)(C)C)CC[C@@H]123195.4Semi standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #2C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=O)CO[Si](C)(C)C)CC[C@@H]123396.7Standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #2C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=O)CO[Si](C)(C)C)CC[C@@H]123664.5Standard polar33892256
18-Hydroxycorticosterone,4TMS,isomer #3C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123284.8Semi standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #3C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123277.7Standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #3C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123703.5Standard polar33892256
18-Hydroxycorticosterone,4TMS,isomer #4C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123170.5Semi standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #4C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123418.0Standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #4C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123735.6Standard polar33892256
18-Hydroxycorticosterone,4TMS,isomer #5C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123195.1Semi standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #5C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123355.7Standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #5C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123781.4Standard polar33892256
18-Hydroxycorticosterone,4TMS,isomer #6C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123219.7Semi standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #6C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123485.5Standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #6C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123718.2Standard polar33892256
18-Hydroxycorticosterone,4TMS,isomer #7C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123240.7Semi standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #7C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123442.2Standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #7C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123756.7Standard polar33892256
18-Hydroxycorticosterone,4TMS,isomer #8C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123161.3Semi standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #8C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123394.1Standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #8C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123716.0Standard polar33892256
18-Hydroxycorticosterone,4TMS,isomer #9C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO)O[Si](C)(C)C)CC[C@@H]123116.5Semi standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #9C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO)O[Si](C)(C)C)CC[C@@H]123335.9Standard non polar33892256
18-Hydroxycorticosterone,4TMS,isomer #9C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO)O[Si](C)(C)C)CC[C@@H]123752.8Standard polar33892256
18-Hydroxycorticosterone,5TMS,isomer #1C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123164.1Semi standard non polar33892256
18-Hydroxycorticosterone,5TMS,isomer #1C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123447.1Standard non polar33892256
18-Hydroxycorticosterone,5TMS,isomer #1C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123571.3Standard polar33892256
18-Hydroxycorticosterone,5TMS,isomer #2C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123205.5Semi standard non polar33892256
18-Hydroxycorticosterone,5TMS,isomer #2C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123389.0Standard non polar33892256
18-Hydroxycorticosterone,5TMS,isomer #2C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C)C[C@]2(CO[Si](C)(C)C)[C@@H](C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123635.6Standard polar33892256
18-Hydroxycorticosterone,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO3716.4Semi standard non polar33892256
18-Hydroxycorticosterone,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO3633.3Semi standard non polar33892256
18-Hydroxycorticosterone,1TBDMS,isomer #3CC(C)(C)[Si](C)(C)O[C@H]1C[C@]2(CO)[C@@H](C(=O)CO)CC[C@H]2[C@@H]2CCC3=CC(=O)CC[C@]3(C)[C@@H]123624.9Semi standard non polar33892256
18-Hydroxycorticosterone,1TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC(CO)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO3658.3Semi standard non polar33892256
18-Hydroxycorticosterone,1TBDMS,isomer #5CC(C)(C)[Si](C)(C)OC(=CO)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO3595.4Semi standard non polar33892256
18-Hydroxycorticosterone,1TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO)[C@@H](C(=O)CO)CC[C@@H]123584.1Semi standard non polar33892256
18-Hydroxycorticosterone,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO3857.2Semi standard non polar33892256
18-Hydroxycorticosterone,2TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC(CO)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO3789.0Semi standard non polar33892256
18-Hydroxycorticosterone,2TBDMS,isomer #11CC(C)(C)[Si](C)(C)OC(=CO)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO3712.9Semi standard non polar33892256
18-Hydroxycorticosterone,2TBDMS,isomer #12CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]2(CO)[C@@H](C(=O)CO)CC[C@@H]123683.5Semi standard non polar33892256
18-Hydroxycorticosterone,2TBDMS,isomer #13CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO)C(=C(CO)O[Si](C)(C)C(C)(C)C)CC[C@@H]123806.0Semi standard non polar33892256
18-Hydroxycorticosterone,2TBDMS,isomer #14CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(CO)[C@@H](C(=CO)O[Si](C)(C)C(C)(C)C)CC[C@@H]123743.6Semi standard non polar33892256
18-Hydroxycorticosterone,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO[Si](C)(C)C(C)(C)C3892.7Semi standard non polar33892256
18-Hydroxycorticosterone,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO3918.2Semi standard non polar33892256
18-Hydroxycorticosterone,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO3860.1Semi standard non polar33892256
18-Hydroxycorticosterone,2TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO3814.1Semi standard non polar33892256
18-Hydroxycorticosterone,2TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O[Si](C)(C)C(C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO3753.7Semi standard non polar33892256
18-Hydroxycorticosterone,2TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C(C)(C)C3863.6Semi standard non polar33892256
18-Hydroxycorticosterone,2TBDMS,isomer #8CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO3744.4Semi standard non polar33892256
18-Hydroxycorticosterone,2TBDMS,isomer #9CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=CO)O[Si](C)(C)C(C)(C)C3771.7Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO[Si](C)(C)C(C)(C)C4012.0Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O[Si](C)(C)C(C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C(C)(C)C3953.8Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #11CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O[Si](C)(C)C(C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO3836.7Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #12CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O[Si](C)(C)C(C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=CO)O[Si](C)(C)C(C)(C)C3888.8Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #13CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C(C)(C)C3976.2Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #14CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@@]43C)[C@@H]1CC[C@@H]2C(=CO)O[Si](C)(C)C(C)(C)C3904.4Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #15CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]2(CO)C(=C(CO)O[Si](C)(C)C(C)(C)C)CC[C@@H]123864.7Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #16CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1[C@@H]2[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]2(CO)[C@@H](C(=CO)O[Si](C)(C)C(C)(C)C)CC[C@@H]123824.2Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO3990.6Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO3961.5Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #4CC(C)(C)[Si](C)(C)OCC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO3876.6Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO[Si](C)(C)C(C)(C)C4077.5Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO[Si](C)(C)C(C)(C)C4062.6Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #7CC(C)(C)[Si](C)(C)OCC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO[Si](C)(C)C(C)(C)C3981.7Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #8CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO4007.9Semi standard non polar33892256
18-Hydroxycorticosterone,3TBDMS,isomer #9CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO3962.8Semi standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO[Si](C)(C)C(C)(C)C4155.7Semi standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO[Si](C)(C)C(C)(C)C4199.7Standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO[Si](C)(C)C(C)(C)C3914.8Standard polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO[Si](C)(C)C(C)(C)C4163.2Semi standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO[Si](C)(C)C(C)(C)C4105.4Standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO[Si](C)(C)C(C)(C)C3935.8Standard polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)OCC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO[Si](C)(C)C(C)(C)C4071.6Semi standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)OCC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO[Si](C)(C)C(C)(C)C4118.1Standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)OCC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO[Si](C)(C)C(C)(C)C3917.0Standard polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO4035.8Semi standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO4117.5Standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO3958.2Standard polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #5CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO4047.1Semi standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #5CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO4022.6Standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #5CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C(C)(C)C)C[C@]12CO4000.4Standard polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #6CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO[Si](C)(C)C(C)(C)C4161.7Semi standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #6CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO[Si](C)(C)C(C)(C)C4200.9Standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #6CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO[Si](C)(C)C(C)(C)C3973.0Standard polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO[Si](C)(C)C(C)(C)C4134.1Semi standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO[Si](C)(C)C(C)(C)C4122.8Standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12CO[Si](C)(C)C(C)(C)C4010.7Standard polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #8CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O[Si](C)(C)C(C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C(C)(C)C4033.0Semi standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #8CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O[Si](C)(C)C(C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C(C)(C)C4066.2Standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #8CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O[Si](C)(C)C(C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C(C)(C)C3946.7Standard polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #9CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O[Si](C)(C)C(C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@@]43C)[C@@H]1CC[C@@H]2C(=CO)O[Si](C)(C)C(C)(C)C4000.0Semi standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #9CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O[Si](C)(C)C(C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@@]43C)[C@@H]1CC[C@@H]2C(=CO)O[Si](C)(C)C(C)(C)C4010.3Standard non polar33892256
18-Hydroxycorticosterone,4TBDMS,isomer #9CC(C)(C)[Si](C)(C)OC[C@]12C[C@H](O[Si](C)(C)C(C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@@]43C)[C@@H]1CC[C@@H]2C(=CO)O[Si](C)(C)C(C)(C)C3968.8Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (Non-derivatized) - 70eV, Positivesplash10-001i-1639000000-7012f18a6579e07dc5712017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (3 TMS) - 70eV, Positivesplash10-03di-1410290000-5789e767e5a0058f10ed2017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_1_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_1_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_1_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_1_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_1_5) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_1_6) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_2_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_2_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_2_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_2_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_2_5) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_2_6) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_2_7) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_2_8) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_2_9) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_2_10) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_2_11) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_2_12) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_2_13) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_2_14) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 18-Hydroxycorticosterone GC-MS (TMS_3_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 18-Hydroxycorticosterone 10V, Positive-QTOFsplash10-01r2-0019000000-8a12570d1c1a01069d092016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 18-Hydroxycorticosterone 20V, Positive-QTOFsplash10-004j-0119000000-2b8864299061070cced52016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 18-Hydroxycorticosterone 40V, Positive-QTOFsplash10-0019-3494000000-ebcb1ff70c533c4c94592016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 18-Hydroxycorticosterone 10V, Negative-QTOFsplash10-03di-0009000000-0a027947a1d058fb84b72016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 18-Hydroxycorticosterone 20V, Negative-QTOFsplash10-03dl-1019000000-cb3605cb617647c036e02016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 18-Hydroxycorticosterone 40V, Negative-QTOFsplash10-05fr-5094000000-8d05b88622baf6731c7f2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 18-Hydroxycorticosterone 10V, Negative-QTOFsplash10-03di-0009000000-0a10b570836098a58b852021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 18-Hydroxycorticosterone 20V, Negative-QTOFsplash10-0zms-3096000000-ebde4d06599fa6ba99f82021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 18-Hydroxycorticosterone 40V, Negative-QTOFsplash10-05fr-1092000000-b70b721681bcc4b0bc162021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 18-Hydroxycorticosterone 10V, Positive-QTOFsplash10-03di-0009000000-728e8f7001bf77edf34e2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 18-Hydroxycorticosterone 20V, Positive-QTOFsplash10-032j-0279000000-46ba785eff196ea28ae22021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 18-Hydroxycorticosterone 40V, Positive-QTOFsplash10-11b9-2690000000-6b57d5653347024bee7a2021-09-22Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
Tissue Locations
  • Adrenal Gland
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.000550-0.00138 uMChildren (1 - 13 years old)BothNormal details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.030 (0.012-0.057) uMChildren (1-13 years old)BothTerminal aldosterone biosynthesis defects details
Associated Disorders and Diseases
Disease References
Terminal aldosterone biosynthesis defects
  1. Peter M, Partsch CJ, Sippell WG: Multisteroid analysis in children with terminal aldosterone biosynthesis defects. J Clin Endocrinol Metab. 1995 May;80(5):1622-7. [PubMed:7745009 ]
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB021945
KNApSAcK IDNot Available
Chemspider ID10748
KEGG Compound IDC01124
BioCyc ID18-HYDROXYCORTICOSTERONE
BiGG IDNot Available
Wikipedia Link18-Hydroxycorticosterone
METLIN ID5308
PubChem Compound11222
PDB IDNot Available
ChEBI ID16485
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDMDB00000144
Good Scents IDNot Available
References
Synthesis ReferenceBoudi, Ahmed; Lemoine, Pascale; Viossat, Bernard; Tomas, Alain; Fiet, Jean; Galons, Herve. A convenient synthesis of 18-hydroxycorticosterone and 18-hydroxy-11-desoxycorticosterone via stereospecific hypoiodination of 20-hydroxysteroids. Tetrahedron (1999), 55(16), 5171-5176.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Sonino N, Chow D, Levine LS, New MI: Clinical response to metyrapone as indicated by measurement of mineralocorticoids and glucocorticoids in normal children. Clin Endocrinol (Oxf). 1981 Jan;14(1):31-9. [PubMed:7226574 ]
  2. Vecsei P, Abdelhamid S, Mittelstadt GV, Lichtwald K, Haack D, Lewicka S: Aldosterone metabolites and possible aldosterone precursors in hypertension. J Steroid Biochem. 1983 Jul;19(1A):345-51. [PubMed:6887870 ]
  3. Kooner JS, Few JD, Lee CY, Taylor GM, James VH: Investigation of the salivary 18-hydroxycorticosterone:aldosterone ratio in man using a direct assay. J Steroid Biochem Mol Biol. 1991 Mar;38(3):377-82. [PubMed:2009228 ]
  4. Gomez-Sanchez CE, Clore JN, Estep HL, Watlington CO: Effect of chronic adrenocorticotropin stimulation on the excretion of 18-hydroxycortisol and 18-oxocortisol. J Clin Endocrinol Metab. 1988 Aug;67(2):322-6. [PubMed:2839536 ]
  5. Honda M, Tsuchiya M, Tamura H, Watanabe H, Izumi Y, Hatano M, Shiratsuchi T, Den K, Kawaoi A, Okano T: In vivo and in vitro studies on steroid metabolism in a case of primary aldosteronism with multiple lesions of adenoma and nodular hyperplasia. Endocrinol Jpn. 1982 Oct;29(5):529-40. [PubMed:6303762 ]
  6. Vecsei P, Benraad TJ, Hofman J, Abdelhamid S, Haack D, Lichtwald K: Direct radioimmunoassays for "aldosterone" and "18-hydroxycorticosterone" in unprocessed urine, and their use in screening to distinguish primary aldosteronism from hypertension. Clin Chem. 1982 Mar;28(3):453-6. [PubMed:7067086 ]

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Gene Name:
CYP11B1
Uniprot ID:
P15538
Molecular weight:
57572.44
General function:
Involved in monooxygenase activity
Specific function:
Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.
Gene Name:
CYP11B2
Uniprot ID:
P19099
Molecular weight:
57559.62
Reactions
Corticosterone + reduced adrenal ferredoxin + Oxygen → 18-Hydroxycorticosterone + oxidized adrenal ferredoxin + Waterdetails
Corticosterone + Reduced adrenal ferredoxin + Oxygen → 18-Hydroxycorticosterone + Oxidized adrenal ferredoxin + Waterdetails
18-Hydroxycorticosterone + Reduced adrenal ferredoxin + Oxygen → Aldosterone + Oxidized adrenal ferredoxin + Waterdetails