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Record Information
Version4.0
StatusExpected but not Quantified
Creation Date2012-09-11 18:45:10 UTC
Update Date2019-07-23 06:14:50 UTC
HMDB IDHMDB0033978
Secondary Accession Numbers
  • HMDB33978
Metabolite Identification
Common NameEthyl acrylate
DescriptionEthyl acrylate is found in pineapple. Ethyl acrylate is a flavouring ingredient Although there are some reports claiming that ethyl acrylate is a carcinogen, major respected bodies regard the evidence of human carcinogenicity as weak and/or inconsistent. The International Agency for Research on Cancer stated, "Overall evaluation, Ethyl acrylate is possibly carcinogenic to humans (Group 2B)." The United States Environmental Protection Agency (EPA) states, "Human studies on occupational exposure to ethyl acrylate… have suggested a relationship between exposure to the chemical(s) and colorectal cancer, but the evidence is conflicting and inconclusive. In a study by the National Toxicology Program (NTP), increased incidences of squamous cell papillomas and carcinomas of the forestomach were observed in rats and mice exposed via gavage (experimentally placing the chemical in the stomach). However, the NTP recently determined that these data were not relevant to human carcinogenicity and removed ethyl acrylate from its list of carcinogens." (Occupational exposure generally involves exposure that occurs regularly, over an extended period of time). Ethyl acrylate is an organic compound primarily used in the preparation of various polymers. It is a clear liquid with an acrid penetrating odor. The human nose is capable of detecting this odor at a thousand times lower concentration then is considered harmful if continuously exposed for some period of time.
Structure
Data?1563862490
Synonyms
ValueSource
2-Propenoic acid ethyl esterHMDB
2-Propenoic acid, ethyl esterHMDB
2-Propenoic acid, ethyl ester, homopolymerHMDB
Acrylic acid ethyl esterHMDB
Acrylic acid, ethyl esterHMDB
Acrylic acid, ethyl ester (inhibited)HMDB
AethylacrylatHMDB
Akrylanem etyluHMDB
Carboset 511HMDB
CH2=chcooc2h5HMDB
EthoxycarbonylethyleneHMDB
Ethyl 2-propenoateHMDB
Ethyl 2-propenoate, homopolymerHMDB
Ethyl acrylate (inhibited)HMDB
Ethyl acrylate homopolymerHMDB
Ethyl acrylate polymerHMDB
Ethyl acrylate, inhibitedHMDB
Ethyl ester OF 2-propenoic acidHMDB
Ethyl propenoateHMDB
Ethyl propenoate, inhibitedHMDB
EthylacrylaatHMDB
EthylakrylatHMDB
Ethylester kyseliny akryloveHMDB
Etil acrilatoHMDB
EtilacrilatuluiHMDB
Etilacrilatului(roumanian)HMDB
FEMA 2418HMDB
Poly(acrylic acid, ethyl ester)HMDB
Poly(ethyl acrylate)HMDB
PolyethylacrylateHMDB
Propenoic acid,ethyl ester (ethylacrylate)HMDB
Chemical FormulaC5H8O2
Average Molecular Weight100.1158
Monoisotopic Molecular Weight100.0524295
IUPAC Nameethyl prop-2-enoate
Traditional Nameethyl acrylate
CAS Registry Number140-88-5
SMILES
CCOC(=O)C=C
InChI Identifier
InChI=1S/C5H8O2/c1-3-5(6)7-4-2/h3H,1,4H2,2H3
InChI KeyJIGUQPWFLRLWPJ-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as acrylic acid esters. These are organic compounds containing and ester acrylic acid (CH2=CHC(=O)OH).
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAcrylic acids and derivatives
Direct ParentAcrylic acid esters
Alternative Parents
Substituents
  • Acrylic acid ester
  • Alpha,beta-unsaturated carboxylic ester
  • Enoate ester
  • Carboxylic acid ester
  • Monocarboxylic acid or derivatives
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Environmental role:

Biological role:

Physical Properties
StateLiquid
Experimental Properties
PropertyValueReference
Melting Point-71.2 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility15 mg/mL at 25 °CNot Available
LogP1.32Not Available
Predicted Properties
PropertyValueSource
Water Solubility38.8 g/LALOGPS
logP1.24ALOGPS
logP1.27ChemAxon
logS-0.41ALOGPS
pKa (Strongest Basic)-6.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area26.3 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity26.81 m³·mol⁻¹ChemAxon
Polarizability10.5 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectrum TypeDescriptionSplash KeyView
GC-MSGC-MS Spectrum - EI-B (Non-derivatized)splash10-0a4i-9000000000-8762b44567cd7afeb692JSpectraViewer | MoNA
GC-MSGC-MS Spectrum - EI-B (Non-derivatized)splash10-0a6r-9000000000-25b2b71f04040f0959ddJSpectraViewer | MoNA
GC-MSGC-MS Spectrum - EI-B (Non-derivatized)splash10-0a4i-9000000000-9fb2ce6a8c6e827cca22JSpectraViewer | MoNA
GC-MSGC-MS Spectrum - EI-B (Non-derivatized)splash10-0a4i-9000000000-96cab8193fbae26c0e12JSpectraViewer | MoNA
GC-MSGC-MS Spectrum - EI-B (Non-derivatized)splash10-0a4i-9000000000-8762b44567cd7afeb692JSpectraViewer | MoNA
GC-MSGC-MS Spectrum - EI-B (Non-derivatized)splash10-0a6r-9000000000-25b2b71f04040f0959ddJSpectraViewer | MoNA
GC-MSGC-MS Spectrum - EI-B (Non-derivatized)splash10-0a4i-9000000000-9fb2ce6a8c6e827cca22JSpectraViewer | MoNA
GC-MSGC-MS Spectrum - EI-B (Non-derivatized)splash10-0a4i-9000000000-96cab8193fbae26c0e12JSpectraViewer | MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-0a6r-9000000000-b44a167f27a11982ce88JSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0udi-6900000000-afe7a2cd2b3f23523df8JSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0a4i-9200000000-b2987d0fef61f6de593eJSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a4i-9000000000-63a2abd18e012c3564b2JSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0f6t-9000000000-b878ab9b418ac14be652JSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0udj-9000000000-75144951146aefa9cb6cJSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0udi-9000000000-e6c22ca53e8d3d79f0b3JSpectraViewer | MoNA
MSMass Spectrum (Electron Ionization)splash10-0a4i-9000000000-200bb2f29d9c1c5820c7JSpectraViewer | MoNA
1D NMR1H NMR SpectrumNot AvailableJSpectraViewer
1D NMR13C NMR SpectrumNot AvailableJSpectraViewer
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB012210
KNApSAcK IDNot Available
Chemspider ID8490
KEGG Compound IDC19238
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkEthyl acrylate
METLIN IDNot Available
PubChem Compound8821
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .