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Record Information
Version4.0
StatusExpected but not Quantified
Creation Date2012-09-11 19:45:35 UTC
Update Date2019-07-23 06:17:01 UTC
HMDB IDHMDB0034831
Secondary Accession Numbers
  • HMDB34831
Metabolite Identification
Common NameOrthoperiodic acid
DescriptionOrthoperiodic acid, also known as H5IO6 or [io(OH)5], belongs to the class of inorganic compounds known as halogen oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is a halogen. Orthoperiodic acid is possibly neutral. Outside of the human body, Orthoperiodic acid has been detected, but not quantified in, milk and milk products. This could make orthoperiodic acid a potential biomarker for the consumption of these foods. Periodate is part of a series of oxyacids in which iodine can assume oxidation states of −1, +1, +3, +5, or +7. This process is often used in labeling saccharides with fluorescent molecules or other tags such as biotin. This can be useful in determining the structure of carbohydrates as periodic acid can be used to open saccharide rings. Metaperiodic acid can also be prepared from various orthoperiodates by treatment with dilute nitric acid. Like all periodates it can exist in two forms: orthoperiodic acid, with the chemical formula H5IO6 and metaperiodic acid, which has the formula HIO4. Orthoperiodic acid forms monoclinic crystals (space group P21/n) consisting of slightly deformed IO6 octahedron interlinked via bridging hydrogens. H5IO6 ⇌ H4IO−6 + H+, pKa 3.29H4IO−6 ⇌ H3IO2−6 + H+, pKa 8.31H3IO2−6 ⇌ H2IO3−6 + H+, pKa 11.60There being two forms of periodic acid, it follows that two types of periodate salts are formed.
Structure
Data?1563862621
Synonyms
ValueSource
[IO(OH)5]ChEBI
H5IO6ChEBI
OrthoperiodateGenerator
Hexaoxoiodic(5-) acidHMDB
Paraperiodic acidHMDB
Pentahydrogen hexaoxoiodate(5-)HMDB
PentahydroxidooxidoiodineHMDB
Pentahydroxy-lambda(7)-iodanoneHMDB
Periodic acidHMDB
Periodic acid (H5io6)HMDB
Periodic acid, crystHMDB
Acids, periodicMeSH
Periodic acid (hio4)MeSH
Acid, paraperiodicMeSH
Acid, periodicMeSH
Periodic acidsMeSH
Chemical FormulaH5IO6
Average Molecular Weight227.9406
Monoisotopic Molecular Weight227.913081312
IUPAC Nametetrahydroxyiodous acid
Traditional Nametetrahydroxyiodous acid
CAS Registry Number10450-60-9
SMILES
O[I](O)(O)(O)(O)=O
InChI Identifier
InChI=1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)
InChI KeyTWLXDPFBEPBAQB-UHFFFAOYSA-N
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as halogen oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is a halogen.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassHalogen organides
Sub ClassHalogen oxides
Direct ParentHalogen oxides
Alternative Parents
Substituents
  • Halogen oxide
  • Inorganic oxide
Molecular FrameworkNot Available
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Role

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point130 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-0.58ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area118.22 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity27.61 m³·mol⁻¹ChemAxon
Polarizability13.13 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Not Available
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB013395
KNApSAcK IDNot Available
Chemspider ID23622
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkPeriodic acid
METLIN IDNot Available
PubChem Compound25289
PDB IDNot Available
ChEBI ID29150
Food Biomarker OntologyNot Available
VMH IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .