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Record Information
Version4.0
StatusDetected and Quantified
Creation Date2012-09-13 11:41:19 UTC
Update Date2019-07-23 06:35:06 UTC
HMDB IDHMDB0041827
Secondary Accession Numbers
  • HMDB41827
Metabolite Identification
Common NameAmmonium
DescriptionAmmonium is an important source of nitrogen for many plant species, especially those growing on hypoxic soils. However, it is also toxic to most crop species and is rarely applied as a sole nitrogen source. The ammonium (more obscurely: aminium) cation is a positively charged polyatomic cation with the chemical formula NH4+. It is formed by the protonation of ammonia (NH3). Ammonium is also a general name for positively charged or protonated substituted amines and quaternary ammonium cations (NR4+), where one or more hydrogen atoms are replaced by organic radical groups (indicated by R). Ammonium is found to be associated with N-acetylglutamate synthetase deficiency, which is an inborn error of metabolism.
Structure
Data?1563863706
Synonyms
ValueSource
[NH4](+)ChEBI
AMMONIUM ionChEBI
Ammonium(1+)ChEBI
NH4+ChEBI
NH4(+)ChEBI
Ammonia ionHMDB
Ammonium chlorideHMDB
AzaniumHMDB
[NH4]+HMDB
Chemical FormulaH4N
Average Molecular Weight18.0385
Monoisotopic Molecular Weight18.034374133
IUPAC Nameazanium
Traditional Nameazanium
CAS Registry Number14798-03-9
SMILES
[NH4+]
InChI Identifier
InChI=1S/H3N/h1H3/p+1
InChI KeyQGZKDVFQNNGYKY-UHFFFAOYSA-O
Chemical Taxonomy
DescriptionThis compound belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other nonmetals'.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassHomogeneous other non-metal compounds
Sub ClassNot Available
Direct ParentHomogeneous other non-metal compounds
Alternative Parents
Substituents
  • Homogeneous other non metal
  • Quaternary ammonium salt
  • Amine
  • Acyclic compound
Molecular FrameworkAcyclic compounds
External Descriptors
Ontology
Disposition

Biological location:

Source:

Role

Biological role:

Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility10.2 mg/mL at 20 °CNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-0.98ChemAxon
pKa (Strongest Basic)8.86ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity16.31 m³·mol⁻¹ChemAxon
Polarizability2.38 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-014i-9000000000-865a280eac64792eb43eJSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-014i-9000000000-865a280eac64792eb43eJSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-014i-9000000000-865a280eac64792eb43eJSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-014i-9000000000-b764e01bee53b44bf449JSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-014i-9000000000-b764e01bee53b44bf449JSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-014i-9000000000-b764e01bee53b44bf449JSpectraViewer | MoNA
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
  • Sweat
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified22-55 uMInfant (0-1 year old)Not SpecifiedNormal details
BloodDetected and Quantified<40 uMAdult (>18 years old)BothNormal details
SweatDetected and Quantified21630-114850 uMAdult (60 years old)Male
Normal
details
SweatDetected and Quantified< 10 uMAdult (40 years old)Male
Normal
details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified86 uMInfant (0-1 year old)MaleCoenzyme Q10 deficiency, primary, 1 details
BloodDetected and Quantified78 uMAdult (>18 years old)Male
N-Acetylglutamate synthetase deficiency
details
Associated Disorders and Diseases
Disease References
N-acetylglutamate synthetase deficiency
  1. Hinnie J, Colombo JP, Wermuth B, Dryburgh FJ: N-Acetylglutamate synthetase deficiency responding to carbamylglutamate. J Inherit Metab Dis. 1997 Nov;20(6):839-40. [PubMed:9427158 ]
Coenzyme Q10 deficiency, primary, 1
  1. Diomedi-Camassei F, Di Giandomenico S, Santorelli FM, Caridi G, Piemonte F, Montini G, Ghiggeri GM, Murer L, Barisoni L, Pastore A, Muda AO, Valente ML, Bertini E, Emma F: COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement. J Am Soc Nephrol. 2007 Oct;18(10):2773-80. doi: 10.1681/ASN.2006080833. Epub 2007 Sep 12. [PubMed:17855635 ]
Associated OMIM IDs
  • 608300 (N-acetylglutamate synthetase deficiency)
  • 607426 (Coenzyme Q10 deficiency, primary, 1)
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID218
KEGG Compound IDC01342
BioCyc IDAMMONIUM
BiGG IDNot Available
Wikipedia LinkAmmonium
METLIN IDNot Available
PubChem Compound16741146
PDB IDNH4
ChEBI ID28938
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available