| Enzymes |
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| Name: |
Cytosolic phospholipase A2
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| Reactions: |
- 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate [RN:R07291]
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| Gene Name: |
PLA2G4A |
| Uniprot ID: |
P47712  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Phospholipase A2
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| Reactions: |
- phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate [RN:R01313]
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| Gene Name: |
PLA2G1B |
| Uniprot ID: |
P04054  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Lactoperoxidase
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| Reactions: |
- donor + H2O2 = oxidized donor + 2 H2O [RN:R03532]
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| Gene Name: |
LPO |
| Uniprot ID: |
P22079  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Myeloperoxidase
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| Reactions: |
- donor + H2O2 = oxidized donor + 2 H2O [RN:R03532]
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| Gene Name: |
MPO |
| Uniprot ID: |
P05164  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Arylsulfatase B
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| Reactions: |
- Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate [RN:R07823] ALL_REAC R07823(G)
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| Gene Name: |
ARSB |
| Uniprot ID: |
P15848  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Type I inositol-1,4,5-trisphosphate 5-phosphatase
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| Reactions: |
- (1) D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate [RN:R03394]
- (2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate [RN:R03430]
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| Gene Name: |
INPP5A |
| Uniprot ID: |
Q14642  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Deoxyribonuclease-1
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| Reactions: |
- Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products
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| Gene Name: |
DNASE1 |
| Uniprot ID: |
P24855  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Steryl-sulfatase
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| Reactions: |
- 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate [RN:R03404]
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| Gene Name: |
STS |
| Uniprot ID: |
P08842  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Fumarylacetoacetase
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| Reactions: |
- 4-fumarylacetoacetate + H2O = acetoacetate + fumarate [RN:R01364]
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| Gene Name: |
FAH |
| Uniprot ID: |
P16930  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Transketolase-like protein 1
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| Reactions: |
- sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate [RN:R01641]
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| Gene Name: |
TKTL1 |
| Uniprot ID: |
P51854  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Transketolase
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| Reactions: |
- sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate [RN:R01641]
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| Gene Name: |
TKT |
| Uniprot ID: |
P29401  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Arachidonate 5-lipoxygenase
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| Reactions: |
- (1) arachidonate + O2 = (5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O (overall reaction) [RN:R08527]
- (2) (1a) arachidonate + O2 = (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate [RN:R01595]
- (3) (1b) (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate = (5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O [RN:R03058]
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| Gene Name: |
ALOX5 |
| Uniprot ID: |
P09917  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Gamma-enolase
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| Reactions: |
- 2-phospho-D-glycerate = phosphoenolpyruvate + H2O [RN:R00658]
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| Gene Name: |
ENO2 |
| Uniprot ID: |
P09104  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Ceramide kinase
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| Reactions: |
- ATP + ceramide = ADP + ceramide 1-phosphate [RN:R01495]
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| Gene Name: |
CERK |
| Uniprot ID: |
Q8TCT0  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Iduronate 2-sulfatase
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| Reactions: |
- Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin [RN:R07812 R07821] ALL_REAC R07812(G) R07821(G) REFERENCE 1 [PMID:6816283] AUTHORS Archer IM, Harper PS, Wusteman FS. TITLE Multiple forms of iduronate 2-sulphate sulphatase in human tissues and body fluids. JOURNAL Biochim. Biophys. Acta. 708 (1982) 134-40. ORGANISM Homo sapiens [GN:hsa] REFERENCE 2 [PMID:4269173] AUTHORS Bach G, Eisenberg F Jr, Cantz M, Neufeld EF. TITLE The defect in the Hunter syndrome: deficiency of sulfoiduronate sulfatase. JOURNAL Proc. Natl. Acad. Sci. U. S. A. 70 (1973) 2134-8. ORGANISM Homo sapiens [GN:hsa] REFERENCE 3 [PMID:6945876] AUTHORS Di Natale P, Ronsisvalle L. TITLE Identification and partial characterization of two enzyme forms of iduronate sulfatase from human placenta. JOURNAL Biochim. Biophys. Acta. 661 (1981) 106-11. ORGANISM Homo sapiens [GN:hsa] REFERENCE 4 [PMID:6950934] AUTHORS Yutaka T, Fluharty AL, Stevens RL, Kihara H. TITLE Purification and some properties of human liver iduronate sulfatase. JOURNAL J. Biochem. (Tokyo). 91 (1982) 433-41. ORGANISM Homo sapiens [GN:hsa]
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| Gene Name: |
IDS |
| Uniprot ID: |
P22304  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
N-acetylglucosamine-6-sulfatase
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| Reactions: |
- Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate [RN:R07808 R07819] ALL_REAC R07808(G) R07819(G)
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| Gene Name: |
GNS |
| Uniprot ID: |
P15586  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Laforin
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| Reactions: |
- protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
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| Gene Name: |
EPM2A |
| Uniprot ID: |
O95278  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Coagulation factor X
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| Reactions: |
- Selective cleavage of Arg!Thr and then Arg!Ile bonds in prothrombin to form thrombin
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| Gene Name: |
F10 |
| Uniprot ID: |
P00742  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Coagulation factor VII
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| Reactions: |
- Selective cleavage of Arg!Ile bond in factor X to form factor Xa INHIBITOR Isoflurophate [CPD:C00202]
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| Gene Name: |
F7 |
| Uniprot ID: |
P08709  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Alpha-amylase 1
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| Reactions: |
- Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units ALL_REAC (other) R02108 R06209(G)
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| Gene Name: |
AMY1A |
| Uniprot ID: |
P04745  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Pancreatic alpha-amylase
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| Reactions: |
- Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units ALL_REAC (other) R02108 R06209(G)
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| Gene Name: |
AMY2A |
| Uniprot ID: |
P04746  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Matrix metalloproteinase-9
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| Reactions: |
- Cleavage of gelatin types I and V and collagen types IV and V COFACTOR Zinc [CPD:C00038]
- Metal [CPD:C00050]
- Calcium [CPD:C00076]
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| Gene Name: |
MMP9 |
| Uniprot ID: |
P14780  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Alpha-amylase 2B
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| Reactions: |
- Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units ALL_REAC (other) R02108 R06209(G)
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| Gene Name: |
AMY2B |
| Uniprot ID: |
P19961  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
N-acetylgalactosamine-6-sulfatase
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| Reactions: |
- Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate [RN:R07806] ALL_REAC R07806(G) REFERENCE 1 [PMID:6939689] AUTHORS Epstein EH Jr, Leventhal ME. TITLE Steroid sulfatase of human leukocytes and epidermis and the diagnosis of recessive X-linked ichthyosis. JOURNAL J. Clin. Invest. 67 (1981) 1257-62. ORGANISM Homo sapiens [GN:hsa] REFERENCE 2 [PMID:6213226] AUTHORS Glossl J, Kresse H. TITLE Impaired degradation of keratan sulphate by Morquio A fibroblasts. JOURNAL Biochem. J. 203 (1982) 335-8. ORGANISM Homo sapiens [GN:hsa] REFERENCE 3 [PMID:7213753] AUTHORS Lim CT, Horwitz AL. TITLE Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase. JOURNAL Biochim. Biophys. Acta. 657 (1981) 344-55. ORGANISM Homo sapiens [GN:hsa] REFERENCE 4 [PMID:6814909] AUTHORS Sorensen SH, Noren O, Sjostrom H, Danielsen EM. TITLE Amphiphilic pig intestinal microvillus maltase/glucoamylase. Structure and specificity. JOURNAL Eur. J. Biochem. 126 (1982) 559-68. ORGANISM Sus scofa [GN:ssc] REFERENCE 5 [PMID:6809361] AUTHORS Yutaka T, Okada S, Kato T, Inui K, Yabuuhi H. TITLE Galactose 6-sulfate sulfatase activity in Morquio syndrome. JOURNAL Clin. Chim. Acta. 122 (1982) 169-80. ORGANISM shark
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| Gene Name: |
GALNS |
| Uniprot ID: |
P34059  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Interstitial collagenase
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| Reactions: |
- Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775!Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue COFACTOR Zinc [CPD:C00038]
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| Gene Name: |
MMP1 |
| Uniprot ID: |
P03956  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Stromelysin-1
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| Reactions: |
- Preferential cleavage where P1', P2' and P3' are hydrophobic residues
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| Gene Name: |
MMP3 |
| Uniprot ID: |
P08254  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Vitamin D 25-hydroxylase
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| Reactions: |
- 5beta-cholestane-3alpha,7alpha,12alpha-triol + NADPH + H+ + O2 = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + NADP+ + H2O [RN:R04807]
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| Gene Name: |
CYP2R1 |
| Uniprot ID: |
Q6VVX0  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
72 kDa type IV collagenase
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| Reactions: |
- Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly!Ile-Ala-Gly-Gln
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| Gene Name: |
MMP2 |
| Uniprot ID: |
P08253  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Matrix metalloproteinase-14
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| Reactions: |
- Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain
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| Gene Name: |
MMP14 |
| Uniprot ID: |
P50281  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Matrilysin
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| Reactions: |
- Cleavage of Ala14!Leu and Tyr16!Leu in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha2(I) > alpha1(I)
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| Gene Name: |
MMP7 |
| Uniprot ID: |
P09237  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Peroxiredoxin-2
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| Reactions: |
- 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH [RN:R07180]
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| Gene Name: |
PRDX2 |
| Uniprot ID: |
P32119  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Dual oxidase 2
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| Reactions: |
- NAD(P)H + H+ + O2 = NAD(P)+ + H2O2 [RN:R07171 R07172]
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| Gene Name: |
DUOX2 |
| Uniprot ID: |
Q9NRD8  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Dual oxidase 1
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| Reactions: |
- NAD(P)H + H+ + O2 = NAD(P)+ + H2O2 [RN:R07171 R07172]
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| Gene Name: |
DUOX1 |
| Uniprot ID: |
Q9NRD9  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Transketolase-like protein 2
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| Reactions: |
- sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate [RN:R01641]
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| Gene Name: |
TKTL2 |
| Uniprot ID: |
Q9H0I9  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Complement C1r subcomponent
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| Reactions: |
- Selective cleavage of Lys(or Arg)!Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42)
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| Gene Name: |
C1R |
| Uniprot ID: |
P00736  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Complement C1s subcomponent precursor
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| Reactions: |
- Cleavage of Arg!Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)!Lys bond in complement component C2 to form C2a and C2b: the classical pathway C3 convertase
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| Gene Name: |
C1S |
| Uniprot ID: |
P09871  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Calpain-3
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| Reactions: |
- Broad endopeptidase activity
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| Gene Name: |
CAPN3 |
| Uniprot ID: |
P20807  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Calpain-8
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| Reactions: |
- Broad endopeptidase specificity
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| Gene Name: |
CAPN8 |
| Uniprot ID: |
A6NHC0  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Furin
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| Reactions: |
- Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg! bonds, where Xaa can by any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors
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| Gene Name: |
FURIN |
| Uniprot ID: |
P09958  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Klotho
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| Reactions: |
- a beta-D-glucuronoside + H2O = D-glucuronate + an alcohol [RN:R01478]
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| Gene Name: |
KL |
| Uniprot ID: |
Q9UEF7  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Mannan-binding lectin serine protease 2
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| Reactions: |
- Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg!Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg!Ala-Leu-Glu-Ile)
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| Gene Name: |
MASP2 |
| Uniprot ID: |
O00187  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Stromelysin-2
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| Reactions: |
- Similar to stromelysin 1, but action on collagen types III, IV and V is weak
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| Gene Name: |
MMP10 |
| Uniprot ID: |
P09238  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Macrophage metalloelastase
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| Reactions: |
- Hydrolysis of soluble and insoluble elastin [1]. Specific cleavages are also produced at -Ala14!Leu- and -Tyr16!Leu- in the B chain of insulin [2]
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| Gene Name: |
MMP12 |
| Uniprot ID: |
P39900  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Neutrophil collagenase
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| Reactions: |
- Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, interstitial collagenase, this enzyme cleaves type III collagen more slowly than type I
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| Gene Name: |
MMP8 |
| Uniprot ID: |
P22894  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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| Name: |
Neuroendocrine convertase 1
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| Reactions: |
- Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg! bonds
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| Gene Name: |
PCSK1 |
| Uniprot ID: |
P29120  |
| Protein Sequence: |
FASTA |
| Gene Sequence: |
FASTA |
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