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Human Metabolome Database Version 3.5

Showing metabocard for Chlorine (HMDB00492)

• Identification
• Taxonomy
• Ontology
• Physical properties
• Spectra
• Biological properties
• Concentrations
• Links
• References

enzymes (102) transporters (8)

• Blood
• Urine

Record Information
Version	3.5
Creation Date	2006-08-15 14:10:24 -0600
Update Date	2013-02-08 17:08:41 -0700
HMDB ID	HMDB00492
Secondary Accession Numbers	HMDB02073
Metabolite Identification
Common Name	Chlorine
Description	Under standard conditions, chlorine exists as a diatomic molecule. Chlorine is a highly toxic, pale yellow-green gas that has a specific strong smell. In nature, chlorine is most abundant as a chloride ion. Physiologically, this it. exists as an ion in the body. The chloride ion is an essential anion that the body needs for many critical functions. It also helps keep the body's acid-base balance. The amount of chloride in the blood is carefully controlled by the kidneys. Chloride ions have important physiological roles. For instance, in the central nervous system, the inhibitory action of glycine and some of the action of GABA relies on the entry of Cl- into specific neurons. Also, the chloride-bicarbonate exchanger biological transport protein relies on the chloride ion to increase the blood's capacity of carbon dioxide, in the form of the bicarbonate ion. Chloride-transporting proteins (CLC) play fundamental roles in many tissues in the plasma membrane as well as in intracellular membranes. CLC proteins form a gene family that comprises nine members in mammals, at least four of which are involved in human genetic diseases. GABA(A) receptors are pentameric complexes that function as ligand-gated chloride ion channels. WNK kinases are a family of serine-threonine kinases that have been shown to play an essential role in the regulation of electrolyte homeostasis, and they are found in diverse epithelia throughout the body that are involved in chloride ion flux. Cystic fibrosis (CF) is caused by alterations in the CF transmembrane conductance regulator (CFTCR) gene that result in deranged sodium and chloride ion transport channels. (PMID: 17539703 , 17729441 , 17562499 , 15300163 ) (For a complete review see Evans, Richard B. Chlorine: state of the art. Lung (2005), 183(3), 151-167. PMID: 16078037 ).
Structure	Download: MOL | SDF | SMILES | InChI Display: 2D Structure | 3D Structure
Synonyms	Bertholite Chloor Chlor Chlore Chloride Chloride ion Chlorine Chlorine gas Cl Cl2 Diatomic chlorine Dichlorine Molecular chlorine
Chemical Formula	Cl
Average Molecular Weight	35.453
Monoisotopic Molecular Weight	34.968852707
IUPAC Name	chloride
Traditional IUPAC Name	chloride
CAS Registry Number	16887-00-6
SMILES	[Cl-]
InChI Identifier	InChI=1S/ClH/h1H/p-1
InChI Key	VEXZGXHMUGYJMC-UHFFFAOYSA-M
Chemical Taxonomy
Kingdom	Inorganic Compounds
Super Class	Homogeneous Non-metal Compounds
Class	Homogeneous Halogens
Sub Class	N/A
Other Descriptors	an anion(Cyc) halide anion(ChEBI) monoatomic chlorine(ChEBI)
Substituents	N/A
Direct Parent	Homogeneous Halogens
Ontology
Status	Detected and Quantified
Origin	Endogenous Food Drug
Biofunction	Osmolyte, enzyme cofactor, signalling
Application	Not Available
Cellular locations	Cytoplasm Extracellular
Physical Properties
State	Gas
Experimental Properties	Property Value Reference Melting Point -101 °C Not Available Boiling Point Not Available Not Available Water Solubility 6.3 mg/mL at 25 °C Not Available LogP Not Available Not Available
Predicted Properties	Property Value Source Water Solubility ALOGPS LogP 0.61 ChemAxon pKa (strongest acidic) -7 ChemAxon Hydrogen Acceptor Count 0 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 0 A2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 5.62 ChemAxon Polarizability 2.39 ChemAxon Formal Charge -1 ChemAxon Physiological Charge -1 ChemAxon
Spectra
	Not Available
Biological Properties
Cellular Locations	Cytoplasm Extracellular
Biofluid Locations	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	All Tissues
Pathways	Not Available
Normal Concentrations
	Biofluid Status Value Age Sex Condition Comments Blood Detected and Quantified 110000.0 +/- 4500.0 uM Newborn (0-30 days old) Not Specified Normal Not Available Blood Detected and Quantified 103200.0 +/- 2640.0 uM Infant (0-1 year old) Not Specified Normal Not Available Blood Detected and Quantified 103700.0 +/- 1900.0 uM Adult (>18 years old) Both Normal Not Available Cerebrospinal Fluid (CSF) Detected and Quantified 0.06 +/- 0.08 uM Adult (>18 years old) Both Normal Not Available Urine Detected and Quantified 8881.6 (5263.2-17763.2) umol/mmol creatinine Adult (>18 years old) Both Normal Not Available
Abnormal Concentrations
	Not Available
Associated Disorders and Diseases
Disease References	None
Associated OMIM IDs	None
External Links
DrugBank ID	Not Available
Phenol Explorer Compound ID	Not Available
Phenol Explorer Metabolite ID	Not Available
FoodDB ID	FDB006557
KNApSAcK ID	Not Available
Chemspider ID	4514529
KEGG Compound ID	Not Available
BioCyc ID	CPD-4521
BiGG ID	50130
Wikipedia Link	Chlorine
NuGOwiki Link	HMDB00492
Metagene Link	HMDB00492
METLIN ID	Not Available
PubChem Compound	24526
PDB ID	CL
ChEBI ID	29311
References
Synthesis Reference	Weber, Rainer; Bulan, Andreas; Haas, Michel; Warsitz, Rafael; Werner, Knud. Production of chlorine from hydrogen chloride and oxygen. PCT Int. Appl. (2007), 30pp. CODEN: PIXXD2 WO 2007134861 A1 20071129 CAN 148:35931 AN 2007:1361621
Material Safety Data Sheet (MSDS)	Download (PDF)
General References	Pubmed: 7539703 Zifarelli G, Pusch M: CLC chloride channels and transporters: a biophysical and physiological perspective. Rev Physiol Biochem Pharmacol. 2007;158:23-76. Pubmed: 17729441 Tarran R, Donaldson S, Boucher RC: Rationale for hypertonic saline therapy for cystic fibrosis lung disease. Semin Respir Crit Care Med. 2007 Jun;28(3):295-302. Pubmed: 17562499 Kahle KT, Wilson FH, Lalioti M, Toka H, Qin H, Lifton RP: WNK kinases: molecular regulators of integrated epithelial ion transport. Curr Opin Nephrol Hypertens. 2004 Sep;13(5):557-62. Pubmed: 15300163

---

Enzymes
Name: Protein arginine N-methyltransferase 3 Reactions: Gene Name: PRMT3 Uniprot ID: O60678 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Glutathione S-transferase theta-1 Reactions: RX + glutathione = HX + R-S-glutathione [RN:R03522 R08511 R08512] Gene Name: GSTT1 Uniprot ID: P30711 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Serine/threonine-protein kinase Sgk1 Reactions: ATP + a protein = ADP + a phosphoprotein [RN:R00162] Gene Name: SGK1 Uniprot ID: O00141 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Serine/threonine-protein kinase WNK4 Reactions: ATP + a protein = ADP + a phosphoprotein [RN:R00162] Gene Name: WNK4 Uniprot ID: Q96J92 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Angiotensin-converting enzyme Reactions: Release of a C-terminal dipeptide, oligopeptide!Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II COFACTOR Zinc [CPD:C00038] INHIBITOR (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(mercaptomethyl)-1-oxoprolyl]g lycine [CPD:C01313] (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(mercaptomethyl)-1-oxoprolyl]- (S)-alanine [CPD:C01314] (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-oxoprolyl ]glycine benzyl ester [CPD:C01315] (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-oxoprolyl ]-(S)-alanine benzyl ester [CPD:C01316] Gene Name: ACE Uniprot ID: P12821 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Protein arginine N-methyltransferase 5 Reactions: S-adenosyl-L-methionine + histone-arginine = S-adenosyl-L-homocysteine + histone-Nomega-methyl-arginine [RN:R04718] Gene Name: PRMT5 Uniprot ID: O14744 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Alpha-amylase 1 Reactions: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units ALL_REAC (other) R02108 R06209(G) Gene Name: AMY1A Uniprot ID: P04745 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Pancreatic alpha-amylase Reactions: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units ALL_REAC (other) R02108 R06209(G) Gene Name: AMY2A Uniprot ID: P04746 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Cystic fibrosis transmembrane conductance regulator Reactions: ATP + H2O = ADP + phosphate [RN:R00086] Gene Name: CFTR Uniprot ID: P13569 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Alpha-amylase 2B Reactions: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units ALL_REAC (other) R02108 R06209(G) Gene Name: AMY2B Uniprot ID: P19961 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Metabotropic glutamate receptor 5 Reactions: Gene Name: GRM5 Uniprot ID: P41594 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit gamma-2 Reactions: Gene Name: GABRG2 Uniprot ID: P18507 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Potassium voltage-gated channel subfamily KQT member 1 Reactions: Gene Name: KCNQ1 Uniprot ID: P51787 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Chloride channel protein 1 Reactions: Gene Name: CLCN1 Uniprot ID: P35523 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Reactions: Gene Name: HCN2 Uniprot ID: Q9UL51 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Equilibrative nucleoside transporter 4 Reactions: Gene Name: SLC29A4 Uniprot ID: Q7RTT9 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Pendrin Reactions: Gene Name: SLC26A4 Uniprot ID: O43511 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 12 member 3 Reactions: --- [] Gene Name: SLC12A3 Uniprot ID: P55017 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Excitatory amino acid transporter 5 Reactions: Gene Name: SLC1A7 Uniprot ID: O00341 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Chloride anion exchanger Reactions: Gene Name: SLC26A3 Uniprot ID: P40879 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 26 member 9 Reactions: Gene Name: SLC26A9 Uniprot ID: Q7LBE3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Anion exchange transporter Reactions: Gene Name: SLC26A7 Uniprot ID: Q8TE54 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Testis anion transporter 1 Reactions: Gene Name: SLC26A8 Uniprot ID: Q96RN1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Large neutral amino acids transporter small subunit 4 Reactions: Gene Name: SLC43A2 Uniprot ID: Q8N370 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Bestrophin-1 Reactions: Gene Name: BEST1 Uniprot ID: O76090 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Bestrophin-2 Reactions: Gene Name: BEST2 Uniprot ID: Q8NFU1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Bestrophin-3 Reactions: Gene Name: BEST3 Uniprot ID: Q8N1M1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Bestrophin-4 Reactions: Gene Name: BEST4 Uniprot ID: Q8NFU0 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 26 member 10 Reactions: Gene Name: SLC26A10 Uniprot ID: Q8NG04 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Prestin Reactions: Gene Name: SLC26A5 Uniprot ID: P58743 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Anoctamin-10 Reactions: Gene Name: ANO10 Uniprot ID: Q9NW15 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Anoctamin-1 Reactions: Gene Name: ANO1 Uniprot ID: Q5XXA6 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Anoctamin-2 Reactions: Gene Name: ANO2 Uniprot ID: Q9NQ90 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Anoctamin-3 Reactions: Gene Name: ANO3 Uniprot ID: Q9BYT9 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Anoctamin-4 Reactions: Gene Name: ANO4 Uniprot ID: Q32M45 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Anoctamin-5 Reactions: Gene Name: ANO5 Uniprot ID: Q75V66 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Anoctamin-6 Reactions: Gene Name: ANO6 Uniprot ID: Q4KMQ2 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Anoctamin-7 Reactions: Gene Name: ANO7 Uniprot ID: Q6IWH7 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Anoctamin-8 Reactions: Gene Name: ANO8 Uniprot ID: Q9HCE9 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Anoctamin-9 Reactions: Gene Name: ANO9 Uniprot ID: A1A5B4 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Calcium-activated chloride channel regulator 2 Reactions: Gene Name: CLCA2 Uniprot ID: Q9UQC9 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Calcium-activated chloride channel regulator 4 Reactions: Gene Name: CLCA4 Uniprot ID: Q14CN2 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Potassium channel subfamily T member 1 Reactions: Gene Name: KCNT1 Uniprot ID: Q5JUK3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Potassium channel subfamily T member 2 Reactions: Gene Name: KCNT2 Uniprot ID: Q6UVM3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Potassium voltage-gated channel subfamily E member 3 Reactions: Gene Name: KCNE3 Uniprot ID: Q9Y6H6 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Phospholemman Reactions: Gene Name: FXYD1 Uniprot ID: O00168 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Angiotensin-converting enzyme 2 Reactions: angiotensin II + H2O = angiotensin-(1--7) + L-phenylalanine Gene Name: ACE2 Uniprot ID: Q9BYF1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Atrial natriuretic peptide receptor 3 Reactions: Gene Name: NPR3 Uniprot ID: P17342 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Barttin Reactions: Gene Name: BSND Uniprot ID: Q8WZ55 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Dipeptidyl peptidase 1 Reactions: Release of an N-terminal dipeptide, Xaa-Yaa!Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro Gene Name: CTSC Uniprot ID: P53634 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Chloride channel CLIC-like protein 1 Reactions: Gene Name: CLCC1 Uniprot ID: Q96S66 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Chloride channel protein ClC-Ka Reactions: Gene Name: CLCNKA Uniprot ID: P51800 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Chloride channel protein ClC-Kb Reactions: Gene Name: CLCNKB Uniprot ID: P51801 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Chloride channel protein 2 Reactions: Gene Name: CLCN2 Uniprot ID: P51788 Protein Sequence: FASTA Gene Sequence: FASTA
Name: H(+)/Cl(-) exchange transporter 3 Reactions: Gene Name: CLCN3 Uniprot ID: P51790 Protein Sequence: FASTA Gene Sequence: FASTA
Name: H(+)/Cl(-) exchange transporter 4 Reactions: Gene Name: CLCN4 Uniprot ID: P51793 Protein Sequence: FASTA Gene Sequence: FASTA
Name: H(+)/Cl(-) exchange transporter 5 Reactions: Gene Name: CLCN5 Uniprot ID: P51795 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Chloride transport protein 6 Reactions: Gene Name: CLCN6 Uniprot ID: P51797 Protein Sequence: FASTA Gene Sequence: FASTA
Name: H(+)/Cl(-) exchange transporter 7 Reactions: Gene Name: CLCN7 Uniprot ID: P51798 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Chloride intracellular channel protein 1 Reactions: Gene Name: CLIC1 Uniprot ID: O00299 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Chloride intracellular channel protein 2 Reactions: Gene Name: CLIC2 Uniprot ID: O15247 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Chloride intracellular channel protein 3 Reactions: Gene Name: CLIC3 Uniprot ID: O95833 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Chloride intracellular channel protein 4 Reactions: Gene Name: CLIC4 Uniprot ID: Q9Y696 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Chloride intracellular channel protein 5 Reactions: Gene Name: CLIC5 Uniprot ID: Q9NZA1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Chloride intracellular channel protein 6 Reactions: Gene Name: CLIC6 Uniprot ID: Q96NY7 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Beta-defensin 104 Reactions: Gene Name: DEFB104A Uniprot ID: Q8WTQ1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: FXYD domain-containing ion transport regulator 3 Reactions: Gene Name: FXYD3 Uniprot ID: Q14802 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit alpha-1 Reactions: Gene Name: GABRA1 Uniprot ID: P14867 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit alpha-2 Reactions: Gene Name: GABRA2 Uniprot ID: P47869 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit alpha-3 Reactions: Gene Name: GABRA3 Uniprot ID: P34903 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit alpha-4 Reactions: Gene Name: GABRA4 Uniprot ID: P48169 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit alpha-5 Reactions: Gene Name: GABRA5 Uniprot ID: P31644 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit alpha-6 Reactions: Gene Name: GABRA6 Uniprot ID: Q16445 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit beta-1 Reactions: Gene Name: GABRB1 Uniprot ID: P18505 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit beta-2 Reactions: Gene Name: GABRB2 Uniprot ID: P47870 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit beta-3 Reactions: Gene Name: GABRB3 Uniprot ID: P28472 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit delta Reactions: Gene Name: GABRD Uniprot ID: O14764 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit epsilon Reactions: Gene Name: GABRE Uniprot ID: P78334 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit gamma-1 Reactions: Gene Name: GABRG1 Uniprot ID: Q8N1C3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit gamma-3 Reactions: Gene Name: GABRG3 Uniprot ID: Q99928 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit pi Reactions: Gene Name: GABRP Uniprot ID: O00591 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit rho-1 Reactions: Gene Name: GABRR1 Uniprot ID: P24046 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit rho-2 Reactions: Gene Name: GABRR2 Uniprot ID: P28476 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit rho-3 Reactions: Gene Name: GABRR3 Uniprot ID: A8MPY1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Gamma-aminobutyric acid receptor subunit theta Reactions: Gene Name: GABRQ Uniprot ID: Q9UN88 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Glycine receptor subunit alpha-1 Reactions: Gene Name: GLRA1 Uniprot ID: P23415 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Glycine receptor subunit alpha-2 Reactions: Gene Name: GLRA2 Uniprot ID: P23416 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Glycine receptor subunit alpha-3 Reactions: Gene Name: GLRA3 Uniprot ID: O75311 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Glycine receptor subunit beta Reactions: Gene Name: GLRB Uniprot ID: P48167 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Golgi-associated PDZ and coiled-coil motif-containing protein Reactions: Gene Name: GOPC Uniprot ID: Q9HD26 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Methylosome subunit pICln Reactions: Gene Name: CLNS1A Uniprot ID: P54105 Protein Sequence: FASTA Gene Sequence: FASTA
Name: NADPH oxidase 3 Reactions: Gene Name: NOX3 Uniprot ID: Q9HBY0 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Serine/threonine-protein kinase OSR1 Reactions: ATP + a protein = ADP + a phosphoprotein [RN:R00162] Gene Name: OXSR1 Uniprot ID: O95747 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF3 Reactions: Gene Name: PDZK1 Uniprot ID: Q5T2W1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 12 member 8 Reactions: Gene Name: SLC12A8 Uniprot ID: A0AV02 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-dependent neutral amino acid transporter B(0)AT1 Reactions: Gene Name: SLC6A19 Uniprot ID: Q695T7 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-coupled monocarboxylate transporter 1 Reactions: Gene Name: SLC5A8 Uniprot ID: Q8N695 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Protein tweety homolog 1 Reactions: Gene Name: TTYH1 Uniprot ID: Q9H313 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Protein tweety homolog 2 Reactions: Gene Name: TTYH2 Uniprot ID: Q9BSA4 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Protein tweety homolog 3 Reactions: Gene Name: TTYH3 Uniprot ID: Q9C0H2 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Serine/threonine-protein kinase WNK1 Reactions: ATP + a protein = ADP + a phosphoprotein [RN:R00162] Gene Name: WNK1 Uniprot ID: Q9H4A3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Glycine receptor subunit alpha-4 Reactions: Gene Name: GLRA4 Uniprot ID: Q5JXX5 Protein Sequence: FASTA Gene Sequence: FASTA

Transporters
Name: High affinity choline transporter 1 Reactions: Gene Name: SLC5A7 Uniprot ID: Q9GZV3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 12 member 5 Reactions: --- [] Gene Name: SLC12A5 Uniprot ID: Q9H2X9 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 12 member 2 Reactions: --- [] Gene Name: SLC12A2 Uniprot ID: P55011 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 12 member 1 Reactions: --- [] Gene Name: SLC12A1 Uniprot ID: Q13621 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 12 member 4 Reactions: --- [] Gene Name: SLC12A4 Uniprot ID: Q9UP95 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 12 member 6 Reactions: Gene Name: SLC12A6 Uniprot ID: Q9UHW9 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 12 member 7 Reactions: Gene Name: SLC12A7 Uniprot ID: Q9Y666 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-driven chloride bicarbonate exchanger Reactions: Gene Name: SLC4A10 Uniprot ID: Q6U841 Protein Sequence: FASTA Gene Sequence: FASTA

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