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Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2013-05-29 19:27:39 UTC
HMDB IDHMDB00559
Secondary Accession NumbersNone
Metabolite Identification
Common Name3-Methoxy-4-hydroxyphenylethyleneglycol sulfate
Description3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) is the major metabolite of noradrenaline in serum. Chronic schizophrenics have lower serum levels than healthy individuals. Treatment of both groups with 7 daily 3-mg doses of Haloperidol caused similar decreases in MHPG-SO4 concentration. (PMID 7343757 ). In human urine, constitutes 44% of the total 3-methoxy-4-hydroxyphenylethylene glycol. (PMID 7379456 ).
Structure
Thumb
Synonyms
  1. (3-Methoxy-4-hydroxyphenyl)ethylene glycol sulfate
  2. (3-Methoxy-4-hydroxyphenyl)ethylene glycol sulphate
  3. (3-Methoxy-4-hydroxyphenyl)glycol O-sulfate
  4. (3-Methoxy-4-hydroxyphenyl)glycol O-sulphate
  5. (3-Methoxy-4-hydroxyphenyl)glycol sulfate ester
  6. (3-Methoxy-4-hydroxyphenyl)glycol sulphate ester
  7. 3-Methoxy-4-hydroxyphenylethyleneglycol sulfate
  8. 3-Methoxy-4-hydroxyphenylethyleneglycol sulphate
  9. 3-Methoxy-4-hydroxyphenylglycol 4-sulfate
  10. 3-Methoxy-4-hydroxyphenylglycol 4-sulphate
  11. MOPEG sulfate
  12. MOPEG sulphate
Chemical FormulaC9H12O7S
Average Molecular Weight264.252
Monoisotopic Molecular Weight264.030373428
IUPAC Name[4-(1,2-dihydroxyethyl)-2-methoxyphenyl]oxidanesulfonic acid
Traditional IUPAC Name[4-(1,2-dihydroxyethyl)-2-methoxyphenyl]oxidanesulfonic acid
CAS Registry Number3415-67-6
SMILES
COC1=C(OS(O)(=O)=O)C=CC(=C1)C(O)CO
InChI Identifier
InChI=1S/C9H12O7S/c1-15-9-4-6(7(11)5-10)2-3-8(9)16-17(12,13)14/h2-4,7,10-11H,5H2,1H3,(H,12,13,14)
InChI KeyWUFPNASKMLJSND-UHFFFAOYSA-N
Chemical Taxonomy
KingdomOrganic Compounds
Super ClassAromatic Homomonocyclic Compounds
ClassPhenols and Derivatives
Sub ClassTyrosols and Derivatives
Other Descriptors
  • Organic Compounds
Substituents
  • 1,2 Diol
  • Alkyl Aryl Ether
  • Anisole
  • Benzyl Alcohol Derivative
  • Organic Sulfuric Acid Monoester
  • Primary Alcohol
  • Secondary Alcohol
  • Sulfate Ester
Direct ParentTyrosols and Derivatives
Ontology
StatusExpected and Not Quantified
Origin
  • Endogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cytoplasm
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
water solubility4.11 g/LALOGPS
logP-1.5ALOGPS
logP-2.3ChemAxon
logS-1.8ALOGPS
pKa (strongest acidic)-2.2ChemAxon
pKa (strongest basic)-3ChemAxon
physiological charge-1ChemAxon
hydrogen acceptor count6ChemAxon
hydrogen donor count3ChemAxon
polar surface area113.29ChemAxon
rotatable bond count5ChemAxon
refractivity57.27ChemAxon
polarizability24.14ChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular Locations
  • Cytoplasm
Biofluid LocationsNot Available
Tissue LocationNot Available
PathwaysNot Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB022119
KNApSAcK IDNot Available
Chemspider ID4039
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
NuGOwiki LinkHMDB00559
Metagene LinkHMDB00559
METLIN ID5543
PubChem Compound4183
PDB IDNot Available
ChEBI ID1091015
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Boobis AR, Murray S, Jones DH, Reid JL, Davies DS: Urinary conjugates of 4-hydroxy-3-methoxyphenylethylene glycol do not provide an index of brain amine turnover in man. Clin Sci (Lond). 1980 Apr;58(4):311-6. Pubmed: 7379456
  2. Hoaki Y, Nishikawa T, Ida Y, Kohno Y, Tanaka M: Effect of haloperidol administration on serum MHPG-SO4 levels in chronic schizophrenics. Kurume Med J. 1981;28(3):197-200. Pubmed: 7343757