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Human Metabolome Database Version 3.5

Showing metabocard for Sodium (HMDB00588)

• Identification
• Taxonomy
• Ontology
• Physical properties
• Spectra
• Biological properties
• Concentrations
• Links
• References

enzymes (173) transporters (23)

• Blood
• Urine

Record Information
Version	3.5
Creation Date	2006-08-15 16:07:35 -0600
Update Date	2013-02-08 11:19:14 -0700
HMDB ID	HMDB00588
Secondary Accession Numbers	None
Metabolite Identification
Common Name	Sodium
Description	Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste." Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.
Structure	Download: MOL | SDF | SMILES | InChI Display: 2D Structure | 3D Structure
Synonyms	Sodium Sodium ion
Chemical Formula	Na
Average Molecular Weight	22.98976928
Monoisotopic Molecular Weight	22.989769675
IUPAC Name	sodium
Traditional IUPAC Name	sodium
CAS Registry Number	7440-23-5
SMILES	[Na+]
InChI Identifier	InChI=1S/Na/q+1
InChI Key	FKNQFGJONOIPTF-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom	Inorganic Compounds
Super Class	Homogeneous Metal Compounds
Class	Homogeneous Alkali Metal Compounds
Sub Class	N/A
Other Descriptors	a cation(Cyc) alkali metal cation(ChEBI) elemental sodium(ChEBI) monoatomic monocation(ChEBI) monovalent inorganic cation(ChEBI)
Substituents	N/A
Direct Parent	Homogeneous Alkali Metal Compounds
Ontology
Status	Detected and Quantified
Origin	Food Drug
Biofunction	Essential minerals
Application	Not Available
Cellular locations	Extracellular Golgi apparatus Peroxisome
Physical Properties
State	Solid
Experimental Properties	Property Value Reference Melting Point 97.82 °C Not Available Boiling Point Not Available Not Available Water Solubility Not Available Not Available LogP Not Available Not Available
Predicted Properties	Property Value Source LogP -0.77 ChemAxon Hydrogen Acceptor Count 0 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 0 A2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 0 ChemAxon Polarizability 1.78 ChemAxon Formal Charge 1 ChemAxon Physiological Charge 1 ChemAxon
Spectra
	Not Available
Biological Properties
Cellular Locations	Extracellular Golgi apparatus Peroxisome
Biofluid Locations	Blood Cerebrospinal Fluid (CSF) Urine
Tissue Location	Kidney
Pathways	Name SMPDB Link KEGG Link Lactose Degradation SMP00457 Not Available Trehalose Degradation SMP00467 Not Available
Normal Concentrations
	Biofluid Status Value Age Sex Condition Comments Blood Detected and Quantified 144000.0 +/- 5700.0 uM Newborn (0-30 days old) Both Normal Not Available Blood Detected and Quantified 139100.0 +/- 2020.0 uM Infant (0-1 year old) Both Normal Not Available Blood Detected and Quantified 142600.0 (138000.0-146000.0) uM Adult (>18 years old) Both Normal Not Available Cerebrospinal Fluid (CSF) Detected and Quantified 109788 +/- 10048 uM Adult (>18 years old) Not Specified Normal Not Available Cerebrospinal Fluid (CSF) Detected and Quantified 145000.0 (137000.0 - 153000.0) uM Adult (>18 years old) Both Normal Not Available Urine Detected and Quantified 12477 (1863.49-37249.07) umol/mmol creatinine Adult (>18 years old) Both Normal by ICP MS Urine Detected and Quantified 14736.8 (5263.15-36842.1) umol/mmol creatinine Adult (>18 years old) Male Normal Not Available Urine Detected and Quantified 9079.00 +/- 329.00 umol/mmol creatinine Adult (>18 years old) Female Normal Not Available Urine Detected and Quantified 10789.00 +/- 394.00 umol/mmol creatinine Adult (>18 years old) Male Normal Not Available
Abnormal Concentrations
	Not Available
Associated Disorders and Diseases
Disease References	None
Associated OMIM IDs	None
External Links
DrugBank ID	Not Available
Phenol Explorer Compound ID	Not Available
Phenol Explorer Metabolite ID	Not Available
FoodDB ID	FDB003523
KNApSAcK ID	Not Available
Chemspider ID	899
KEGG Compound ID	C01330
BioCyc ID	Not Available
BiGG ID	37376
Wikipedia Link	Sodium
NuGOwiki Link	HMDB00588
Metagene Link	HMDB00588
METLIN ID	3192
PubChem Compound	923
PDB ID	NA
ChEBI ID	29101
References
Synthesis Reference	Not Available
Material Safety Data Sheet (MSDS)	Download (PDF)
General References	Felder RA, Jose PA: Mechanisms of disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity. Nat Clin Pract Nephrol. 2006 Nov;2(11):637-50. Pubmed: 17066056 Achard JM, Hadchouel J, Faure S, Jeunemaitre X: Inherited sodium avid states. Adv Chronic Kidney Dis. 2006 Apr;13(2):118-23. Pubmed: 16580612 Fox CS, Larson MG, Hwang SJ, Leip EP, Rifai N, Levy D, Benjamin EJ, Murabito JM, Meigs JB, Vasan RS: Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sample. Kidney Int. 2006 Jun;69(11):2064-9. Pubmed: 16572107

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Enzymes
Name: Ubiquitin-conjugating enzyme E2 E3 Reactions: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine [RN:R03876] Gene Name: UBE2E3 Uniprot ID: Q969T4 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Corticosteroid 11-beta-dehydrogenase isozyme 2 Reactions: --- [] Gene Name: HSD11B2 Uniprot ID: P80365 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Reactions: Gene Name: HCN1 Uniprot ID: O60741 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/potassium-transporting ATPase subunit beta-3 Reactions: Gene Name: ATP1B3 Uniprot ID: P54709 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/potassium-transporting ATPase subunit beta-2 Reactions: Gene Name: ATP1B2 Uniprot ID: P14415 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/potassium-transporting ATPase subunit beta-1 Reactions: Gene Name: ATP1B1 Uniprot ID: P05026 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Serine/threonine-protein kinase Sgk1 Reactions: ATP + a protein = ADP + a phosphoprotein [RN:R00162] Gene Name: SGK1 Uniprot ID: O00141 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Protein ATP1B4 Reactions: Gene Name: ATP1B4 Uniprot ID: Q9UN42 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/potassium-transporting ATPase subunit alpha-1 Reactions: ATP + H2O + Na+in + K+out = ADP + phosphate + Na+out + K+in [RN:R00086] Gene Name: ATP1A1 Uniprot ID: P05023 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/potassium-transporting ATPase subunit alpha-3 Reactions: ATP + H2O + Na+in + K+out = ADP + phosphate + Na+out + K+in [RN:R00086] Gene Name: ATP1A3 Uniprot ID: P13637 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/potassium-transporting ATPase subunit alpha-2 Reactions: ATP + H2O + Na+in + K+out = ADP + phosphate + Na+out + K+in [RN:R00086] Gene Name: ATP1A2 Uniprot ID: P50993 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Beta-1-syntrophin Reactions: Gene Name: SNTB1 Uniprot ID: Q13884 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Phosphate-regulating neutral endopeptidase Reactions: Gene Name: PHEX Uniprot ID: P78562 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Neutral and basic amino acid transport protein rBAT Reactions: --- [] Gene Name: SLC3A1 Uniprot ID: Q07837 Protein Sequence: FASTA Gene Sequence: FASTA
Name: B(0,+)-type amino acid transporter 1 Reactions: --- [] Gene Name: SLC7A9 Uniprot ID: P82251 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/nucleoside cotransporter 1 Reactions: Gene Name: SLC28A1 Uniprot ID: O00337 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Tenascin-R Reactions: Gene Name: TNR Uniprot ID: Q92752 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Transient receptor potential cation channel subfamily M member 2 Reactions: ADP-ribose + H2O = AMP + D-ribose 5-phosphate [RN:R01054] Gene Name: TRPM2 Uniprot ID: O94759 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/nucleoside cotransporter 2 Reactions: Gene Name: SLC28A2 Uniprot ID: O43868 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Transient receptor potential cation channel subfamily M member 8 Reactions: Gene Name: TRPM8 Uniprot ID: Q7Z2W7 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Amiloride-sensitive sodium channel subunit alpha Reactions: Gene Name: SCNN1A Uniprot ID: P37088 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium- and chloride-dependent GABA transporter 3 Reactions: Gene Name: SLC6A11 Uniprot ID: P48066 Protein Sequence: FASTA Gene Sequence: FASTA
Name: P3 protein Reactions: Gene Name: SLC10A3 Uniprot ID: P09131 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium- and chloride-dependent glycine transporter 1 Reactions: --- [] Gene Name: SLC6A9 Uniprot ID: P48067 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 13 member 3 Reactions: --- [] Gene Name: SLC13A3 Uniprot ID: Q8WWT9 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Low affinity sodium-glucose cotransporter Reactions: Gene Name: SLC5A4 Uniprot ID: Q9NY91 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-dependent dopamine transporter Reactions: --- [] Gene Name: SLC6A3 Uniprot ID: Q01959 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/hydrogen exchanger 1 Reactions: --- [] Gene Name: SLC9A1 Uniprot ID: P19634 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Reactions: Gene Name: HCN2 Uniprot ID: Q9UL51 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-dependent multivitamin transporter Reactions: --- [] Gene Name: SLC5A6 Uniprot ID: Q9Y289 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Renin Reactions: Cleavage of Leu! bond in angiotensinogen to generate angiotensin I Gene Name: REN Uniprot ID: P00797 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Mineralocorticoid receptor Reactions: Gene Name: NR3C2 Uniprot ID: P08235 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Equilibrative nucleoside transporter 4 Reactions: Gene Name: SLC29A4 Uniprot ID: Q7RTT9 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium- and chloride-dependent betaine transporter Reactions: Gene Name: SLC6A12 Uniprot ID: P48065 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/myo-inositol cotransporter Reactions: Gene Name: SLC5A3 Uniprot ID: P53794 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sialin Reactions: Gene Name: SLC17A5 Uniprot ID: Q9NRA2 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium- and chloride-dependent GABA transporter 1 Reactions: Gene Name: SLC6A1 Uniprot ID: P30531 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/hydrogen exchanger 3 Reactions: Gene Name: SLC9A3 Uniprot ID: P48764 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/iodide cotransporter Reactions: Gene Name: SLC5A5 Uniprot ID: Q92911 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium- and chloride-dependent creatine transporter 1 Reactions: --- [] Gene Name: SLC6A8 Uniprot ID: P48029 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium- and chloride-dependent taurine transporter Reactions: --- [] Gene Name: SLC6A6 Uniprot ID: P31641 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/glucose cotransporter 1 Reactions: Gene Name: SLC5A1 Uniprot ID: P13866 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Amiloride-sensitive sodium channel subunit gamma Reactions: Gene Name: SCNN1G Uniprot ID: P51170 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Steroidogenic factor 1 Reactions: Gene Name: NR5A1 Uniprot ID: Q13285 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Cystine/glutamate transporter Reactions: --- [] Gene Name: SLC7A11 Uniprot ID: Q9UPY5 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Asc-type amino acid transporter 1 Reactions: Gene Name: SLC7A10 Uniprot ID: Q9NS82 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-dependent phosphate transport protein 4 Reactions: Gene Name: SLC17A3 Uniprot ID: O00476 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-dependent phosphate transporter 2 Reactions: Gene Name: SLC20A2 Uniprot ID: Q08357 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Large neutral amino acids transporter small subunit 3 Reactions: Gene Name: SLC43A1 Uniprot ID: O75387 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-dependent phosphate transporter 1 Reactions: Gene Name: SLC20A1 Uniprot ID: Q8WUM9 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 13 member 1 Reactions: --- [] Gene Name: SLC13A1 Uniprot ID: Q9BZW2 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Pendrin Reactions: Gene Name: SLC26A4 Uniprot ID: O43511 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-dependent phosphate transport protein 3 Reactions: Gene Name: SLC17A2 Uniprot ID: O00624 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/hydrogen exchanger 5 Reactions: Gene Name: SLC9A5 Uniprot ID: Q14940 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/calcium exchanger 1 Reactions: --- [] Gene Name: SLC8A1 Uniprot ID: P32418 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/potassium/calcium exchanger 4 Reactions: Gene Name: SLC24A4 Uniprot ID: Q8NFF2 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Cytosolic beta-glucosidase Reactions: Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose ALL_REAC (other) R00026 R02887 R03527 R04949 R04998 R06077(G) R06092(G) Gene Name: GBA3 Uniprot ID: Q9H227 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/hydrogen exchanger 8 Reactions: Gene Name: SLC9A8 Uniprot ID: Q9Y2E8 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/hydrogen exchanger 2 Reactions: Gene Name: SLC9A2 Uniprot ID: Q9UBY0 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Y+L amino acid transporter 1 Reactions: Gene Name: SLC7A7 Uniprot ID: Q9UM01 Protein Sequence: FASTA Gene Sequence: FASTA
Name: 4F2 cell-surface antigen heavy chain Reactions: Gene Name: SLC3A2 Uniprot ID: P08195 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Excitatory amino acid transporter 3 Reactions: --- [] Gene Name: SLC1A1 Uniprot ID: P43005 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/potassium/calcium exchanger 2 Reactions: Gene Name: SLC24A2 Uniprot ID: Q9UI40 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 13 member 4 Reactions: Gene Name: SLC13A4 Uniprot ID: Q9UKG4 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 12 member 3 Reactions: --- [] Gene Name: SLC12A3 Uniprot ID: P55017 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Neutral amino acid transporter A Reactions: --- [] Gene Name: SLC1A4 Uniprot ID: P43007 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Cationic amino acid transporter 3 Reactions: --- [] Gene Name: SLC7A3 Uniprot ID: Q8WY07 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 23 member 1 Reactions: --- [] Gene Name: SLC23A1 Uniprot ID: Q9UHI7 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium- and chloride-dependent GABA transporter 2 Reactions: Gene Name: SLC6A13 Uniprot ID: Q9NSD5 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/potassium/calcium exchanger 1 Reactions: Gene Name: SLC24A1 Uniprot ID: O60721 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-coupled neutral amino acid transporter 4 Reactions: Gene Name: SLC38A4 Uniprot ID: Q969I6 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Excitatory amino acid transporter 1 Reactions: --- [] Gene Name: SLC1A3 Uniprot ID: P43003 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 23 member 2 Reactions: Gene Name: SLC23A2 Uniprot ID: Q9UGH3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Carbonic anhydrase 4 Reactions: H2CO3 = CO2 + H2O [RN:R00132] Gene Name: CA4 Uniprot ID: P22748 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/potassium/calcium exchanger 3 Reactions: Gene Name: SLC24A3 Uniprot ID: Q9HC58 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/potassium-transporting ATPase subunit alpha-4 Reactions: ATP + H2O + Na+in + K+out = ADP + phosphate + Na+out + K+in [RN:R00086] Gene Name: ATP1A4 Uniprot ID: Q13733 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Excitatory amino acid transporter 2 Reactions: Gene Name: SLC1A2 Uniprot ID: P43004 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Large neutral amino acids transporter small subunit 1 Reactions: Gene Name: SLC7A5 Uniprot ID: Q01650 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/calcium exchanger 3 Reactions: Gene Name: SLC8A3 Uniprot ID: P57103 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/calcium exchanger 2 Reactions: Gene Name: SLC8A2 Uniprot ID: Q9UPR5 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Excitatory amino acid transporter 5 Reactions: Gene Name: SLC1A7 Uniprot ID: O00341 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium- and chloride-dependent glycine transporter 2 Reactions: --- [] Gene Name: SLC6A5 Uniprot ID: Q9Y345 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 13 member 2 Reactions: --- [] Gene Name: SLC13A2 Uniprot ID: Q13183 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-dependent phosphate transport protein 1 Reactions: Gene Name: SLC17A1 Uniprot ID: Q14916 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-dependent proline transporter Reactions: --- [] Gene Name: SLC6A7 Uniprot ID: Q99884 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Excitatory amino acid transporter 4 Reactions: Gene Name: SLC1A6 Uniprot ID: P48664 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/glucose cotransporter 2 Reactions: Gene Name: SLC5A2 Uniprot ID: P31639 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) Reactions: --- [] Gene Name: SLC6A14 Uniprot ID: Q9UN76 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-coupled neutral amino acid transporter 2 Reactions: Gene Name: SLC38A2 Uniprot ID: Q96QD8 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-coupled neutral amino acid transporter 1 Reactions: Gene Name: SLC38A1 Uniprot ID: Q9H2H9 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-coupled neutral amino acid transporter 5 Reactions: Gene Name: SLC38A5 Uniprot ID: Q8WUX1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Vesicular glutamate transporter 3 Reactions: Gene Name: SLC17A8 Uniprot ID: Q8NDX2 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Vesicular glutamate transporter 2 Reactions: Gene Name: SLC17A6 Uniprot ID: Q9P2U8 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Vesicular glutamate transporter 1 Reactions: Gene Name: SLC17A7 Uniprot ID: Q9P2U7 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-independent sulfate anion transporter Reactions: Gene Name: SLC26A11 Uniprot ID: Q86WA9 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Anion exchange transporter Reactions: Gene Name: SLC26A7 Uniprot ID: Q8TE54 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/glucose cotransporter 4 Reactions: Gene Name: SLC5A9 Uniprot ID: Q2M3M2 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Large neutral amino acids transporter small subunit 4 Reactions: Gene Name: SLC43A2 Uniprot ID: Q8N370 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Putative small intestine sodium-dependent phosphate transport protein Reactions: Gene Name: SLC17A4 Uniprot ID: Q9Y2C5 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 13 member 5 Reactions: Gene Name: SLC13A5 Uniprot ID: Q86YT5 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-coupled monocarboxylate transporter 2 Reactions: Gene Name: SLC5A12 Uniprot ID: Q1EHB4 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/glucose cotransporter 5 Reactions: Gene Name: SLC5A10 Uniprot ID: A0PJK1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/myo-inositol cotransporter 2 Reactions: Gene Name: SLC5A11 Uniprot ID: Q8WWX8 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/hydrogen exchanger 4 Reactions: Gene Name: SLC9A4 Uniprot ID: Q6AI14 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Lipase member H Reactions: Gene Name: LIPH Uniprot ID: Q8WWY8 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Lipase member I Reactions: Gene Name: LIPI Uniprot ID: Q6XZB0 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/hydrogen exchanger 10 Reactions: Gene Name: SLC9A10 Uniprot ID: Q4G0N8 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/potassium-transporting ATPase subunit gamma Reactions: Gene Name: FXYD2 Uniprot ID: P54710 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Potassium channel subfamily T member 1 Reactions: Gene Name: KCNT1 Uniprot ID: Q5JUK3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Potassium channel subfamily T member 2 Reactions: Gene Name: KCNT2 Uniprot ID: Q6UVM3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium leak channel non-selective protein Reactions: Gene Name: NALCN Uniprot ID: Q8IZF0 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/potassium/calcium exchanger 5 Reactions: Gene Name: SLC24A5 Uniprot ID: Q71RS6 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/potassium/calcium exchanger 6 Reactions: Gene Name: SLC24A6 Uniprot ID: Q6J4K2 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Prostaglandin E2 receptor EP3 subtype Reactions: Gene Name: PTGER3 Uniprot ID: P43115 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium- and chloride-dependent transporter XTRP3 Reactions: Gene Name: SLC6A20 Uniprot ID: Q9NP91 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Alpha-1-syntrophin Reactions: Gene Name: SNTA1 Uniprot ID: Q13424 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Beta-2-syntrophin Reactions: Gene Name: SNTB2 Uniprot ID: Q13425 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Tescalcin Reactions: Gene Name: TESC Uniprot ID: Q96BS2 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Protein tyrosine phosphatase type IVA 3 Reactions: protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585] Gene Name: PTP4A3 Uniprot ID: O75365 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Reactions: Gene Name: HCN4 Uniprot ID: Q9Y3Q4 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Beta-defensin 104 Reactions: Gene Name: DEFB104A Uniprot ID: Q8WTQ1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-dependent neutral amino acid transporter B(0)AT1 Reactions: Gene Name: SLC6A19 Uniprot ID: Q695T7 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-coupled monocarboxylate transporter 1 Reactions: Gene Name: SLC5A8 Uniprot ID: Q8N695 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Serine/threonine-protein kinase WNK1 Reactions: ATP + a protein = ADP + a phosphoprotein [RN:R00162] Gene Name: WNK1 Uniprot ID: Q9H4A3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Methionine aminopeptidase 1 Reactions: Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides Gene Name: METAP1 Uniprot ID: P53582 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Protein tyrosine phosphatase type IVA 1 Reactions: protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585] Gene Name: PTP4A1 Uniprot ID: Q93096 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Protein tyrosine phosphatase type IVA 2 Reactions: protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585] Gene Name: PTP4A2 Uniprot ID: Q12974 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Amiloride-sensitive cation channel 1, neuronal Reactions: Gene Name: ACCN1 Uniprot ID: Q16515 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Amiloride-sensitive cation channel 2, neuronal Reactions: Gene Name: ACCN2 Uniprot ID: P78348 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Amiloride-sensitive cation channel 3 Reactions: Gene Name: ACCN3 Uniprot ID: Q9UHC3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Amiloride-sensitive cation channel 4 Reactions: Gene Name: ACCN4 Uniprot ID: Q96FT7 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Amiloride-sensitive cation channel 5 Reactions: Gene Name: ACCN5 Uniprot ID: Q9NY37 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Arginine vasopressin-induced protein 1 Reactions: Gene Name: AVPI1 Uniprot ID: Q5T686 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Cyclin-D1-binding protein 1 Reactions: Gene Name: CCNDBP1 Uniprot ID: O95273 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 Reactions: Gene Name: HCN3 Uniprot ID: Q9P1Z3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-dependent glucose transporter 1 Reactions: Gene Name: NAGLT1 Uniprot ID: Q5TF39 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Neurofascin Reactions: Gene Name: NFASC Uniprot ID: O94856 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/bile acid cotransporter 4 Reactions: Gene Name: SLC10A4 Uniprot ID: Q96EP9 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/bile acid cotransporter 5 Reactions: Gene Name: SLC10A5 Uniprot ID: Q5PT55 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/bile acid cotransporter 7 Reactions: Gene Name: SLC10A7 Uniprot ID: Q0GE19 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Protein OSCP1 Reactions: Gene Name: OSCP1 Uniprot ID: Q8WVF1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: 3-hydroxyacyl-CoA dehydratase 3 Reactions: Gene Name: PTPLAD1 Uniprot ID: Q9P035 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Regulator of differentiation 1 Reactions: Gene Name: ROD1 Uniprot ID: O95758 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Probable sodium-coupled neutral amino acid transporter 6 Reactions: Gene Name: SLC38A6 Uniprot ID: Q8IZM9 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Putative sodium-coupled neutral amino acid transporter 8 Reactions: Gene Name: SLC38A8 Uniprot ID: A6NNN8 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Putative sodium-coupled neutral amino acid transporter 10 Reactions: Gene Name: SLC38A10 Uniprot ID: Q9HBR0 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Putative sodium-coupled neutral amino acid transporter 11 Reactions: Gene Name: SLC38A11 Uniprot ID: Q08AI6 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Orphan sodium- and chloride-dependent neurotransmitter transporter NTT73 Reactions: Gene Name: SLC6A15 Uniprot ID: Q9H2J7 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 Reactions: Gene Name: SLC6A16 Uniprot ID: Q9GZN6 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Orphan sodium- and chloride-dependent neurotransmitter transporter NTT4 Reactions: Gene Name: SLC6A17 Uniprot ID: Q9H1V8 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-dependent neutral amino acid transporter B(0)AT3 Reactions: Gene Name: SLC6A18 Uniprot ID: Q96N87 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 7 member 13 Reactions: Gene Name: SLC7A13 Uniprot ID: Q8TCU3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium channel protein type 1 subunit alpha Reactions: Gene Name: SCN1A Uniprot ID: P35498 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium channel subunit beta-1 Reactions: Gene Name: SCN1B Uniprot ID: Q07699 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium channel protein type 2 subunit alpha Reactions: Gene Name: SCN2A Uniprot ID: Q99250 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium channel subunit beta-2 Reactions: Gene Name: SCN2B Uniprot ID: O60939 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium channel protein type 3 subunit alpha Reactions: Gene Name: SCN3A Uniprot ID: Q9NY46 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium channel subunit beta-3 Reactions: Gene Name: SCN3B Uniprot ID: Q9NY72 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium channel protein type 4 subunit alpha Reactions: Gene Name: SCN4A Uniprot ID: P35499 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium channel subunit beta-4 Reactions: Gene Name: SCN4B Uniprot ID: Q8IWT1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium channel protein type 5 subunit alpha Reactions: Gene Name: SCN5A Uniprot ID: Q14524 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium channel protein type 7 subunit alpha Reactions: Gene Name: SCN7A Uniprot ID: Q01118 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium channel protein type 8 subunit alpha Reactions: Gene Name: SCN8A Uniprot ID: Q9UQD0 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium channel protein type 9 subunit alpha Reactions: Gene Name: SCN9A Uniprot ID: Q15858 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium channel protein type 10 subunit alpha Reactions: Gene Name: SCN10A Uniprot ID: Q9Y5Y9 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium channel protein type 11 subunit alpha Reactions: Gene Name: SCN11A Uniprot ID: Q9UI33 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Amiloride-sensitive sodium channel subunit beta Reactions: Gene Name: SCNN1B Uniprot ID: P51168 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Amiloride-sensitive sodium channel subunit delta Reactions: Gene Name: SCNN1D Uniprot ID: P51172 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Secreted frizzled-related protein 4 Reactions: Gene Name: SFRP4 Uniprot ID: Q6FHJ7 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 10 member 6 Reactions: Gene Name: SLC10A6 Uniprot ID: Q3KNW5 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sorbin and SH3 domain-containing protein 2 Reactions: Gene Name: SORBS2 Uniprot ID: O94875 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Membrane transport protein XK Reactions: Gene Name: XK Uniprot ID: P51811 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Y+L amino acid transporter 2 Reactions: Gene Name: SLC7A6 Uniprot ID: Q92536 Protein Sequence: FASTA Gene Sequence: FASTA

Transporters
Name: Solute carrier family 22 member 5 Reactions: --- [] Gene Name: SLC22A5 Uniprot ID: O76082 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Neutral amino acid transporter B(0) Reactions: --- [] Gene Name: SLC1A5 Uniprot ID: Q15758 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-dependent noradrenaline transporter Reactions: --- [] Gene Name: SLC6A2 Uniprot ID: P23975 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-dependent serotonin transporter Reactions: --- [] Gene Name: SLC6A4 Uniprot ID: P31645 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Equilibrative nucleoside transporter 1 Reactions: --- [] Gene Name: SLC29A1 Uniprot ID: Q99808 Protein Sequence: FASTA Gene Sequence: FASTA
Name: High affinity choline transporter 1 Reactions: Gene Name: SLC5A7 Uniprot ID: Q9GZV3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Large neutral amino acids transporter small subunit 2 Reactions: --- [] Gene Name: SLC7A8 Uniprot ID: Q9UHI5 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 22 member 4 Reactions: --- [] Gene Name: SLC22A4 Uniprot ID: Q9H015 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Ileal sodium/bile acid cotransporter Reactions: --- [] Gene Name: SLC10A2 Uniprot ID: Q12908 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium/bile acid cotransporter Reactions: --- [] Gene Name: SLC10A1 Uniprot ID: Q14973 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 22 member 16 Reactions: Gene Name: SLC22A16 Uniprot ID: Q86VW1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 12 member 2 Reactions: --- [] Gene Name: SLC12A2 Uniprot ID: P55011 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Electrogenic sodium bicarbonate cotransporter 1 Reactions: Gene Name: SLC4A4 Uniprot ID: Q9Y6R1 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 12 member 1 Reactions: --- [] Gene Name: SLC12A1 Uniprot ID: Q13621 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-coupled neutral amino acid transporter 3 Reactions: --- [] Gene Name: SLC38A3 Uniprot ID: Q99624 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium-driven chloride bicarbonate exchanger Reactions: Gene Name: SLC4A10 Uniprot ID: Q6U841 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Sodium bicarbonate cotransporter 3 Reactions: Gene Name: SLC4A7 Uniprot ID: Q9Y6M7 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 28 member 3 Reactions: Gene Name: SLC28A3 Uniprot ID: Q9HAS3 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Monocarboxylate transporter 10 Reactions: Gene Name: SLC16A10 Uniprot ID: Q8TF71 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Electroneutral sodium bicarbonate exchanger 1 Reactions: Gene Name: SLC4A8 Uniprot ID: Q2Y0W8 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Electrogenic sodium bicarbonate cotransporter 4 Reactions: Gene Name: SLC4A5 Uniprot ID: Q9BY07 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 22 member 6 Reactions: Gene Name: SLC22A6 Uniprot ID: Q4U2R8 Protein Sequence: FASTA Gene Sequence: FASTA
Name: Solute carrier family 22 member 7 Reactions: Gene Name: SLC22A7 Uniprot ID: Q9Y694 Protein Sequence: FASTA Gene Sequence: FASTA

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government.