Human Metabolome Database Version 3.5

Showing metabocard for Sodium (HMDB00588)

Record Information
Version 3.5
Creation Date 2006-08-15 16:07:35 -0600
Update Date 2013-02-08 11:19:14 -0700
HMDB ID HMDB00588
Secondary Accession Numbers None
Metabolite Identification
Common Name Sodium
Description Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste." Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. Sodium
  2. Sodium ion
Chemical Formula Na
Average Molecular Weight 22.98976928
Monoisotopic Molecular Weight 22.989769675
IUPAC Name sodium
Traditional IUPAC Name sodium
CAS Registry Number 7440-23-5
SMILES [Na+]
InChI Identifier InChI=1S/Na/q+1
InChI Key FKNQFGJONOIPTF-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom Inorganic Compounds
Super Class Homogeneous Metal Compounds
Class Homogeneous Alkali Metal Compounds
Sub Class N/A
Other Descriptors
  • a cation(Cyc)
  • alkali metal cation(ChEBI)
  • elemental sodium(ChEBI)
  • monoatomic monocation(ChEBI)
  • monovalent inorganic cation(ChEBI)
Substituents
  • N/A
Direct Parent Homogeneous Alkali Metal Compounds
Ontology
Status Detected and Quantified
Origin
  • Drug
  • Food
Biofunction
  • Essential minerals
Application Not Available
Cellular locations
  • Extracellular
  • Golgi apparatus
  • Peroxisome
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point 97.82 °C Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
LogP -0.77 ChemAxon
Hydrogen Acceptor Count 0 ChemAxon
Hydrogen Donor Count 0 ChemAxon
Polar Surface Area 0 A2 ChemAxon
Rotatable Bond Count 0 ChemAxon
Refractivity 0 ChemAxon
Polarizability 1.78 ChemAxon
Formal Charge 1 ChemAxon
Physiological Charge 1 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations
  • Extracellular
  • Golgi apparatus
  • Peroxisome
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Location
  • Kidney
Pathways
Name SMPDB Link KEGG Link
Lactose Degradation SMP00457 Not Available
Trehalose Degradation SMP00467 Not Available
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
144000.0 +/- 5700.0 uM Newborn (0-30 days old) Both Normal
  • Geigy Scient...
Blood Detected and Quantified
139100.0 +/- 2020.0 uM Infant (0-1 year old) Both Normal
  • Geigy Scient...
Blood Detected and Quantified
142600.0 (138000.0-146000.0) uM Adult (>18 years old) Both Normal
  • Geigy Scient...
Cerebrospinal Fluid (CSF) Detected and Quantified
109788 +/- 10048 uM Adult (>18 years old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
145000.0 (137000.0 - 153000.0) uM Adult (>18 years old) Both Normal
  • Geigy Scient...
Urine Detected and Quantified
12477 (1863.49-37249.07) umol/mmol creatinine Adult (>18 years old) Both Comment Normal
Urine Detected and Quantified
14736.8 (5263.15-36842.1) umol/mmol creatinine Adult (>18 years old) Male Normal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
Urine Detected and Quantified
9079.00 +/- 329.00 umol/mmol creatinine Adult (>18 years old) Female Normal
Urine Detected and Quantified
10789.00 +/- 394.00 umol/mmol creatinine Adult (>18 years old) Male Normal
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID Not Available
DrugBank Metabolite ID Not Available
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB003523
KNApSAcK ID Not Available
Chemspider ID 899 Link_out
KEGG Compound ID C01330 Link_out
BioCyc ID Not Available
BiGG ID 37376 Link_out
Wikipedia Link Sodium Link_out
NuGOwiki Link HMDB00588 Link_out
Metagene Link HMDB00588 Link_out
METLIN ID 3192 Link_out
PubChem Compound 923 Link_out
PDB ID NA Link_out
ChEBI ID 29101 Link_out
References
Synthesis Reference Not Available
Material Safety Data Sheet (MSDS) Download (PDF)
General References
  1. Felder RA, Jose PA: Mechanisms of disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity. Nat Clin Pract Nephrol. 2006 Nov;2(11):637-50. Pubmed: 17066056 Link_out
  2. Achard JM, Hadchouel J, Faure S, Jeunemaitre X: Inherited sodium avid states. Adv Chronic Kidney Dis. 2006 Apr;13(2):118-23. Pubmed: 16580612 Link_out
  3. Fox CS, Larson MG, Hwang SJ, Leip EP, Rifai N, Levy D, Benjamin EJ, Murabito JM, Meigs JB, Vasan RS: Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sample. Kidney Int. 2006 Jun;69(11):2064-9. Pubmed: 16572107 Link_out

Enzymes

Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 173 enzymes in total.

Name: Ubiquitin-conjugating enzyme E2 E3
Reactions: Not Available
Gene Name: UBE2E3
Uniprot ID: Q969T4 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Corticosteroid 11-beta-dehydrogenase isozyme 2
Reactions: Not Available
Gene Name: HSD11B2
Uniprot ID: P80365 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Reactions: Not Available
Gene Name: HCN1
Uniprot ID: O60741 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium/potassium-transporting ATPase subunit beta-3
Reactions: Not Available
Gene Name: ATP1B3
Uniprot ID: P54709 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium/potassium-transporting ATPase subunit beta-2
Reactions: Not Available
Gene Name: ATP1B2
Uniprot ID: P14415 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium/potassium-transporting ATPase subunit beta-1
Reactions: Not Available
Gene Name: ATP1B1
Uniprot ID: P05026 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Serine/threonine-protein kinase Sgk1
Reactions: Not Available
Gene Name: SGK1
Uniprot ID: O00141 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Protein ATP1B4
Reactions: Not Available
Gene Name: ATP1B4
Uniprot ID: Q9UN42 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium/potassium-transporting ATPase subunit alpha-1
Reactions: Not Available
Gene Name: ATP1A1
Uniprot ID: P05023 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium/potassium-transporting ATPase subunit alpha-3
Reactions: Not Available
Gene Name: ATP1A3
Uniprot ID: P13637 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium/potassium-transporting ATPase subunit alpha-2
Reactions: Not Available
Gene Name: ATP1A2
Uniprot ID: P50993 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Beta-1-syntrophin
Reactions: Not Available
Gene Name: SNTB1
Uniprot ID: Q13884 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Phosphate-regulating neutral endopeptidase
Reactions: Not Available
Gene Name: PHEX
Uniprot ID: P78562 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Neutral and basic amino acid transport protein rBAT
Reactions: Not Available
Gene Name: SLC3A1
Uniprot ID: Q07837 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: B(0,+)-type amino acid transporter 1
Reactions: Not Available
Gene Name: SLC7A9
Uniprot ID: P82251 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium/nucleoside cotransporter 1
Reactions: Not Available
Gene Name: SLC28A1
Uniprot ID: O00337 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Tenascin-R
Reactions: Not Available
Gene Name: TNR
Uniprot ID: Q92752 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Transient receptor potential cation channel subfamily M member 2
Reactions: Not Available
Gene Name: TRPM2
Uniprot ID: O94759 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium/nucleoside cotransporter 2
Reactions: Not Available
Gene Name: SLC28A2
Uniprot ID: O43868 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Transient receptor potential cation channel subfamily M member 8
Reactions: Not Available
Gene Name: TRPM8
Uniprot ID: Q7Z2W7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Amiloride-sensitive sodium channel subunit alpha
Reactions: Not Available
Gene Name: SCNN1A
Uniprot ID: P37088 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium- and chloride-dependent GABA transporter 3
Reactions: Not Available
Gene Name: SLC6A11
Uniprot ID: P48066 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: P3 protein
Reactions: Not Available
Gene Name: SLC10A3
Uniprot ID: P09131 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium- and chloride-dependent glycine transporter 1
Reactions: Not Available
Gene Name: SLC6A9
Uniprot ID: P48067 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Solute carrier family 13 member 3
Reactions: Not Available
Gene Name: SLC13A3
Uniprot ID: Q8WWT9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Low affinity sodium-glucose cotransporter
Reactions: Not Available
Gene Name: SLC5A4
Uniprot ID: Q9NY91 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium-dependent dopamine transporter
Reactions: Not Available
Gene Name: SLC6A3
Uniprot ID: Q01959 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium/hydrogen exchanger 1
Reactions: Not Available
Gene Name: SLC9A1
Uniprot ID: P19634 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Reactions: Not Available
Gene Name: HCN2
Uniprot ID: Q9UL51 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium-dependent multivitamin transporter
Reactions: Not Available
Gene Name: SLC5A6
Uniprot ID: Q9Y289 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Renin
Reactions: Not Available
Gene Name: REN
Uniprot ID: P00797 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Mineralocorticoid receptor
Reactions: Not Available
Gene Name: NR3C2
Uniprot ID: P08235 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Equilibrative nucleoside transporter 4
Reactions: Not Available
Gene Name: SLC29A4
Uniprot ID: Q7RTT9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium- and chloride-dependent betaine transporter
Reactions: Not Available
Gene Name: SLC6A12
Uniprot ID: P48065 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium/myo-inositol cotransporter
Reactions: Not Available
Gene Name: SLC5A3
Uniprot ID: P53794 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sialin
Reactions: Not Available
Gene Name: SLC17A5
Uniprot ID: Q9NRA2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium- and chloride-dependent GABA transporter 1
Reactions: Not Available
Gene Name: SLC6A1
Uniprot ID: P30531 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium/hydrogen exchanger 3
Reactions: Not Available
Gene Name: SLC9A3
Uniprot ID: P48764 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium/iodide cotransporter
Reactions: Not Available
Gene Name: SLC5A5
Uniprot ID: Q92911 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium- and chloride-dependent creatine transporter 1
Reactions: Not Available
Gene Name: SLC6A8
Uniprot ID: P48029 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium- and chloride-dependent taurine transporter
Reactions: Not Available
Gene Name: SLC6A6
Uniprot ID: P31641 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium/glucose cotransporter 1
Reactions: Not Available
Gene Name: SLC5A1
Uniprot ID: P13866 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Amiloride-sensitive sodium channel subunit gamma
Reactions: Not Available
Gene Name: SCNN1G
Uniprot ID: P51170 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Steroidogenic factor 1
Reactions: Not Available
Gene Name: NR5A1
Uniprot ID: Q13285 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cystine/glutamate transporter
Reactions: Not Available
Gene Name: SLC7A11
Uniprot ID: Q9UPY5 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Asc-type amino acid transporter 1
Reactions: Not Available
Gene Name: SLC7A10
Uniprot ID: Q9NS82 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium-dependent phosphate transport protein 4
Reactions: Not Available
Gene Name: SLC17A3
Uniprot ID: O00476 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium-dependent phosphate transporter 2
Reactions: Not Available
Gene Name: SLC20A2
Uniprot ID: Q08357 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Large neutral amino acids transporter small subunit 3
Reactions: Not Available
Gene Name: SLC43A1
Uniprot ID: O75387 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium-dependent phosphate transporter 1
Reactions: Not Available
Gene Name: SLC20A1
Uniprot ID: Q8WUM9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Transporters
Name: Solute carrier family 22 member 5
Reactions: Not Available
Gene Name: SLC22A5
Uniprot ID: O76082 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Neutral amino acid transporter B(0)
Reactions: Not Available
Gene Name: SLC1A5
Uniprot ID: Q15758 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium-dependent noradrenaline transporter
Reactions: Not Available
Gene Name: SLC6A2
Uniprot ID: P23975 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium-dependent serotonin transporter
Reactions: Not Available
Gene Name: SLC6A4
Uniprot ID: P31645 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Equilibrative nucleoside transporter 1
Reactions: Not Available
Gene Name: SLC29A1
Uniprot ID: Q99808 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: High affinity choline transporter 1
Reactions: Not Available
Gene Name: SLC5A7
Uniprot ID: Q9GZV3 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Large neutral amino acids transporter small subunit 2
Reactions: Not Available
Gene Name: SLC7A8
Uniprot ID: Q9UHI5 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Solute carrier family 22 member 4
Reactions: Not Available
Gene Name: SLC22A4
Uniprot ID: Q9H015 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ileal sodium/bile acid cotransporter
Reactions: Not Available
Gene Name: SLC10A2
Uniprot ID: Q12908 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium/bile acid cotransporter
Reactions: Not Available
Gene Name: SLC10A1
Uniprot ID: Q14973 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Solute carrier family 22 member 16
Reactions: Not Available
Gene Name: SLC22A16
Uniprot ID: Q86VW1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Solute carrier family 12 member 2
Reactions: Not Available
Gene Name: SLC12A2
Uniprot ID: P55011 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Electrogenic sodium bicarbonate cotransporter 1
Reactions: Not Available
Gene Name: SLC4A4
Uniprot ID: Q9Y6R1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Solute carrier family 12 member 1
Reactions: Not Available
Gene Name: SLC12A1
Uniprot ID: Q13621 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium-coupled neutral amino acid transporter 3
Reactions: Not Available
Gene Name: SLC38A3
Uniprot ID: Q99624 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium-driven chloride bicarbonate exchanger
Reactions: Not Available
Gene Name: SLC4A10
Uniprot ID: Q6U841 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sodium bicarbonate cotransporter 3
Reactions: Not Available
Gene Name: SLC4A7
Uniprot ID: Q9Y6M7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Solute carrier family 28 member 3
Reactions: Not Available
Gene Name: SLC28A3
Uniprot ID: Q9HAS3 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Monocarboxylate transporter 10
Reactions: Not Available
Gene Name: SLC16A10
Uniprot ID: Q8TF71 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Electroneutral sodium bicarbonate exchanger 1
Reactions: Not Available
Gene Name: SLC4A8
Uniprot ID: Q2Y0W8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Electrogenic sodium bicarbonate cotransporter 4
Reactions: Not Available
Gene Name: SLC4A5
Uniprot ID: Q9BY07 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Solute carrier family 22 member 6
Reactions: Not Available
Gene Name: SLC22A6
Uniprot ID: Q4U2R8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Solute carrier family 22 member 7
Reactions: Not Available
Gene Name: SLC22A7
Uniprot ID: Q9Y694 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA