Record Information
Version3.6
Creation Date2006-08-15 22:07:35 UTC
Update Date2013-02-08 18:19:14 UTC
HMDB IDHMDB00588
Secondary Accession NumbersNone
Metabolite Identification
Common NameSodium
DescriptionSodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste." Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.
Structure
Thumb
Synonyms
  1. Sodium
  2. Sodium ion
Chemical FormulaNa
Average Molecular Weight22.98976928
Monoisotopic Molecular Weight22.989769675
IUPAC Namesodium
Traditional IUPAC Namesodium
CAS Registry Number7440-23-5
SMILES
[Na+]
InChI Identifier
InChI=1S/Na/q+1
InChI KeyFKNQFGJONOIPTF-UHFFFAOYSA-N
Chemical Taxonomy
KingdomInorganic Compounds
Super ClassHomogeneous Metal Compounds
ClassHomogeneous Alkali Metal Compounds
Sub ClassN/A
Other Descriptors
  • a cation(Cyc)
  • alkali metal cation(ChEBI)
  • elemental sodium(ChEBI)
  • monoatomic monocation(ChEBI)
  • monovalent inorganic cation(ChEBI)
Substituents
  • N/A
Direct ParentHomogeneous Alkali Metal Compounds
Ontology
StatusDetected and Quantified
Origin
  • Drug
  • Food
Biofunction
  • Essential minerals
ApplicationNot Available
Cellular locations
  • Extracellular
  • Golgi apparatus
  • Peroxisome
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point97.82 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-0.77ChemAxon
physiological charge1ChemAxon
hydrogen acceptor count0ChemAxon
hydrogen donor count0ChemAxon
polar surface area0ChemAxon
rotatable bond count0ChemAxon
refractivity0ChemAxon
polarizability1.78ChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular Locations
  • Extracellular
  • Golgi apparatus
  • Peroxisome
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Location
  • Kidney
Pathways
NameSMPDB LinkKEGG Link
Lactose DegradationSMP00457Not Available
Trehalose DegradationSMP00467Not Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodDetected and Quantified144000.0 +/- 5700.0 uMNewborn (0-30 days old)BothNormal
  • Geigy Scient...
BloodDetected and Quantified139100.0 +/- 2020.0 uMInfant (0-1 year old)BothNormal
  • Geigy Scient...
BloodDetected and Quantified142600.0 (138000.0-146000.0) uMAdult (>18 years old)BothNormal
  • Geigy Scient...
Cerebrospinal Fluid (CSF)Detected and Quantified109788 +/- 10048 uMAdult (>18 years old)Not SpecifiedNormal
Cerebrospinal Fluid (CSF)Detected and Quantified145000.0 (137000.0 - 153000.0) uMAdult (>18 years old)BothNormal
  • Geigy Scient...
UrineDetected and Quantified12477 (1863.49-37249.07) umol/mmol creatinineAdult (>18 years old)BothCommentNormal
UrineDetected and Quantified14736.8 (5263.15-36842.1) umol/mmol creatinineAdult (>18 years old)MaleNormal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
UrineDetected and Quantified9079.00 +/- 329.00 umol/mmol creatinineAdult (>18 years old)FemaleNormal
UrineDetected and Quantified10789.00 +/- 394.00 umol/mmol creatinineAdult (>18 years old)MaleNormal
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB003523
KNApSAcK IDNot Available
Chemspider ID899
KEGG Compound IDC01330
BioCyc IDNot Available
BiGG ID37376
Wikipedia LinkSodium
NuGOwiki LinkHMDB00588
Metagene LinkHMDB00588
METLIN ID3192
PubChem Compound923
PDB IDNA
ChEBI ID29101
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Fox CS, Larson MG, Hwang SJ, Leip EP, Rifai N, Levy D, Benjamin EJ, Murabito JM, Meigs JB, Vasan RS: Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sample. Kidney Int. 2006 Jun;69(11):2064-9. Pubmed: 16572107
  2. Felder RA, Jose PA: Mechanisms of disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity. Nat Clin Pract Nephrol. 2006 Nov;2(11):637-50. Pubmed: 17066056
  3. Achard JM, Hadchouel J, Faure S, Jeunemaitre X: Inherited sodium avid states. Adv Chronic Kidney Dis. 2006 Apr;13(2):118-23. Pubmed: 16580612

Only showing the first 50 proteins. There are 196 proteins in total.

Enzymes

Gene Name:
UBE2E3
Uniprot ID:
Q969T4
Gene Name:
ATP1B4
Uniprot ID:
Q9UN42
Gene Name:
SNTB1
Uniprot ID:
Q13884
Gene Name:
SLC7A9
Uniprot ID:
P82251
Gene Name:
SLC28A1
Uniprot ID:
O00337
Gene Name:
TNR
Uniprot ID:
Q92752
Gene Name:
SLC28A2
Uniprot ID:
O43868
Gene Name:
SLC10A3
Uniprot ID:
P09131
Gene Name:
SLC13A3
Uniprot ID:
Q8WWT9
Gene Name:
SLC6A3
Uniprot ID:
Q01959
Gene Name:
SLC9A1
Uniprot ID:
P19634
31. Renin
Gene Name:
REN
Uniprot ID:
P00797
Gene Name:
NR3C2
Uniprot ID:
P08235
Gene Name:
SLC29A4
Uniprot ID:
Q7RTT9
Gene Name:
SLC5A3
Uniprot ID:
P53794
36. Sialin
Gene Name:
SLC17A5
Uniprot ID:
Q9NRA2
Gene Name:
SLC9A3
Uniprot ID:
P48764
Gene Name:
SLC5A5
Uniprot ID:
Q92911
Gene Name:
SLC5A1
Uniprot ID:
P13866
Gene Name:
NR5A1
Uniprot ID:
Q13285
Gene Name:
SLC7A11
Uniprot ID:
Q9UPY5
Gene Name:
SLC7A10
Uniprot ID:
Q9NS82
Gene Name:
SLC20A2
Uniprot ID:
Q08357
Gene Name:
SLC20A1
Uniprot ID:
Q8WUM9

Transporters

Gene Name:
SLC22A5
Uniprot ID:
O76082
Gene Name:
SLC1A5
Uniprot ID:
Q15758
Gene Name:
SLC6A4
Uniprot ID:
P31645
Gene Name:
SLC29A1
Uniprot ID:
Q99808
Gene Name:
SLC5A7
Uniprot ID:
Q9GZV3
Gene Name:
SLC22A4
Uniprot ID:
Q9H015
Gene Name:
SLC10A2
Uniprot ID:
Q12908
Gene Name:
SLC10A1
Uniprot ID:
Q14973
Gene Name:
SLC22A16
Uniprot ID:
Q86VW1
Gene Name:
SLC12A2
Uniprot ID:
P55011
Gene Name:
SLC12A1
Uniprot ID:
Q13621
Gene Name:
SLC4A7
Uniprot ID:
Q9Y6M7
Gene Name:
SLC28A3
Uniprot ID:
Q9HAS3
Gene Name:
SLC16A10
Uniprot ID:
Q8TF71
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Gene Name:
SLC22A7
Uniprot ID:
Q9Y694

Only showing the first 50 proteins. There are 196 proteins in total.