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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-10-30 10:32:48 UTC
Update Date2022-03-07 03:17:33 UTC
HMDB IDHMDB0059594
Secondary Accession Numbers
  • HMDB59594
Metabolite Identification
Common Name2-hydroxy-dAMP
Description2-hydroxy-dAMP, also known as 2-HO-dAMP, belongs to the class of organic compounds known as purine 2'-deoxyribonucleoside monophosphates. These are purine nucleotides with monophosphate group linked to the ribose moiety lacking a hydroxyl group at position 2. 2-hydroxy-dAMP is a moderately basic compound (based on its pKa). A purine 2'-deoxyribonucleoside 5'-monophosphate in which the purine moiety is 2-hydroxyadenine.
Structure
Data?1563865952
Synonyms
ValueSource
2'-Deoxy-2-hydroxyadenosine 5'-(dihydrogen phosphate)ChEBI
2'-Deoxyisoguanosine monophosphateChEBI
2-HO-dAMPChEBI
2-OH-dAMPChEBI
2'-Deoxy-2-hydroxyadenosine 5'-(dihydrogen phosphoric acid)Generator
2'-Deoxyisoguanosine monophosphoric acidGenerator
Chemical FormulaC10H14N5O7P
Average Molecular Weight347.2212
Monoisotopic Molecular Weight347.063084339
IUPAC Name{[(2R,3S,5R)-5-(6-amino-2-hydroxy-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid
Traditional Name[(2R,3S,5R)-5-(6-amino-2-hydroxypurin-9-yl)-3-hydroxyoxolan-2-yl]methoxyphosphonic acid
CAS Registry NumberNot Available
SMILES
[H][C@]1(O)C[C@@]([H])(O[C@]1([H])COP(O)(O)=O)N1C=NC2=C(N)N=C(O)N=C12
InChI Identifier
InChI=1S/C10H14N5O7P/c11-8-7-9(14-10(17)13-8)15(3-12-7)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1
InChI KeyGEQDRKVFKBSPSW-KVQBGUIXSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as purine 2'-deoxyribonucleoside monophosphates. These are purine nucleotides with monophosphate group linked to the ribose moiety lacking a hydroxyl group at position 2.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
ClassPurine nucleotides
Sub ClassPurine deoxyribonucleotides
Direct ParentPurine 2'-deoxyribonucleoside monophosphates
Alternative Parents
Substituents
  • Purine 2'-deoxyribonucleoside monophosphate
  • 6-aminopurine
  • Purinone
  • Imidazopyrimidine
  • Purine
  • Aminopyrimidine
  • Pyrimidone
  • Monoalkyl phosphate
  • N-substituted imidazole
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Pyrimidine
  • Alkyl phosphate
  • Heteroaromatic compound
  • Tetrahydrofuran
  • Azole
  • Imidazole
  • Secondary alcohol
  • Oxacycle
  • Organoheterocyclic compound
  • Azacycle
  • Organic oxygen compound
  • Organonitrogen compound
  • Alcohol
  • Organic nitrogen compound
  • Organopnictogen compound
  • Organooxygen compound
  • Amine
  • Primary amine
  • Organic oxide
  • Hydrocarbon derivative
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
  • purine 2'-deoxyribonucleoside 5'-monophosphate (CHEBI:63211 )
Ontology
Physiological effectNot Available
DispositionNot Available
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility2.91 g/LALOGPS
logP-1.5ALOGPS
logP-3ChemAxon
logS-2.1ALOGPS
pKa (Strongest Acidic)1.07ChemAxon
pKa (Strongest Basic)1.72ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count10ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area186.07 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity74.48 m³·mol⁻¹ChemAxon
Polarizability29.67 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+175.42731661259
DarkChem[M-H]-171.60431661259
DeepCCS[M-2H]-195.84630932474
DeepCCS[M+Na]+170.26130932474
AllCCS[M+H]+174.732859911
AllCCS[M+H-H2O]+171.732859911
AllCCS[M+NH4]+177.532859911
AllCCS[M+Na]+178.332859911
AllCCS[M-H]-170.332859911
AllCCS[M+Na-2H]-169.932859911
AllCCS[M+HCOO]-169.632859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
2-hydroxy-dAMP[H][C@]1(O)C[C@@]([H])(O[C@]1([H])COP(O)(O)=O)N1C=NC2=C(N)N=C(O)N=C123895.9Standard polar33892256
2-hydroxy-dAMP[H][C@]1(O)C[C@@]([H])(O[C@]1([H])COP(O)(O)=O)N1C=NC2=C(N)N=C(O)N=C122535.5Standard non polar33892256
2-hydroxy-dAMP[H][C@]1(O)C[C@@]([H])(O[C@]1([H])COP(O)(O)=O)N1C=NC2=C(N)N=C(O)N=C123368.2Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
2-hydroxy-dAMP,1TMS,isomer #1C[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N)N=C(O)N=C32)O[C@@H]1COP(=O)(O)O3213.8Semi standard non polar33892256
2-hydroxy-dAMP,1TMS,isomer #2C[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O)O)O3)C2=N13167.5Semi standard non polar33892256
2-hydroxy-dAMP,1TMS,isomer #3C[Si](C)(C)OP(=O)(O)OC[C@H]1O[C@@H](N2C=NC3=C(N)N=C(O)N=C32)C[C@@H]1O3320.6Semi standard non polar33892256
2-hydroxy-dAMP,1TMS,isomer #4C[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O)O13282.7Semi standard non polar33892256
2-hydroxy-dAMP,2TMS,isomer #1C[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O)O3)C2=N13096.2Semi standard non polar33892256
2-hydroxy-dAMP,2TMS,isomer #2C[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N)N=C(O)N=C32)O[C@@H]1COP(=O)(O)O[Si](C)(C)C3246.5Semi standard non polar33892256
2-hydroxy-dAMP,2TMS,isomer #3C[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O)O13194.3Semi standard non polar33892256
2-hydroxy-dAMP,2TMS,isomer #4C[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C)O3)C2=N13178.6Semi standard non polar33892256
2-hydroxy-dAMP,2TMS,isomer #5C[Si](C)(C)NC1=NC(O[Si](C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O)O13151.7Semi standard non polar33892256
2-hydroxy-dAMP,2TMS,isomer #6C[Si](C)(C)OP(=O)(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=C(O)N=C32)C[C@@H]1O)O[Si](C)(C)C3280.8Semi standard non polar33892256
2-hydroxy-dAMP,2TMS,isomer #7C[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C)O13289.0Semi standard non polar33892256
2-hydroxy-dAMP,2TMS,isomer #8C[Si](C)(C)N(C1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O)O1)[Si](C)(C)C3184.9Semi standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #1C[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C)O3)C2=N13126.3Semi standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #1C[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C)O3)C2=N13052.7Standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #10C[Si](C)(C)OP(=O)(O)OC[C@H]1O[C@@H](N2C=NC3=C(N([Si](C)(C)C)[Si](C)(C)C)N=C(O)N=C32)C[C@@H]1O3216.8Semi standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #10C[Si](C)(C)OP(=O)(O)OC[C@H]1O[C@@H](N2C=NC3=C(N([Si](C)(C)C)[Si](C)(C)C)N=C(O)N=C32)C[C@@H]1O3316.4Standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #2C[Si](C)(C)NC1=NC(O[Si](C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O)O13079.3Semi standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #2C[Si](C)(C)NC1=NC(O[Si](C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O)O13209.0Standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #3C[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N)N=C(O)N=C32)O[C@@H]1COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C3212.1Semi standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #3C[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N)N=C(O)N=C32)O[C@@H]1COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C3111.1Standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #4C[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C)O13207.6Semi standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #4C[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C)O13221.1Standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #5C[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N([Si](C)(C)C)[Si](C)(C)C)N=C(O)N=C32)O[C@@H]1COP(=O)(O)O3123.0Semi standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #5C[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N([Si](C)(C)C)[Si](C)(C)C)N=C(O)N=C32)O[C@@H]1COP(=O)(O)O3313.5Standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #6C[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O3)C2=N13150.8Semi standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #6C[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O3)C2=N13102.8Standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #7C[Si](C)(C)NC1=NC(O[Si](C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C)O13170.0Semi standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #7C[Si](C)(C)NC1=NC(O[Si](C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C)O13221.7Standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #8C[Si](C)(C)OC1=NC(N([Si](C)(C)C)[Si](C)(C)C)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O)O)O3)C2=N13091.4Semi standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #8C[Si](C)(C)OC1=NC(N([Si](C)(C)C)[Si](C)(C)C)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O)O)O3)C2=N13328.2Standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #9C[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O13245.5Semi standard non polar33892256
2-hydroxy-dAMP,3TMS,isomer #9C[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O13250.8Standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #1C[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O3)C2=N13133.5Semi standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #1C[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O3)C2=N13034.8Standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #2C[Si](C)(C)NC1=NC(O[Si](C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C)O13146.8Semi standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #2C[Si](C)(C)NC1=NC(O[Si](C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C)O13172.0Standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #3C[Si](C)(C)OC1=NC(N([Si](C)(C)C)[Si](C)(C)C)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O)O3)C2=N13069.2Semi standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #3C[Si](C)(C)OC1=NC(N([Si](C)(C)C)[Si](C)(C)C)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O)O3)C2=N13298.7Standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #4C[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O13182.5Semi standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #4C[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O13224.9Standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #5C[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N([Si](C)(C)C)[Si](C)(C)C)N=C(O)N=C32)O[C@@H]1COP(=O)(O)O[Si](C)(C)C3171.4Semi standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #5C[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N([Si](C)(C)C)[Si](C)(C)C)N=C(O)N=C32)O[C@@H]1COP(=O)(O)O[Si](C)(C)C3298.2Standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #6C[Si](C)(C)NC1=NC(O[Si](C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O13183.9Semi standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #6C[Si](C)(C)NC1=NC(O[Si](C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O13211.6Standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #7C[Si](C)(C)OC1=NC(N([Si](C)(C)C)[Si](C)(C)C)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C)O3)C2=N13150.7Semi standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #7C[Si](C)(C)OC1=NC(N([Si](C)(C)C)[Si](C)(C)C)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C)O3)C2=N13299.2Standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #8C[Si](C)(C)OP(=O)(OC[C@H]1O[C@@H](N2C=NC3=C(N([Si](C)(C)C)[Si](C)(C)C)N=C(O)N=C32)C[C@@H]1O)O[Si](C)(C)C3208.0Semi standard non polar33892256
2-hydroxy-dAMP,4TMS,isomer #8C[Si](C)(C)OP(=O)(OC[C@H]1O[C@@H](N2C=NC3=C(N([Si](C)(C)C)[Si](C)(C)C)N=C(O)N=C32)C[C@@H]1O)O[Si](C)(C)C3333.0Standard non polar33892256
2-hydroxy-dAMP,5TMS,isomer #1C[Si](C)(C)NC1=NC(O[Si](C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O13177.5Semi standard non polar33892256
2-hydroxy-dAMP,5TMS,isomer #1C[Si](C)(C)NC1=NC(O[Si](C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O13157.3Standard non polar33892256
2-hydroxy-dAMP,5TMS,isomer #2C[Si](C)(C)OC1=NC(N([Si](C)(C)C)[Si](C)(C)C)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C)O3)C2=N13152.5Semi standard non polar33892256
2-hydroxy-dAMP,5TMS,isomer #2C[Si](C)(C)OC1=NC(N([Si](C)(C)C)[Si](C)(C)C)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C)O3)C2=N13240.7Standard non polar33892256
2-hydroxy-dAMP,5TMS,isomer #3C[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N([Si](C)(C)C)[Si](C)(C)C)N=C(O)N=C32)O[C@@H]1COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C3185.5Semi standard non polar33892256
2-hydroxy-dAMP,5TMS,isomer #3C[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N([Si](C)(C)C)[Si](C)(C)C)N=C(O)N=C32)O[C@@H]1COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C3272.4Standard non polar33892256
2-hydroxy-dAMP,5TMS,isomer #4C[Si](C)(C)OC1=NC(N([Si](C)(C)C)[Si](C)(C)C)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O3)C2=N13199.1Semi standard non polar33892256
2-hydroxy-dAMP,5TMS,isomer #4C[Si](C)(C)OC1=NC(N([Si](C)(C)C)[Si](C)(C)C)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O3)C2=N13273.5Standard non polar33892256
2-hydroxy-dAMP,6TMS,isomer #1C[Si](C)(C)OC1=NC(N([Si](C)(C)C)[Si](C)(C)C)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O3)C2=N13224.8Semi standard non polar33892256
2-hydroxy-dAMP,6TMS,isomer #1C[Si](C)(C)OC1=NC(N([Si](C)(C)C)[Si](C)(C)C)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)O3)C2=N13197.8Standard non polar33892256
2-hydroxy-dAMP,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N)N=C(O)N=C32)O[C@@H]1COP(=O)(O)O3486.9Semi standard non polar33892256
2-hydroxy-dAMP,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O)O)O3)C2=N13397.7Semi standard non polar33892256
2-hydroxy-dAMP,1TBDMS,isomer #3CC(C)(C)[Si](C)(C)OP(=O)(O)OC[C@H]1O[C@@H](N2C=NC3=C(N)N=C(O)N=C32)C[C@@H]1O3554.5Semi standard non polar33892256
2-hydroxy-dAMP,1TBDMS,isomer #4CC(C)(C)[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O)O13482.4Semi standard non polar33892256
2-hydroxy-dAMP,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O)O3)C2=N13585.6Semi standard non polar33892256
2-hydroxy-dAMP,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N)N=C(O)N=C32)O[C@@H]1COP(=O)(O)O[Si](C)(C)C(C)(C)C3717.8Semi standard non polar33892256
2-hydroxy-dAMP,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O)O13614.9Semi standard non polar33892256
2-hydroxy-dAMP,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O3)C2=N13621.7Semi standard non polar33892256
2-hydroxy-dAMP,2TBDMS,isomer #5CC(C)(C)[Si](C)(C)NC1=NC(O[Si](C)(C)C(C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O)O13557.2Semi standard non polar33892256
2-hydroxy-dAMP,2TBDMS,isomer #6CC(C)(C)[Si](C)(C)OP(=O)(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=C(O)N=C32)C[C@@H]1O)O[Si](C)(C)C(C)(C)C3725.6Semi standard non polar33892256
2-hydroxy-dAMP,2TBDMS,isomer #7CC(C)(C)[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O13715.0Semi standard non polar33892256
2-hydroxy-dAMP,2TBDMS,isomer #8CC(C)(C)[Si](C)(C)N(C1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O)O1)[Si](C)(C)C(C)(C)C3600.2Semi standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O3)C2=N13765.6Semi standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O3)C2=N13670.5Standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #10CC(C)(C)[Si](C)(C)OP(=O)(O)OC[C@H]1O[C@@H](N2C=NC3=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N=C(O)N=C32)C[C@@H]1O3806.4Semi standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #10CC(C)(C)[Si](C)(C)OP(=O)(O)OC[C@H]1O[C@@H](N2C=NC3=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N=C(O)N=C32)C[C@@H]1O3927.5Standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)NC1=NC(O[Si](C)(C)C(C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O)O13689.8Semi standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)NC1=NC(O[Si](C)(C)C(C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O)O13870.4Standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N)N=C(O)N=C32)O[C@@H]1COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3832.7Semi standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N)N=C(O)N=C32)O[C@@H]1COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3682.4Standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #4CC(C)(C)[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O13841.9Semi standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #4CC(C)(C)[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O13852.2Standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #5CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N=C(O)N=C32)O[C@@H]1COP(=O)(O)O3727.9Semi standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #5CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N=C(O)N=C32)O[C@@H]1COP(=O)(O)O3948.5Standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O3)C2=N13780.1Semi standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O3)C2=N13666.9Standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #7CC(C)(C)[Si](C)(C)NC1=NC(O[Si](C)(C)C(C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O13790.9Semi standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #7CC(C)(C)[Si](C)(C)NC1=NC(O[Si](C)(C)C(C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O13861.4Standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #8CC(C)(C)[Si](C)(C)OC1=NC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O)O)O3)C2=N13696.2Semi standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #8CC(C)(C)[Si](C)(C)OC1=NC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O)O)O3)C2=N13949.9Standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #9CC(C)(C)[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O13885.3Semi standard non polar33892256
2-hydroxy-dAMP,3TBDMS,isomer #9CC(C)(C)[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O13851.8Standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O3)C2=N13934.8Semi standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=NC(N)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O3)C2=N13738.7Standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)NC1=NC(O[Si](C)(C)C(C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O13913.6Semi standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)NC1=NC(O[Si](C)(C)C(C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O13966.7Standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC1=NC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O)O3)C2=N13842.0Semi standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC1=NC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C2N=CN([C@H]3C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O)O)O3)C2=N14070.2Standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O13975.1Semi standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)NC1=NC(O)=NC2=C1N=CN2[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O13953.5Standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #5CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N=C(O)N=C32)O[C@@H]1COP(=O)(O)O[Si](C)(C)C(C)(C)C3901.8Semi standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #5CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](N2C=NC3=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N=C(O)N=C32)O[C@@H]1COP(=O)(O)O[Si](C)(C)C(C)(C)C4050.8Standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #6CC(C)(C)[Si](C)(C)NC1=NC(O[Si](C)(C)C(C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O13947.2Semi standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #6CC(C)(C)[Si](C)(C)NC1=NC(O[Si](C)(C)C(C)(C)C)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O13953.9Standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC1=NC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O3)C2=N13902.1Semi standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC1=NC(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)=C2N=CN([C@H]3C[C@H](O)[C@@H](COP(=O)(O)O[Si](C)(C)C(C)(C)C)O3)C2=N14058.6Standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #8CC(C)(C)[Si](C)(C)OP(=O)(OC[C@H]1O[C@@H](N2C=NC3=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N=C(O)N=C32)C[C@@H]1O)O[Si](C)(C)C(C)(C)C3933.1Semi standard non polar33892256
2-hydroxy-dAMP,4TBDMS,isomer #8CC(C)(C)[Si](C)(C)OP(=O)(OC[C@H]1O[C@@H](N2C=NC3=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N=C(O)N=C32)C[C@@H]1O)O[Si](C)(C)C(C)(C)C4043.7Standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 2-hydroxy-dAMP GC-MS (Non-derivatized) - 70eV, Positivesplash10-0002-9311000000-d3a733f71ea5104021772017-09-20Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-hydroxy-dAMP GC-MS (2 TMS) - 70eV, Positivesplash10-01ot-8922400000-06c1f8038d2ded04d5252017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-hydroxy-dAMP GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-hydroxy-dAMP 10V, Positive-QTOFsplash10-0udi-0901000000-df1333834dbc263fe3f32017-10-06Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-hydroxy-dAMP 20V, Positive-QTOFsplash10-0udi-0900000000-f1177603229cfc26bfe52017-10-06Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-hydroxy-dAMP 40V, Positive-QTOFsplash10-0udi-0900000000-172318ac6d54fe3338d12017-10-06Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-hydroxy-dAMP 10V, Negative-QTOFsplash10-002b-5109000000-4d29a72b499ff32dc95c2017-10-06Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-hydroxy-dAMP 20V, Negative-QTOFsplash10-004i-9400000000-61a7c83f5835448eed502017-10-06Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-hydroxy-dAMP 40V, Negative-QTOFsplash10-004i-9000000000-07134af81f89006ad08f2017-10-06Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-hydroxy-dAMP 10V, Negative-QTOFsplash10-0002-1009000000-26798da1f29beddf1b8b2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-hydroxy-dAMP 20V, Negative-QTOFsplash10-004j-9203000000-2864aed181d34ffaf1b12021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-hydroxy-dAMP 40V, Negative-QTOFsplash10-004i-9000000000-0f86acaefb874926ae3f2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-hydroxy-dAMP 10V, Positive-QTOFsplash10-0f6t-0449000000-0270416f895f5196f2c92021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-hydroxy-dAMP 20V, Positive-QTOFsplash10-0udi-0910000000-42fd7c19e325257d266f2021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-hydroxy-dAMP 40V, Positive-QTOFsplash10-0udi-2900000000-a8e9bee314f31d024d722021-09-25Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDC19970
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound6323381
PDB ID0UH
ChEBI ID63211
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Fujikawa K, Kamiya H, Yakushiji H, Fujii Y, Nakabeppu Y, Kasai H: The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein. J Biol Chem. 1999 Jun 25;274(26):18201-5. [PubMed:10373420 ]
  2. Sakai Y, Furuichi M, Takahashi M, Mishima M, Iwai S, Shirakawa M, Nakabeppu Y: A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1. J Biol Chem. 2002 Mar 8;277(10):8579-87. Epub 2001 Dec 27. [PubMed:11756418 ]

Enzymes

General function:
Involved in 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
Specific function:
Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.
Gene Name:
NUDT1
Uniprot ID:
P36639
Molecular weight:
17951.435
Reactions
2-hydroxy-dATP + Water → 2-hydroxy-dAMP + Pyrophosphatedetails