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Record Information
Version4.0
StatusDetected and Quantified
Creation Date2017-03-23 02:20:52 UTC
Update Date2019-02-12 00:06:13 UTC
HMDB IDHMDB0062496
Secondary Accession Numbers
  • HMDB62496
Metabolite Identification
Common NameMalonyl-Carnitin
DescriptionMalonyl-Carnitin, also known as D,L-Carnitine or CARNITINE chloride, is classified as a member of the Carnitines. Carnitines are organic compounds containing the quaternary ammonium compound carnitine. Malonyl-Carnitin is considered to be slightly soluble (in water) and acidic. Malonyl-Carnitin can be synthesized from butyrate. It is also a parent compound for other transformation products, including but not limited to, O-sebacoylcarnitine, O-(4,8-dimethylnonanoyl)carnitine, and O-(11-carboxyundecanoyl)carnitine. Malonyl-Carnitin can be found in Avocado
Structure
Data?1549929973
Synonyms
ValueSource
(-)-CarnitineChEBI
(-)-L-CarnitineChEBI
3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner saltChEBI
CarnicorChEBI
CarniteneChEBI
CarnitineChEBI
CarnitorChEBI
KarnitinChEBI
LevocarnitineChEBI
Vitamin BTChEBI
(-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrateHMDB
(R)-(3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxideHMDB
(R)-CarnitineHMDB
(S)-CarnitineHMDB
1-CarnitineHMDB
3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminiumHMDB
3-Hydroxy-4-trimethylammoniobutanoateHMDB
3-Hydroxy-4-trimethylammoniobutanoic acidHMDB
BicarnesineHMDB
CarnikingHMDB
Carniking 50HMDB
CarnileanHMDB
CarnipassHMDB
Carnipass 20HMDB
D-CarnitineHMDB
delta-CarnitineHMDB
DL-CarnitineHMDB
gamma-Trimethyl-ammonium-beta-hydroxybutirateHMDB
gamma-Trimethyl-beta-hydroxybutyrobetaineHMDB
gamma-Trimethyl-hydroxybutyrobetaineHMDB
L-(-)-CarnitineHMDB
L-gamma-Trimethyl-beta-hydroxybutyrobetaineHMDB
LevocarnitinaHMDB
LevocarnitinumHMDB
R-(-)-3-Hydroxy-4-trimethylaminobutyrateHMDB
L CarnitineMeSH
Chemical FormulaC7H15NO3
Average Molecular Weight161.1989
Monoisotopic Molecular Weight161.105193351
IUPAC Name(3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate
Traditional NameL-carnitine
CAS Registry Number461-06-3
SMILES
C[N+](C)(C)CC(O)CC([O-])=O
InChI Identifier
InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3
InChI KeyPHIQHXFUZVPYII-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as carnitines. These are organic compounds containing the quaternary ammonium compound carnitine.
KingdomOrganic compounds
Super ClassOrganic nitrogen compounds
ClassOrganonitrogen compounds
Sub ClassQuaternary ammonium salts
Direct ParentCarnitines
Alternative Parents
Substituents
  • Carnitine
  • Beta-hydroxy acid
  • Short-chain hydroxy acid
  • Fatty acid
  • Hydroxy acid
  • Tetraalkylammonium salt
  • 1,2-aminoalcohol
  • Carboxylic acid salt
  • Secondary alcohol
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Organic oxygen compound
  • Organooxygen compound
  • Organic zwitterion
  • Organic salt
  • Hydrocarbon derivative
  • Organic oxide
  • Carbonyl group
  • Organopnictogen compound
  • Amine
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Disposition

Biological location:

Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility5.33 g/lALOGPS
LogP-2.90ALOGPS
Predicted Properties
PropertyValueSource
logP-2.9ALOGPS
logP-4.9ChemAxon
logS-1.6ALOGPS
pKa (Strongest Acidic)4.2ChemAxon
pKa (Strongest Basic)-3.6ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area60.36 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity63.49 m³·mol⁻¹ChemAxon
Polarizability16.93 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-00di-9100000000-1b25dacb04c3ed5be8d0JSpectraViewer | MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positivesplash10-00di-9100000000-c15eaa190d1e28a4839aJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-03di-0900000000-9b579c570aab7c7d3a21JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-0ik9-0900000000-e37d3def2de1af5bd2f5JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-0ue9-8900000000-cf37f0a721cd52d86e8eJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-0r0c-9200000000-a11a4872036f3c33d25aJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-0a4l-9000000000-2402e260a330ff1772a1JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT , positivesplash10-0w29-6900000000-d0136248acdd706e650bJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-0ik9-2900000000-61732bb10307f2b183caJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-0zg0-9400000000-15c3db3324f1d46d3c7cJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-0ik9-2900000000-ee79f10dce9fc09246ecJSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-01ox-0900000000-3bffd5143cf8b072299eJSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-00kf-0900000000-e68f553bcb15d3ef5b47JSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-00di-9200000000-c5b43723951af6da48cfJSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-03di-1900000000-dd1b1a023937cdcb11afJSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-114i-3900000000-9f24d3bc535736149e2aJSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0a4l-9000000000-632ef17d9dde38586990JSpectraViewer | MoNA
1D NMR1H NMR SpectrumNot AvailableJSpectraViewer
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified46.8 (24.8) uMAdult (>18 years old)FemaleLate-onset preeclampsia details
BloodDetected and Quantified27.8 (20.0) uMAdult (>18 years old)FemalePregnancy details
BloodDetected and Quantified50.65(14.14) uMAdult (>18 years old)BothHeart failure with preserved ejection fraction details
Associated Disorders and Diseases
Disease References
Late-onset preeclampsia
  1. Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: First-trimester metabolomic detection of late-onset preeclampsia. Am J Obstet Gynecol. 2013 Jan;208(1):58.e1-7. doi: 10.1016/j.ajog.2012.11.003. Epub 2012 Nov 13. [PubMed:23159745 ]
Pregnancy
  1. Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: First-trimester metabolomic detection of late-onset preeclampsia. Am J Obstet Gynecol. 2013 Jan;208(1):58.e1-7. doi: 10.1016/j.ajog.2012.11.003. Epub 2012 Nov 13. [PubMed:23159745 ]
Associated OMIM IDsNone
DrugBank IDDB00583
Phenol Explorer Compound IDNot Available
FoodDB IDFDB000572
KNApSAcK IDNot Available
Chemspider ID2006614
KEGG Compound IDC00318
BioCyc IDCARNITINE
BiGG ID34600
Wikipedia LinkCarnitine
METLIN ID52
PubChem Compound2724480
PDB ID1NDF
ChEBI ID16347
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available