Showing metabocard for Chenodeoxycholic acid glycine conjugate (HMDB00637)

General function:

Involved in thiolester hydrolase activity

Specific function:

Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.

Gene Name:

BAAT

Uniprot ID:

Q14032

Molecular weight:

46298.865

Reactions

General function:

Involved in glycine N-acyltransferase activity

Specific function:

Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.

Gene Name:

GLYAT

Uniprot ID:

Q6IB77

Molecular weight:

18506.33

General function:

Involved in glycine N-acyltransferase activity

Specific function:

Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.

Gene Name:

GLYATL1

Uniprot ID:

Q969I3

Molecular weight:

35100.895

General function:

Involved in glycine N-acyltransferase activity

Specific function:

Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine.

Gene Name:

GLYATL2

Uniprot ID:

Q8WU03

Molecular weight:

34277.055

General function:

Involved in glycine N-acyltransferase activity

Specific function:

Acyltransferase which transfers the acyl group to the N- terminus of glycine

Gene Name:

GLYATL3

Uniprot ID:

Q5SZD4

Molecular weight:

32703.3