Human Metabolome Database Version 3.5

Showing metabocard for Fe2+ (HMDB00692)

Record Information
Version 3.5
Creation Date 2006-08-16 06:15:16 -0600
Update Date 2013-05-15 14:27:23 -0600
HMDB ID HMDB00692
Secondary Accession Numbers None
Metabolite Identification
Common Name Fe2+
Description Iron is a chemical element with the symbol Fe and atomic number 26. Iron makes up 5% of the Earth's crust and is second in abundance to aluminium among the metals and fourth in abundance among the elements. Physiologically, it. exists as an ion in the body. Iron (as Fe2+, ferrous ion) is a necessary trace element used by all known living organisms. Iron-containing enzymes, usually containing heme prosthetic groups, participate in catalysis of oxidation reactions in biology, and in transport of a number of soluble gases. Iron is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Inorganic iron involved in redox reactions is also found in the iron-sulfur clusters of many enzymes, such as nitrogenase (involved in the synthesis of ammonia from nitrogen and hydrogen) and hydrogenase. A class of non-heme iron proteins is responsible for a wide range of functions such as ribonucleotide reductase (reduces ribose to deoxyribose; DNA biosynthesis) and purple acid phosphatase (hydrolysis of phosphate esters). When the body is fighting a bacterial infection, the body sequesters iron inside of cells (mostly stored in the storage molecule ferritin) so that it cannot be used by bacteria. Depletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia. Humans experience iron toxicity above 20 milligrams of iron for every kilogram of weight, and 60 milligrams per kilogram is a lethal dose. Over-consumption of iron, often the result of children eating large quantities of ferrous sulfate tablets intended for adult consumption, is the most common toxicological cause of death in children under six. The DRI lists the Tolerable Upper Intake Level (UL) for adults as 45 mg/day. For children under fourteen years old the UL is 40 mg/day. Iron is a metal extracted from iron ore, and is almost never found in the free elemental state.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. Armco iron
  2. Carbonyl iron
  3. FE
  4. Ferrovac e
  5. Hematite
  6. Infed
  7. Limonite
  8. LOHA
  9. Magnetite
  10. Malleable iron
  11. Metopirone
  12. Metyrapone
  13. Pzh2M
  14. PZHO
  15. Remko
  16. Suy-B 2
  17. Taconite
  18. Venofer
  19. Wrought iron
Chemical Formula Fe
Average Molecular Weight 55.845
Monoisotopic Molecular Weight 55.934942133
IUPAC Name iron(2+) ion
Traditional IUPAC Name iron ion(2+)
CAS Registry Number 15438-31-0
SMILES [Fe++]
InChI Identifier InChI=1S/Fe/q+2
InChI Key CWYNVVGOOAEACU-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom Inorganic Compounds
Super Class Homogeneous Metal Compounds
Class Homogeneous Transition Metal Compounds
Sub Class N/A
Other Descriptors
  • iron group element atom(ChEBI)
Substituents
  • N/A
Direct Parent Homogeneous Transition Metal Compounds
Ontology
Status Detected and Quantified
Origin
  • Drug
  • Food
Biofunction
  • Component of Porphyrin and chlorophyll metabolism
  • DNA component
  • Enzyme co-factor
  • Essential minerals
Application Not Available
Cellular locations
  • Extracellular
  • Mitochondria
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point 1538 °C Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
LogP -0.77 ChemAxon
Hydrogen Acceptor Count 0 ChemAxon
Hydrogen Donor Count 0 ChemAxon
Polar Surface Area 0 A2 ChemAxon
Rotatable Bond Count 0 ChemAxon
Refractivity 0 ChemAxon
Polarizability 1.78 ChemAxon
Formal Charge 2 ChemAxon
Physiological Charge 2 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations
  • Extracellular
  • Mitochondria
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Location
  • Liver
  • Brain
Pathways Not Available
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
9766 +/- 1246 uM Adult (>18 years old) Both Comment Normal
Blood Detected and Quantified
8050.0 (7500.0-8600.0) uM Adult (>18 years old) Female Comment Normal
  • Geigy Scient...
Blood Detected and Quantified
8950.0 (7900.0-10000.0) uM Adult (>18 years old) Male Comment Normal
  • Geigy Scient...
Cerebrospinal Fluid (CSF) Detected and Quantified
3.6 +/- 3.6 uM Elderly (>65 years old) Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
9.293 +/- 1.140 uM Adult (>18 years old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.8 (0.3-0.5) uM Adult (>18 years old) Both Normal
  • Geigy Scient...
Cerebrospinal Fluid (CSF) Detected and Quantified
0.783 +/- 0.551 uM Adult (>18 years old) Female Normal
Urine Detected and Quantified
0.0890 (0.0025-0.4579) umol/mmol creatinine Adult (>18 years old) Both Comment Normal
Urine Detected and Quantified
0.11 (0.0-0.14) umol/mmol creatinine Adult (>18 years old) Both Normal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
Urine Detected and Quantified
0.029 (0.014-0.053) umol/mmol creatinine Adult (>18 years old) Male Normal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified 8631 +/- 1497 uM Adult (>18 years old) Both Comment Multiple sclerosis
Blood Detected and Quantified 20.1 +/- 7.7 uM Adult (>18 years old) Both Parkinson's disease
Blood Detected and Quantified 16.3 +/- 7.7 uM Elderly (>65 years old) Both Alzheimer's disease
Cerebrospinal Fluid (CSF) Detected and Quantified 0.488 +/- 0.374 uM Adult (>18 years old) Not Specified fibromyalgia
Cerebrospinal Fluid (CSF) Detected and Quantified 1.8 +/- 1.8 uM Elderly (>65 years old) Both Alzheimer's disease
Cerebrospinal Fluid (CSF) Detected and Quantified 2.5 +/- 1.8 uM Elderly (>65 years old) Not Specified Alzheimer's disease
Associated Disorders and Diseases
Disease References
Alzheimer's disease
  • Molina JA, Jimenez-Jimenez FJ, Aguilar MV, Meseguer I, Mateos-Vega CJ, Gonzalez-Munoz MJ, de Bustos F, Porta J, Orti-Pareja M, Zurdo M, Barrios E, Martinez-Para MC: Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease. J Neural Transm. 1998;105(4-5):479-88. Pubmed: 9720975 Link_out
  • Bocca B, Forte G, Petrucci F, Pino A, Marchione F, Bomboi G, Senofonte O, Giubilei F, Alimonti A: Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease. Ann Ist Super Sanita. 2005;41(2):197-203. Pubmed: 16244393 Link_out
      Multiple sclerosis
      • Forte G, Visconti A, Santucci S, Ghazaryan A, Figa-Talamanca L, Cannoni S, Bocca B, Pino A, Violante N, Alimonti A, Salvetti M, Ristori G: Quantification of chemical elements in blood of patients affected by multiple sclerosis. Ann Ist Super Sanita. 2005;41(2):213-6. Pubmed: 16244395 Link_out
          Parkinson's disease
          • Forte G, Alimonti A, Pino A, Stanzione P, Brescianini S, Brusa L, Sancesario G, Violante N, Bocca B: Metals and oxidative stress in patients with Parkinson's disease. Ann Ist Super Sanita. 2005;41(2):189-95. Pubmed: 16244392 Link_out
              Associated OMIM IDs
              DrugBank ID DB01592 Link_out
              DrugBank Metabolite ID Not Available
              Phenol Explorer Compound ID Not Available
              Phenol Explorer Metabolite ID Not Available
              FoodDB ID FDB016251
              KNApSAcK ID Not Available
              Chemspider ID 25394 Link_out
              KEGG Compound ID C14818 Link_out
              BioCyc ID Ferric-Hydroxamate-Complexes Link_out
              BiGG ID 33552 Link_out
              Wikipedia Link Ferrous_ion Link_out
              NuGOwiki Link HMDB00692 Link_out
              Metagene Link HMDB00692 Link_out
              METLIN ID Not Available
              PubChem Compound 27284 Link_out
              PDB ID FE2 Link_out
              ChEBI ID 29033 Link_out
              References
              Synthesis Reference Not Available
              Material Safety Data Sheet (MSDS) Download (PDF)
              General References
              1. Gal S, Fridkin M, Amit T, Zheng H, Youdim MB: M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase-ab inhibitory activity for Parkinson's disease. J Neural Transm Suppl. 2006;(70):447-56. Pubmed: 17017567 Link_out
              2. Piga A, Galanello R, Forni GL, Cappellini MD, Origa R, Zappu A, Donato G, Bordone E, Lavagetto A, Zanaboni L, Sechaud R, Hewson N, Ford JM, Opitz H, Alberti D: Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload. Haematologica. 2006 Jul;91(7):873-80. Pubmed: 16818273 Link_out
              3. Nasolodin VV, Zaitseva IP, Gladkikh IP, Voronin SM: [Correction of iron and immune deficiencies in students from a higher humanitarian educational establishment] Gig Sanit. 2005 Sep-Oct;(5):64-7. Pubmed: 16277000 Link_out
              4. Custodio PJ, Carvalho ML, Nunes F, Pedroso S, Campos A: Direct analysis of human blood (mothers and newborns) by energy dispersive X-ray fluorescence. J Trace Elem Med Biol. 2005;19(2-3):151-8. Epub 2005 Oct 24. Pubmed: 16325530 Link_out
              5. Agarwal MB: Exjade (ICL 670): A new oral iron chelator. J Assoc Physicians India. 2006 Mar;54:214-7. Pubmed: 16800349 Link_out
              6. Cortese S, Konofal E, Lecendreux M, Mouren MC, Bernardina BD: Restless legs syndrome triggered by heart surgery. Pediatr Neurol. 2006 Sep;35(3):223-6. Pubmed: 16939866 Link_out
              7. Barkova EN, Nazarenko EV, Zhdanova EV: Diurnal variations in qualitative composition of breast milk in women with iron deficiency. Bull Exp Biol Med. 2005 Oct;140(4):394-6. Pubmed: 16671562 Link_out
              8. Christoforidis A, Haritandi A, Tsitouridis I, Tsatra I, Tsantali H, Karyda S, Dimitriadis AS, Athanassiou-Metaxa M: Correlative study of iron accumulation in liver, myocardium, and pituitary assessed with MRI in young thalassemic patients. J Pediatr Hematol Oncol. 2006 May;28(5):311-5. Pubmed: 16772883 Link_out
              9. Kom GD, Schwedhelm E, Nielsen P, Boger RH: Increased urinary excretion of 8-iso-prostaglandin F2alpha in patients with HFE-related hemochromatosis: a case-control study. Free Radic Biol Med. 2006 Apr 1;40(7):1194-200. Epub 2005 Dec 13. Pubmed: 16545687 Link_out
              10. Gerlach M, Double KL, Youdim MB, Riederer P: Potential sources of increased iron in the substantia nigra of parkinsonian patients. J Neural Transm Suppl. 2006;(70):133-42. Pubmed: 17017520 Link_out
              11. Jost PJ, Stengel SM, Huber W, Sarbia M, Peschel C, Duyster J: Very severe iron-deficiency anemia in a patient with celiac disease and bulimia nervosa: a case report. Int J Hematol. 2005 Nov;82(4):310-1. Pubmed: 16298820 Link_out
              12. St Pierre TG, Clark PR, Chua-Anusorn W: Measurement and mapping of liver iron concentrations using magnetic resonance imaging. Ann N Y Acad Sci. 2005;1054:379-85. Pubmed: 16339686 Link_out
              13. Clardy SL, Earley CJ, Allen RP, Beard JL, Connor JR: Ferritin subunits in CSF are decreased in restless legs syndrome. J Lab Clin Med. 2006 Feb;147(2):67-73. Pubmed: 16459164 Link_out
              14. Grosse R, Lund U, Caruso V, Fischer R, Janka GE, Magnano C, Engelhardt R, Durken M, Nielsen P: Non-transferrin-bound iron during blood transfusion cycles in beta-thalassemia major. Ann N Y Acad Sci. 2005;1054:429-32. Pubmed: 16339692 Link_out
              15. Anderson LJ, Westwood MA, Prescott E, Walker JM, Pennell DJ, Wonke B: Development of thalassaemic iron overload cardiomyopathy despite low liver iron levels and meticulous compliance to desferrioxamine. Acta Haematol. 2006;115(1-2):106-8. Pubmed: 16424659 Link_out
              16. Matinaho S, Karhumaki P, Parkkinen J: Bicarbonate inhibits the growth of Staphylococcus epidermidis in platelet concentrates by lowering the level of non-transferrin-bound iron. Transfusion. 2005 Nov;45(11):1768-73. Pubmed: 16271102 Link_out
              17. Blanck HM, Cogswell ME, Gillespie C, Reyes M: Iron supplement use and iron status among US adults: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr. 2005 Nov;82(5):1024-31. Pubmed: 16280434 Link_out
              18. Yarali N, Fisgin T, Duru F, Kara A, Ecin N, Fitoz S, Erden I: Subcutaneous bolus injection of deferoxamine is an alternative method to subcutaneous continuous infusion. J Pediatr Hematol Oncol. 2006 Jan;28(1):11-6. Pubmed: 16394886 Link_out
              19. Walter PB, Fung EB, Killilea DW, Jiang Q, Hudes M, Madden J, Porter J, Evans P, Vichinsky E, Harmatz P: Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease. Br J Haematol. 2006 Oct;135(2):254-63. Pubmed: 17010049 Link_out
              20. Kontoghiorghes GJ, Kolnagou A: Molecular factors and mechanisms affecting iron and other metal excretion or absorption in health and disease: the role of natural and synthetic chelators. Curr Med Chem. 2005;12(23):2695-709. Pubmed: 16305466 Link_out

              Enzymes

              Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 189 enzymes in total.

              Name: 5-aminolevulinate synthase, erythroid-specific, mitochondrial
              Reactions: Not Available
              Gene Name: ALAS2
              Uniprot ID: P22557 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: 85/88 kDa calcium-independent phospholipase A2
              Reactions: Not Available
              Gene Name: PLA2G6
              Uniprot ID: O60733 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Tartrate-resistant acid phosphatase type 5
              Reactions: Not Available
              Gene Name: ACP5
              Uniprot ID: P13686 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Ribonucleoside-diphosphate reductase large subunit
              Reactions: Not Available
              Gene Name: RRM1
              Uniprot ID: P23921 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Ribonucleoside-diphosphate reductase subunit M2
              Reactions: Not Available
              Gene Name: RRM2
              Uniprot ID: P31350 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH-ubiquinone oxidoreductase chain 1
              Reactions: Not Available
              Gene Name: MT-ND1
              Uniprot ID: P03886 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
              Reactions: Not Available
              Gene Name: NDUFB1
              Uniprot ID: O75438 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
              Reactions: Not Available
              Gene Name: NDUFS2
              Uniprot ID: O75306 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
              Reactions: Not Available
              Gene Name: SDHC
              Uniprot ID: Q99643 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
              Reactions: Not Available
              Gene Name: PAOX
              Uniprot ID: Q6QHF9 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
              Reactions: Not Available
              Gene Name: NDUFA12
              Uniprot ID: Q9UI09 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
              Reactions: Not Available
              Gene Name: NDUFA1
              Uniprot ID: O15239 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
              Reactions: Not Available
              Gene Name: NDUFA4L2
              Uniprot ID: Q9NRX3 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
              Reactions: Not Available
              Gene Name: NDUFA3
              Uniprot ID: O95167 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
              Reactions: Not Available
              Gene Name: NDUFA8
              Uniprot ID: P51970 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4
              Reactions: Not Available
              Gene Name: NDUFA4
              Uniprot ID: O00483 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH-ubiquinone oxidoreductase chain 4L
              Reactions: Not Available
              Gene Name: MT-ND4L
              Uniprot ID: P03901 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
              Reactions: Not Available
              Gene Name: NDUFA11
              Uniprot ID: Q86Y39 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Lathosterol oxidase
              Reactions: Not Available
              Gene Name: SC5DL
              Uniprot ID: O75845 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
              Reactions: Not Available
              Gene Name: NDUFS4
              Uniprot ID: O43181 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
              Reactions: Not Available
              Gene Name: NDUFS3
              Uniprot ID: O75489 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
              Reactions: Not Available
              Gene Name: NDUFS5
              Uniprot ID: O43920 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
              Reactions: Not Available
              Gene Name: NDUFV2
              Uniprot ID: P19404 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
              Reactions: Not Available
              Gene Name: NDUFA10
              Uniprot ID: O95299 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
              Reactions: Not Available
              Gene Name: NDUFA6
              Uniprot ID: P56556 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
              Reactions: Not Available
              Gene Name: NDUFB4
              Uniprot ID: O95168 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
              Reactions: Not Available
              Gene Name: SDHA
              Uniprot ID: P31040 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Heme oxygenase 2
              Reactions:
              Heme + AH(2) + Oxygen unknown Biliverdin + Fe2+ + CO + A + Water details
              Gene Name: HMOX2
              Uniprot ID: P30519 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
              Reactions: Not Available
              Gene Name: NDUFS8
              Uniprot ID: O00217 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH-ubiquinone oxidoreductase chain 2
              Reactions: Not Available
              Gene Name: MT-ND2
              Uniprot ID: P03891 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
              Reactions: Not Available
              Gene Name: NDUFA7
              Uniprot ID: O95182 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
              Reactions: Not Available
              Gene Name: NDUFA2
              Uniprot ID: O43678 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
              Reactions: Not Available
              Gene Name: NDUFS1
              Uniprot ID: P28331 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
              Reactions: Not Available
              Gene Name: NDUFB5
              Uniprot ID: O43674 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 subunit C2
              Reactions: Not Available
              Gene Name: NDUFC2
              Uniprot ID: O95298 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
              Reactions: Not Available
              Gene Name: NDUFB3
              Uniprot ID: O43676 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
              Reactions: Not Available
              Gene Name: NDUFB7
              Uniprot ID: P17568 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Acyl carrier protein, mitochondrial
              Reactions: Not Available
              Gene Name: NDUFAB1
              Uniprot ID: O14561 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
              Reactions: Not Available
              Gene Name: NDUFA5
              Uniprot ID: Q16718 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
              Reactions: Not Available
              Gene Name: ETFDH
              Uniprot ID: Q16134 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
              Reactions: Not Available
              Gene Name: NDUFA9
              Uniprot ID: Q16795 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH-ubiquinone oxidoreductase chain 4
              Reactions: Not Available
              Gene Name: MT-ND4
              Uniprot ID: P03905 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
              Reactions: Not Available
              Gene Name: SDHD
              Uniprot ID: O14521 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
              Reactions: Not Available
              Gene Name: NDUFS7
              Uniprot ID: O75251 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Xanthine dehydrogenase/oxidase
              Reactions: Not Available
              Gene Name: XDH
              Uniprot ID: P47989 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
              Reactions: Not Available
              Gene Name: NDUFV1
              Uniprot ID: P49821 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
              Reactions: Not Available
              Gene Name: NDUFB9
              Uniprot ID: Q9Y6M9 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH-ubiquinone oxidoreductase chain 6
              Reactions: Not Available
              Gene Name: MT-ND6
              Uniprot ID: P03923 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
              Reactions: Not Available
              Gene Name: NDUFA13
              Uniprot ID: Q9P0J0 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
              Reactions: Not Available
              Gene Name: NDUFS6
              Uniprot ID: O75380 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Transporters
              Name: Cubilin
              Reactions: Not Available
              Gene Name: CUBN
              Uniprot ID: O60494 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Proton-coupled folate transporter
              Reactions: Not Available
              Gene Name: SLC46A1
              Uniprot ID: Q96NT5 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA