Human Metabolome Database Version 3.5

Showing metabocard for 5-Hydroxyindoleacetic acid (HMDB00763)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:09:16 -0700
HMDB ID HMDB00763
Secondary Accession Numbers None
Metabolite Identification
Common Name 5-Hydroxyindoleacetic acid
Description 5-hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors. (NCI).
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. 5-HIAA
  2. 5-Hydroxy-1H-indole-3-acetate
  3. 5-Hydroxy-1H-indole-3-acetic acid
  4. 5-Hydroxy-3-indolylacetate
  5. 5-Hydroxy-IAA
  6. 5-Hydroxy-Indole-3-acetate
  7. 5-Hydroxy-Indole-3-acetic acid
  8. 5-Hydroxyheteroauxin
  9. 5-Hydroxyindol-3-ylacetate
  10. 5-Hydroxyindol-3-ylacetic acid
  11. 5-Hydroxyindole acetate
  12. 5-Hydroxyindole-3-acetate
  13. 5-Hydroxyindole-3-acetic acid
  14. 5-Hydroxyindoleacetate
  15. 5-Hydroxyindoleacetic acid
  16. 5-Oxyindoleacetate
  17. 5-Oxyindoleacetic acid
  18. 5HIAA
  19. Hydroxyindoleacetate
Chemical Formula C10H9NO3
Average Molecular Weight 191.1834
Monoisotopic Molecular Weight 191.058243159
IUPAC Name 2-(5-hydroxy-1H-indol-3-yl)acetic acid
Traditional IUPAC Name (5-hydroxy-1H-indol-3-yl)acetic acid
CAS Registry Number 54-16-0
SMILES OC(=O)CC1=CNC2=CC=C(O)C=C12
InChI Identifier InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)
InChI Key DUUGKQCEGZLZNO-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Aromatic Heteropolycyclic Compounds
Class Indoles
Sub Class Indolyl Carboxylic Acids and Derivatives
Other Descriptors
  • Indoles
  • indole-3-acetic acids(ChEBI)
Substituents
  • Carboxylic Acid
  • Phenol
  • Phenol Derivative
  • Pyrrole
Direct Parent Indole-3-acetic Acid Derivatives
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction Not Available
Application Not Available
Cellular locations
  • Cytoplasm
  • Mitochondria
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point 161 - 163 °C Not Available
Boiling Point Not Available Not Available
Water Solubility 24 mg/mL Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility 1.8 g/L ALOGPS
LogP 1.28 ALOGPS
LogP 1.41 ChemAxon
LogS -2.03 ALOGPS
pKa (strongest acidic) 4.22 ChemAxon
pKa (strongest basic) -5.5 ChemAxon
Hydrogen Acceptor Count 3 ChemAxon
Hydrogen Donor Count 3 ChemAxon
Polar Surface Area 73.32 A2 ChemAxon
Rotatable Bond Count 2 ChemAxon
Refractivity 50.43 ChemAxon
Polarizability 18.71 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -1 ChemAxon
Spectra
Gas-MS Spectrum
1H NMR Spectrum
MS/MS Spectrum Quattro_QQQ 10
MS/MS Spectrum Quattro_QQQ 25
MS/MS Spectrum Quattro_QQQ 40
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 10
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 20
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 30
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 40
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 50
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 10
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 20
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 30
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 40
MS/MS Spectrum LC-ESI-QQ (API3000, Applied Biosystems) 50
MS/MS Spectrum GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies )
MS/MS Spectrum GC-MS
[1H,13C] 2D NMR Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Mitochondria
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Location
  • Testes
  • Liver
  • Brain
  • Prostate
  • Nerve Cells
  • Platelet
  • Spleen
  • Hippocampus
  • Central Nervous System
  • Spinal Cord
  • Hypothalamus
Pathways
Name SMPDB Link KEGG Link
Tryptophan Metabolism SMP00063 map00380 Link_out
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
0.0516 +/- 0.0068 uM Adult (>18 years old) Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.307 (0.152-0.462) uM Infant (0-1 year old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.428-1.122 uM Children (1-13 year old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.119-0.608 uM Children (1-13 year old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.07-0.14 uM Adult (>18 years old) Not Specified Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.109-0.214 uM Children (1-13 year old) Male Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.1-0.245 uM Children (1-13 year old) Male Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.61 +/- 0.06 uM Children (1-13 year old) Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.4 +/- 0.07 uM Adult (>18 years old) Male Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.47 (0.15-0.80) uM Infant (0-1 year old) Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.025 +/- 0.011 uM Adult (>18 years old) Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
0.143 +/- 0.045 uM Adult (>18 years old) Both Normal
  • Geigy Scient...
Urine Detected and Quantified
3.0 (0.48-4.5) umol/mmol creatinine Children (1-13 year old) Both Normal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
Urine Detected and Quantified
1.57 +/- 0.38 umol/mmol creatinine Adult (>18 years old) Both Normal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
Urine Detected and Quantified
4.75 +/- 5.38 umol/mmol creatinine Infant (0-1 year old) Both Normal
Urine Detected and Quantified
1.18 umol/mmol creatinine Adult (>18 years old) Both Normal
Urine Detected and Quantified
11.0 (4.0-18.0) umol/mmol creatinine Infant (0-1 year old) Not Specified Normal
Urine Detected but not Quantified
Not Applicable Adult (>18 years old) Both Comment Normal
Urine Detected and Quantified
1.5 (0-7.2) umol/mmol creatinine Adult (>18 years old) Both Normal
Urine Detected and Quantified
1.1 +/- 0.5 umol/mmol creatinine Adult (>18 years old) Both Normal
Urine Detected and Quantified
2.4 +/- 0.40 umol/mmol creatinine Adult (>18 years old) Both Normal
Urine Detected and Quantified
2.9 (0.4-5.8) umol/mmol creatinine Adult (>18 years old) Both Comment Normal
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified 0.0475 +/- 0.0130 uM Adult (>18 years old) Male Schizophrenia
Blood Detected and Quantified 0.0449 +/- 0.0140 uM Adult (>18 years old) Female Schizophrenia
Cerebrospinal Fluid (CSF) Detected and Quantified 0.0703 +/- 0.0254 uM Adult (>18 years old) Both celiac disease
Cerebrospinal Fluid (CSF) Detected and Quantified 0.22725 (0.117-0.519) uM Newborn (0-30 days old) Not Specified PNPO deficiency
Cerebrospinal Fluid (CSF) Detected and Quantified 0.0045 (0.004-0.005) uM Children (1-13 year old) Male sepiapterin reductase deficiency
Cerebrospinal Fluid (CSF) Detected and Quantified 0.0025 (0.0000-0.0050) uM Infant (0-1 year old) Male Aromatic L-amino acid decarboxylase deficiency
Cerebrospinal Fluid (CSF) Detected and Quantified 0.519 uM Newborn (0-30 days old) Not Specified PNPO deficiency
Cerebrospinal Fluid (CSF) Detected and Quantified 0.122 uM Newborn (0-30 days old) Not Specified PNPO deficiency
Cerebrospinal Fluid (CSF) Detected and Quantified 0.117 uM Newborn (0-30 days old) Not Specified PNPO deficiency
Cerebrospinal Fluid (CSF) Detected and Quantified 0.151 uM Newborn (0-30 days old) Not Specified PNPO deficiency
Cerebrospinal Fluid (CSF) Detected and Quantified 0.071 +/- 0.0268 uM Adult (>18 years old) Not Specified celiac disease
Cerebrospinal Fluid (CSF) Detected and Quantified 0.33 +/- 0.04 uM Children (1-13 year old) Both Epilepsy
Cerebrospinal Fluid (CSF) Detected and Quantified 0.1491 +/- 0.0591 uM Adult (>18 years old) Not Specified Leuprolide acetate-induce hypogonadism
Cerebrospinal Fluid (CSF) Detected and Quantified 0.1373 +/- 0.0457 uM Adult (>18 years old) Not Specified Leuprolide acetate-induced hypogonadism with testosterone replacment
Cerebrospinal Fluid (CSF) Detected and Quantified 0.08 +/- 0.08 uM Adult (>18 years old) Both Comment Major depression
Cerebrospinal Fluid (CSF) Detected and Quantified 0.0887 +/- 0.0385 uM Not Specified Not Specified Bipolar with childhood ADHD (attention-deficit hyperactivity disorder)
Cerebrospinal Fluid (CSF) Detected and Quantified 0.116 +/- 0.0479 uM Not Specified Not Specified pure bipolar
Cerebrospinal Fluid (CSF) Detected and Quantified 0.126 +/- 0.0526 uM Not Specified Not Specified Control (men)
Cerebrospinal Fluid (CSF) Detected and Quantified 0.096 +/- 0.0384 uM Not Specified Female Control (women)
Cerebrospinal Fluid (CSF) Detected and Quantified 0.112 +/- 0.0483 uM Not Specified Not Specified With lithium treatment
Cerebrospinal Fluid (CSF) Detected and Quantified 0.0983 +/- 0.0444 uM Not Specified Not Specified Without lithium treatment
Cerebrospinal Fluid (CSF) Detected and Quantified 0.0912 +/- 0.0387 uM Not Specified Not Specified With antipsychotic treatment
Cerebrospinal Fluid (CSF) Detected and Quantified 0.123 +/- 0.0505 uM Not Specified Not Specified Without antipsychotic treatment
Cerebrospinal Fluid (CSF) Detected and Quantified 0.116 +/- 0.053 uM Not Specified Not Specified With episodes of interpersonal violence
Cerebrospinal Fluid (CSF) Detected and Quantified 0.104 +/- 0.0386 uM Not Specified Not Specified Without episodes of interpersonal violence
Cerebrospinal Fluid (CSF) Detected and Quantified 0.1 +/- 0.01 uM Adult (>18 years old) Both Friedreich's ataxia
Cerebrospinal Fluid (CSF) Detected and Quantified 0.11 +/- 0.01 uM Adult (>18 years old) Both Olivopontocerebellar atrophy (OPCA)
Cerebrospinal Fluid (CSF) Detected and Quantified 0.1 +/- 0.02 uM Adult (>18 years old) Both Spastic Ataxia
Cerebrospinal Fluid (CSF) Detected and Quantified 0.019 +/- 0.0094 uM Adult (>18 years old) Both Schizophrenia
Urine Detected and Quantified 0.9 +/- 0.0 umol/mmol creatinine Infant (0-1 year old) Male Aromatic L-amino acid decarboxylase deficiency
Urine Detected and Quantified 5.0 umol/mmol creatinine Adult (>18 years old) Male Carcinoid tumors
Associated Disorders and Diseases
Disease References
Epilepsy
  • Shaywitz BA, Cohen DJ, Bowers MB: Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. Neurology. 1975 Jan;25(1):72-9. Pubmed: 803305 Link_out
      Major depressive disorder
      • Sheline Y, Bardgett ME, Csernansky JG: Correlated reductions in cerebrospinal fluid 5-HIAA and MHPG concentrations after treatment with selective serotonin reuptake inhibitors. J Clin Psychopharmacol. 1997 Feb;17(1):11-4. Pubmed: 9004051 Link_out
          Friedreich's ataxia
          • Botez MI, Young SN: Biogenic amine metabolites and thiamine in cerebrospinal fluid in heredo-degenerative ataxias. Can J Neurol Sci. 2001 May;28(2):134-40. Pubmed: 11383938 Link_out
              Olivopontocerebral atrophy
              • Botez MI, Young SN: Biogenic amine metabolites and thiamine in cerebrospinal fluid in heredo-degenerative ataxias. Can J Neurol Sci. 2001 May;28(2):134-40. Pubmed: 11383938 Link_out
                  Hereditary spastic paraplegia
                  • Botez MI, Young SN: Biogenic amine metabolites and thiamine in cerebrospinal fluid in heredo-degenerative ataxias. Can J Neurol Sci. 2001 May;28(2):134-40. Pubmed: 11383938 Link_out
                      Schizophrenia
                      • Alfredsson G, Wiesel FA: Monoamine metabolites and amino acids in serum from schizophrenic patients before and during sulpiride treatment. Psychopharmacology (Berl). 1989;99(3):322-7. Pubmed: 2480613 Link_out
                      • Do KQ, Lauer CJ, Schreiber W, Zollinger M, Gutteck-Amsler U, Cuenod M, Holsboer F: gamma-Glutamylglutamine and taurine concentrations are decreased in the cerebrospinal fluid of drug-naive patients with schizophrenic disorders. J Neurochem. 1995 Dec;65(6):2652-62. Pubmed: 7595563 Link_out
                          Aromatic L-amino acid decarboxylase deficiency
                          • Abdenur JE, Abeling N, Specola N, Jorge L, Schenone AB, van Cruchten AC, Chamoles NA: Aromatic l-aminoacid decarboxylase deficiency: unusual neonatal presentation and additional findings in organic acid analysis. Mol Genet Metab. 2006 Jan;87(1):48-53. Epub 2005 Nov 9. Pubmed: 16288991 Link_out
                              Associated OMIM IDs
                              • 608516 Link_out (Major depressive disorder)
                              • 229300 Link_out (Friedreich's ataxia)
                              • 182601 Link_out (Hereditary spastic paraplegia)
                              • 181500 Link_out (Schizophrenia)
                              • 107930 Link_out (Aromatic L-amino acid decarboxylase deficiency)
                              DrugBank ID Not Available
                              DrugBank Metabolite ID Not Available
                              Phenol Explorer Compound ID Not Available
                              Phenol Explorer Metabolite ID Not Available
                              FoodDB ID FDB001403
                              KNApSAcK ID C00000104 Link_out
                              Chemspider ID 1760 Link_out
                              KEGG Compound ID C05635 Link_out
                              BioCyc ID 5-HYDROXYINDOLE_ACETATE Link_out
                              BiGG ID 46167 Link_out
                              Wikipedia Link 5-Hydroxyindoleacetic acid Link_out
                              NuGOwiki Link HMDB00763 Link_out
                              Metagene Link HMDB00763 Link_out
                              METLIN ID 2975 Link_out
                              PubChem Compound 1826 Link_out
                              PDB ID HID Link_out
                              ChEBI ID 27823 Link_out
                              References
                              Synthesis Reference Asero, B.; Colo, V. A.; Vercellone, A. Preparation of 5-hydroxy-3-indoleacetic acid. Farmaco, Edizione Scientifica (1956), 11 219-20.
                              Material Safety Data Sheet (MSDS) Not Available
                              General References
                              1. Carpenter LL, Anderson GM, Siniscalchi JM, Chappell PB, Price LH: Acute changes in cerebrospinal fluid 5-HIAA following oral paroxetine challenge in healthy humans. Neuropsychopharmacology. 2003 Feb;28(2):339-47. Pubmed: 12589387 Link_out
                              2. Owens MJ, Nemeroff CB: Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem. 1994 Feb;40(2):288-95. Pubmed: 7508830 Link_out
                              3. Li JM, Kong LD, Wang YM, Cheng CH, Zhang WY, Tan WZ: Behavioral and biochemical studies on chronic mild stress models in rats treated with a Chinese traditional prescription Banxia-houpu decoction. Life Sci. 2003 Nov 21;74(1):55-73. Pubmed: 14575813 Link_out
                              4. Christofides J, Bridel M, Egerton M, Mackay GM, Forrest CM, Stoy N, Darlington LG, Stone TW: Blood 5-hydroxytryptamine, 5-hydroxyindoleacetic acid and melatonin levels in patients with either Huntington's disease or chronic brain injury. J Neurochem. 2006 May;97(4):1078-88. Epub 2006 Mar 29. Pubmed: 16573644 Link_out
                              5. Csernansky JG, Sheline YI: Abnormalities of serotonin metabolism and nonpsychotic psychiatric disorders. Ann Clin Psychiatry. 1993 Dec;5(4):275-81. Pubmed: 8312985 Link_out
                              6. Rotondo A, Schuebel K, Bergen A, Aragon R, Virkkunen M, Linnoila M, Goldman D, Nielsen D: Identification of four variants in the tryptophan hydroxylase promoter and association to behavior. Mol Psychiatry. 1999 Jul;4(4):360-8. Pubmed: 10483053 Link_out
                              7. Walendzik H, Zimmer G, Skopp G: [Serotonin, 5-hydroxyindolylacetic acid and cholesterol content in blood, cerebrospinal fluid and brain areas for differentiation of suicidal from non-suicidal cause of death] Arch Kriminol. 2000 May-Jun;205(5-6):131-44. Pubmed: 10923167 Link_out
                              8. Fukuda H, Nakamura S, Hara K, Udaka F, Kameyama M: [Study on the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in the lumbar cerebrospinal fluid (CSF) in neurological diseases] Rinsho Shinkeigaku. 1989 Sep;29(9):1192-4. Pubmed: 2480863 Link_out
                              9. Meltzer H: Serotonergic dysfunction in depression. Br J Psychiatry Suppl. 1989 Dec;(8):25-31. Pubmed: 2692637 Link_out
                              10. Yamamoto M: Depression in Parkinson's disease: its prevalence, diagnosis, and neurochemical background. J Neurol. 2001 Sep;248 Suppl 3:III5-11. Pubmed: 11697689 Link_out
                              11. Korpi ER, Kleinman JE, Goodman SI, Phillips I, DeLisi LE, Linnoila M, Wyatt RJ: Serotonin and 5-hydroxyindoleacetic acid in brains of suicide victims. Comparison in chronic schizophrenic patients with suicide as cause of death. Arch Gen Psychiatry. 1986 Jun;43(6):594-600. Pubmed: 2423050 Link_out
                              12. Castejon AM, Paez X, Hernandez L, Cubeddu LX: Use of intravenous microdialysis to monitor changes in serotonin release and metabolism induced by cisplatin in cancer patients: comparative effects of granisetron and ondansetron. J Pharmacol Exp Ther. 1999 Dec;291(3):960-6. Pubmed: 10565811 Link_out
                              13. Lambert GW, Kaye DM, Cox HS, Vaz M, Turner AG, Jennings GL, Esler MD: Regional 5-hydroxyindoleacetic acid production in humans. Life Sci. 1995;57(3):255-67. Pubmed: 7541101 Link_out
                              14. Borg S, Kvande H, Liljeberg P, Mossberg D, Valverius P: 5-Hydroxyindoleacetic acid in cerebrospinal fluid in alcoholic patients under different clinical conditions. Alcohol. 1985 May-Jun;2(3):415-8. Pubmed: 2411275 Link_out
                              15. Celada P, Sarrias MJ, Artigas F: Serotonin and 5-hydroxyindoleacetic acid in plasma. Potential use as peripheral measures of MAO-A activity. J Neural Transm Suppl. 1990;32:149-54. Pubmed: 1708403 Link_out
                              16. Feldman JM: Urinary serotonin in the diagnosis of carcinoid tumors. Clin Chem. 1986 May;32(5):840-4. Pubmed: 2421946 Link_out
                              17. Mann JJ, McBride PA, Brown RP, Linnoila M, Leon AC, DeMeo M, Mieczkowski T, Myers JE, Stanley M: Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients. Arch Gen Psychiatry. 1992 Jun;49(6):442-6. Pubmed: 1376106 Link_out
                              18. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411 Link_out

                              Enzymes
                              Name: Acetylserotonin O-methyltransferase
                              Reactions:
                              S-Adenosylmethionine + 5-Hydroxyindoleacetic acid unknown S-Adenosylhomocysteine + 5-Methoxyindoleacetate details
                              Gene Name: ASMT
                              Uniprot ID: P46597 Link_out
                              Protein Sequence: FASTA
                              Gene Sequence: FASTA
                              Name: Aldehyde oxidase
                              Reactions:
                              5-Hydroxyindoleacetaldehyde + Oxygen + Water unknown 5-Hydroxyindoleacetic acid + Hydrogen peroxide details
                              Gene Name: AOX1
                              Uniprot ID: Q06278 Link_out
                              Protein Sequence: FASTA
                              Gene Sequence: FASTA
                              Name: 4-trimethylaminobutyraldehyde dehydrogenase
                              Reactions:
                              5-Hydroxyindoleacetaldehyde + NAD + Water unknown 5-Hydroxyindoleacetic acid + Hydrogen Ion + NADH details
                              Gene Name: ALDH9A1
                              Uniprot ID: P49189 Link_out
                              Protein Sequence: FASTA
                              Gene Sequence: FASTA
                              Name: Alpha-aminoadipic semialdehyde dehydrogenase
                              Reactions:
                              5-Hydroxyindoleacetaldehyde + NAD + Water unknown 5-Hydroxyindoleacetic acid + Hydrogen Ion + NADH details
                              Gene Name: ALDH7A1
                              Uniprot ID: P49419 Link_out
                              Protein Sequence: FASTA
                              Gene Sequence: FASTA
                              Name: Aldehyde dehydrogenase family 1 member A3
                              Reactions: Not Available
                              Gene Name: ALDH1A3
                              Uniprot ID: P47895 Link_out
                              Protein Sequence: FASTA
                              Gene Sequence: FASTA
                              Name: Aldehyde dehydrogenase, mitochondrial
                              Reactions:
                              5-Hydroxyindoleacetaldehyde + NAD + Water unknown 5-Hydroxyindoleacetic acid + Hydrogen Ion + NADH details
                              Gene Name: ALDH2
                              Uniprot ID: P05091 Link_out
                              Protein Sequence: FASTA
                              Gene Sequence: FASTA
                              Name: Fatty aldehyde dehydrogenase
                              Reactions:
                              5-Hydroxyindoleacetaldehyde + NAD + Water unknown 5-Hydroxyindoleacetic acid + Hydrogen Ion + NADH details
                              Gene Name: ALDH3A2
                              Uniprot ID: P51648 Link_out
                              Protein Sequence: FASTA
                              Gene Sequence: FASTA
                              Name: Aldehyde dehydrogenase X, mitochondrial
                              Reactions:
                              5-Hydroxyindoleacetaldehyde + NAD + Water unknown 5-Hydroxyindoleacetic acid + Hydrogen Ion + NADH details
                              Gene Name: ALDH1B1
                              Uniprot ID: P30837 Link_out
                              Protein Sequence: FASTA
                              Gene Sequence: FASTA