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Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:15:11 UTC
HMDB IDHMDB0000802
Secondary Accession Numbers
  • HMDB00802
Metabolite Identification
Common NamePterin
DescriptionPterin, also known as 4-oxopterin or pteridoxamine, belongs to the class of organic compounds known as pterins and derivatives. These are polycyclic aromatic compounds containing a pterin moiety, which consist of a pteridine ring bearing a ketone and an amine group to form 2-aminopteridin-4(3H)-one. Pterin exists in all living organisms, ranging from bacteria to humans. In humans, pterin is involved in the caffeine metabolism pathway. Pterin is found, on average, in the highest concentration within soy beans (Glycine max). Pterin has also been detected, but not quantified in, a few different foods, such as anatidaes (Anatidae), chickens (Gallus gallus), and domestic pigs (Sus scrofa domestica). This could make pterin a potential biomarker for the consumption of these foods. Pterin is a primary metabolite. Primary metabolites are metabolically or physiologically essential metabolites. They are directly involved in an organism’s growth, development or reproduction. Based on a literature review a significant number of articles have been published on Pterin.
Structure
Data?1676999711
Synonyms
ValueSource
2-Amino-4-hydroxypteridineChEBI
2-Amino-4-oxopteridineKegg
2-Amino-1H-pteridin-4-oneHMDB
2-Amino-3H-pteridin-4-oneHMDB
2-Amino-4(1H)-pteridinoneHMDB
2-Amino-4(3H)-pteridinoneHMDB
2-Amino-4-pteridinolHMDB
2-Amino-4-pteridoneHMDB
2-Amino-quinonoid dihydropterinHMDB
2-Aminopteridin-4-oneHMDB
4-oxo-2-AminopteridineHMDB
4-OxopterinHMDB
PteridoxamineHMDB
PterineHMDB
2-Amino-4-hydroxyaminopteridineHMDB
AHAPTHMDB
Chemical FormulaC6H5N5O
Average Molecular Weight163.1368
Monoisotopic Molecular Weight163.049409807
IUPAC Name2-amino-3,4-dihydropteridin-4-one
Traditional Name2-amino-4-oxopteridine
CAS Registry Number2236-60-4
SMILES
NC1=NC2=NC=CN=C2C(=O)N1
InChI Identifier
InChI=1S/C6H5N5O/c7-6-10-4-3(5(12)11-6)8-1-2-9-4/h1-2H,(H3,7,9,10,11,12)
InChI KeyHNXQXTQTPAJEJL-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as pterins and derivatives. These are polycyclic aromatic compounds containing a pterin moiety, which consist of a pteridine ring bearing a ketone and an amine group to form 2-aminopteridin-4(3H)-one.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPteridines and derivatives
Sub ClassPterins and derivatives
Direct ParentPterins and derivatives
Alternative Parents
Substituents
  • Pterin
  • Aminopyrimidine
  • Pyrimidone
  • Pyrazine
  • Pyrimidine
  • Heteroaromatic compound
  • Vinylogous amide
  • Azacycle
  • Amine
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Organic oxygen compound
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Organic nitrogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.18 mg/mLNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-Not Available129.2http://allccs.zhulab.cn/database/detail?ID=AllCCS00002132
[M+H]+Not Available128.9http://allccs.zhulab.cn/database/detail?ID=AllCCS00002132
Predicted Molecular Properties
PropertyValueSource
Water Solubility1.49 g/LALOGPS
logP-0.86ALOGPS
logP-0.96ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)10ChemAxon
pKa (Strongest Basic)-1.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area93.26 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity41.82 m³·mol⁻¹ChemAxon
Polarizability14.46 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+135.25531661259
DarkChem[M-H]-134.12731661259
AllCCS[M+H]+135.15932859911
AllCCS[M-H]-130.63432859911
DeepCCS[M+H]+130.8130932474
DeepCCS[M-H]-127.42730932474
DeepCCS[M-2H]-164.60330932474
DeepCCS[M+Na]+139.79530932474
AllCCS[M+H]+135.232859911
AllCCS[M+H-H2O]+130.632859911
AllCCS[M+NH4]+139.432859911
AllCCS[M+Na]+140.632859911
AllCCS[M-H]-130.632859911
AllCCS[M+Na-2H]-131.332859911
AllCCS[M+HCOO]-132.032859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
PterinNC1=NC2=NC=CN=C2C(=O)N12546.6Standard polar33892256
PterinNC1=NC2=NC=CN=C2C(=O)N11892.5Standard non polar33892256
PterinNC1=NC2=NC=CN=C2C(=O)N12129.2Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Pterin,1TMS,isomer #1C[Si](C)(C)NC1=NC2=NC=CN=C2C(=O)[NH]12061.7Semi standard non polar33892256
Pterin,1TMS,isomer #1C[Si](C)(C)NC1=NC2=NC=CN=C2C(=O)[NH]12104.0Standard non polar33892256
Pterin,1TMS,isomer #1C[Si](C)(C)NC1=NC2=NC=CN=C2C(=O)[NH]13211.3Standard polar33892256
Pterin,1TMS,isomer #2C[Si](C)(C)N1C(N)=NC2=NC=CN=C2C1=O1977.5Semi standard non polar33892256
Pterin,1TMS,isomer #2C[Si](C)(C)N1C(N)=NC2=NC=CN=C2C1=O2010.8Standard non polar33892256
Pterin,1TMS,isomer #2C[Si](C)(C)N1C(N)=NC2=NC=CN=C2C1=O3225.0Standard polar33892256
Pterin,2TMS,isomer #1C[Si](C)(C)N(C1=NC2=NC=CN=C2C(=O)[NH]1)[Si](C)(C)C1885.1Semi standard non polar33892256
Pterin,2TMS,isomer #1C[Si](C)(C)N(C1=NC2=NC=CN=C2C(=O)[NH]1)[Si](C)(C)C2069.8Standard non polar33892256
Pterin,2TMS,isomer #1C[Si](C)(C)N(C1=NC2=NC=CN=C2C(=O)[NH]1)[Si](C)(C)C3005.6Standard polar33892256
Pterin,2TMS,isomer #2C[Si](C)(C)NC1=NC2=NC=CN=C2C(=O)N1[Si](C)(C)C1956.5Semi standard non polar33892256
Pterin,2TMS,isomer #2C[Si](C)(C)NC1=NC2=NC=CN=C2C(=O)N1[Si](C)(C)C2086.3Standard non polar33892256
Pterin,2TMS,isomer #2C[Si](C)(C)NC1=NC2=NC=CN=C2C(=O)N1[Si](C)(C)C2970.4Standard polar33892256
Pterin,3TMS,isomer #1C[Si](C)(C)N(C1=NC2=NC=CN=C2C(=O)N1[Si](C)(C)C)[Si](C)(C)C1979.1Semi standard non polar33892256
Pterin,3TMS,isomer #1C[Si](C)(C)N(C1=NC2=NC=CN=C2C(=O)N1[Si](C)(C)C)[Si](C)(C)C2127.7Standard non polar33892256
Pterin,3TMS,isomer #1C[Si](C)(C)N(C1=NC2=NC=CN=C2C(=O)N1[Si](C)(C)C)[Si](C)(C)C2721.5Standard polar33892256
Pterin,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC1=NC2=NC=CN=C2C(=O)[NH]12257.9Semi standard non polar33892256
Pterin,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC1=NC2=NC=CN=C2C(=O)[NH]12222.2Standard non polar33892256
Pterin,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC1=NC2=NC=CN=C2C(=O)[NH]13285.9Standard polar33892256
Pterin,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)N1C(N)=NC2=NC=CN=C2C1=O2193.7Semi standard non polar33892256
Pterin,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)N1C(N)=NC2=NC=CN=C2C1=O2190.9Standard non polar33892256
Pterin,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)N1C(N)=NC2=NC=CN=C2C1=O3238.7Standard polar33892256
Pterin,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)N(C1=NC2=NC=CN=C2C(=O)[NH]1)[Si](C)(C)C(C)(C)C2303.9Semi standard non polar33892256
Pterin,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)N(C1=NC2=NC=CN=C2C(=O)[NH]1)[Si](C)(C)C(C)(C)C2431.7Standard non polar33892256
Pterin,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)N(C1=NC2=NC=CN=C2C(=O)[NH]1)[Si](C)(C)C(C)(C)C3038.9Standard polar33892256
Pterin,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)NC1=NC2=NC=CN=C2C(=O)N1[Si](C)(C)C(C)(C)C2329.6Semi standard non polar33892256
Pterin,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)NC1=NC2=NC=CN=C2C(=O)N1[Si](C)(C)C(C)(C)C2428.0Standard non polar33892256
Pterin,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)NC1=NC2=NC=CN=C2C(=O)N1[Si](C)(C)C(C)(C)C3028.5Standard polar33892256
Pterin,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)N(C1=NC2=NC=CN=C2C(=O)N1[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2517.6Semi standard non polar33892256
Pterin,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)N(C1=NC2=NC=CN=C2C(=O)N1[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2736.4Standard non polar33892256
Pterin,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)N(C1=NC2=NC=CN=C2C(=O)N1[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2893.1Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Pterin GC-MS (Non-derivatized) - 70eV, Positivesplash10-03di-3900000000-e0c5aa11edc5408b2afd2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Pterin GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Pterin GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Pterin Quattro_QQQ 10V, Positive-QTOF (Annotated)splash10-03di-0900000000-815f9d4247cb9067f9fb2012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pterin Quattro_QQQ 25V, Positive-QTOF (Annotated)splash10-014l-5900000000-6bd37ba7d9f26d33ffd52012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pterin Quattro_QQQ 40V, Positive-QTOF (Annotated)splash10-014l-9100000000-b809a46cbde852be02de2012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pterin , positive-QTOFsplash10-03di-0900000000-71eab96d7f1dfed519632017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pterin 10V, Positive-QTOFsplash10-03di-1900000000-36d14ee4f35692f07bee2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pterin 35V, Positive-QTOFsplash10-03di-0900000000-7d6238777a46df27af012021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pterin 40V, Positive-QTOFsplash10-066u-9000000000-289c0930b78dd1447e102021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pterin 20V, Positive-QTOFsplash10-066r-4900000000-8c47f8f3ca753ec1cf6f2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pterin 40V, Negative-QTOFsplash10-0aor-9300000000-938f26c8bed8f1edc1852021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pterin 20V, Negative-QTOFsplash10-014i-3900000000-ca751d8c09c98e0c9d3d2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pterin 35V, Negative-QTOFsplash10-03di-0900000000-a67b522aa27e6f75f46e2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Pterin 10V, Negative-QTOFsplash10-03di-0900000000-ad3fade684bdebfb41e32021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pterin 10V, Positive-QTOFsplash10-03di-0900000000-f1eb4d0b367f209bc7662017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pterin 20V, Positive-QTOFsplash10-03di-0900000000-a250d1c9d32e286b29f62017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pterin 40V, Positive-QTOFsplash10-0007-9300000000-190579d7d5ba6d0c14c52017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pterin 10V, Negative-QTOFsplash10-03di-0900000000-4005b83e558e2b0c57722017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pterin 20V, Negative-QTOFsplash10-03di-0900000000-a4698cb941c94fd087992017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pterin 40V, Negative-QTOFsplash10-00kf-9000000000-8ed28777d0de229aa6a32017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pterin 10V, Negative-QTOFsplash10-03di-0900000000-99937f8026369fb0e1832021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pterin 20V, Negative-QTOFsplash10-03xr-2900000000-41450f7664125a38cc972021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pterin 40V, Negative-QTOFsplash10-00kf-9000000000-5a06c4c35a067e936a162021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pterin 10V, Positive-QTOFsplash10-03di-0900000000-0dba7b98ddf974fcc10c2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pterin 20V, Positive-QTOFsplash10-03di-0900000000-ba39f053d7d33e17ee002021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Pterin 40V, Positive-QTOFsplash10-0006-9100000000-7334fbd934d9e46491f72021-09-23Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Experimental 2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, 100%_DMSO, experimental)2012-12-05Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
Biospecimen Locations
  • Blood
  • Feces
  • Urine
Tissue Locations
  • Epidermis
  • Fibroblasts
  • Liver
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedCancer patients undergoing total body irradiation details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal cancer
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothColorectal Cancer details
UrineDetected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedCancer patients undergoing total body irradiation details
Associated Disorders and Diseases
Disease References
Colorectal cancer
  1. Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [PubMed:25037050 ]
  2. Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016. [PubMed:27015276 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB005613
KNApSAcK IDC00003101
Chemspider ID65806
KEGG Compound IDC00715
BioCyc ID2-AMINO-4-HYDROXYPTERIDINE
BiGG IDNot Available
Wikipedia LinkPterin
METLIN ID5766
PubChem Compound73000
PDB IDNot Available
ChEBI ID18265
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDrw1279311
References
Synthesis ReferenceTaylor, Edward C.; Kobylecki, Ryszard. Pteridines. 43. A facile synthesis of 6-chloropterin and 2,4-diamino-6-chloropteridine. Journal of Organic Chemistry (1978), 43(4), 680-3.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Bonafe L, Thony B, Penzien JM, Czarnecki B, Blau N: Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia. Am J Hum Genet. 2001 Aug;69(2):269-77. Epub 2001 Jul 6. [PubMed:11443547 ]
  2. Dhondt JL, Cotton RG, Danks DM: Liver enzyme activities in hyperphenylalaninaemia due to a defective synthesis of tetrahydrobiopterin. J Inherit Metab Dis. 1985;8(2):47-8. [PubMed:3939528 ]
  3. Kaufman S, Kapatos G, Rizzo WB, Schulman JD, Tamarkin L, Van Loon GR: Tetrahydropterin therapy for hyperphenylalaninemia caused by defective synthesis of tetrahydrobiopterin. Ann Neurol. 1983 Sep;14(3):308-15. [PubMed:6139056 ]
  4. Katoh S, Sueoka T, Matsuura S, Sugimoto T: Biopterin and neopterin in human saliva. Life Sci. 1989;45(26):2561-8. [PubMed:2615555 ]
  5. Dhondt JL, Tilmont P, Ringel J, Farriaux JP: Pterins analysis in amniotic fluid for the prenatal diagnosis of GTP cyclohydrolase deficiency. J Inherit Metab Dis. 1990;13(6):879-82. [PubMed:2079836 ]
  6. Bonafe L, Thony B, Leimbacher W, Kierat L, Blau N: Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts. Clin Chem. 2001 Mar;47(3):477-85. [PubMed:11238300 ]
  7. Krumdieck CL, Fukushima K, Fukushima T, Shiota T, Butterworth CE Jr: A long-term study of the excretion of folate and pterins in a human subject after ingestion of 14C folic acid, with observations on the effect of diphenylhydantoin administration. Am J Clin Nutr. 1978 Jan;31(1):88-93. [PubMed:413430 ]
  8. Han F, Huynh BH, Shi H, Lin B, Ma Y: Pteridine analysis in urine by capillary electrophoresis using laser-induced fluorescence detection. Anal Chem. 1999 Apr 1;71(7):1265-9. [PubMed:10204031 ]
  9. Yamamoto T, Moriwaki Y, Takahashi S, Tsutsumi Z, Yamakita J, Nasako Y, Hiroishi K, Higashino K: Determination of human plasma xanthine oxidase activity by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1996 Jun 7;681(2):395-400. [PubMed:8811453 ]
  10. Beckman JS, Parks DA, Pearson JD, Marshall PA, Freeman BA: A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues. Free Radic Biol Med. 1989;6(6):607-15. [PubMed:2753392 ]
  11. Gordon JH, Perry KO: Pre- and postsynaptic neurochemical alterations following estrogen-induced striatal dopamine hypo- and hypersensitivity. Brain Res Bull. 1983 Apr;10(4):425-8. [PubMed:6134572 ]
  12. Stupperich E: Recent advances in elucidation of biological corrinoid functions. FEMS Microbiol Rev. 1993 Nov;12(4):349-65. [PubMed:8268006 ]
  13. Niederwieser A, Blau N, Wang M, Joller P, Atares M, Cardesa-Garcia J: GTP cyclohydrolase I deficiency, a new enzyme defect causing hyperphenylalaninemia with neopterin, biopterin, dopamine, and serotonin deficiencies and muscular hypotonia. Eur J Pediatr. 1984 Feb;141(4):208-14. [PubMed:6734669 ]
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  15. Rokos H, Beazley WD, Schallreuter KU: Oxidative stress in vitiligo: photo-oxidation of pterins produces H(2)O(2) and pterin-6-carboxylic acid. Biochem Biophys Res Commun. 2002 Apr 12;292(4):805-11. [PubMed:11944885 ]

Enzymes

General function:
Involved in cobalamin binding
Specific function:
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
Gene Name:
MTR
Uniprot ID:
Q99707
Molecular weight:
140525.91