Showing metabocard for Propyl alcohol (HMDB0000820)

General function:

Involved in arylesterase activity

Specific function:

Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.

Gene Name:

PON3

Uniprot ID:

Q15166

Molecular weight:

39607.185

General function:

Involved in arylesterase activity

Specific function:

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.

Gene Name:

PON1

Uniprot ID:

P27169

Molecular weight:

39730.99

General function:

Involved in arylesterase activity

Specific function:

Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.

Gene Name:

PON2

Uniprot ID:

Q15165

Molecular weight:

39380.535

General function:

Involved in catalytic activity

Specific function:

Not Available

Gene Name:

ALPI

Uniprot ID:

P09923

Molecular weight:

56811.695

General function:

Involved in acid phosphatase activity

Specific function:

Not Available

Gene Name:

ACP2

Uniprot ID:

P11117

Molecular weight:

48343.92

General function:

Involved in catalytic activity

Specific function:

This isozyme may play a role in skeletal mineralization.

Gene Name:

ALPL

Uniprot ID:

P05186

Molecular weight:

57304.435

General function:

Involved in hydrolase activity

Specific function:

Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

Gene Name:

ACP5

Uniprot ID:

P13686

Molecular weight:

36598.47

General function:

Involved in catalytic activity

Specific function:

Not Available

Gene Name:

ALPPL2

Uniprot ID:

P10696

Molecular weight:

57376.515

General function:

Involved in oxidoreductase activity

Specific function:

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.

Gene Name:

ALDH1B1

Uniprot ID:

P30837

Molecular weight:

57248.96

General function:

Involved in sulfotransferase activity

Specific function:

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.

Gene Name:

SULT2B1

Uniprot ID:

O00204

Molecular weight:

39598.595

Reactions

General function:

Involved in zinc ion binding

Specific function:

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity).

Gene Name:

SORD

Uniprot ID:

Q00796

Molecular weight:

38324.25

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).

Gene Name:

AKR1A1

Uniprot ID:

P14550

Molecular weight:

36572.71

General function:

Involved in zinc ion binding

Specific function:

Not Available

Gene Name:

ADH4

Uniprot ID:

P08319

Molecular weight:

40221.335

General function:

Involved in zinc ion binding

Specific function:

Not Available

Gene Name:

ADH1B

Uniprot ID:

P00325

Molecular weight:

39835.17

General function:

Involved in zinc ion binding

Specific function:

Not Available

Gene Name:

ADH1A

Uniprot ID:

P07327

Molecular weight:

39858.37

General function:

Involved in zinc ion binding

Specific function:

Not Available

Gene Name:

ADH6

Uniprot ID:

P28332

Molecular weight:

39072.275

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

Plays an important role in the degradation of dermatan and keratan sulfates.

Gene Name:

GUSB

Uniprot ID:

P08236

Molecular weight:

74731.46

General function:

Involved in alpha-L-fucosidase activity

Specific function:

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Gene Name:

FUCA2

Uniprot ID:

Q9BTY2

Molecular weight:

54066.31

General function:

Involved in zinc ion binding

Specific function:

Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids.

Gene Name:

MECR

Uniprot ID:

Q9BV79

Molecular weight:

32228.0

General function:

Involved in lysozyme activity

Specific function:

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents

Gene Name:

LYZ

Uniprot ID:

P61626

Molecular weight:

16536.9

References

1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

General function:

Involved in phosphatidylcholine-retinol O-acyltransfera

Specific function:

Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.

Gene Name:

LRAT

Uniprot ID:

O95237

Molecular weight:

25702.635

General function:

Involved in sequence-specific DNA binding transcription factor activity

Specific function:

Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element

Gene Name:

NR1I3

Uniprot ID:

Q14994

Molecular weight:

39942.1

General function:

Involved in zinc ion binding

Specific function:

Not Available

Gene Name:

ZADH2

Uniprot ID:

Q8N4Q0

Molecular weight:

40140.1

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities.

Gene Name:

ADHFE1

Uniprot ID:

Q8IWW8

Molecular weight:

50307.42

General function:

Involved in catalytic activity

Specific function:

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates.

Gene Name:

FAR2

Uniprot ID:

Q96K12

Molecular weight:

59437.92

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl-CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo.

Gene Name:

AWAT2

Uniprot ID:

Q6E213

Molecular weight:

38093.25

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling (By similarity).

Gene Name:

KL

Uniprot ID:

Q9UEF7

Molecular weight:

116179.815

General function:

Involved in acid phosphatase activity

Specific function:

Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage.

Gene Name:

ACPT

Uniprot ID:

Q9BZG2

Molecular weight:

46089.015

General function:

Lipid transport and metabolism

Specific function:

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity).

Gene Name:

CES5A

Uniprot ID:

Q6NT32

Molecular weight:

63925.82

General function:

Involved in acid phosphatase activity

Specific function:

Not Available

Gene Name:

ACPL2

Uniprot ID:

Q8TE99

Molecular weight:

55239.395

General function:

Involved in zinc ion binding

Specific function:

Not Available

Gene Name:

VAT1L

Uniprot ID:

Q9HCJ6

Molecular weight:

45899.2

General function:

Involved in zinc ion binding

Specific function:

May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent naphtoquinone reductase activity, with a preference for 1,2-naphtoquinone over 1,4- naphtoquinone. Has low NADPH-dependent diamine reductase activity (in vitro)

Gene Name:

TP53I3

Uniprot ID:

Q53FA7

Molecular weight:

35535.9

General function:

Involved in zinc ion binding

Specific function:

Possesses ATPase activity. Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation

Gene Name:

VAT1

Uniprot ID:

Q99536

Molecular weight:

41920.0

General function:

Involved in zinc ion binding

Specific function:

Appears to be a potent inhibitor of regeneration following spinal cord injury

Gene Name:

RTN4IP1

Uniprot ID:

Q8WWV3

Molecular weight:

43589.4