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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-05-30 20:55:48 UTC
HMDB IDHMDB0000842
Secondary Accession Numbers
  • HMDB00842
Metabolite Identification
Common NameQuinaldic acid
DescriptionQuinaldic acid, also known as quinaldate, 2-carboxyquinoline, or quinoline-2-carboxylic acid, belongs to the class of organic compounds known as quinoline carboxylic acids. These are quinolines in which the quinoline ring system is substituted by a carboxyl group at one or more positions. The quinoline ring system is a double-ring structure composed of a benzene and a pyridine ring fused at two adjacent carbon atoms. Quinaldic acid is a quinoline having a carboxy group at the 2-position. It is a solid that is moderately soluble in water with a melting point of 156°C. Quinaldic acid is a metabolite of tryptophan degradation that is formed via the kynurenine pathway; it is formed through the dehydroxylation of the intermediate kynurenic acid (PMID: 13385219 ). It is excreted in urine, and its urine concentration is decreased in individuals suffering from chronic alcoholism (PMID: 25754126 ). Quinaldic acid has been shown to inhibit proinsulin synthesis in pancreatic islet cells (PMID: 373355 ). Quinaldic acid has been shown to have anti-proliferative or anti-tumour effects and has been found to alter the expression of the p53 tumour suppressor gene as well as the phosphorylation of the p53 protein in in vitro studies (PMID: 30780127 ).
Structure
Data?1676999713
Synonyms
ValueSource
2-CarboxyquinolineChEBI
2-ChinolincarbonsaeureChEBI
2-QuinolinecarboxylateChEBI
2-Quinolinecarboxylic acidChEBI
ChinaldinsaeureChEBI
QuinaldateChEBI
Quinaldinic acidChEBI
Quinoline-2-carboxylic acidChEBI
QuinaldinateGenerator
Quinoline-2-carboxylateGenerator
2-QuinolinylcarboxylateHMDB
2-Quinolinylcarboxylic acidHMDB
Quinolin-2-carboxylateHMDB
Quinolin-2-carboxylic acidHMDB
Quinaldic acidKEGG
Chemical FormulaC10H7NO2
Average Molecular Weight173.1681
Monoisotopic Molecular Weight173.047678473
IUPAC Namequinoline-2-carboxylic acid
Traditional Namequinaldic acid
CAS Registry Number93-10-7
SMILES
OC(=O)C1=NC2=C(C=CC=C2)C=C1
InChI Identifier
InChI=1S/C10H7NO2/c12-10(13)9-6-5-7-3-1-2-4-8(7)11-9/h1-6H,(H,12,13)
InChI KeyLOAUVZALPPNFOQ-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as quinoline carboxylic acids. These are quinolines in which the quinoline ring system is substituted by a carboxyl group at one or more positions.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassQuinolines and derivatives
Sub ClassQuinoline carboxylic acids
Direct ParentQuinoline carboxylic acids
Alternative Parents
Substituents
  • Quinoline-2-carboxylic acid
  • Pyridine carboxylic acid
  • Pyridine carboxylic acid or derivatives
  • Benzenoid
  • Pyridine
  • Heteroaromatic compound
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Azacycle
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Organooxygen compound
  • Organonitrogen compound
  • Organopnictogen compound
  • Organic oxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effect
Disposition
ProcessNot Available
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point156 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility14 mg/mLNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+Not Available132.6http://allccs.zhulab.cn/database/detail?ID=AllCCS00002168
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.76 g/LALOGPS
logP1.44ALOGPS
logP0.79ChemAxon
logS-2.4ALOGPS
pKa (Strongest Acidic)1.1ChemAxon
pKa (Strongest Basic)5.22ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area50.19 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity46.86 m³·mol⁻¹ChemAxon
Polarizability17.27 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+138.55331661259
DarkChem[M-H]-135.46731661259
AllCCS[M+H]+135.99532859911
AllCCS[M-H]-134.70332859911
DeepCCS[M+H]+136.24830932474
DeepCCS[M-H]-133.85230932474
DeepCCS[M-2H]-169.00430932474
DeepCCS[M+Na]+143.46330932474
AllCCS[M+H]+136.032859911
AllCCS[M+H-H2O]+131.432859911
AllCCS[M+NH4]+140.332859911
AllCCS[M+Na]+141.532859911
AllCCS[M-H]-134.732859911
AllCCS[M+Na-2H]-134.932859911
AllCCS[M+HCOO]-135.332859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
Quinaldic acidOC(=O)C1=NC2=C(C=CC=C2)C=C12740.7Standard polar33892256
Quinaldic acidOC(=O)C1=NC2=C(C=CC=C2)C=C11637.3Standard non polar33892256
Quinaldic acidOC(=O)C1=NC2=C(C=CC=C2)C=C11750.5Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Quinaldic acid,1TMS,isomer #1C[Si](C)(C)OC(=O)C1=CC=C2C=CC=CC2=N11764.7Semi standard non polar33892256
Quinaldic acid,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)C1=CC=C2C=CC=CC2=N12011.1Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Quinaldic acid GC-EI-TOF (Non-derivatized)splash10-0fc0-0940000000-3bb36ccb17eab5d4f2162017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Quinaldic acid GC-EI-TOF (Non-derivatized)splash10-0fc0-0940000000-3bb36ccb17eab5d4f2162018-05-18HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Quinaldic acid GC-MS (Non-derivatized) - 70eV, Positivesplash10-0umi-0900000000-201cc84404bb06e3a79c2017-08-28Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Quinaldic acid GC-MS (1 TMS) - 70eV, Positivesplash10-05fr-9830000000-ff13ca054f835c494e4c2017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Quinaldic acid GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Quinaldic acid GC-MS (TBDMS_1_1) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid Quattro_QQQ 10V, Positive-QTOF (Annotated)splash10-0089-1900000000-2ac6cea8f0ab44545a022012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid Quattro_QQQ 25V, Positive-QTOF (Annotated)splash10-004i-5900000000-0a29a5dcbe75bd2bfd652012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid Quattro_QQQ 40V, Positive-QTOF (Annotated)splash10-0089-1900000000-2ac6cea8f0ab44545a022012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid , positive-QTOFsplash10-006t-0900000000-e801df9cf80a4e3c1a8f2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid 10V, Negative-QTOFsplash10-0fi9-1900000000-0953adea831044cdee872021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid 20V, Negative-QTOFsplash10-000i-1900000000-3596e390d786fc0eb7492021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid 35V, Negative-QTOFsplash10-0udi-0900000000-a239b63d7915ec730a132021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid 40V, Positive-QTOFsplash10-004i-3900000000-3abada564f98738b98e82021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid 35V, Positive-QTOFsplash10-002b-0900000000-bbdb7985eb8859a589182021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid 35V, Positive-QTOFsplash10-006t-0900000000-d8dd2cceb2e32bda860a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid 20V, Positive-QTOFsplash10-004i-0900000000-849a617e507a37a3486e2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid 10V, Positive-QTOFsplash10-004i-0900000000-5c60ff7dd4db050c5a552021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid 20V, Negative-QTOFsplash10-004i-0900000000-f9801a644f0f5e8f799c2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid 40V, Negative-QTOFsplash10-004i-9200000000-5dfac4a5ac7a15be046a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid 40V, Negative-QTOFsplash10-0udi-5900000000-8c00a2a9c83a1524bd282021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Quinaldic acid 10V, Negative-QTOFsplash10-004i-0900000000-63da7eb04eb3050c09282021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Quinaldic acid 10V, Positive-QTOFsplash10-05fr-0900000000-5b312e8793ea2ae6634a2017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Quinaldic acid 20V, Positive-QTOFsplash10-05fr-0900000000-b7ccc79163ed5305afc02017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Quinaldic acid 40V, Positive-QTOFsplash10-0pb9-1900000000-75c1b662031ae1eb4e662017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Quinaldic acid 10V, Negative-QTOFsplash10-00di-0900000000-3fb80b1e9de6c0075e622017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Quinaldic acid 20V, Negative-QTOFsplash10-0fi0-0900000000-be8f80ef49f6303bd5aa2017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Quinaldic acid 40V, Negative-QTOFsplash10-004i-0900000000-3e533cb46184c1bb44792017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Quinaldic acid 10V, Negative-QTOFsplash10-004i-0900000000-09b95cea4d0438cedeb02021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Quinaldic acid 20V, Negative-QTOFsplash10-004i-0900000000-ab7ccc734ae03b00fe882021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Quinaldic acid 40V, Negative-QTOFsplash10-004i-0900000000-bd7d9eec2154eb38701f2021-09-23Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Experimental 1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, experimental)2012-12-04Wishart LabView Spectrum
Experimental 2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, CDCl3, experimental)2012-12-05Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
UrineDetected and Quantified0.01 (0.01-0.02) umol/mmol creatinineNewborn (0-30 days old)Both
Normal
    • Analysis of 40 NI...
details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedCancer patients undergoing total body irradiation details
UrineDetected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedCancer patients undergoing total body irradiation details
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB02428
Phenol Explorer Compound IDNot Available
FooDB IDFDB022275
KNApSAcK IDC00056094
Chemspider ID6857
KEGG Compound IDC06325
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN ID5805
PubChem Compound7124
PDB IDNot Available
ChEBI ID18386
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDrw1050261
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Epand RM: The role of dietary ergothioneine in the development of diabetes mellitus. Med Hypotheses. 1982 Aug;9(2):207-13. [PubMed:7144630 ]
  2. Okamoto H, Miyamoto S, Mabuchi H, Takeda R: Inhibition effect of quinaldic acid on glucose-induced insulin release from isolated Langerhans islets of the rat. Biochem Biophys Res Commun. 1974 Jul 24;59(2):623-9. [PubMed:4368820 ]
  3. Ektova LV, Iartseva IV, Khorosheva EV, Ivanova TP, Iavorskaia NP, Mel'nik SIa: [Synthesis and biological properties of pyrimidine 2'-deoxynucleosides modified by a residue of quinaldic acid]. Bioorg Khim. 1995 Aug;21(8):625-31. [PubMed:8540903 ]
  4. KAIHARA M, PRICE JM, TAKAHASHI H: The conversion of kynurenic acid to quinaldic acid by humans and rats. J Biol Chem. 1956 Dec;223(2):705-8. [PubMed:13385219 ]
  5. Mittal A, Dabur R: Detection of new human metabolic urinary markers in chronic alcoholism and their reversal by aqueous extract of Tinospora cordifolia stem. Alcohol Alcohol. 2015 May;50(3):271-81. doi: 10.1093/alcalc/agv012. Epub 2015 Mar 8. [PubMed:25754126 ]
  6. Noto Y, Okamoto H: Inhibition by kynurenine metabolites of proinsulin synthesis in isolated pancreatic islets. Acta Diabetol Lat. 1978 Sep-Dec;15(5-6):273-82. doi: 10.1007/BF02590750. [PubMed:373355 ]
  7. Langner E, Jeleniewicz W, Turski WA, Plech T: Quinaldic acid induces changes in the expression of p53 tumor suppressor both on protein and gene level in colon cancer LS180 cells. Pharmacol Rep. 2019 Apr;71(2):189-193. doi: 10.1016/j.pharep.2018.10.016. Epub 2018 Oct 30. [PubMed:30780127 ]