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Human Metabolome Database Version 2.5

 

Showing metabocard for Taurodeoxycholic acid (HMDB00896)

Legend: metabolite field enzyme field

Version 2.5
Creation Date 2005-11-16 15:48:42
Update Date 2010-04-22 10:33:34
Accession Number HMDB00896
Secondary Accession Numbers HMDB04011
Common Name Taurodeoxycholic acid
Description Taurodeoxycholic acid is a bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. Bile acids are steroid acids found predominantly in bile of mammals. The distinction between different bile acids is minute, depends only on presence or absence of hydroxyl groups on positions 3, 7, and 12. Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Bile acids are also steroidal amphipathic molecules derived from the catabolism of cholesterol. They modulate bile flow and lipid secretion, are essential for the absorption of dietary fats and vitamins, and have been implicated in the regulation of all the key enzymes involved in cholesterol homeostasis. Bile acids recirculate through the liver, bile ducts, small intestine and portal vein to form an enterohepatic circuit. They exist as anions at physiological pH and, consequently, require a carrier for transport across the membranes of the enterohepatic tissues. The unique detergent properties of bile acids are essential for the digestion and intestinal absorption of hydrophobic nutrients. Bile acids have potent toxic properties (e.g., membrane disruption) and there are a plethora of mechanisms to limit their accumulation in blood and tissues. (PMID: 11316487, 16037564, 12576301, 11907135)
Synonyms
  1. Deoxycholyltaurine
  2. Deoxytaurocholate
  3. Deoxytaurocholic acid
  4. N-(3a,12a-dihydroxy-5b-cholan-24-oyl)-Taurine
  5. Sodium taurodeoxycholate
  6. Sodium taurodeoxylate
  7. Taurodeoxycholic acid
  8. Taurodeoxycholic acid sodium salt
  9. Taurodeoxycholic acid sodium salt hydrate
  10. Taurodesoxycholate
  11. Taurodesoxycholic acid
  12. Tudcabil
Chemical IUPAC Name 2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid
Chemical Formula C26H45NO6S
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Cholesterols and derivatives
Class
  • Bile Acids
Sub Class
  • Taurinated bile acids
Family
  • Microbial Metabolite
Species
  • secondary alcohol
  • secondary carboxylic acid amide
  • sulfonic acid
Biofunction
  • Hormones, Membrane component
Application
—
Source
  • Endogenous
Average Molecular Weight 499.704
Monoisotopic Molecular Weight 499.296753
Isomeric SMILES C[C@H](CCC(=O)NCCS(O)(=O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
Canonical SMILES CC(CCC(=O)NCCS(O)(=O)=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C
KEGG Compound ID C05463 Link Image
BioCyc ID Not Available
BiGG ID Not Available
Wikipedia Link Not Available
NuGOwiki Link HMDB00896 Link Image
Metagene Link HMDB00896 Link Image
METLIN ID 5853 Link Image
PubChem Compound 10594 Link Image
PubChem Substance 7823 Link Image
ChEBI ID 9410 Link Image
CAS Registry Number 516-50-7
InChI Identifier InChI=1/C26H45NO6S/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-/m1/s1
Synthesis Reference Parenti, Massimo. Preparation of tauroursodesoxycholic acid dihydrate. Eur. Pat. Appl. (1990), 3 pp. CODEN: EPXXDW EP 400695 A2 19901205 CAN 114:82269 AN 1991:82269
Melting Point (Experimental) 204 - 208 oC
Experimental Water Solubility 41 mg/mL [HMP experimental] Source: PhysProp
Predicted Water Solubility 7.76e-03 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge -1
State Solid
Experimental LogP/Hydrophobicity Not Available Source: PhysProp
Predicted LogP/Hydrophobicity 1.19 [Predicted by ALOGPS]; 4.4 [Predicted by PubChem via XLOGP] Calculated using ALOGPS
Material Safety Data Sheet (MSDS)
MOL File Show Link Image
SDF File Show Link Image
PDB File Show Link Image
2D Structure
3D Structure
Experimental PDB ID Not Available
Experimental 1H NMR Spectrum Download Spectrum
Download FID (Varian)
Show Experimental Conditions Link Image
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Download Spectrum
Download FID (Bruker)
Show Experimental Conditions Link Image
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum
Low Energy
Download File
Show Experimental Conditions Link Image
Medium Energy
Download File
Show Experimental Conditions Link Image
High Energy
Download File
Show Experimental Conditions Link Image
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location
  • Membrane
Biofluid Location
  • Bile
  • Blood
Tissue Location
Tissue References
Intestine —
Concentrations (Normal)
Biofluid Bile
Value > 0.01 uM
Age Adult:>18 yrs old
Sex Both
Patient information Normal
Comments Not Available
References
  • Bloch CA, Watkins JB: Determination of conjugated bile acids in human bile and duodenal fluid by reverse-phase high-performance liquid chromatography. J Lipid Res. 1978 May;19(4):510-3. [PubMed Link Image]
Biofluid Blood
Value 0.062 (0.000-0.177) uM
Age Adult:>18 yrs old
Sex N/A
Patient information Normal
Comments Not Available
References
  • Tagliacozzi D, Mozzi AF, Casetta B, Bertucci P, Bernardini S, Di Ilio C, Urbani A, Federici G: Quantitative analysis of bile acids in human plasma by liquid chromatography-electrospray tandem mass spectrometry: a simple and rapid one-step method. Clin Chem Lab Med. 2003 Dec;41(12):1633-41. [PubMed Link Image]
  • Bloch CA, Watkins JB: Determination of conjugated bile acids in human bile and duodenal fluid by reverse-phase high-performance liquid chromatography. J Lipid Res. 1978 May;19(4):510-3. [PubMed Link Image]
Concentrations (Abnormal) Not Available
Associated Disorders Not Available
OMIM ID Not Available
Pathways
Name SMPDB Link KEGG Link
Bile Acid Biosynthesis SMP00035 Link Image map00120 Link Image
General References
  1. Bloch CA, Watkins JB: Determination of conjugated bile acids in human bile and duodenal fluid by reverse-phase high-performance liquid chromatography. J Lipid Res. 1978 May;19(4):510-3. [PubMed Link Image]
  2. Foley DP, Collins BR, Magee JC, Platt JL, Katz E, Harland RC, Meyers WC, Chari RS: Bile acids in xenogeneic ex-vivo liver perfusion: function of xenoperfused livers and compatibility with human bile salts and porcine livers. Transplantation. 2000 Jan 27;69(2):242-8. [PubMed Link Image]
  3. Bretagne JF, Vidon N, L'Hirondel C, Bernier JJ: Increased cell loss in the human jejunum induced by laxatives (ricinoleic acid, dioctyl sodium sulphosuccinate, magnesium sulphate, bile salts). Gut. 1981 Apr;22(4):264-9. [PubMed Link Image]
  4. Leveau P, Wang X, Sun Z, Borjesson A, Andersson E, Andersson R: Severity of pancreatitis-associated gut barrier dysfunction is reduced following treatment with the PAF inhibitor lexipafant. Biochem Pharmacol. 2005 May 1;69(9):1325-31. [PubMed Link Image]
  5. Burkard I, von Eckardstein A, Rentsch KM: Differentiated quantification of human bile acids in serum by high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 5;826(1-2):147-59. Epub 2005 Sep 22. [PubMed Link Image]
  6. Lim HJ, Kim SY, Lee WK: Isolation of cholesterol-lowering lactic acid bacteria from human intestine for probiotic use. J Vet Sci. 2004 Dec;5(4):391-5. [PubMed Link Image]
  7. Muhlbauer M, Allard B, Bosserhoff AK, Kiessling S, Herfarth H, Rogler G, Scholmerich J, Jobin C, Hellerbrand C: Differential effects of deoxycholic acid and taurodeoxycholic acid on NF-kappa B signal transduction and IL-8 gene expression in colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G1000-8. Epub 2004 Jan 15. [PubMed Link Image]
  8. Pouwels MJ, Tack CJ, Span PN, Olthaar AJ, Sweep CG, Huvers FC, Lutterman JA, Hermus AR: Role of hexosamines in insulin resistance and nutrient sensing in human adipose and muscle tissue. J Clin Endocrinol Metab. 2004 Oct;89(10):5132-7. [PubMed Link Image]
  9. Elkins CA, Mullis LB: Bile-mediated aminoglycoside sensitivity in Lactobacillus species likely results from increased membrane permeability attributable to cholic acid. Appl Environ Microbiol. 2004 Dec;70(12):7200-9. [PubMed Link Image]
  10. Aubert E, Sbarra V, Le Petit-Thevenin J, Valette A, Lombardo D: Site-directed mutagenesis of the basic N-terminal cluster of pancreatic bile salt-dependent lipase. Functional significance. J Biol Chem. 2002 Sep 20;277(38):34987-96. Epub 2002 Jul 10. [PubMed Link Image]
  11. Xie Q, Li GM, Zhou XQ, Liao D, Yu H, Guo Q: [Effect of Tauroursodeoxycholic acid on cytochrome C-mediated apoptosis in HepG2 cells] Zhonghua Gan Zang Bing Za Zhi. 2003 May;11(5):298-301. [PubMed Link Image]
Metabolic Enzymes
  1. Choloylglycine hydrolase
  2. Choloylglycine hydrolase
  3. Bile salt hydrolase
  4. Choloylglycine hydrolase
  5. Bile salt hydrolase
  6. Bile salt hydrolase
  7. Choloylglycine hydrolase
  8. Putative choloylglycine hydrolase
  9. Choloylglycine hydrolase
  10. Choloylglycine hydrolase
  11. Choloylglycine hydrolase
  12. Choloylglycine hydrolase family protein
  13. Choloylglycine hydrolase family protein
  14. Choloylglycine hydrolase
  15. Conjugated bile acid hydrolase
Enzyme 1 [top]
Enzyme 1 ID 15841
Enzyme 1 Name Choloylglycine hydrolase
Enzyme 1 Synonyms Not Available
Enzyme 1 Gene Name bsh2
Enzyme 1 Protein Sequence >Choloylglycine hydrolase 
MCTSLTYTNSHGGHFLARTMDFNVDFETRIMFMPRHYRVTGDLGDFTTTYGFIGAGRQLN
HEIFTDGVNECGVSIAALYFPNHAIYQPHSNQDKIDLAPHDFVAWVLGKITSVADLRERV
KDVQLISSTAELINEIPPLHFIISDQTGETAVLEPTSGELRLLNNPVGVLTNSPNLKWQL
QNLSKYGTLTNTERPLNKFINYQPGSQGPGTGALGLPGDYTSMSRFARTVFLKHYAQVPA
TTTDTVNLLQHILNAVTIPKGAKVAANGQATYTEYRSYMDLNHQTYALELYENPGVIQQV
NLTDHLLEKQTVPLEYVLSRTPHVQLLTPDVATLPAAH
Enzyme 1 Number of Residues 338
Enzyme 1 Molecular Weight 37541.2
Enzyme 1 Theoretical pI 6.39
Enzyme 1 GO Classification Not Available
Enzyme 1 General Function Cell wall/membrane/envelope biogenesis
Enzyme 1 Specific Function Not Available
Enzyme 1 Pathways Not Available
Enzyme 1 Reactions
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + glycine [RN:R05835]
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 28269860 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID Q890F5 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name Q890F5_LACPL Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >1017 bp 
ATGTGCACTAGTCTAACTTATACAAATAGTCATGGAGGCCACTTCTTAGCTCGTACAATG
GATTTTAACGTTGACTTTGAGACCCGTATTATGTTCATGCCTCGACATTACCGCGTGACG
GGTGACCTTGGTGATTTCACCACGACTTATGGCTTTATTGGCGCGGGTCGCCAACTGAAC
CATGAAATTTTCACGGACGGCGTTAACGAATGTGGTGTCAGCATCGCAGCACTCTACTTT
CCGAATCATGCAATTTACCAGCCTCACAGTAACCAAGACAAAATCGATCTCGCACCCCAC
GATTTCGTCGCCTGGGTACTCGGAAAAATCACCAGTGTTGCTGACCTACGTGAGCGCGTC
AAAGACGTTCAATTAATTAGTAGCACGGCAGAATTAATTAACGAAATTCCACCACTTCAC
TTTATCATCAGTGACCAAACCGGTGAAACCGCCGTCTTGGAACCAACTAGCGGCGAGCTT
CGCCTGCTTAATAACCCAGTCGGCGTCCTGACCAATTCACCAAACCTCAAATGGCAGCTA
CAAAACTTAAGTAAGTATGGCACCCTGACTAACACCGAGCGACCACTAAATAAATTCATT
AACTACCAACCTGGTTCACAGGGACCTGGTACGGGCGCATTAGGTCTACCTGGTGACTAT
ACTTCGATGTCTCGCTTTGCACGGACCGTCTTCTTGAAACACTATGCGCAAGTGCCAGCG
ACAACAACAGATACAGTCAACTTACTTCAACACATCTTGAATGCTGTGACTATTCCCAAG
GGCGCCAAAGTAGCCGCCAACGGCCAAGCAACCTATACTGAGTACCGTAGCTACATGGAT
TTGAATCATCAAACGTACGCACTAGAACTGTACGAAAATCCGGGAGTGATTCAGCAAGTT
AACTTAACGGATCATTTATTAGAAAAACAGACCGTTCCGTTAGAATACGTCCTTAGTCGC
ACCCCACACGTCCAGTTACTAACTCCCGATGTTGCCACCTTGCCAGCGGCCCATTAA
Enzyme 1 GenBank Gene ID AL935252 Link Image
Enzyme 1 GeneCard ID bsh2 Link Image
Enzyme 1 GenAtlas ID Not Available
Enzyme 1 HGNC ID Not Available
Enzyme 1 Chromosome Location Not Available
Enzyme 1 Locus lp_0067
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References
  1. Kleerebezem M, Boekhorst J, van Kranenburg R, Molenaar D, Kuipers OP, Leer R, Tarchini R, Peters SA, Sandbrink HM, Fiers MW, Stiekema W, Lankhorst RM, Bron PA, Hoffer SM, Groot MN, Kerkhoven R, de Vries M, Ursing B, de Vos WM, Siezen RJ: Complete genome sequence of Lactobacillus plantarum WCFS1. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1990-5. Epub 2003 Feb 3. [PubMed Link Image]
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 15842
Enzyme 2 Name Choloylglycine hydrolase
Enzyme 2 Synonyms Not Available
Enzyme 2 Gene Name bsh4
Enzyme 2 Protein Sequence >Choloylglycine hydrolase 
MCTSLTYLDTDNHRYFARTMDFPTTTPWRPIFLPRRYPWPTGLATTRMTQYAILGGGRLP
DHFKACLMADSINEAGLVCAELYLPHAVEYATQSQVNQINLTPQAFINWALGEHQSVAAV
IADLPSVNLVGASWGDDTGEVYPFHWYLSDAHTSAVIEPTGGPLTVQPNPAGVLTNTPVL
SDHQRRLNRYLAVSGNQITTATRQAAQHVIQTKQPLPSGPIPTDRFIHMALRRLGTPQLA
PQQVPTTLFRWLQEVSLPYHADRRHLISHNYTHYRCLITLATRTYRFIPRTTGHEQRLTL
TPEMATTWRTPYLFPAD
Enzyme 2 Number of Residues 317
Enzyme 2 Molecular Weight 35766.4
Enzyme 2 Theoretical pI 8.59
Enzyme 2 GO Classification Not Available
Enzyme 2 General Function Cell wall/membrane/envelope biogenesis
Enzyme 2 Specific Function Not Available
Enzyme 2 Pathways Not Available
Enzyme 2 Reactions
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + glycine [RN:R05835]
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • None
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 28271943 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID Q88UC9 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name Q88UC9_LACPL Link Image
Enzyme 2 PDB ID Not Available
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >954 bp 
ATGTGTACCAGCTTAACTTATCTTGATACTGACAATCACCGCTACTTCGCCCGCACCATG
GACTTTCCAACAACGACACCTTGGCGGCCAATTTTTTTGCCGCGCCGTTATCCGTGGCCA
ACTGGGTTAGCGACGACGCGTATGACGCAGTATGCCATTCTCGGTGGTGGTCGGCTACCT
GACCACTTTAAGGCTTGTTTGATGGCTGACAGCATTAACGAAGCTGGTTTGGTGTGTGCT
GAACTGTACTTGCCCCACGCCGTTGAATACGCCACTCAATCACAAGTCAACCAAATTAAT
TTAACACCCCAAGCCTTCATCAACTGGGCTTTAGGTGAACACCAATCAGTCGCAGCCGTG
ATCGCCGATCTGCCAAGTGTTAACCTGGTCGGTGCGTCCTGGGGTGATGACACTGGTGAA
GTCTATCCCTTTCACTGGTATCTCAGTGATGCACACACCAGTGCCGTCATCGAACCCACT
GGTGGCCCACTGACGGTGCAACCGAATCCAGCCGGCGTCCTGACCAATACACCAGTCCTA
AGCGACCATCAGCGCCGACTAAATCGTTATTTAGCAGTATCTGGCAACCAGATTACAACT
GCCACTCGTCAGGCTGCTCAGCACGTGATTCAGACTAAGCAACCATTACCGAGCGGGCCG
ATTCCCACTGATCGTTTCATTCACATGGCACTTCGACGACTGGGAACACCGCAGCTAGCA
CCGCAACAAGTGCCGACCACTTTATTCCGCTGGCTACAAGAAGTAAGCTTGCCATACCAC
GCCGACCGTCGCCATCTCATCAGCCACAACTACACGCACTATCGTTGTTTGATCACGTTA
GCGACTCGTACTTACCGCTTTATTCCACGCACGACTGGTCACGAACAACGACTGACACTA
ACACCTGAAATGGCAACAACCTGGCGAACACCGTACCTCTTTCCTGCCGATTGA
Enzyme 2 GenBank Gene ID AL935259 Link Image
Enzyme 2 GeneCard ID bsh4 Link Image
Enzyme 2 GenAtlas ID Not Available
Enzyme 2 HGNC ID Not Available
Enzyme 2 Chromosome Location Not Available
Enzyme 2 Locus lp_2572
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References
  1. Kleerebezem M, Boekhorst J, van Kranenburg R, Molenaar D, Kuipers OP, Leer R, Tarchini R, Peters SA, Sandbrink HM, Fiers MW, Stiekema W, Lankhorst RM, Bron PA, Hoffer SM, Groot MN, Kerkhoven R, de Vries M, Ursing B, de Vos WM, Siezen RJ: Complete genome sequence of Lactobacillus plantarum WCFS1. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1990-5. Epub 2003 Feb 3. [PubMed Link Image]
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 15843
Enzyme 3 Name Bile salt hydrolase
Enzyme 3 Synonyms
  1. SubName: Choloylglycine hydrolase
Enzyme 3 Gene Name bsh3
Enzyme 3 Protein Sequence >Bile salt hydrolase 
MCTSLTIQTTAGDQFLARTMDFAFELGGRPVAIPRNHHFDSVTNADGFDSPYSFVGTGRD
LNGYIFVDGVNEHGVSAAALYFSGQAHFTQQTKAGKVNLAPHEVLMWILGNVKSTAELGE
RIADLNVMEAAAPLLNIVVPLHWIISDKSGSTYVLELENDGVHYMKNPVGVMTNTPDFEW
HLKNLSNYVNLQPGPHPSRQYGDMTVNPFGPGTGALGMPGDYTSVARFVRTVFMREHTDA
VTTDAEAVNALSHMLNSVEIPKGVKMQDNGTPDYTQYRAYMSMNEPAFYMQPYADQTITR
VELTPALMTAAQPTEFELKTTQQFRLAN
Enzyme 3 Number of Residues 328
Enzyme 3 Molecular Weight 36166.6
Enzyme 3 Theoretical pI 5.12
Enzyme 3 GO Classification Not Available
Enzyme 3 General Function Cell wall/membrane/envelope biogenesis
Enzyme 3 Specific Function Not Available
Enzyme 3 Pathways Not Available
Enzyme 3 Reactions
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + glycine [RN:R05835]
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • None
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 28272546 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID Q88SP0 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name Q88SP0_LACPL Link Image
Enzyme 3 PDB ID Not Available
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >987 bp 
ATGTGTACTAGTTTAACGATTCAAACCACGGCGGGTGATCAGTTTTTAGCACGCACCATG
GACTTTGCTTTTGAACTTGGTGGTCGACCAGTGGCAATCCCACGGAATCACCATTTTGAC
AGTGTTACCAATGCGGACGGTTTTGATAGCCCGTATAGCTTTGTTGGAACGGGCCGTGAC
TTAAATGGCTATATCTTTGTCGATGGTGTCAATGAGCACGGGGTCAGTGCTGCTGCACTC
TATTTCTCGGGACAAGCTCACTTTACTCAGCAGACTAAGGCTGGCAAGGTTAACTTGGCA
CCCCACGAAGTTTTAATGTGGATTTTAGGAAACGTGAAGAGCACCGCTGAATTAGGCGAA
CGGATTGCTGACTTGAACGTGATGGAAGCCGCCGCACCACTATTGAATATTGTGGTACCA
CTACACTGGATCATTAGTGACAAGAGTGGTTCTACTTACGTCTTAGAATTGGAAAATGAC
GGTGTTCACTACATGAAGAATCCGGTGGGCGTCATGACGAACACACCAGATTTTGAATGG
CACCTCAAGAATTTGAGTAATTACGTCAACTTACAACCCGGTCCTCATCCTAGTCGTCAG
TATGGTGACATGACGGTGAATCCTTTCGGCCCTGGAACTGGGGCGTTGGGAATGCCTGGT
GACTATACGTCAGTTGCACGCTTCGTTCGGACGGTCTTCATGCGTGAACATACGGATGCA
GTAACGACTGATGCAGAAGCTGTCAACGCATTATCACACATGCTGAACTCAGTGGAGATT
CCTAAGGGCGTTAAGATGCAAGATAACGGGACGCCAGATTATACCCAGTACCGCGCCTAT
ATGAGCATGAATGAACCAGCATTTTACATGCAACCATACGCGGATCAGACGATTACGCGG
GTCGAATTGACACCAGCTTTAATGACGGCCGCGCAACCGACTGAATTTGAATTAAAGACA
ACCCAACAGTTCCGGTTAGCAAACTAA
Enzyme 3 GenBank Gene ID AL935261 Link Image
Enzyme 3 GeneCard ID bsh3 Link Image
Enzyme 3 GenAtlas ID Not Available
Enzyme 3 HGNC ID Not Available
Enzyme 3 Chromosome Location Not Available
Enzyme 3 Locus lp_3362
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References
  1. Kleerebezem M, Boekhorst J, van Kranenburg R, Molenaar D, Kuipers OP, Leer R, Tarchini R, Peters SA, Sandbrink HM, Fiers MW, Stiekema W, Lankhorst RM, Bron PA, Hoffer SM, Groot MN, Kerkhoven R, de Vries M, Ursing B, de Vos WM, Siezen RJ: Complete genome sequence of Lactobacillus plantarum WCFS1. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1990-5. Epub 2003 Feb 3. [PubMed Link Image]
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 15844
Enzyme 4 Name Choloylglycine hydrolase
Enzyme 4 Synonyms
  1. Bile salt hydrolase
  2. Conjugated bile acid hydrolase
  3. CBAH
Enzyme 4 Gene Name cbh
Enzyme 4 Protein Sequence >Choloylglycine hydrolase 
MCTAITYQSYNNYFGRNFDYEISYNEMVTITPRKYPLVFRKVENLDHHYAIIGITADVES
YPLYYDAMNEKGLCIAGLNFAGYADYKKYDADKVNITPFELIPWLLGQFSSVREVKKNIQ
KLNLVNINFSEQLPLSPLHWLVADKQESIVIESVKEGLKIYDNPVGVLTNNPNFDYQLFN
LNNYRALSNSTPQNSFSEKVDLDSYSRGMGGLGLPGDLSSMSRFVRAAFTKLNSLSMQTE
SGSVSQFFHILGSVEQQKGLCEVTDGKYEYTIYSSCCDMDKGVYYYRTYDNSQINSVSLN
HEHLDTTELISYPLRSEAQYYAVN
Enzyme 4 Number of Residues 324
Enzyme 4 Molecular Weight 37041.3
Enzyme 4 Theoretical pI 4.92
Enzyme 4 GO Classification Not Available
Enzyme 4 General Function Cell wall/membrane/envelope biogenesis
Enzyme 4 Specific Function The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut
Enzyme 4 Pathways Not Available
Enzyme 4 Reactions
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + glycine [RN:R05835]
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein 28272688 Link Image
Enzyme 4 UniProtKB/Swiss-Prot ID Q06115 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name CBH_LACPL Link Image
Enzyme 4 PDB ID Not Available
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence >975 bp 
ATGTGTACTGCCATAACTTATCAATCTTATAATAATTACTTCGGTAGAAATTTCGATTAT
GAAATTTCATACAATGAAATGGTTACGATTACGCCTAGAAAATATCCACTAGTATTTCGT
AAGGTGGAGAACTTAGATCACCATTATGCAATAATTGGAATTACTGCTGATGTAGAAAGC
TATCCACTTTACTACGATGCGATGAATGAAAAAGGCTTGTGTATTGCGGGATTAAATTTT
GCAGGTTATGCTGATTATAAAAAATATGATGCTGATAAAGTTAATATCACACCATTTGAA
TTAATTCCTTGGTTATTGGGACAATTTTCAAGTGTTAGAGAAGTGAAAAAGAACATACAA
AAACTAAACTTGGTTAATATTAATTTTAGTGAACAATTACCATTATCACCGCTACATTGG
TTGGTTGCTGATAAACAGGAATCGATAGTTATTGAAAGTGTCAAAGAAGGACTAAAAATT
TACGACAATCCAGTAGGTGTGTTAACAAACAATCCTAATTTTGACTACCAATTATTTAAT
TTGAACAACTATCGTGCCTTATCAAATAGCACACCCCAAAATAGTTTTTCGGAAAAAGTG
GATTTAGATAGTTATAGTAGAGGAATGGGCGGACTAGGATTACCTGGAGACTTGTCCTCA
ATGTCTAGATTTGTCAGAGCCGCTTTTACTAAATTAAACTCGTTGTCGATGCAGACAGAG
AGTGGCAGTGTTAGTCAGTTTTTCCATATACTAGGGTCTGTAGAACAACAAAAAGGGCTA
TGTGAAGTTACTGACGGAAAGTACGAATATACAATCTATTCTTCTTGTTGTGATATGGAC
AAAGGAGTTTATTACTATAGAACTTATGACAATAGTCAAATTAACAGTGTCAGTTTAAAC
CATGAGCACTTGGATACGACTGAATTAATTTCTTATCCATTACGATCAGAAGCACAATAC
TATGCAGTTAACTAA
Enzyme 4 GenBank Gene ID AL935262 Link Image
Enzyme 4 GeneCard ID cbh Link Image
Enzyme 4 GenAtlas ID Not Available
Enzyme 4 HGNC ID Not Available
Enzyme 4 Chromosome Location Not Available
Enzyme 4 Locus lp_3536
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References
  1. Christiaens H, Leer RJ, Pouwels PH, Verstraete W: Cloning and expression of a conjugated bile acid hydrolase gene from Lactobacillus plantarum by using a direct plate assay. Appl Environ Microbiol. 1992 Dec;58(12):3792-8. [PubMed Link Image]
  2. Kleerebezem M, Boekhorst J, van Kranenburg R, Molenaar D, Kuipers OP, Leer R, Tarchini R, Peters SA, Sandbrink HM, Fiers MW, Stiekema W, Lankhorst RM, Bron PA, Hoffer SM, Groot MN, Kerkhoven R, de Vries M, Ursing B, de Vos WM, Siezen RJ: Complete genome sequence of Lactobacillus plantarum WCFS1. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1990-5. Epub 2003 Feb 3. [PubMed Link Image]
Enzyme 4 Metabolite References Not Available
Enzyme 5 [top]
Enzyme 5 ID 15845
Enzyme 5 Name Bile salt hydrolase
Enzyme 5 Synonyms Not Available
Enzyme 5 Gene Name bshA
Enzyme 5 Protein Sequence >Bile salt hydrolase 
MCTSIIFSPKDHYFGRNLDLEITFGQQVVITPRNYTFKFRKMPSLKKHYAMIGISLDMDD
YPLYFDATNEKGLGMAGLNYPGNATYYEEKENKDNIASFEFIPWILGQCSTISEVKDLLS
RINIADLNFSEKMQASSLHWLIADKTGTSLVVETDKDGMHIYDNPVGCLTNNPQFPKQLF
NLNNYADVSPKMPKNNFSDKVNMAGYSRGLGSHNLPGGMDSESRFVRVAFNKFNAPIAET
EEENIDTYFHILHSVEQQKGLDEVGPNSFEYTIYSDGTNLDKGIFYYTTYSNKQINVVDM
NKEDLDSSNLITYDMLDKTKFNHQN
Enzyme 5 Number of Residues 325
Enzyme 5 Molecular Weight 37080.3
Enzyme 5 Theoretical pI 4.86
Enzyme 5 GO Classification Not Available
Enzyme 5 General Function Cell wall/membrane/envelope biogenesis
Enzyme 5 Specific Function Not Available
Enzyme 5 Pathways Not Available
Enzyme 5 Reactions Not Available
Enzyme 5 Pfam Domain Function
Enzyme 5 Signals
  • None
Enzyme 5 Transmembrane Regions
  • None
Enzyme 5 Essentiality Not Available
Enzyme 5 GenBank ID Protein 58254514 Link Image
Enzyme 5 UniProtKB/Swiss-Prot ID Q5FKM3 Link Image
Enzyme 5 UniProtKB/Swiss-Prot Entry Name Q5FKM3_LACAC Link Image
Enzyme 5 PDB ID Not Available
Enzyme 5 Cellular Location Not Available
Enzyme 5 Gene Sequence >978 bp 
ATGTGTACATCAATTATATTCAGTCCCAAAGATCATTACTTTGGTCGTAACCTTGATTTA
GAAATTACTTTTGGTCAACAAGTTGTTATTACGCCACGCAATTACACTTTTAAATTCCGT
AAGATGCCCAGTTTAAAAAAGCACTATGCAATGATTGGTATCTCATTAGATATGGATGAT
TATCCCCTATATTTCGACGCTACAAATGAAAAAGGTTTAGGTATGGCCGGACTCAACTAT
CCAGGAAATGCTACATATTATGAAGAAAAAGAAAATAAAGATAATATTGCTTCCTTTGAA
TTCATCCCTTGGATTTTAGGACAGTGTAGCACTATTAGCGAAGTAAAGGATTTACTTAGC
AGAATCAACATCGCCGATTTAAATTTCAGCGAAAAAATGCAAGCCTCCTCTCTTCACTGG
CTTATTGCAGATAAAACAGGTACATCATTAGTTGTTGAAACAGACAAAGATGGAATGCAT
ATTTATGATAATCCAGTTGGCTGCTTAACTAATAATCCACAATTTCCAAAGCAATTATTC
AATTTAAATAACTATGCTGACGTATCTCCAAAAATGCCTAAAAATAACTTCTCAGATAAA
GTAAATATGGCTGGCTACAGCCGTGGATTAGGGTCTCACAACTTACCAGGTGGAATGGAT
TCTGAATCACGTTTTGTCAGAGTAGCTTTCAATAAATTTAATGCTCCAATTGCTGAAACC
GAAGAAGAAAATATTGATACTTACTTCCACATTTTACATTCGGTTGAACAACAAAAGGGA
CTGGATGAAGTTGGTCCAAACTCATTTGAATATACAATTTATTCTGATGGAACTAACTTA
GACAAAGGTATTTTCTACTACACCACTTATTCAAACAAACAAATTAACGTTGTTGATATG
AATAAAGAAGATCTAGATAGCAGCAATTTGATCACTTATGATATGCTTGATAAAACTAAA
TTTAACCATCAAAACTAA
Enzyme 5 GenBank Gene ID CP000033 Link Image
Enzyme 5 GeneCard ID bshA Link Image
Enzyme 5 GenAtlas ID Not Available
Enzyme 5 HGNC ID Not Available
Enzyme 5 Chromosome Location Not Available
Enzyme 5 Locus LBA0892
Enzyme 5 SNPs SNPJam Report Link Image
Enzyme 5 General References
  1. Altermann E, Russell WM, Azcarate-Peril MA, Barrangou R, Buck BL, McAuliffe O, Souther N, Dobson A, Duong T, Callanan M, Lick S, Hamrick A, Cano R, Klaenhammer TR: Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):3906-12. Epub 2005 Jan 25. [PubMed Link Image]
Enzyme 5 Metabolite References Not Available
Enzyme 6 [top]
Enzyme 6 ID 15846
Enzyme 6 Name Bile salt hydrolase
Enzyme 6 Synonyms Not Available
Enzyme 6 Gene Name bshB
Enzyme 6 Protein Sequence >Bile salt hydrolase 
MCTSICYNPNDHYFGRNLDYEIAYGQKVVIVPRNYEFKYREMPSQKMHYAFIGVSVVNDD
YPLLCDAINEKGLGIAGLNFQGPNHYFPKIEGKKNIASFELMPYLLSNCENTDDVKEILD
NANILNISFSANYPAADLHWILSDKAGKSIVVESTNSGLHIYDNPVNVLTNNPEFPDQLI
KLSDYADVTPHNPKNTLVPNVDLNLYSRGLGTHHLPGGMDSSSRFVKVAFVLAHTPQGKN
EVENVTNYFHILHSVEQPDGLDEVEDNRYEYTMYTDCMNLDKGILYFTTYDNNRINAVDM
HKADLDSEDLICYDLFKKQDIEYMN
Enzyme 6 Number of Residues 325
Enzyme 6 Molecular Weight 37056.3
Enzyme 6 Theoretical pI 4.60
Enzyme 6 GO Classification Not Available
Enzyme 6 General Function Cell wall/membrane/envelope biogenesis
Enzyme 6 Specific Function Not Available
Enzyme 6 Pathways Not Available
Enzyme 6 Reactions
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + glycine [RN:R05835]
Enzyme 6 Pfam Domain Function
Enzyme 6 Signals
  • None
Enzyme 6 Transmembrane Regions
  • None
Enzyme 6 Essentiality Not Available
Enzyme 6 GenBank ID Protein 58254686 Link Image
Enzyme 6 UniProtKB/Swiss-Prot ID Q5FK51 Link Image
Enzyme 6 UniProtKB/Swiss-Prot Entry Name Q5FK51_LACAC Link Image
Enzyme 6 PDB ID Not Available
Enzyme 6 Cellular Location Not Available
Enzyme 6 Gene Sequence >978 bp 
ATGTGTACATCAATTTGTTATAATCCTAACGATCATTATTTTGGTAGAAATCTTGACTAT
GAAATTGCTTATGGTCAAAAAGTAGTCATTGTACCAAGAAACTACGAATTTAAGTATAGA
GAAATGCCCTCTCAAAAGATGCATTATGCTTTTATCGGAGTATCTGTAGTTAATGATGAT
TATCCATTATTATGTGATGCAATTAATGAAAAGGGGCTTGGTATTGCAGGATTAAATTTT
CAAGGTCCTAATCATTACTTTCCTAAAATCGAAGGTAAGAAGAATATTGCTTCTTTTGAA
TTAATGCCATACTTATTAAGTAATTGTGAAAATACTGACGATGTTAAAGAAATCTTAGAT
AATGCAAATATTTTAAATATTAGCTTTTCAGCAAATTATCCTGCAGCTGATTTACATTGG
ATTTTAAGTGATAAAGCTGGTAAGAGTATCGTAGTTGAATCAACCAATTCAGGTTTACAT
ATTTATGATAATCCAGTGAATGTCTTAACTAACAATCCTGAATTTCCGGATCAATTAATT
AAATTAAGTGACTACGCCGACGTTACTCCACATAATCCTAAGAATACATTGGTTCCTAAT
GTTGATCTTAATCTATATAGTAGAGGCTTAGGTACTCACCACTTACCTGGTGGAATGGAT
TCTAGCTCTCGATTTGTTAAGGTAGCTTTTGTCTTGGCACACACTCCACAAGGAAAAAAT
GAAGTGGAAAATGTTACTAATTATTTCCATATTCTGCATTCAGTAGAACAACCTGATGGT
TTAGATGAAGTAGAAGATAATCGCTATGAATATACTATGTATACAGATTGTATGAACTTA
GATAAAGGTATTTTGTACTTTACTACTTATGACAATAATCGGATTAATGCAGTAGATATG
CATAAAGCAGATTTAGATTCAGAAGATTTAATCTGCTACGATTTGTTTAAGAAACAAGAT
ATTGAATATATGAATTAA
Enzyme 6 GenBank Gene ID CP000033 Link Image
Enzyme 6 GeneCard ID bshB Link Image
Enzyme 6 GenAtlas ID Not Available
Enzyme 6 HGNC ID Not Available
Enzyme 6 Chromosome Location Not Available
Enzyme 6 Locus LBA1078
Enzyme 6 SNPs SNPJam Report Link Image
Enzyme 6 General References
  1. Altermann E, Russell WM, Azcarate-Peril MA, Barrangou R, Buck BL, McAuliffe O, Souther N, Dobson A, Duong T, Callanan M, Lick S, Hamrick A, Cano R, Klaenhammer TR: Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):3906-12. Epub 2005 Jan 25. [PubMed Link Image]
Enzyme 6 Metabolite References Not Available
Enzyme 7 [top]
Enzyme 7 ID 15847
Enzyme 7 Name Choloylglycine hydrolase
Enzyme 7 Synonyms Not Available
Enzyme 7 Gene Name Not Available
Enzyme 7 Protein Sequence >Choloylglycine hydrolase 
MCTGVRFSDDEGNTYFGRNLDWSFSYGETILVTPRGYHYDTVFGAGGKAKPNAVIGVGVV
MADRPMYFDCANEHGLAIAGLNFPGYASFVHEPVEGTENVATFEFPLWVARNFDSVDEVE
EALRNVTLVSQIVPGQQESLLHWFIGDGKRSIVVEQMADGMHVHHDDVDVLTNQPTFDFH
MENLRNYMCVSNEMAEPTSWGKASLTAWGAGVGMHGIPGDVSSPSRFVRVAYTNAHYPQQ
NDEAANVSRLFHTLGSVQMVDGMAKMGDGQFERTLFTSGYSSKTNTYYMNTYDDPAIRSY
AMADYDMDSSELISVAR
Enzyme 7 Number of Residues 317
Enzyme 7 Molecular Weight 35124.9
Enzyme 7 Theoretical pI 4.49
Enzyme 7 GO Classification Not Available
Enzyme 7 General Function Cell wall/membrane/envelope biogenesis
Enzyme 7 Specific Function Not Available
Enzyme 7 Pathways Not Available
Enzyme 7 Reactions Not Available
Enzyme 7 Pfam Domain Function
Enzyme 7 Signals
  • None
Enzyme 7 Transmembrane Regions
  • None
Enzyme 7 Essentiality Not Available
Enzyme 7 GenBank ID Protein 23326016 Link Image
Enzyme 7 UniProtKB/Swiss-Prot ID Q8G653 Link Image
Enzyme 7 UniProtKB/Swiss-Prot Entry Name Q8G653_BIFLO Link Image
Enzyme 7 PDB ID Not Available
Enzyme 7 Cellular Location Not Available
Enzyme 7 Gene Sequence >954 bp 
ATGTGCACTGGTGTCCGTTTCTCCGATGATGAGGGCAACACCTATTTCGGCCGTAATCTC
GACTGGAGTTTCTCATATGGGGAGACCATCCTGGTTACTCCGCGCGGCTACCACTATGAC
ACGGTGTTTGGTGCGGGCGGCAAGGCGAAGCCGAACGCGGTGATCGGCGTGGGTGTGGTC
ATGGCCGATAGGCCGATGTATTTCGACTGCGCCAATGAACATGGTCTGGCCATCGCCGGC
TTGAATTTCCCCGGCTACGCCTCGTTCGTCCACGAACCGGTCGAAGGCACGGAAAACGTC
GCCACGTTCGAATTTCCGCTGTGGGTGGCGCGTAATTTCGACTCCGTCGACGAGGTCGAG
GAGGCGCTCAGGAACGTGACGCTCGTCTCCCAGATCGTGCCGGGACAGCAGGAGTCTCTG
CTGCACTGGTTCATCGGCGACGGCAAGCGCAGCATCGTCGTCGAGCAGATGGCCGATGGC
ATGCACGTGCATCATGATGACGTCGATGTGCTGACCAATCAGCCGACGTTCGACTTCCAT
ATGGAAAACCTGCGCAACTACATGTGCGTCAGCAACGAGATGGCCGAACCGACTTCATGG
GGCAAGGCCTCCTTGACCGCCTGGGGTGCGGGTGTGGGCATGCATGGCATCCCGGGCGAC
GTGAGTTCCCCGTCGCGCTTCGTTCGTGTGGCCTACACCAACGCGCATTACCCGCAGCAG
AACGATGAAGCCGCCAATGTGTCGCGCCTGTTCCACACCCTCGGCTCCGTGCAGATGGTG
GACGGCATGGCGAAGATGGGCGACGGCCAGTTCGAACGCACGCTGTTCACCAGCGGATAT
TCGTCCAAGACCAACACCTATTACATGAACACCTATGATGACCCCGCCATCCGTTCCTAC
GCCATGGCCGATTACGATATGGATTCCTCGGAGCTCATCAGCGTCGCCCGATGA
Enzyme 7 GenBank Gene ID AE014295 Link Image
Enzyme 7 GeneCard ID Not Available
Enzyme 7 GenAtlas ID Not Available
Enzyme 7 HGNC ID Not Available
Enzyme 7 Chromosome Location Not Available
Enzyme 7 Locus BL0796
Enzyme 7 SNPs Not Available
Enzyme 7 General References
  1. Schell MA, Karmirantzou M, Snel B, Vilanova D, Berger B, Pessi G, Zwahlen MC, Desiere F, Bork P, Delley M, Pridmore RD, Arigoni F: The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14422-7. Epub 2002 Oct 15. [PubMed Link Image]
Enzyme 7 Metabolite References Not Available
Enzyme 8 [top]
Enzyme 8 ID 15848
Enzyme 8 Name Putative choloylglycine hydrolase
Enzyme 8 Synonyms Not Available
Enzyme 8 Gene Name cbh
Enzyme 8 Protein Sequence >Putative choloylglycine hydrolase 
MKSKDGATVVARTIEWAESVMNCMYVVVPRAQELQSLTPSGMDGLKFRAKHGFVGLAVEQ
KEFVVEGMNEKGLSAGLYYFPNYGRYPVYDAAQRDKSLADFQLVSYVLAECSTVDEVKEA
LSQVRVINIDPRSSTVHWRFTEASGRQVVLEIVNEMMNFYDNPLGVLTNSPGLEWHWTNL
NNYINLQPGTLPEHNFGPLEPKSFGHGSGLLGLPGDFTPPSRFVRATFFQLTAPQQPDAK
GSVFQAFHILNNFDIPTGSEQPWGKASANVPSATQFTVACDIRDQKVYYRTMYNSNIRCI
DLKTINFDNVKYQADPLDETKEQPVEMKVIK
Enzyme 8 Number of Residues 331
Enzyme 8 Molecular Weight 37167.9
Enzyme 8 Theoretical pI 5.68
Enzyme 8 GO Classification Not Available
Enzyme 8 General Function Cell wall/membrane/envelope biogenesis
Enzyme 8 Specific Function Not Available
Enzyme 8 Pathways Not Available
Enzyme 8 Reactions
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + glycine [RN:R05835]
Enzyme 8 Pfam Domain Function
Enzyme 8 Signals
  • None
Enzyme 8 Transmembrane Regions
  • None
Enzyme 8 Essentiality Not Available
Enzyme 8 GenBank ID Protein 60492444 Link Image
Enzyme 8 UniProtKB/Swiss-Prot ID Q5LF84 Link Image
Enzyme 8 UniProtKB/Swiss-Prot Entry Name Q5LF84_BACFN Link Image
Enzyme 8 PDB ID Not Available
Enzyme 8 Cellular Location Not Available
Enzyme 8 Gene Sequence >996 bp 
TTGAAGAGCAAGGATGGTGCAACCGTTGTCGCACGTACCATTGAATGGGCGGAAAGTGTA
ATGAACTGTATGTATGTGGTTGTGCCGCGCGCTCAAGAGTTGCAGTCACTGACTCCCTCC
GGTATGGATGGACTTAAGTTCAGGGCAAAGCATGGCTTTGTGGGCCTGGCGGTAGAGCAG
AAGGAATTTGTGGTGGAGGGCATGAACGAAAAGGGACTTTCCGCCGGATTATACTATTTT
CCGAACTATGGTAGGTATCCTGTTTATGATGCGGCACAGAGGGACAAGAGTCTTGCGGAT
TTTCAGTTGGTATCATATGTGCTGGCAGAATGCAGCACGGTAGATGAAGTGAAGGAGGCC
CTTTCGCAGGTGCGTGTCATCAATATTGATCCCCGTTCGTCCACGGTGCATTGGCGCTTT
ACCGAAGCATCCGGAAGACAGGTGGTGTTGGAGATTGTAAATGAAATGATGAACTTCTAC
GACAATCCATTGGGCGTGTTAACCAATTCACCGGGTCTTGAATGGCATTGGACCAATCTG
AACAATTACATCAACCTACAACCGGGCACGTTACCTGAACATAACTTCGGGCCGTTGGAG
CCGAAGTCTTTCGGGCATGGCAGTGGTCTGCTGGGACTTCCCGGTGATTTTACACCTCCA
TCCCGTTTTGTGCGTGCCACCTTTTTCCAACTTACGGCACCACAACAACCCGATGCAAAA
GGAAGTGTGTTCCAAGCGTTCCATATTCTGAACAACTTTGATATTCCGACGGGTAGTGAA
CAGCCCTGGGGAAAGGCGTCAGCCAATGTACCGAGTGCCACCCAGTTTACCGTTGCGTGC
GATATACGGGACCAGAAGGTTTATTATCGTACCATGTACAACAGCAACATCCGTTGCATT
GATTTGAAAACGATAAATTTCGACAATGTAAAATATCAAGCGGATCCTTTGGATGAAACG
AAGGAGCAACCGGTGGAAATGAAAGTGATAAAATAG
Enzyme 8 GenBank Gene ID CR626927 Link Image
Enzyme 8 GeneCard ID cbh Link Image
Enzyme 8 GenAtlas ID Not Available
Enzyme 8 HGNC ID Not Available
Enzyme 8 Chromosome Location Not Available
Enzyme 8 Locus BF1508
Enzyme 8 SNPs SNPJam Report Link Image
Enzyme 8 General References
  1. Cerdeno-Tarraga AM, Patrick S, Crossman LC, Blakely G, Abratt V, Lennard N, Poxton I, Duerden B, Harris B, Quail MA, Barron A, Clark L, Corton C, Doggett J, Holden MT, Larke N, Line A, Lord A, Norbertczak H, Ormond D, Price C, Rabbinowitsch E, Woodward J, Barrell B, Parkhill J: Extensive DNA inversions in the B. fragilis genome control variable gene expression. Science. 2005 Mar 4;307(5714):1463-5. [PubMed Link Image]
Enzyme 8 Metabolite References Not Available
Enzyme 9 [top]
Enzyme 9 ID 15849
Enzyme 9 Name Choloylglycine hydrolase
Enzyme 9 Synonyms Not Available
Enzyme 9 Gene Name Not Available
Enzyme 9 Protein Sequence >Choloylglycine hydrolase 
MRRKIMMATLIVIAVNFIWSGQPVKACTRAVYIGPDNMVITGRTMDWKEDIQSNLYLFPR
GIKRAGYNKGNTVEWISKYGSIVATGYDIGTCDGMNEKGLVASLLFLPESIYVRRNDTRP
VMGISIWTQYVLDNFATVSEAVEELKKQTFRIDAPDMPNGSASTLHMAITDETGNSAVLE
YIDGNLIIHEGKEYQVMTNSPRYDLQLAVNDYWKEVGGLNMLPGTNRSSDRFVRASFYIH
AIPQTSDAKIAVPSVLSVMRNVSVPFGITTPDKPYISSTRWRSVSDQKNRVYYFESTLTP
NLFWIDLHKVDFSPNASIKKLSLTHGEVYAGDVVKDFKDSRSFTFMFELPK
Enzyme 9 Number of Residues 351
Enzyme 9 Molecular Weight 39629.0
Enzyme 9 Theoretical pI 8.54
Enzyme 9 GO Classification Not Available
Enzyme 9 General Function Cell wall/membrane/envelope biogenesis
Enzyme 9 Specific Function Not Available
Enzyme 9 Pathways Not Available
Enzyme 9 Reactions Not Available
Enzyme 9 Pfam Domain Function
Enzyme 9 Signals
  • None
Enzyme 9 Transmembrane Regions
  • None
Enzyme 9 Essentiality Not Available
Enzyme 9 GenBank ID Protein 52214205 Link Image
Enzyme 9 UniProtKB/Swiss-Prot ID Q64PP5 Link Image
Enzyme 9 UniProtKB/Swiss-Prot Entry Name Q64PP5_BACFR Link Image
Enzyme 9 PDB ID Not Available
Enzyme 9 Cellular Location Not Available
Enzyme 9 Gene Sequence >1056 bp 
ATGAATAAAATTGTATCGTTTTTTATTTTAATTCTTGTTTGTTCTTGTTCAGATAGGAAA
GAGCATATAGCAAATATTCTGTCAATGAATTCTATAGATATTAAAACTAATAGGATTAAT
AAAGACGAAGTAATTGCTAGAGGTGCATTTCCTTTTGAAATGATTGATTCATTATTCTTT
CTTTTCAATGGAGATCCTTCGTCTGGAGCATTGGTTTTATGTGAATCGAATGCTTCCGAA
CTGGGACACTTCTTGCAAAAAGGAAATGGTTTTGGAGAATGTATCACTCCTGGATATATA
GGACATTGCAATGATACTATTTATGTTTCTGAACGTTCTAGAACAAGGCGAATGACTTAT
TTACTATCAAATCATAATGATAGTTTGCAATATAAGTGTCTTGAAGATGTTAGTCCTAAA
ATGAATTCAGAATTTTATTATCAGATTTGTCGTCTACAAAGTGGTTTATTTGTAGGTGCC
CGTTTATTTGGAAAAGAACATTTGTTTACATTGTTAGACGAAAGTTTGGATACACTTACC
ACTTTTGCACGGGTGCCGATAGACATTGAGGAAAATGCAAATAATAAGCTCGCTCCTTTT
ATTGGTCATTTATGTATAGATGATAATACGGTTTATTATGCTTCTAATGACTTTTCTTAT
ATGGCTGCTTATGATATTTTATCTGAGAAAGAGATAAAACCAGTATTTGAGAGGATGTAT
ATATCTCCAATAATCCAAAAATCAGCGAATGGGATTTCATTAGATAAATACAAACATCTT
TTGGGCTTTGGTGATATCAGGGTTTATCAGAATTATATTTTTGCGACGTATATAGGGAAA
CCTGATATAACAATGGATCAAGAGAATGATATTTCAGCTTTAGTCCCCACTCATTTGCTG
GTTTTTAATAAAGATGGAGTTCCAATTGTAAAATTTAAGTTTCCGTTTAAAATAAGATCA
TTCGTGTTTACCAAATCCAAGATGTATCTATTAGATGTGGATTGTAATATAGAATCTGTC
GATTTGGTAGAGTTGTGGAAGCATTTGCCCGATTGA
Enzyme 9 GenBank Gene ID AP006841 Link Image
Enzyme 9 GeneCard ID Not Available
Enzyme 9 GenAtlas ID Not Available
Enzyme 9 HGNC ID Not Available
Enzyme 9 Chromosome Location Not Available
Enzyme 9 Locus BF3794
Enzyme 9 SNPs Not Available
Enzyme 9 General References
  1. Kuwahara T, Yamashita A, Hirakawa H, Nakayama H, Toh H, Okada N, Kuhara S, Hattori M, Hayashi T, Ohnishi Y: Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14919-24. Epub 2004 Oct 4. [PubMed Link Image]
Enzyme 9 Metabolite References Not Available
Enzyme 10 [top]
Enzyme 10 ID 15850
Enzyme 10 Name Choloylglycine hydrolase
Enzyme 10 Synonyms
  1. Bile salt hydrolase
  2. Conjugated bile acid hydrolase
  3. CBAH
Enzyme 10 Gene Name cbh
Enzyme 10 Protein Sequence >Choloylglycine hydrolase 
MCTGLALETKDGLHLFGRNMDIEYSFNQSIIFIPRNFKCVNKSNKKELTTKYAVLGMGTI
FDDYPTFADGMNEKGLGCAGLNFPVYVSYSKEDIEGKTNIPVYNFLLWVLANFSSVEEVK
EALKNANIVDIPISENIPNTTLHWMISDITGKSIVVEQTKEKLNVFDNNIGVLTNSPTFD
WHVANLNQYVGLRYNQVPEFKLGDQSLTALGQGTGLVGLPGDFTPASRFIRVAFLRDAMI
KNDKDSIDLIEFFHILNNVAMVRGSTRTVEEKSDLTQYTSCMCLEKGIYYYNTYENNQIN
AIDMNKENLDGNEIKTYKYNKTLSINHVN
Enzyme 10 Number of Residues 329
Enzyme 10 Molecular Weight 37185.0
Enzyme 10 Theoretical pI 5.07
Enzyme 10 GO Classification Not Available
Enzyme 10 General Function Cell wall/membrane/envelope biogenesis
Enzyme 10 Specific Function The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut
Enzyme 10 Pathways Not Available
Enzyme 10 Reactions
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + glycine [RN:R05835]
Enzyme 10 Pfam Domain Function
Enzyme 10 Signals
  • None
Enzyme 10 Transmembrane Regions
  • None
Enzyme 10 Essentiality Not Available
Enzyme 10 GenBank ID Protein Not Available
Enzyme 10 UniProtKB/Swiss-Prot ID P54965 Link Image
Enzyme 10 UniProtKB/Swiss-Prot Entry Name CBH_CLOPE Link Image
Enzyme 10 PDB ID 2BJF Link Image
Enzyme 10 PDB File Show
Enzyme 10 3D Structure
Enzyme 10 Cellular Location Not Available
Enzyme 10 Gene Sequence >990 bp 
ATGTGTACAGGATTAGCCTTAGAAACAAAAGATGGATTACATTTGTTTGGAAGAAATATG
GATATTGAATATTCATTTAATCAATCTATTATATTTATTCCTAGGAATTTTAAATGTGTA
AACAAATCAAACAAAAAAGAATTAACAACAAAATATGCTGTTCTTGGAATGGGAACTATT
TTTGATGATTATCCTACCTTTGCAGATGGTATGAATGAAAAGGGATTAGGGTGTGCTGGC
TTAAATTTCCCTGTTTATGTTAGCTATTCTAAAGAAGATATAGAAGGTAAAACTAATATT
CCAGTATATAATTTCTTATTATGGGTTTTAGCTAATTTTAGCTCAGTAGAAGAGGTAAAG
GAAGCATTAAAAAATGCTAATATAGTGGATATACCTATTAGCGAAAATATTCCTAATACA
ACTCTTCATTGGATGATAAGCGATATAACAGGAAAGTCTATTGTGGTTGAACAAACAAAG
GAAAAATTAAATGTATTTGATAATAATATTGGAGTATTAACTAATTCACCTACTTTTGAT
TGGCATGTAGCAAATTTAAATCAATATGTAGGTTTGAGATATAATCAAGTTCCAGAATTT
AAGTTAGGAGATCAATCTTTAACTGCTTTAGGTCAAGGAACTGGTTTAGTAGGATTACCA
GGGGACTTTACACCTGCATCTAGATTTATAAGAGTAGCATTTTTAAGAGATGCAATGATA
AAAAATGATAAAGATTCAATAGACTTAATTGAATTTTTCCATATATTAAATAATGTTGCT
ATGGTAAGAGGATCAACTAGAACTGTAGAAGAAAAAAGTGATCTTACTCAATATACAAGT
TGCATGTGTTTAGAAAAAGGAATTTATTATTATAATACCTATGAAAATAATCAAATTAAT
GCAATAGACATGAATAAAGAAAACTTAGATGGAAATGAAATTAAAACATATAAATACAAC
AAAACTTTAAGTATTAATCATGTAAATTAG
Enzyme 10 GenBank Gene ID U20191 Link Image
Enzyme 10 GeneCard ID cbh Link Image
Enzyme 10 GenAtlas ID Not Available
Enzyme 10 HGNC ID Not Available
Enzyme 10 Chromosome Location Not Available
Enzyme 10 Locus Not Available
Enzyme 10 SNPs SNPJam Report Link Image
Enzyme 10 General References
  1. Coleman JP, Hudson LL: Cloning and characterization of a conjugated bile acid hydrolase gene from Clostridium perfringens. Appl Environ Microbiol. 1995 Jul;61(7):2514-20. [PubMed Link Image]
  2. Shimizu T, Ohtani K, Hirakawa H, Ohshima K, Yamashita A, Shiba T, Ogasawara N, Hattori M, Kuhara S, Hayashi H: Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):996-1001. Epub 2002 Jan 15. [PubMed Link Image]
  3. Rossocha M, Schultz-Heienbrok R, von Moeller H, Coleman JP, Saenger W: Conjugated bile acid hydrolase is a tetrameric N-terminal thiol hydrolase with specific recognition of its cholyl but not of its tauryl product. Biochemistry. 2005 Apr 19;44(15):5739-48. [PubMed Link Image]
Enzyme 10 Metabolite References Not Available
Enzyme 11 [top]
Enzyme 11 ID 15851
Enzyme 11 Name Choloylglycine hydrolase
Enzyme 11 Synonyms Not Available
Enzyme 11 Gene Name cbh
Enzyme 11 Protein Sequence >Choloylglycine hydrolase 
MCTGLALETKDGLHLFGRNMDIEYSFNQSIIFIPRNFKCVNKSNKKELTTKYAVLGMGTI
FDDYPTFADGMNEKGLGCAGLNFPVYVSYSKEDIEGKTNIPVYNFLLWVLANFSSVEEVK
EALKNANIVDIPISENIPNTTLHWMISDITGKSIVVEQTKEKLNVFDNNIGVLTNSPTFD
WHVANLNQYVGLRYNQVPEFKLGDQSLTALGQGTGLVGLPGDFTPASRFIRVAFLRDAMI
KNDKDSIDLIEFFHILNNVAMVRGSTRTVEEKSDLTQYTSCMCLEKGIYYYNTYENNQIN
AIDMNKENLDGNEIKTYKYNKTLSINHVN
Enzyme 11 Number of Residues 329
Enzyme 11 Molecular Weight 37185.0
Enzyme 11 Theoretical pI 5.07
Enzyme 11 GO Classification Not Available
Enzyme 11 General Function Cell wall/membrane/envelope biogenesis
Enzyme 11 Specific Function Not Available
Enzyme 11 Pathways Not Available
Enzyme 11 Reactions
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + glycine [RN:R05835]
Enzyme 11 Pfam Domain Function
Enzyme 11 Signals
  • None
Enzyme 11 Transmembrane Regions
  • None
Enzyme 11 Essentiality Not Available
Enzyme 11 GenBank ID Protein 110675334 Link Image
Enzyme 11 UniProtKB/Swiss-Prot ID Q0TT83 Link Image
Enzyme 11 UniProtKB/Swiss-Prot Entry Name Q0TT83_CLOP1 Link Image
Enzyme 11 PDB ID 2BJF Link Image
Enzyme 11 PDB File Show
Enzyme 11 3D Structure
Enzyme 11 Cellular Location Not Available
Enzyme 11 Gene Sequence >990 bp 
ATGTGTACAGGATTAGCCTTAGAAACAAAAGATGGATTGCATTTATTTGGAAGAAATATG
GATATTGAATATTCATTTAATCAATCTATTATATTTATTCCTAGAAACTTTAAATGTGTA
AACAAATCAAACAAAAAAGAATTAACAACAAAATATGCTGTTCTTGGAATGGGAACTATT
TTTGATGATTATCCTACCTTTGCAGATGGTATGAATGAAAAGGGATTAGGATGTGCTGGC
TTAAATTTCCCTGTTTATGTTAGCTATTCTAAAGAAGATATAGAAGGTAAAACTAATATT
CCAGTATATAATTTCTTATTATGGGTTTTAGCTAATTTTAGCTCGGTAGAAGAGGTAAAG
GAAGCATTAAAAAATGCTAATATAGTGGATATACCTATTAGCGAAAATATTCCTAATACA
ACTCTTCATTGGATGATAAGCGATATAACAGGAAAGTCTATTGTAGTTGAACAAACAAAG
GAAAAATTAAATGTCTTTGATAATAATATTGGAGTATTAACTAATTCACCTACTTTTGAT
TGGCATGTAGCAAATTTAAATCAATATGTAGGTTTGAGATATAATCAAGTTCCAGAATTT
AAGTTAGGAGATCAATCTTTAACTGCTCTAGGTCAAGGAACTGGTTTAGTAGGATTACCA
GGGGACTTTACACCTGCATCTAGATTTATAAGAGTAGCATTTTTAAGAGATGCAATGATA
AAAAATGATAAAGATTCAATAGACTTAATTGAATTTTTCCATATATTAAATAATGTTGCT
ATGGTAAGAGGATCAACTAGAACTGTAGAAGAAAAAAGTGATCTTACTCAATATACAAGT
TGCATGTGCTTAGAAAAAGGAATTTATTATTATAATACCTATGAAAATAATCAAATTAAT
GCAATAGACATGAATAAAGAAAACTTAGATGGAAATGAAATTAAAACATATAAATACAAC
AAAACTTTAAGTATTAATCATGTAAATTAG
Enzyme 11 GenBank Gene ID CP000246 Link Image
Enzyme 11 GeneCard ID cbh Link Image
Enzyme 11 GenAtlas ID Not Available
Enzyme 11 HGNC ID Not Available
Enzyme 11 Chromosome Location Not Available
Enzyme 11 Locus CPF_0705
Enzyme 11 SNPs SNPJam Report Link Image
Enzyme 11 General References
  1. Myers GS, Rasko DA, Cheung JK, Ravel J, Seshadri R, DeBoy RT, Ren Q, Varga J, Awad MM, Brinkac LM, Daugherty SC, Haft DH, Dodson RJ, Madupu R, Nelson WC, Rosovitz MJ, Sullivan SA, Khouri H, Dimitrov GI, Watkins KL, Mulligan S, Benton J, Radune D, Fisher DJ, Atkins HS, Hiscox T, Jost BH, Billington SJ, Songer JG, McClane BA, Titball RW, Rood JI, Melville SB, Paulsen IT: Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Res. 2006 Aug;16(8):1031-40. Epub 2006 Jul 6. [PubMed Link Image]
Enzyme 11 Metabolite References Not Available
Enzyme 12 [top]
Enzyme 12 ID 15852
Enzyme 12 Name Choloylglycine hydrolase family protein
Enzyme 12 Synonyms Not Available
Enzyme 12 Gene Name Not Available
Enzyme 12 Protein Sequence >Choloylglycine hydrolase family protein 
MCTHIHISSVNNNLYWGRTLDTSFNPFEVGSKITIVPRNFTLETQSKPWKTKYAFLGINL
CGSTLFFDGVNEKGLAGGLLFLKACTWDKKENIEKQGLIAINSGEIVTWILSNFESVSDI
KNNISKVVVTSDDIPSLGELGKGNPITAHYTFTDKMGESVVLEPTNHGHFRVFDNTVGVM
ANDPTFDWHMTNLANYLQVQGFNKQQNHLNSKTVITPISNGTGLLGLPGDYTSPSRFVRV
AYLRNLIGDITDEEAPARLFSILNSVWVPKDVERFYEDKKESDFSSYMCAYDQSLGKLYL
RVFNDIDTKEFSLENVKENELVTYSI
Enzyme 12 Number of Residues 326
Enzyme 12 Molecular Weight 36671.2
Enzyme 12 Theoretical pI 5.40
Enzyme 12 GO Classification Not Available
Enzyme 12 General Function Cell wall/membrane/envelope biogenesis
Enzyme 12 Specific Function Not Available
Enzyme 12 Pathways Not Available
Enzyme 12 Reactions Not Available
Enzyme 12 Pfam Domain Function
Enzyme 12 Signals
  • None
Enzyme 12 Transmembrane Regions
  • None
Enzyme 12 Essentiality Not Available
Enzyme 12 GenBank ID Protein 110675253 Link Image
Enzyme 12 UniProtKB/Swiss-Prot ID Q0TRE6 Link Image
Enzyme 12 UniProtKB/Swiss-Prot Entry Name Q0TRE6_CLOP1 Link Image
Enzyme 12 PDB ID Not Available
Enzyme 12 Cellular Location Not Available
Enzyme 12 Gene Sequence >981 bp 
ATGGTAGGAATTATTCTTGCTAGTCATGGGGAATTTGCTAAAGGCATATTACAATCTGGC
TCAATGATTTTTGGAGAACAGGAAAATGTAAAAGCTGTTACATTAATGCCGAGTGAAGGA
CCTGATGATATTAGAGCAAAAATGAAAGAAGCAATCGCTTCCTTTGATAATCAAGATGAG
GTTTTATTCTTAGTTGATCTATGGGGTGGAACACCATTTAACCAAGCAGATAGCCTAGTT
GAAGAACATAAAGACAAATGGGCAATCGTAGCTGGTATGAATTTACCAATGGTTATTGAA
GCTTATGCTTCTCGTTTCTCAATGGAATCAGCACAAGAAATTGCTGCTAATATTCTAAAG
TCAGCTAGAGAAGGAGTTAAAGTTAAGCCTGAATCATTAGAACCTGAAGAATCTACTAAA
GCTACTACAGATTCTGCTCAACAATCTAACAATGTAGGTGCGCCTGGCTCTTTTGAATAC
GTTTTGGCACGTATTGATTCACGTTTACTTCATGGTCAAGTAGCAACTGCTTGGACAAAA
ACTGTAAAACCAACAAGAATTATTGTTGTATCAGACGATGTAGCTAAAGATGAACTTCGT
AAGAAATTGATTCAACAAGCAGCTCCTCCTGGAGTTAAAGCGCATACTGTTCCAGTTAGT
CAAATGATTAAGCTTGCAAAAGATGATCAACACTTTGGAGGACAGCGTGCATTACTTCTT
TTTGAAAACCCAGAAGATGTACTTAGAGCAGTAGAGGGAGGAGTACCTATAAAGACAGTT
AATGTTGGTTCTATGGCTCACTCTCCAGGTAAGGTTCAACCAAATAAAGTACTTGCTTTT
AATCAAGAAGATATTGACACTTTTAATAAACTTAAAGAAGCTGGATTAGATTTTGATGTT
CGTAAAGTTCCAAATGATACAAAAGGAAATATGGATGAAATTCTTAAAAAAGCACAAGAG
GAATTAAATAAATTAAAATAA
Enzyme 12 GenBank Gene ID CP000246 Link Image
Enzyme 12 GeneCard ID Not Available
Enzyme 12 GenAtlas ID Not Available
Enzyme 12 HGNC ID Not Available
Enzyme 12 Chromosome Location Not Available
Enzyme 12 Locus CPF_1348
Enzyme 12 SNPs Not Available
Enzyme 12 General References
  1. Myers GS, Rasko DA, Cheung JK, Ravel J, Seshadri R, DeBoy RT, Ren Q, Varga J, Awad MM, Brinkac LM, Daugherty SC, Haft DH, Dodson RJ, Madupu R, Nelson WC, Rosovitz MJ, Sullivan SA, Khouri H, Dimitrov GI, Watkins KL, Mulligan S, Benton J, Radune D, Fisher DJ, Atkins HS, Hiscox T, Jost BH, Billington SJ, Songer JG, McClane BA, Titball RW, Rood JI, Melville SB, Paulsen IT: Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Res. 2006 Aug;16(8):1031-40. Epub 2006 Jul 6. [PubMed Link Image]
Enzyme 12 Metabolite References Not Available
Enzyme 13 [top]
Enzyme 13 ID 15853
Enzyme 13 Name Choloylglycine hydrolase family protein
Enzyme 13 Synonyms Not Available
Enzyme 13 Gene Name Not Available
Enzyme 13 Protein Sequence >Choloylglycine hydrolase family protein 
MCTHIHISSVNNNLYWGRTLDTSFNPFEVGSKITIVPRNFTLQTESNPWKTKYSFLGINL
CGSTLFFDGVNEKGLAGGLLFLKACTWDKKENIEKQGLTAINSGEIVPWILSNFESVSDI
KNNISKVVVTPDDIPSLGELGKGNPITAHYTFTDKMGESVVLEPTDHGHFRVFDNNVGVM
ANDPTFDWHMTNLANYLQVQGFNKQQNHLNSKTVITPISNGTGLLGLPGDYTSPSRFVRV
AYLRNLIGDVTDEEAPARLFSILNSVWVPKDVERFYEDKKESDFSSYMCAYDQKLGKLYL
RVFNDIDTKEFSLENVKENELVTYSI
Enzyme 13 Number of Residues 326
Enzyme 13 Molecular Weight 36708.2
Enzyme 13 Theoretical pI 5.21
Enzyme 13 GO Classification Not Available
Enzyme 13 General Function Cell wall/membrane/envelope biogenesis
Enzyme 13 Specific Function Not Available
Enzyme 13 Pathways Not Available
Enzyme 13 Reactions Not Available
Enzyme 13 Pfam Domain Function
Enzyme 13 Signals
  • None
Enzyme 13 Transmembrane Regions
  • None
Enzyme 13 Essentiality Not Available
Enzyme 13 GenBank ID Protein 110682688 Link Image
Enzyme 13 UniProtKB/Swiss-Prot ID Q0STT0 Link Image
Enzyme 13 UniProtKB/Swiss-Prot Entry Name Q0STT0_CLOPS Link Image
Enzyme 13 PDB ID Not Available
Enzyme 13 Cellular Location Not Available
Enzyme 13 Gene Sequence >981 bp 
ATGGTAGGAATTATTCTTGCTAGTCACGGAGAATTTGCTAAAGGAATATTACAATCTGGC
TCAATGATTTTTGGAGAACAGGAAAATGTAAAAGCTGTTACATTGATGCCTAGCGAAGGA
CCAGATGATATTAAAGCAAAGATGAAAGAAGCAATTGCTTCCTTTGATAATCAAGATGAG
GTTTTATTCTTAGTTGACCTATGGGGTGGAACACCATTTAATCAAGCAAACAGCCTAGTA
GAAGAACATGCAGATAAATGGGCAATCGTAGCTGGAATGAATTTACCGATGGTTATTGAA
GCTTATGCTTCACGTTTTTCAATGGAATCAGCACAAGAAATTGCTGTTAATATTCTAAAG
TCAGCTAGAGATGGAGTTAAAGTTAAGCCAGAATCATTAGAACCAGAAGAGGATACTAAA
ACAAATACAGATTCTGCACAACAATCTAATAATGTAGGTGCACCTGGCTCTTTTGAATAC
GTTTTGGCACGTATTGATTCACGTTTACTTCATGGTCAAGTAGCTACTGCTTGGACAAAA
ACTGTAAAACCAACAAGAATTATTGTTGTATCAGACGATGTAGCTAAAGATGAACTTCGT
AAGAAATTGATTCAACAAGCAGCTCCTCCTGGAGTTAAAGCACATACTGTTCCAGTTAGC
CAAATGATTAAGCTTGCAAAAGATGACCAACACTTTGGAGGACAACGTGCGTTACTTCTT
TTTGAAAATCCAGAAGATGTACTAAGAGCAGTAGAGGGAGGAGTACCTATAAAGACAGTT
AATGTTGGTTCTATGGCTCACTCTCCTGGAAAGGTTCAACCAAATAAAGTACTTGCTTTC
GATCAAGAAGATATTGATACTTTTAAGAAGCTTAAAGAAGCTGGATTGGATTTCGATGTT
CGTAAAGTTCCAAATGATACAAAAGGAAATATGGACGAAATTCTTAAAAAGGCACAAGAG
GAATTAAATAAATTAAAGTAA
Enzyme 13 GenBank Gene ID CP000312 Link Image
Enzyme 13 GeneCard ID Not Available
Enzyme 13 GenAtlas ID Not Available
Enzyme 13 HGNC ID Not Available
Enzyme 13 Chromosome Location Not Available
Enzyme 13 Locus CPR_1155
Enzyme 13 SNPs Not Available
Enzyme 13 General References
  1. Myers GS, Rasko DA, Cheung JK, Ravel J, Seshadri R, DeBoy RT, Ren Q, Varga J, Awad MM, Brinkac LM, Daugherty SC, Haft DH, Dodson RJ, Madupu R, Nelson WC, Rosovitz MJ, Sullivan SA, Khouri H, Dimitrov GI, Watkins KL, Mulligan S, Benton J, Radune D, Fisher DJ, Atkins HS, Hiscox T, Jost BH, Billington SJ, Songer JG, McClane BA, Titball RW, Rood JI, Melville SB, Paulsen IT: Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Res. 2006 Aug;16(8):1031-40. Epub 2006 Jul 6. [PubMed Link Image]
Enzyme 13 Metabolite References Not Available
Enzyme 14 [top]
Enzyme 14 ID 15854
Enzyme 14 Name Choloylglycine hydrolase
Enzyme 14 Synonyms
  1. SubName: Choloylglycine hydrolase family protein
  2. SubName: EF0040
Enzyme 14 Gene Name ef0040
Enzyme 14 Protein Sequence >Choloylglycine hydrolase 
MCTAITYVSKDHYFGRNFDYEISYNEVVTITPRNYKFSFREVGNLDHHFAIIGIAAGIAD
YPLYYDAINEKGLGMAGLNFSGYADYKKIEEGKENVSPFEFIPWVLGQCSTVDEAKKLLK
NLNLVNINFSDELPLSPLHWLLADKEQSIVVESTKEGLRVFDNPVGVLTNNPTFDYQLFN
LNNYRVLSTRTPKNNFSDQIELDIYSRGMGGIGLPGDLSSVSRFVKATFTKLNSVSRSSE
YESISQFFHILSSVEQQKGLCDVGDEKYEYTIYSSCCNLEKGIYYYRTYDNSQITAVDMN
KENLEKDSLIVYPMVETQQINYAN
Enzyme 14 Number of Residues 324
Enzyme 14 Molecular Weight 36932.2
Enzyme 14 Theoretical pI 4.65
Enzyme 14 GO Classification Not Available
Enzyme 14 General Function Cell wall/membrane/envelope biogenesis
Enzyme 14 Specific Function Not Available
Enzyme 14 Pathways Not Available
Enzyme 14 Reactions Not Available
Enzyme 14 Pfam Domain Function
Enzyme 14 Signals
  • None
Enzyme 14 Transmembrane Regions
  • None
Enzyme 14 Essentiality Not Available
Enzyme 14 GenBank ID Protein 29342582 Link Image
Enzyme 14 UniProtKB/Swiss-Prot ID Q8KUA7 Link Image
Enzyme 14 UniProtKB/Swiss-Prot Entry Name Q8KUA7_ENTFA Link Image
Enzyme 14 PDB ID Not Available
Enzyme 14 Cellular Location Not Available
Enzyme 14 Gene Sequence >975 bp 
GTGAGGAAAGAGACACGTGTTTCTTCATTGGTTCAAATAATCCGAGCAATCTTCAGGAAG
AAAGAGAAAGAACCAGAAAATTCTCGAACCATTCGTTTTTCGCCACGTTCGGCGAAAAGT
ATTTACTCAATGGTGTTTTTCCTTTTATTTTTCTTGATAAGCTTATTTTTATTAATGAGT
TTTGGACGATTAAACACGCTTACAAGGCTTGCGATGCAAAAGCAAGTAAATCGTGAGGAA
ATTATTGAAAGCGTGAATAAAGGCGTAGCTGCAAGTGATCAATTGAAATATGACGGAATG
AAACTTGTGGATCGATTATTTACAGTGTCCTCAAAATTAGAAGGAAAAGAGTACTGGGAA
GCGCAAATAACCCCTTATTTAGCTGCTGGATTGCGTGCAGAAGATTTAGGTCTTGATAAG
ACAAATGATGACCGCGTTGCACGAAATGTACGCTTTATTCGATTAGAAACAGTTGATTAT
AAAGAATCACTTTACAGCTTGTACTATGATGTCCGTTTTACTGAAGGGAAAGAATGGCGC
CAAGTGCAAGTGATTTTGCCTGTTAGTTATGCAGAAAATGAACTGAAGTTGCTTGATAGA
CCAACGTTAATGAATTTAGCGAAGACAAGTGAGAGTAACAAAGTTGTGTATGACGAGCAA
CGTTTTATACCTAAAGGAAAAGAAGTCAATGAAGAAGAAACAAAAAAACTAACGGAATTT
ACCAATCGTTTCTTTGAATTATATGTAAAAAATGATGAAAAGTTAGGACTAATTGCGAAT
GTAAAAGGACTAGAACATGCGACGTTAGAAAAAGTAGATATTACAAGTCTAAGAGAAACA
GGCCAAGGGATCTATGATGTTCGAGGAACCTATCAATTCAGTTATGAAGGGAAAAGTCCG
CTAACGTCTAACTTCTCATTACAAATTGAAGCAACAAAAGATAGTTATTTTATTAAAAAA
ATGAATGGAGTGTAA
Enzyme 14 GenBank Gene ID AE016830 Link Image
Enzyme 14 GeneCard ID ef0040 Link Image
Enzyme 14 GenAtlas ID Not Available
Enzyme 14 HGNC ID Not Available
Enzyme 14 Chromosome Location Not Available
Enzyme 14 Locus EF_0521
Enzyme 14 SNPs SNPJam Report Link Image
Enzyme 14 General References
  1. Shankar N, Baghdayan AS, Gilmore MS: Modulation of virulence within a pathogenicity island in vancomycin-resistant Enterococcus faecalis. Nature. 2002 Jun 13;417(6890):746-50. [PubMed Link Image]
  2. Paulsen IT, Banerjei L, Myers GS, Nelson KE, Seshadri R, Read TD, Fouts DE, Eisen JA, Gill SR, Heidelberg JF, Tettelin H, Dodson RJ, Umayam L, Brinkac L, Beanan M, Daugherty S, DeBoy RT, Durkin S, Kolonay J, Madupu R, Nelson W, Vamathevan J, Tran B, Upton J, Hansen T, Shetty J, Khouri H, Utterback T, Radune D, Ketchum KA, Dougherty BA, Fraser CM: Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science. 2003 Mar 28;299(5615):2071-4. [PubMed Link Image]
Enzyme 14 Metabolite References Not Available
Enzyme 15 [top]
Enzyme 15 ID 16696
Enzyme 15 Name Conjugated bile acid hydrolase
Enzyme 15 Synonyms Not Available
Enzyme 15 Gene Name cbaH
Enzyme 15 Protein Sequence >Conjugated bile acid hydrolase 
MCTGVRFSDDEGNTYFGRNLDWSFSYGETILVTPRGYHYDTVFGAGGKAKPNAVIGVGVV
MADRPMYFDCANEHGLAIAGLNFPGYASFVHEPVEGTENVATFEFPLWVARNFDSVDEVE
EALRNVTLVSQIVPGQQESLLHWFIGDGKRSIVVEQMADGMHVHHDDVDVLTNQPTFDFH
MENLRNYMCVSNEMAEPTSWGKASLTAWGAGVGMHGIPGDVSSPSRFVRVAYTNAHYPQQ
NDEAANVSRLFHTLGSVQMVDGMAKMGDGQFERTLFTSGYSSKTNTYYMNTYDDPAIRSY
AMADYDMDSSELISVAR
Enzyme 15 Number of Residues 317
Enzyme 15 Molecular Weight 35124.9
Enzyme 15 Theoretical pI 4.49
Enzyme 15 GO Classification Not Available
Enzyme 15 General Function Cell wall/membrane/envelope biogenesis
Enzyme 15 Specific Function Not Available
Enzyme 15 Pathways Not Available
Enzyme 15 Reactions Not Available
Enzyme 15 Pfam Domain Function
Enzyme 15 Signals
  • None
Enzyme 15 Transmembrane Regions
  • None
Enzyme 15 Essentiality Not Available
Enzyme 15 GenBank ID Protein 189427834 Link Image
Enzyme 15 UniProtKB/Swiss-Prot ID B3DS63 Link Image
Enzyme 15 UniProtKB/Swiss-Prot Entry Name B3DS63_BIFLD Link Image
Enzyme 15 PDB ID Not Available
Enzyme 15 Cellular Location Not Available
Enzyme 15 Gene Sequence >954 bp 
ATGTGCACTGGTGTCCGTTTCTCCGATGATGAGGGCAACACCTATTTCGGCCGTAATCTC
GACTGGAGTTTCTCATATGGGGAGACCATCCTGGTTACTCCGCGCGGCTACCACTATGAC
ACGGTGTTTGGTGCGGGCGGCAAGGCGAAGCCGAACGCGGTGATCGGCGTGGGTGTGGTC
ATGGCCGATAGGCCGATGTATTTCGACTGCGCCAATGAACATGGTCTGGCCATCGCCGGC
TTGAATTTCCCCGGCTACGCCTCGTTCGTCCACGAACCGGTCGAAGGCACGGAAAACGTC
GCCACGTTCGAATTTCCGCTGTGGGTGGCGCGTAATTTCGACTCCGTCGACGAGGTCGAG
GAGGCGCTCAGGAACGTGACGCTCGTCTCCCAGATCGTGCCGGGACAGCAGGAGTCTCTG
CTGCACTGGTTCATCGGCGACGGCAAGCGCAGCATCGTCGTCGAGCAGATGGCCGATGGC
ATGCACGTGCATCATGATGACGTCGATGTGCTGACCAATCAGCCGACGTTCGACTTCCAT
ATGGAAAACCTGCGCAACTACATGTGCGTCAGCAACGAGATGGCCGAACCGACTTCATGG
GGCAAGGCCTCCTTGACCGCCTGGGGTGCGGGTGTGGGCATGCATGGCATCCCGGGCGAC
GTGAGTTCCCCGTCGCGCTTCGTTCGTGTGGCCTACACCAACGCGCATTACCCGCAGCAG
AACGATGAAGCCGCCAATGTGTCGCGCCTGTTCCACACCCTCGGCTCCGTGCAGATGGTG
GACGGCATGGCGAAGATGGGCGACGGCCAGTTCGAACGCACGCTGTTCACCAGCGGATAT
TCGTCCAAGACCAACACCTATTACATGAACACCTATGATGACCCCGCCATCCGTTCCTAC
GCCATGGCCGATTACGATATGGATTCCTCGGAGCTCATCAGCGTCGCCCGATGA
Enzyme 15 GenBank Gene ID CP000605 Link Image
Enzyme 15 GeneCard ID cbaH Link Image
Enzyme 15 GenAtlas ID Not Available
Enzyme 15 HGNC ID Not Available
Enzyme 15 Chromosome Location Not Available
Enzyme 15 Locus BLD_0536
Enzyme 15 SNPs SNPJam Report Link Image
Enzyme 15 General References
  1. Lee JH, Karamychev VN, Kozyavkin SA, Mills D, Pavlov AR, Pavlova NV, Polouchine NN, Richardson PM, Shakhova VV, Slesarev AI, Weimer B, O'Sullivan DJ: Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth. BMC Genomics. 2008 May 27;9:247. [PubMed Link Image]
Enzyme 15 Metabolite References Not Available