Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2013-02-09 00:09:33 UTC
HMDB IDHMDB00905
Secondary Accession NumbersNone
Metabolite Identification
Common NameDeoxyadenosine monophosphate
DescriptionAdenosine is a nucleoside comprised of adenine attached to a ribose (ribofuranose) moiety via a -N9-glycosidic bond. Deoxyadenosine monophosphate is a derivative of the common nucleic acid ATP, or adenosine triphosphate, in which the -OH (hydroxyl) group on the 2' carbon on the nucleotide's pentose has been removed (hence the deoxy- part of the name). Additionally, the monophosphate of the name indicates that two of the phosphoryl groups of GTP have been removed, most likely by hydrolysis. Deoxyadenosine monophosphate is abbreviated dAMP. (Wikipedia).
Structure
Thumb
Synonyms
  1. 2'-dAMP
  2. 2'-Deoxy-5'-adenylate
  3. 2'-Deoxy-5'-adenylic acid
  4. 2'-Deoxy-Adenosine 5'-phosphorate
  5. 2'-Deoxy-Adenosine 5'-phosphoric acid
  6. 2'-Deoxy-AMP
  7. 2'-Deoxyadenosine 5'-monophosphate
  8. 2'-Deoxyadenosine 5'-phosphate
  9. 2'-Deoxyadenosine monophosphate
  10. 2'-Deoxyadenosine-5'-monophosphate
  11. 2'-Deoxyadenosine-5'-phosphate
  12. 2'-Deoxyadenylate
  13. 2'-Deoxyadenylic acid
  14. dAMP
  15. Deoxy-5'-adenylate
  16. Deoxy-5'-adenylic acid
  17. Deoxy-AMP
  18. Deoxyadenosine 5'-monophosphate
  19. Deoxyadenosine 5'-phosphate
  20. Deoxyadenosine monophosphate
  21. Deoxyadenosine-phosphate
  22. Deoxyadenylate
  23. Deoxyadenylic acid
  24. PdA
Chemical FormulaC10H14N5O6P
Average Molecular Weight331.2218
Monoisotopic Molecular Weight331.068169717
IUPAC Name{[(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid
Traditional IUPAC Name[(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxyphosphonic acid
CAS Registry Number653-63-4
SMILES
NC1=NC=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COP(O)(O)=O)O1
InChI Identifier
InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/t5-,6+,7+/m0/s1
InChI KeyKHWCHTKSEGGWEX-RRKCRQDMSA-N
Chemical Taxonomy
KingdomOrganic Compounds
Super ClassNucleosides, Nucleotides, and Analogues
ClassPurine Nucleotides
Sub ClassPurine Deoxyribonucleotides
Other Descriptors
  • 2'-deoxyadenosine 5'-phosphate(ChEBI)
  • Aromatic Heteropolycyclic Compounds
  • Deoxyribonucleotides(KEGG)
  • Organic Compounds
  • purine 2'-deoxyribonucleoside 5'-monophosphate(ChEBI)
Substituents
  • Aminopyrimidine
  • Imidazole
  • Imidazopyrimidine
  • Organic Hypophosphite
  • Organic Phosphite
  • Oxolane
  • Phosphoric Acid Ester
  • Purine
  • Pyrimidine
  • Secondary Alcohol
Direct ParentPurine 2'-deoxyribonucleoside Monophosphates
Ontology
StatusExpected and Not Quantified
Origin
  • Endogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Lysosome
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point148 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
water solubility2.71 g/LALOGPS
logP-2.4ALOGPS
logP-3.9ChemAxon
logS-2.1ALOGPS
pKa (strongest acidic)1.23ChemAxon
pKa (strongest basic)4.98ChemAxon
physiological charge-2ChemAxon
hydrogen acceptor count9ChemAxon
hydrogen donor count4ChemAxon
polar surface area165.84ChemAxon
rotatable bond count4ChemAxon
refractivity72.56ChemAxon
polarizability28.98ChemAxon
Spectra
Spectra
Biological Properties
Cellular Locations
  • Lysosome
Biofluid LocationsNot Available
Tissue Location
  • Liver
  • Spleen
Pathways
NameSMPDB LinkKEGG Link
Purine MetabolismSMP00050map00230
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB022311
KNApSAcK IDNot Available
Chemspider ID12079
KEGG Compound IDC00360
BioCyc IDDAMP
BiGG ID34735
Wikipedia LinkDeoxyadenosine monophosphate
NuGOwiki LinkHMDB00905
Metagene LinkHMDB00905
METLIN ID3461
PubChem Compound12599
PDB IDD5M
ChEBI ID17713
References
Synthesis ReferenceScarano, E. Incorporation of adenine-C14 into deoxyadenylic acid. Bollettino - Societa Italiana di Biologia Sperimentale (1958), 34 1620-1.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Hohenester E, Hutchinson WL, Pepys MB, Wood SP: Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP. J Mol Biol. 1997 Jun 20;269(4):570-8. Pubmed: 9217261
  2. Avkin S, Adar S, Blander G, Livneh Z: Quantitative measurement of translesion replication in human cells: evidence for bypass of abasic sites by a replicative DNA polymerase. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3764-9. Epub 2002 Mar 12. Pubmed: 11891323
  3. Duarte V, Muller JG, Burrows CJ: Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine. Nucleic Acids Res. 1999 Jan 15;27(2):496-502. Pubmed: 9862971
  4. Chen XR, Li GM, Wang JR, Chen JJ: [Portal hemodynamics in patients with different syndromes of cirrhosis] Zhong Xi Yi Jie He Xue Bao. 2004 May;2(3):178-81. Pubmed: 15339437
  5. Zhong H, Zang KT: Therapeutic approaches for chronic gastralgia based on differentiation of symptoms and signs. Di Yi Jun Yi Da Xue Xue Bao. 2002 Jul;22(7):639-40. Pubmed: 12376299
  6. Hashimoto K, Tominaga Y, Nakabeppu Y, Moriya M: Futile short-patch DNA base excision repair of adenine:8-oxoguanine mispair. Nucleic Acids Res. 2004 Nov 5;32(19):5928-34. Print 2004. Pubmed: 15531653
  7. Zhang Q, Zhang WT, Wei JJ, Wang XB, Liu P: [Combined use of factor analysis and cluster analysis in classification of traditional Chinese medical syndromes in patients with posthepatitic cirrhosis] Zhong Xi Yi Jie He Xue Bao. 2005 Jan;3(1):14-8. Pubmed: 15644152
  8. Levine RL, Yang IY, Hossain M, Pandya GA, Grollman AP, Moriya M: Mutagenesis induced by a single 1,N6-ethenodeoxyadenosine adduct in human cells. Cancer Res. 2000 Aug 1;60(15):4098-104. Pubmed: 10945616

Enzymes

Gene Name:
NT5E
Uniprot ID:
P21589
Reactions
Deoxyadenosine monophosphate + Water unknown Deoxyadenosine + Phosphoric aciddetails
Gene Name:
NT5C1B
Uniprot ID:
Q96P26
Reactions
Deoxyadenosine monophosphate + Water unknown Deoxyadenosine + Phosphoric aciddetails
Gene Name:
NT5C1A
Uniprot ID:
Q9BXI3
Reactions
Deoxyadenosine monophosphate + Water unknown Deoxyadenosine + Phosphoric aciddetails
Gene Name:
NT5C
Uniprot ID:
Q8TCD5
Reactions
Deoxyadenosine monophosphate + Water unknown Deoxyadenosine + Phosphoric aciddetails
Gene Name:
NT5M
Uniprot ID:
Q9NPB1
Reactions
Deoxyadenosine monophosphate + Water unknown Deoxyadenosine + Phosphoric aciddetails
Gene Name:
AK1
Uniprot ID:
P00568
Reactions
Adenosine triphosphate + Deoxyadenosine monophosphate unknown ADP + dADPdetails
Gene Name:
AK4
Uniprot ID:
P27144
Reactions
Adenosine triphosphate + Deoxyadenosine monophosphate unknown ADP + dADPdetails
Gene Name:
AK7
Uniprot ID:
Q96M32
Reactions
Adenosine triphosphate + Deoxyadenosine monophosphate unknown ADP + dADPdetails
Gene Name:
AK5
Uniprot ID:
Q9Y6K8
Reactions
Adenosine triphosphate + Deoxyadenosine monophosphate unknown ADP + dADPdetails
Gene Name:
NT5C3
Uniprot ID:
Q9H0P0
Reactions
Deoxyadenosine monophosphate + Water unknown Deoxyadenosine + Phosphoric aciddetails
Gene Name:
NT5C2
Uniprot ID:
P49902
Reactions
Deoxyadenosine monophosphate + Water unknown Deoxyadenosine + Phosphoric aciddetails
Gene Name:
AK2
Uniprot ID:
P54819
Reactions
Adenosine triphosphate + Deoxyadenosine monophosphate unknown ADP + dADPdetails