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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:15:19 UTC
HMDB IDHMDB0000940
Secondary Accession Numbers
  • HMDB00940
Metabolite Identification
Common NameThreonolactone
DescriptionThreonolactone belongs to the class of organic compounds known as gamma butyrolactones. Gamma butyrolactones are compounds containing a gamma butyrolactone moiety, which consists of an aliphatic five-member ring with four carbon atoms, one oxygen atom, and bears a ketone group on the carbon adjacent to the oxygen atom. Threonolactone has been detected, but not quantified in, a few different foods, such as anatidaes (Anatidae), chickens (Gallus gallus), and domestic pigs (Sus scrofa domestica). This could make threonolactone a potential biomarker for the consumption of these foods. Threonolactone is a secondary metabolite. Secondary metabolites are metabolically or physiologically non-essential metabolites that may serve a role as defense or signalling molecules. In some cases they are simply molecules that arise from the incomplete metabolism of other secondary metabolites. Based on a literature review a significant number of articles have been published on Threonolactone.
Structure
Data?1676999719
Synonyms
ValueSource
L-Threonic acid-1,4-lactoneChEBI
Threonic acid-1,4-lactoneChEBI
L-Threonate-1,4-lactoneGenerator
Threonate-1,4-lactoneGenerator
3,4-Bis[(trimethylsilyl)oxy]dihydro-cis-2(3H)-furanoneHMDB
Bis-TMS-threono-1,4-lactoneHMDB
cis-Dihydro-3,4-bis[(trimethylsilyl)oxy]-2(3H)-furanoneHMDB
Di-TMS-threono-1,4-lactoneHMDB
Chemical FormulaC4H6O4
Average Molecular Weight118.088
Monoisotopic Molecular Weight118.02660868
IUPAC Name(3R,4S)-3,4-dihydroxyoxolan-2-one
Traditional Name(3R,4S)-3,4-dihydroxyoxolan-2-one
CAS Registry Number21730-93-8
SMILES
O[C@H]1COC(=O)[C@@H]1O
InChI Identifier
InChI=1S/C4H6O4/c5-2-1-8-4(7)3(2)6/h2-3,5-6H,1H2/t2-,3+/m0/s1
InChI KeySGMJBNSHAZVGMC-STHAYSLISA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as gamma butyrolactones. Gamma butyrolactones are compounds containing a gamma butyrolactone moiety, which consists of an aliphatic five-member ring with four carbon atoms, one oxygen atom, and bears a ketone group on the carbon adjacent to the oxygen atom.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassLactones
Sub ClassGamma butyrolactones
Direct ParentGamma butyrolactones
Alternative Parents
Substituents
  • Gamma butyrolactone
  • Tetrahydrofuran
  • Secondary alcohol
  • Carboxylic acid ester
  • 1,2-diol
  • Oxacycle
  • Monocarboxylic acid or derivatives
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility1240 g/LALOGPS
logP-1.7ALOGPS
logP-1.5ChemAxon
logS1.02ALOGPS
pKa (Strongest Acidic)11.66ChemAxon
pKa (Strongest Basic)-3.6ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area66.76 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity22.85 m³·mol⁻¹ChemAxon
Polarizability9.87 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+123.13431661259
DarkChem[M-H]-118.30531661259
AllCCS[M+H]+126.52432859911
AllCCS[M-H]-118.24732859911
DeepCCS[M+H]+128.10530932474
DeepCCS[M-H]-126.24630932474
DeepCCS[M-2H]-161.79630932474
DeepCCS[M+Na]+135.89530932474
AllCCS[M+H]+126.532859911
AllCCS[M+H-H2O]+121.732859911
AllCCS[M+NH4]+131.032859911
AllCCS[M+Na]+132.332859911
AllCCS[M-H]-118.232859911
AllCCS[M+Na-2H]-120.832859911
AllCCS[M+HCOO]-123.632859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
ThreonolactoneO[C@H]1COC(=O)[C@@H]1O2308.9Standard polar33892256
ThreonolactoneO[C@H]1COC(=O)[C@@H]1O1156.7Standard non polar33892256
ThreonolactoneO[C@H]1COC(=O)[C@@H]1O1289.1Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Threonolactone,1TMS,isomer #1C[Si](C)(C)O[C@H]1COC(=O)[C@@H]1O1296.7Semi standard non polar33892256
Threonolactone,1TMS,isomer #2C[Si](C)(C)O[C@H]1C(=O)OC[C@@H]1O1276.0Semi standard non polar33892256
Threonolactone,2TMS,isomer #1C[Si](C)(C)O[C@H]1COC(=O)[C@@H]1O[Si](C)(C)C1410.0Semi standard non polar33892256
Threonolactone,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)O[C@H]1COC(=O)[C@@H]1O1506.1Semi standard non polar33892256
Threonolactone,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)O[C@H]1C(=O)OC[C@@H]1O1519.2Semi standard non polar33892256
Threonolactone,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)O[C@H]1COC(=O)[C@@H]1O[Si](C)(C)C(C)(C)C1834.6Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Threonolactone GC-MS (Non-derivatized) - 70eV, Positivesplash10-0006-9000000000-63c53760143cd20448732017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Threonolactone GC-MS (2 TMS) - 70eV, Positivesplash10-0fki-9430000000-f0cfa4e00daeb540aee72017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Threonolactone GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Threonolactone GC-MS (TMS_1_1) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Threonolactone GC-MS (TMS_1_2) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Threonolactone GC-MS (TBDMS_1_1) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Threonolactone GC-MS (TBDMS_1_2) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Threonolactone GC-MS (TBDMS_2_1) - 70eV, PositiveNot Available2021-11-06Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Threonolactone 10V, Positive-QTOFsplash10-0gb9-1900000000-d7d529471e146551a4702017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Threonolactone 20V, Positive-QTOFsplash10-0uxr-1900000000-7e70d7eac9b72e1cbd362017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Threonolactone 40V, Positive-QTOFsplash10-0a4l-9100000000-7a95b8e64f0d366b41012017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Threonolactone 10V, Negative-QTOFsplash10-014i-2900000000-c877a9861f0a9e0fa9472017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Threonolactone 20V, Negative-QTOFsplash10-014j-8900000000-874d13e11592fe389a742017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Threonolactone 40V, Negative-QTOFsplash10-006x-9000000000-295d5454144b0a74cb002017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Threonolactone 10V, Negative-QTOFsplash10-00di-9100000000-ccaaa47150cc978a00b92021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Threonolactone 20V, Negative-QTOFsplash10-0a4l-9000000000-07ca8b081361da8d614e2021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Threonolactone 40V, Negative-QTOFsplash10-0006-9000000000-846eebab9a9caa26cce62021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Threonolactone 10V, Positive-QTOFsplash10-0udi-6900000000-fde995765993269b5d052021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Threonolactone 20V, Positive-QTOFsplash10-0007-9100000000-11a72527d4f24a67775b2021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Threonolactone 40V, Positive-QTOFsplash10-0007-9000000000-f1bef05a8557507531322021-09-25Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022328
KNApSAcK IDNot Available
Chemspider ID2006913
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN ID5888
PubChem Compound2724794
PDB IDNot Available
ChEBI ID71176
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNakaminami, Gen; Edo, Haruo; Nakagawa, Masazumi. Syntheses of L-threose and methyl di-O-acetyl-L-threuronate from (+)-tartaric acid. Bulletin of the Chemical Society of Japan (1973), 46(1), 266-9.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. (). Kurata, T; Miyake, N; Otsuka, Y. Formation of L-threonolactone and oxalic acid in the autoxidation reaction of L-ascorbic acid - Possible involvement of singlet oxygen. Bioscience, Biotechnology, and Biochemistry, Volume 60, Issue 7, pp. 1212-1214. . .