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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:15:41 UTC
HMDB IDHMDB0001429
Secondary Accession Numbers
  • HMDB0000973
  • HMDB0002105
  • HMDB0002142
  • HMDB0005947
  • HMDB00973
  • HMDB01429
  • HMDB02105
  • HMDB02142
  • HMDB05947
Metabolite Identification
Common NamePhosphate
DescriptionPhosphate is a salt of phosphoric acid and is an essential component of life. Organic phosphates are important in biochemistry, biogeochemistry, and ecology. In biological systems, phosphorus is found as a free phosphate ion in solution and is called inorganic phosphate, to distinguish it from phosphates bound in various phosphate esters. Inorganic phosphate is generally denoted Pi and at physiological (neutral) pH primarily consists of a mixture of HPO2-4 and H2PO-4 ions. Phosphates are most commonly found in the form of adenosine phosphates (AMP, ADP, and ATP) and in DNA and RNA, and can be released by the hydrolysis of ATP or ADP. Similar reactions exist for the other nucleoside diphosphates and triphosphates. Phosphoanhydride bonds in ADP and ATP, or other nucleoside diphosphates and triphosphates, contain high amounts of energy which give them their vital role in all living organisms. Phosphate must be actively transported into cells against its electrochemical gradient. In vertebrates, two unrelated families of Na+-dependent Pi transporters carry out this task. Remarkably, the two families transport different Pi species: whereas type II Na+/Pi cotransporters (SCL34) prefer divalent HPO4(2), type III Na+/Pi cotransporters (SLC20) transport monovalent H2PO4. The SCL34 family comprises both electrogenic and electroneutral members that are expressed in various epithelia and other polarized cells. Through regulated activity in apical membranes of the gut and kidney, they maintain body Pi homeostasis, and in salivary and mammary glands, liver, and testes they play a role in modulating the Pi content of luminal fluids. Phosphate levels in the blood play an important role in hormone signalling and in bone homeostasis. In classical endocrine regulation, low serum phosphate induces the renal production of the secosteroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). This active metabolite of vitamin D acts to restore circulating mineral (i.e. phosphate and calcium) levels by increasing absorption in the intestine, reabsorption in the kidney, and mobilization of calcium and phosphate from bone. Thus, chronic renal failure is associated with hyperparathyroidism, which in turn contributes to osteomalacia (softening of the bones). Another complication of chronic renal failure is hyperphosphatemia (low levels of phosphate in the blood). Hyperphosphatemia (excess levels of phosphate in the blood) is a prevalent condition in kidney dialysis patients and is associated with increased risk of mortality. Hypophosphatemia (hungry bone syndrome) has been associated with postoperative electrolyte aberrations and after parathyroidectomy (PMID: 17581921 , 11169009 , 11039261 , 9159312 , 17625581 ). Fibroblast growth factor 23 (FGF-23) has recently been recognized as a key mediator of phosphate homeostasis and its most notable effect is the promotion of phosphate excretion. FGF-23 was discovered to be involved in diseases such as autosomal dominant hypophosphatemic rickets, X-linked hypophosphatemia, and tumour-induced osteomalacia in which phosphate wasting was coupled to inappropriately low levels of 1,25(OH)2D3. FGF-23 is regulated by dietary phosphate in humans. In particular, it was found that phosphate restriction decreased FGF-23, and phosphate loading increased FGF-23. In agriculture, phosphate refers to one of the three primary plant nutrients, and it is a component of fertilizers. In ecological terms, because of its important role in biological systems, phosphate is a highly sought after resource. Consequently, it is often a limiting reagent in environments, and its availability may govern the rate of growth of organisms. Addition of high levels of phosphate to environments and to micro-environments in which it is typically rare can have significant ecological consequences. In the context of pollution, phosphates are a principal component of total dissolved solids, a major indicator of water quality. Dihydrogen phosphate is an inorganic salt used in numerous analytical methods, and in buffer solutions (PMID: 15369738 ). It is one of several forms of the phosphate ion that can exist physiologically. It readily forms salts with sodium or potassium cations.
Structure
Data?1676999741
Synonyms
ValueSource
[PO(OH)3]ChEBI
Acide phosphoriqueChEBI
Acidum phosphoricumChEBI
H3PO4ChEBI
Orthophosphoric acidChEBI
PhosphorsaeureloesungenChEBI
PhosphorsaeureChEBI
Phosphoric acidKegg
OrthophosphateGenerator
Concise etchantMeSH
CondactMeSH
K-EtchantMeSH
Uni-etchMeSH
PhosphateChEBI
Diphosphate tetrasodiumHMDB
MarphosHMDB
NFBHMDB
ortho- Phosphoric acidHMDB
Phosphoric acid (acd/name 4.0)HMDB
Sodium pyrophosphateHMDB
Sodium pyrophosphate decahydrateHMDB
Sodium pyrophosphate decahydrate biochemicaHMDB
SonacHMDB
Tetra-sodium pyrophosphateHMDB
Tetrasodium pyrophosphate 10-hydrateHMDB
Tetrasodium pyrophosphate decahydrateHMDB
White phosphoric acidHMDB
Hydrogen phosphoric acidGenerator
Dihydrogen phosphateHMDB
Hydrogen phosphateHMDB
Chemical FormulaH3O4P
Average Molecular Weight97.9952
Monoisotopic Molecular Weight97.976895096
IUPAC Namephosphoric acid
Traditional Namephosphoric acid
CAS Registry Number14265-44-2
SMILES
OP(O)(O)=O
InChI Identifier
InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)
InChI KeyNBIIXXVUZAFLBC-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as non-metal phosphates. These are inorganic non-metallic compounds containing a phosphate as its largest oxoanion.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassNon-metal oxoanionic compounds
Sub ClassNon-metal phosphates
Direct ParentNon-metal phosphates
Alternative Parents
Substituents
  • Non-metal phosphate
  • Inorganic oxide
Molecular FrameworkNot Available
External Descriptors
Ontology
Physiological effectNot Available
DispositionNot Available
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point41.00 to 44.00 °C. @ 760.00 mm HgThe Good Scents Company Information System
Boiling Point158.00 °C. @ 760.00 mm HgThe Good Scents Company Information System
Water Solubility1000 mg/mLMERCK INDEX (1996)
LogP-2.150The Good Scents Company Information System
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
logP-1ChemAxon
pKa (Strongest Acidic)1.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area77.76 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity14.65 m³·mol⁻¹ChemAxon
Polarizability5.81 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M+H]+120.04630932474
DeepCCS[M-H]-117.3830932474
DeepCCS[M-2H]-153.71730932474
DeepCCS[M+Na]+128.2630932474
AllCCS[M+H]+117.532859911
AllCCS[M+H-H2O]+113.232859911
AllCCS[M+NH4]+121.632859911
AllCCS[M+Na]+122.732859911
AllCCS[M-H]-131.732859911
AllCCS[M+Na-2H]-137.432859911
AllCCS[M+HCOO]-143.732859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
PhosphateOP(O)(O)=O2102.0Standard polar33892256
PhosphateOP(O)(O)=O1058.3Standard non polar33892256
PhosphateOP(O)(O)=O1059.9Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Phosphate,1TMS,isomer #1C[Si](C)(C)OP(=O)(O)O1173.7Semi standard non polar33892256
Phosphate,1TMS,isomer #1C[Si](C)(C)OP(=O)(O)O1068.7Standard non polar33892256
Phosphate,1TMS,isomer #1C[Si](C)(C)OP(=O)(O)O1578.2Standard polar33892256
Phosphate,2TMS,isomer #1C[Si](C)(C)OP(=O)(O)O[Si](C)(C)C1209.0Semi standard non polar33892256
Phosphate,2TMS,isomer #1C[Si](C)(C)OP(=O)(O)O[Si](C)(C)C1179.7Standard non polar33892256
Phosphate,2TMS,isomer #1C[Si](C)(C)OP(=O)(O)O[Si](C)(C)C1343.5Standard polar33892256
Phosphate,3TMS,isomer #1C[Si](C)(C)OP(=O)(O[Si](C)(C)C)O[Si](C)(C)C1254.1Semi standard non polar33892256
Phosphate,3TMS,isomer #1C[Si](C)(C)OP(=O)(O[Si](C)(C)C)O[Si](C)(C)C1301.5Standard non polar33892256
Phosphate,3TMS,isomer #1C[Si](C)(C)OP(=O)(O[Si](C)(C)C)O[Si](C)(C)C1239.3Standard polar33892256
Phosphate,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O)O1440.0Semi standard non polar33892256
Phosphate,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O)O1312.0Standard non polar33892256
Phosphate,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O)O1755.2Standard polar33892256
Phosphate,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O)O[Si](C)(C)C(C)(C)C1664.0Semi standard non polar33892256
Phosphate,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O)O[Si](C)(C)C(C)(C)C1605.0Standard non polar33892256
Phosphate,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O)O[Si](C)(C)C(C)(C)C1630.9Standard polar33892256
Phosphate,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C1885.5Semi standard non polar33892256
Phosphate,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C1908.7Standard non polar33892256
Phosphate,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OP(=O)(O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C1634.3Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Hydrogen phosphate GC-MS (3 TMS)splash10-0002-0794000000-6c866e626b9356994d462014-06-16HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Hydrogen phosphate EI-B (Non-derivatized)splash10-0002-0394000000-3a469377821d88bd699f2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Hydrogen phosphate GC-MS (Non-derivatized)splash10-0002-0794000000-6c866e626b9356994d462017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Hydrogen phosphate GC-EI-TOF (Non-derivatized)splash10-000t-0972000000-2ddd7182426dbace53422017-09-12HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Hydrogen phosphate GC-MS (Non-derivatized) - 70eV, Positivesplash10-0002-9000000000-1805c2208b5ff15a75b12016-09-22Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Hydrogen phosphate GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate Quattro_QQQ 10V, N/A-QTOF (Annotated)splash10-000t-9000000000-0e85f764ac98e89497592012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate Quattro_QQQ 25V, N/A-QTOF (Annotated)splash10-001i-9000000000-869a362083996a0cec772012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate Quattro_QQQ 40V, N/A-QTOF (Annotated)splash10-03di-9000000000-801101cccfd6c25271d42012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate LC-ESI-QTOF 10V, positive-QTOFsplash10-0002-9000000000-6f386712e664a4b37a0f2020-07-21HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate LC-ESI-QTOF 20V, positive-QTOFsplash10-0002-9000000000-94c04c712e24776fb3332020-07-21HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate LC-ESI-QTOF 40V, positive-QTOFsplash10-0002-9000000000-9cc1283f5af78eb261242020-07-21HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate LC-ESI-QFT , negative-QTOFsplash10-0002-9000000000-c1da993c0996e8d608302020-07-21HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate LC-ESI-QTOF 35V, negative-QTOFsplash10-002b-9000000000-ccb36e7b3439fcc253132020-07-21HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate LC-ESI-QTOF 10V, negative-QTOFsplash10-004i-9000000000-e618cbd5a94aa5860a292020-07-21HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate LC-ESI-QTOF 20V, negative-QTOFsplash10-004i-9000000000-b7f0efd9272b1a27eac42020-07-21HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate LC-ESI-QTOF 40V, negative-QTOFsplash10-004i-9000000000-8cadeed88c84e8c2b6c22020-07-21HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate n/a 6V, negative-QTOFsplash10-014i-9000000000-093cd2a2a662118d84322020-07-21HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate n/a 6V, negative-QTOFsplash10-004i-9000000000-46d4cee1b5ac630ba9b82020-07-21HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate QqQ 1V, negative-QTOFsplash10-0006-0090000000-40333890e636692e79702020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate QqQ 2V, negative-QTOFsplash10-0006-0190000000-52fa21c93ab4c97f8df22020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate QqQ 3V, negative-QTOFsplash10-0006-0490000000-32e316211facaa3d3bb22020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate QqQ 4V, negative-QTOFsplash10-0005-0960000000-bd7aaa47a8ffd82012d32020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate QqQ 5V, negative-QTOFsplash10-0002-0920000000-463d7b1bf72bcc10126f2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phosphate QqQ 6V, negative-QTOFsplash10-0002-0910000000-3c9c666ac95b68e432242020-07-22HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Phosphate 10V, Positive-QTOFsplash10-0002-9000000000-12a5e23d24cd494e99c12016-09-14Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Phosphate 20V, Positive-QTOFsplash10-0002-9000000000-91e06ca38117aabdb14c2016-09-14Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Phosphate 40V, Positive-QTOFsplash10-000t-9000000000-19b1c041aa5e2adcc3e62016-09-14Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Phosphate 10V, Negative-QTOFsplash10-0002-9000000000-e56eecd6724dfbf741602016-09-14Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Phosphate 20V, Negative-QTOFsplash10-004i-9000000000-0a46ba32971030356ac52016-09-14Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Phosphate 40V, Negative-QTOFsplash10-004i-9000000000-3a53d27e23b39429d0922016-09-14Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
  • Lysosome
  • Endoplasmic reticulum
  • Golgi apparatus
  • Peroxisome
Biospecimen Locations
  • Blood
  • Feces
  • Saliva
  • Sweat
  • Urine
Tissue Locations
  • Kidney
  • Liver
  • Placenta
  • Prostate
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified379.1 +/- 31.6 uMAdult (>18 years old)MaleNormal details
BloodDetected and Quantified820.4 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified1400-2200 uMNot SpecifiedNot SpecifiedNormal details
BloodDetected and Quantified589.65-1105.60 uMNewborn (0 - <14 days old)Both
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified505.42-884.45 uMInfant (15 days - <1 year old)Both
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified452.77-716.01 uMChildren (1 - <5 years old)Both
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified431.71-621.24 uMChildren (5 - <13 years old)Both
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified336.94-579.12 uMAdolescent (13 - <16 years old)Female
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified305.36-526.47 uMAdolescent (16 - <19 years old)Both
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified368.53-652.83 uMAdolescent (13 - <16 years old)Male
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified1100 +/- 190 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified1200-1960 uMInfant (0-1 year old)Not SpecifiedNormal details
BloodDetected and Quantified400.120-684.417 uMChildren (1-13 years old)Not SpecifiedNormal details
BloodDetected and Quantified1100.0 (810.0-1450.0) uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
BloodDetected and Quantified1200-2000 uMInfant (0-1 year old)Not SpecifiedNormal details
BloodDetected and Quantified1000-2200 uMChildren (1-13 years old)Not SpecifiedNormal details
FecesDetected but not QuantifiedNot QuantifiedNot SpecifiedNot Specified
Normal
details
FecesDetected but not QuantifiedNot QuantifiedInfant (0-1 year old)Both
Normal
details
FecesDetected but not QuantifiedNot QuantifiedInfant (0-1 year old)Not Specified
Normal
details
FecesDetected but not QuantifiedNot QuantifiedInfant (0-1 year old)Not Specified
Normal
details
FecesDetected but not QuantifiedNot QuantifiedInfant (0-1 year old)Not AvailableNormal details
FecesDetected but not QuantifiedNot QuantifiedNot SpecifiedNot Specified
Normal
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified27850 +/- 36040 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified28550 +/- 33790 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified21450 +/- 21020 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified17620 +/- 13800 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified21630 +/- 15830 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified24100 +/- 16390 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified22690 +/- 19270 uMAdult (>18 years old)Both
Normal
details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal
details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal
details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal
details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal
details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal
details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal
details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal
details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal
details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal
details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Male
Normal
details
SalivaDetected and Quantified2787.81 +/- 1528.51 uMAdult (>18 years old)BothNormal
    • Zerihun T. Dame, ...
details
SweatDetected but not QuantifiedNot QuantifiedAdult BothNormal details
UrineDetected and Quantified784 (425-1170) umol/mmol creatinineAdult (>18 years old)Both
Normal
details
UrineDetected and Quantified1000-4900 umol/mmol creatinineAdult (>18 years old)BothNormal
    • Great Plains Labo...
details
UrineDetected and Quantified1364.27 +/- 915.27 umol/mmol creatinineInfant (0-1 year old)BothNormal details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified450 +/- 30 uMAdult (>18 years old)Not Specified
Hypophosphatemia
details
BloodDetected and Quantified290 +/- 50 uMAdult (>18 years old)Not Specified
Hypophosphatemia
details
BloodDetected and Quantified2800 uMInfant (0-1 year old)FemalePyroglutamic aciduria details
BloodDetected and Quantified653.0 +/- 126.0 uMAdult (>18 years old)BothHemodialysis details
BloodDetected and Quantified2700-4700 uMInfant (0-1 year old)BothHypoparathyroidism-retardation-dysmorphism syndrome details
BloodDetected and Quantified1300 +/- 170 uMAdult (>18 years old)Both
Hypophosphatasia, infantile
details
BloodDetected and Quantified126.354 uMAdult (>18 years old)FemaleFanconi syndrome details
BloodDetected and Quantified315.885 uMChildren (1-13 years old)FemaleHyperphosphatasia details
BloodDetected and Quantified270 (0-540) uMAdult (>18 years old)Not Specified
Hypophosphatemia
details
BloodDetected and Quantified610 +/- 130 uMAdult (>18 years old)Not Specified
Hypophosphatemia
details
BloodDetected and Quantified1700-2000 uMInfant (0-1 year old)Not SpecifiedOculocerebrorenal Syndrome of Lowe details
BloodDetected and Quantified900-2000 uMChildren (1-13 years old)Not SpecifiedOculocerebrorenal Syndrome of Lowe details
BloodDetected and Quantified800-1400 uMAdolescent (13-18 years old)Not SpecifiedOculocerebrorenal Syndrome of Lowe details
BloodDetected and Quantified1000-1300 uMAdult (>18 years old)Not SpecifiedOculocerebrorenal Syndrome of Lowe details
BloodDetected and Quantified231.649 uMAdult (>18 years old)Male
Bartter Syndrome, Type 4A, Neonatal, with Sensorineural Deafness
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal cancer
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal cancer
details
FecesDetected but not QuantifiedNot QuantifiedNot SpecifiedNot Specified
Cryptosporidium infection
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothColorectal Cancer details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)MaleSupragingival Plaque details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothBladder cancer details
Associated Disorders and Diseases
Disease References
Hemodialysis
  1. Oikawa O, Higuchi T, Yamazaki T, Yamamoto C, Fukuda N, Matsumoto K: Evaluation of serum fetuin-A relationships with biochemical parameters in patients on hemodialysis. Clin Exp Nephrol. 2007 Dec;11(4):304-8. Epub 2007 Dec 21. [PubMed:18085392 ]
Hypophosphatemia
  1. Amanzadeh J, Reilly RF Jr: Hypophosphatemia: an evidence-based approach to its clinical consequences and management. Nat Clin Pract Nephrol. 2006 Mar;2(3):136-48. [PubMed:16932412 ]
Bartter Syndrome, Type 4A, Neonatal, with Sensorineural Deafness
  1. Heilberg IP, Totoli C, Calado JT: Adult presentation of Bartter syndrome type IV with erythrocytosis. Einstein (Sao Paulo). 2015 Oct-Dec;13(4):604-6. doi: 10.1590/S1679-45082015RC3013. Epub 2015 Oct 30. [PubMed:26537508 ]
Fanconi syndrome
  1. Cheng HM, Jap TS, Ho LT: Fanconi syndrome: report of a case. J Formos Med Assoc. 1990 Dec;89(12):1115-7. [PubMed:1982686 ]
Hyperphosphatasia
  1. Saki F, Karamizadeh Z, Nasirabadi S, Mumm S, McAlister WH, Whyte MP: Juvenile paget's disease in an Iranian kindred with vitamin D deficiency and novel homozygous TNFRSF11B mutation. J Bone Miner Res. 2013 Jun;28(6):1501-8. doi: 10.1002/jbmr.1868. [PubMed:23322328 ]
Hypoparathyroidism-retardation-dysmorphism syndrome
  1. Sanjad SA, Sakati NA, Abu-Osba YK, Kaddoura R, Milner RD: A new syndrome of congenital hypoparathyroidism, severe growth failure, and dysmorphic features. Arch Dis Child. 1991 Feb;66(2):193-6. [PubMed:2001103 ]
Hypophosphatasia
  1. Chodirker BN, Evans JA, Seargeant LE, Cheang MS, Greenberg CR: Hyperphosphatemia in infantile hypophosphatasia: implications for carrier diagnosis and screening. Am J Hum Genet. 1990 Feb;46(2):280-5. [PubMed:2301398 ]
Oculocerebrorenal syndrome
  1. Charnas LR, Bernardini I, Rader D, Hoeg JM, Gahl WA: Clinical and laboratory findings in the oculocerebrorenal syndrome of Lowe, with special reference to growth and renal function. N Engl J Med. 1991 May 9;324(19):1318-25. doi: 10.1056/NEJM199105093241904. [PubMed:2017228 ]
Colorectal cancer
  1. Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016. [PubMed:27275383 ]
  2. Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016. [PubMed:27015276 ]
  3. Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [PubMed:25037050 ]
Supragingival Plaque
  1. Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26. [PubMed:31026179 ]
Associated OMIM IDs
  • 602522 (Bartter Syndrome, Type 4A, Neonatal, with Sensorineural Deafness)
  • 239000 (Hyperphosphatasia)
  • 241410 (Hypoparathyroidism-retardation-dysmorphism syndrome)
  • 241500 (Hypophosphatasia)
  • 309000 (Oculocerebrorenal syndrome)
  • 114500 (Colorectal cancer)
DrugBank IDDB09394
Phenol Explorer Compound IDNot Available
FooDB IDFDB013380
KNApSAcK IDC00007408
Chemspider ID979
KEGG Compound IDC00009
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkPhosphoric_Acid
METLIN IDNot Available
PubChem Compound1004
PDB IDNot Available
ChEBI ID26078
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDMDB00013437
Good Scents IDrw1033561
References
Synthesis ReferenceCremer, Josef; Hartmann, Fridolin; Rodis, Franz; Hinz, Arnulf. Preparation of alkali or alkaline earth phosphates with simultaneous recovery of volatile mineral acids. Ger. (1966), 2 pp. CODEN: GWXXAW DE 1227435 19661027 CAN 66:12584 AN 1967:12584
Material Safety Data Sheet (MSDS)Download (PDF)
General References
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  27. Bragadeesh TK, Mathur G, Clark AL, Cleland JG: Novel cardiac myosin activators for acute heart failure. Expert Opin Investig Drugs. 2007 Oct;16(10):1541-8. [PubMed:17922619 ]
  28. Worthington HV, Clarkson JE, Eden OB: Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD000978. [PubMed:17943748 ]
  29. Nixon GF, Mathieson FA, Hunter I: The potential roles of sphingolipids in vascular smooth-muscle function. Biochem Soc Trans. 2007 Nov;35(Pt 5):908-9. [PubMed:17956243 ]
  30. Johnson D, Shepherd RM, Gill D, Gorman T, Smith DM, Dunne MJ: Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells. Biochem Soc Trans. 2007 Nov;35(Pt 5):1208-10. [PubMed:17956314 ]
  31. Ku NO, Strnad P, Zhong BH, Tao GZ, Omary MB: Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies. Hepatology. 2007 Nov;46(5):1639-49. [PubMed:17969036 ]
  32. Beutler E, Duparc S: Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development. Am J Trop Med Hyg. 2007 Oct;77(4):779-89. [PubMed:17978087 ]
  33. Van Brocklyn JR: Sphingolipid signaling pathways as potential therapeutic targets in gliomas. Mini Rev Med Chem. 2007 Oct;7(10):984-90. [PubMed:17979800 ]
  34. Raben DM, Tu-Sekine B: Nuclear diacylglycerol kinases: regulation and roles. Front Biosci. 2008 Jan 1;13:590-7. [PubMed:17981572 ]
  35. Dubin A, Estenssoro E: Mechanisms of tissue hypercarbia in sepsis. Front Biosci. 2008 Jan 1;13:1340-51. [PubMed:17981634 ]
  36. Deng ZL, Sharff KA, Tang N, Song WX, Luo J, Luo X, Chen J, Bennett E, Reid R, Manning D, Xue A, Montag AG, Luu HH, Haydon RC, He TC: Regulation of osteogenic differentiation during skeletal development. Front Biosci. 2008 Jan 1;13:2001-21. [PubMed:17981687 ]
  37. Liu X, Elojeimy S, Turner LS, Mahdy AE, Zeidan YH, Bielawska A, Bielawski J, Dong JY, El-Zawahry AM, Guo GW, Hannun YA, Holman DH, Rubinchik S, Szulc Z, Keane TE, Tavassoli M, Norris JS: Acid ceramidase inhibition: a novel target for cancer therapy. Front Biosci. 2008 Jan 1;13:2293-8. [PubMed:17981711 ]
  38. Su N, Du X, Chen L: FGF signaling: its role in bone development and human skeleton diseases. Front Biosci. 2008 Jan 1;13:2842-65. [PubMed:17981758 ]
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  40. Zeitels SM, Burns JA: Office-based laryngeal laser surgery with the 532-nm pulsed-potassium-titanyl-phosphate laser. Curr Opin Otolaryngol Head Neck Surg. 2007 Dec;15(6):394-400. [PubMed:17986877 ]
  41. Pebay A, Bonder CS, Pitson SM: Stem cell regulation by lysophospholipids. Prostaglandins Other Lipid Mediat. 2007 Nov;84(3-4):83-97. Epub 2007 Sep 5. [PubMed:17991611 ]
  42. Komarova YA, Mehta D, Malik AB: Dual regulation of endothelial junctional permeability. Sci STKE. 2007 Nov 13;2007(412):re8. [PubMed:18000237 ]
  43. Burger EL, Patel V: Calcium phosphates as bone graft extenders. Orthopedics. 2007 Nov;30(11):939-42. [PubMed:18019987 ]
  44. Qin C, D'Souza R, Feng JQ: Dentin matrix protein 1 (DMP1): new and important roles for biomineralization and phosphate homeostasis. J Dent Res. 2007 Dec;86(12):1134-41. [PubMed:18037646 ]
  45. Andress DL: Bone and mineral guidelines for patients with chronic kidney disease: a call for revision. Clin J Am Soc Nephrol. 2008 Jan;3(1):179-83. Epub 2007 Dec 5. [PubMed:18057310 ]
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  50. Damron TA: Use of 3D beta-tricalcium phosphate (Vitoss) scaffolds in repairing bone defects. Nanomedicine (Lond). 2007 Dec;2(6):763-75. [PubMed:18095844 ]
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  59. Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Only showing the first 10 proteins. There are 789 proteins in total.

Enzymes

General function:
Involved in hydrolase activity
Specific function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
Gene Name:
NT5E
Uniprot ID:
P21589
Molecular weight:
57948.125
Reactions
A 5'-ribonucleotide + Water → a ribonucleoside + Phosphatedetails
Adenosine monophosphate + Water → Adenosine + Phosphatedetails
Cytidine monophosphate + Water → Cytidine + Phosphatedetails
Uridine 5'-monophosphate + Water → Uridine + Phosphatedetails
Inosinic acid + Water → Inosine + Phosphatedetails
Guanosine monophosphate + Water → Guanosine + Phosphatedetails
5-Thymidylic acid + Water → Thymidine + Phosphatedetails
dCMP + Water → Deoxycytidine + Phosphatedetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphatedetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphatedetails
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphatedetails
Xanthylic acid + Water → Xanthosine + Phosphatedetails
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphatedetails
General function:
Involved in nucleotide binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).
Gene Name:
NT5C1B
Uniprot ID:
Q96P26
Molecular weight:
68803.055
Reactions
A 5'-ribonucleotide + Water → a ribonucleoside + Phosphatedetails
Adenosine monophosphate + Water → Adenosine + Phosphatedetails
Cytidine monophosphate + Water → Cytidine + Phosphatedetails
Uridine 5'-monophosphate + Water → Uridine + Phosphatedetails
Inosinic acid + Water → Inosine + Phosphatedetails
Guanosine monophosphate + Water → Guanosine + Phosphatedetails
5-Thymidylic acid + Water → Thymidine + Phosphatedetails
dCMP + Water → Deoxycytidine + Phosphatedetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphatedetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphatedetails
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphatedetails
Xanthylic acid + Water → Xanthosine + Phosphatedetails
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphatedetails
General function:
Involved in nucleotide binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
Gene Name:
NT5C1A
Uniprot ID:
Q9BXI3
Molecular weight:
41020.145
Reactions
A 5'-ribonucleotide + Water → a ribonucleoside + Phosphatedetails
Adenosine monophosphate + Water → Adenosine + Phosphatedetails
Cytidine monophosphate + Water → Cytidine + Phosphatedetails
Uridine 5'-monophosphate + Water → Uridine + Phosphatedetails
Inosinic acid + Water → Inosine + Phosphatedetails
Guanosine monophosphate + Water → Guanosine + Phosphatedetails
5-Thymidylic acid + Water → Thymidine + Phosphatedetails
dCMP + Water → Deoxycytidine + Phosphatedetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphatedetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphatedetails
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphatedetails
Xanthylic acid + Water → Xanthosine + Phosphatedetails
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphatedetails
General function:
Involved in metal ion binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Gene Name:
NT5C
Uniprot ID:
Q8TCD5
Molecular weight:
Not Available
Reactions
Adenosine monophosphate + Water → Adenosine + Phosphatedetails
Cytidine monophosphate + Water → Cytidine + Phosphatedetails
Uridine 5'-monophosphate + Water → Uridine + Phosphatedetails
Inosinic acid + Water → Inosine + Phosphatedetails
Guanosine monophosphate + Water → Guanosine + Phosphatedetails
5-Thymidylic acid + Water → Thymidine + Phosphatedetails
dCMP + Water → Deoxycytidine + Phosphatedetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphatedetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphatedetails
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphatedetails
Xanthylic acid + Water → Xanthosine + Phosphatedetails
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphatedetails
General function:
Involved in phosphatase activity
Specific function:
Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Gene Name:
NT5M
Uniprot ID:
Q9NPB1
Molecular weight:
Not Available
Reactions
Adenosine monophosphate + Water → Adenosine + Phosphatedetails
Cytidine monophosphate + Water → Cytidine + Phosphatedetails
Uridine 5'-monophosphate + Water → Uridine + Phosphatedetails
Inosinic acid + Water → Inosine + Phosphatedetails
Guanosine monophosphate + Water → Guanosine + Phosphatedetails
5-Thymidylic acid + Water → Thymidine + Phosphatedetails
dCMP + Water → Deoxycytidine + Phosphatedetails
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Phosphatedetails
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Phosphatedetails
Nicotinamide ribotide + Water → Nicotinamide riboside + Phosphatedetails
Xanthylic acid + Water → Xanthosine + Phosphatedetails
Nicotinic acid mononucleotide + Water → Nicotinic acid ribonucleoside + Phosphatedetails
General function:
Involved in ATP citrate synthase activity
Specific function:
ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
Gene Name:
ACLY
Uniprot ID:
P53396
Molecular weight:
120838.27
Reactions
ADP + Phosphate + Acetyl-CoA + Oxalacetic acid → Adenosine triphosphate + Citric acid + Coenzyme Adetails
Adenosine triphosphate + Citric acid + Coenzyme A → ADP + Phosphate + Acetyl-CoA + Oxalacetic aciddetails
General function:
Involved in acetyl-CoA carboxylase activity
Specific function:
ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Gene Name:
ACACB
Uniprot ID:
O00763
Molecular weight:
276538.575
Reactions
Adenosine triphosphate + Acetyl-CoA + Hydrogen carbonate → ADP + Phosphate + Malonyl-CoAdetails
Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + Phosphate + carboxy-biotin-[carboxyl-carrier-protein]details
Adenosine triphosphate + Holo-[carboxylase] + Hydrogen carbonate → ADP + Phosphate + Carboxybiotin-carboxyl-carrier proteindetails
General function:
Involved in catalytic activity
Specific function:
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
Gene Name:
PC
Uniprot ID:
P11498
Molecular weight:
129632.565
Reactions
Adenosine triphosphate + Pyruvic acid + Hydrogen carbonate → ADP + Phosphate + Oxalacetic aciddetails
General function:
Involved in acetate-CoA ligase activity
Specific function:
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
Gene Name:
ACSS1
Uniprot ID:
Q9NUB1
Molecular weight:
74625.88
General function:
Involved in acetyl-CoA carboxylase activity
Specific function:
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Gene Name:
ACACA
Uniprot ID:
Q13085
Molecular weight:
269997.01
Reactions
Adenosine triphosphate + Acetyl-CoA + Hydrogen carbonate → ADP + Phosphate + Malonyl-CoAdetails
Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + Phosphate + carboxy-biotin-[carboxyl-carrier-protein]details
Adenosine triphosphate + Holo-[carboxylase] + Hydrogen carbonate → ADP + Phosphate + Carboxybiotin-carboxyl-carrier proteindetails

Transporters

General function:
Involved in ATP binding
Specific function:
Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Gene Name:
ATP7B
Uniprot ID:
P35670
Molecular weight:
157261.34
General function:
Involved in ATP binding
Specific function:
May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
Gene Name:
ATP7A
Uniprot ID:
Q04656
Molecular weight:
163372.275

Only showing the first 10 proteins. There are 789 proteins in total.