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Human Metabolome Database Version 2.5

 

Showing metabocard for S-Adenosylmethioninamine (HMDB00988)

Legend: metabolite field enzyme field

Version 2.5
Creation Date 2005-11-16 15:48:42
Update Date 2009-05-05 20:58:25
Accession Number HMDB00988
Secondary Accession Numbers Not Available
Common Name S-Adenosylmethioninamine
Description S-Adenosylmethioninamine is a biological sulfonium compound known as the major biological methyl donor. It is also a donor of methylene groups, amino groups, ribosyl groups and aminopropyl groups (PMID 15130560). S-Adenosylmethioninamine is a prodcut of enzyme adenosylmethionine decarboxylase [EC 4.1.1.50] in methionine metabolism pathway (KEGG).
Synonyms
  1. (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt
  2. S-Adenosyl-L-methioninamine
  3. S-adenosylmethioninamine
  4. dAdoMet
  5. decarboxylated AdoMet
  6. decarboxylated S-adenosylmethionine
  7. decarboxylated SAM
Chemical IUPAC Name 3-aminopropyl-[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl]-methyl-sulfonium
Chemical Formula C14H23N6O3S
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Nucleosides and Nucleoside conjugates
Class
  • Nucleoside Analogues
Sub Class
  • Methylated nucleosides
Family
  • Mammalian Metabolite
Species
  • cation
  • secondary alcohol
  • 1,2-diol
  • primary amine
  • primary aliphatic amine (alkylamine)
  • primary aromatic amine
  • aromatic compound
  • heterocyclic compound
Biofunction
  • Component of Arginine and proline metabolism
  • Component of beta-Alanine metabolism
Application
—
Source
  • Endogenous
Average Molecular Weight 355.436
Monoisotopic Molecular Weight 355.155243
Isomeric SMILES C[S+](CCCN)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N
Canonical SMILES C[S+](CCCN)CC1OC(C(O)C1O)N1C=NC2=C1N=CN=C2N
KEGG Compound ID C01137 Link Image
BioCyc ID S-ADENOSYLMETHIONINAMINE Link Image
BiGG ID 36895 Link Image
Wikipedia Link Not Available
NuGOwiki Link HMDB00988 Link Image
Metagene Link HMDB00988 Link Image
METLIN ID 3501 Link Image
PubChem Compound 1078 Link Image
PubChem Substance 3154 Link Image
ChEBI ID 15625 Link Image
CAS Registry Number 22365-13-5
InChI Identifier InChI=1/C14H23N6O3S/c1-24(4-2-3-15)5-8-10(21)11(22)14(23-8)20-7-19-9-12(16)17-6-18-13(9)20/h6-8,10-11,14,21-22H,2-5,15H2,1H3,(H2,16,17,18)/q+1/t8-,10-,11-,14-,24?/m1/s1
Synthesis Reference Pegg, Anthony E. Assay of aminopropyltransferases. Methods in Enzymology (1983), 94(Polyamines), 260-5.
Melting Point (Experimental) Not Available
Experimental Water Solubility Not Available Source: PhysProp
Predicted Water Solubility 1.27 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge 2
State Solid
Experimental LogP/Hydrophobicity Not Available Source: PhysProp
Predicted LogP/Hydrophobicity 0.28 [Predicted by ALOGPS] Calculated using ALOGPS
Material Safety Data Sheet (MSDS) Not Available
MOL File Show
SDF File Show
PDB File Show
2D Structure
3D Structure
Experimental PDB ID Not Available
Experimental 1H NMR Spectrum Not Available
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum Not Available
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location
  • Cytoplasm
Biofluid Location Not Available
Tissue Location Not Available
Concentrations (Normal) Not Available
Concentrations (Abnormal) Not Available
Associated Disorders Not Available
OMIM ID Not Available
Pathways
Name SMPDB Link KEGG Link
Methionine Metabolism SMP00033 Link Image map00270 Link Image
Spermidine and Spermine Biosynthesis SMP00445 Link Image
General References
  1. Fontecave M, Atta M, Mulliez E: S-adenosylmethionine: nothing goes to waste. Trends Biochem Sci. 2004 May;29(5):243-9. [PubMed Link Image]
Metabolic Enzymes
  1. Spermine synthase
  2. Spermidine synthase
  3. Spermidine synthase (Spermidine synthase, isoform CRA_a)
  4. Adenosylmethionine decarboxylase 1
Enzyme 1 [top]
Enzyme 1 ID 5449
Enzyme 1 Name Spermine synthase
Enzyme 1 Synonyms
  1. Spermidine aminopropyltransferase
  2. SPMSY
Enzyme 1 Gene Name SMS
Enzyme 1 Protein Sequence >Spermine synthase 
MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSFAN
LRIYPHGLVLLDLQSYDGDAQGKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAI
DRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRA
IMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDV
LDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILD
LSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTV
WKKAKP
Enzyme 1 Number of Residues 366
Enzyme 1 Molecular Weight 41269
Enzyme 1 Theoretical pI 4.62
Enzyme 1 GO Classification
Function
  • catalytic activity
Process
—
Component
—
Enzyme 1 General Function Amino acid transport and metabolism
Enzyme 1 Specific Function S-adenosylmethioninamine + spermidine = 5'- methylthioadenosine + spermine
Enzyme 1 Pathways
Enzyme 1 Reactions
  • S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 791051 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID P52788 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name SPSY_HUMAN Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >1107 bp 
ATGCCTGGGGCAGCAGCACGGCACAGCACGCTCGACTTCATGCTCGGCGCCAAAGCTGAT
GGTGAGACCATTCTAAAAGGCCTCCAGTCCATTTTCCAGGAGCAGGGGATGGCGGAGTCG
GTGCACACCTGGCAGGACCATGGCTATTTAGCAACCTACACAAACAAGAACGGCAGCTTT
GCCAATTTGAGAATTTACCCACATGGATTGGTGTTGCTGGACCTTCAGAGTTATGATGGT
GATGCGCAAGGCAAAGAAGAGATCGACAGTATTTTGAACAAAGTAGAGGAAAGAATGAAA
GAATTGAGTCAGGACAGTACTGGGCGGGTGAAACGATTACCACCCATAGTGCGAGGAGGA
GCCATCGACAGATACTGGCCCACCGCCGACGGGCGCCTGGTTGAATATGACATAGATGAA
GTGGTATATGACGAAGATTCACCTTATCAAAATATAAAAATTCTACACTCGAAGCAGTTT
GGAAATATTCTCATCCTTAGTGGGGATGTTAATTTGGCAGAGAGTGATTTGGCATATACC
CGGGCCATCATGGGCAGTGGCAAAGAAGATTACACTGGCAAAGATGTACTCATTCTGGGA
GGTGGAGACGGAGGCATATTGTGTGAAATAGTCAAACTAAAACCAAAGATGGTCACTATG
GTAGAGATTGACCAAATGGTGATTGATGGGTGTAAGAAATACATGCGAAAAACGTGTGGC
GATGTCTTAGACAATCTTAAAGGAGACTGCTATCAGGTTCTAATAGAAGACTGTATCCCG
GTACTGAAGAGGTACGCCAAAGAAGGGAGAGAATTTGATTATGTGATTAATGATTTGACA
GCTGTTCCAATCTCCACGTCTCCAGAAGAAGATTCCACATGGGAGTTTCTCAGACTGATT
CTTGACCTCTCAATGAAAGTGTTGAAACAGGATGGGAAATATTTTACACAGGGGAACTGT
GTCAATCTGACAGAAGCACTGTCGCTCTATGAAGAACAGCTGGGGCGCCTGTATTGTCCT
GTGGAATTTTCAAAGGAGATCGTCTGTGTCCCTTCATACTTGGAATTGTGGGTATTTTAC
ACTGTTTGGAAGAAAGCTAAACCCTGA
Enzyme 1 GenBank Gene ID Z49099 Link Image
Enzyme 1 GeneCard ID SMS Link Image
Enzyme 1 GenAtlas ID SMS Link Image
Enzyme 1 HGNC ID HGNC:11123 Link Image
Enzyme 1 Chromosome Location X
Enzyme 1 Locus Xp22.1
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References
  1. Korhonen VP, Halmekyto M, Kauppinen L, Myohanen S, Wahlfors J, Keinanen T, Hyvonen T, Alhonen L, Eloranta T, Janne J: Molecular cloning of a cDNA encoding human spermine synthase. DNA Cell Biol. 1995 Oct;14(10):841-7. [PubMed Link Image]
  2. Grieff M, Whyte MP, Thakker RV, Mazzarella R: Sequence analysis of 139 kb in Xp22.1 containing spermine synthase and the 5' region of PEX. Genomics. 1997 Sep 1;44(2):227-31. [PubMed Link Image]
  3. Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol. 2003 May;21(5):566-9. Epub 2003 Mar 31. [PubMed Link Image]
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 5450
Enzyme 2 Name Spermidine synthase
Enzyme 2 Synonyms
  1. Putrescine aminopropyltransferase
  2. SPDSY
Enzyme 2 Gene Name SRM
Enzyme 2 Protein Sequence >Spermidine synthase 
MEPGPDGPAASGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYG
NVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESV
VQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGP
AESLFKESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQSLFPVVAYAYCTIPT
YPSGQIGFMLCSKNPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALND
VS
Enzyme 2 Number of Residues 302
Enzyme 2 Molecular Weight 33825
Enzyme 2 Theoretical pI 5.17
Enzyme 2 GO Classification
Function
  • catalytic activity
Process
—
Component
—
Enzyme 2 General Function Amino acid transport and metabolism
Enzyme 2 Specific Function S-adenosylmethioninamine + putrescine = 5'- methylthioadenosine + spermidine
Enzyme 2 Pathways
Enzyme 2 Reactions
  • S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • None
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 531202 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID P19623 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name SPEE_HUMAN Link Image
Enzyme 2 PDB ID 1ZDZ Link Image
Enzyme 2 PDB File Show
Enzyme 2 3D Structure
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >909 bp 
ATGGAGCCCGGCCCCGACGGCCCCGCCGCCTCCGGCCCCGCCGCCATCCGCGAGGGCTGG
TTCCGCGAGACCTGCAGCCTGTGGCCCGGCCAGGCCCTGTCGCTGCAGGTGGAGCAGCTG
CTCCACCACCGGCGCTCGCGCTACCAGGACATCCTCGTCTTCCGCAGTAAGACCTATGGC
AACGTGCTGGTGTTGGACGGTGTCATCCAGTGCACGGAGAGAGACGAGTTCTCCTACCAG
GAGATGATCGCCAACCTGCCTCTCTGCAGCCACCCCAACCCGCGAAAGGTGCTGATCATC
GGGGGCGGAGATGGAGGTGTCCTGCGGGAGGTGGTGAAGCACCCCTCCGTGGAGTCCGTG
GTCCAGTGTGAGATCGACGAGGATGTCATCCAAGTCTCCAAGAAGTTCCTGCCAGGCATG
GCCATTGGCTACTCTAGCTCGAAGGTGACCCTACATGTGGGTGACGGTTTTGAGTTCATG
AAACAGAATCAGGATGCCTTCGACGTGATCATCACTGACTCCTCAGACCCCATGGGCCCC
GCCGAAAGTCTCTTCAAGGAGTCCTATTACCAGCTCATGAAGACAGCCCTCAAGGAAGAT
GGTGTCCTCTGCTGCCAGGGCGAGTGCGAGTGGCTGCACCTGGACCTCATCAAGGAGATG
CGGCAGTTCTGCCAGTCCCTGTTCCCCGTGGTGGCCTATGCCTACTGCACCATCCCCACC
TACCCCAGCGGCCAGATCGGCTTCATGCTGTGCAGCAAGAACCCGAGCACGAACTTCCAG
GAGCCGGTGCAGCCGCTGACACAGCAGCAGGTGGCGCAGATGCAGCTGAAGTACTACAAC
TCCGACGTGCACCGCGCCGCCTTTGTGCTGCCCGAGTTTGCCCGCAAGGCCCTGAATGAT
GTGAGCTGA
Enzyme 2 GenBank Gene ID M34338 Link Image
Enzyme 2 GeneCard ID SRM Link Image
Enzyme 2 GenAtlas ID SRM Link Image
Enzyme 2 HGNC ID HGNC:11296 Link Image
Enzyme 2 Chromosome Location 1
Enzyme 2 Locus 1p36-p22
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References
  1. Wahlfors J, Alhonen L, Kauppinen L, Hyvonen T, Janne J, Eloranta TO: Human spermidine synthase: cloning and primary structure. DNA Cell Biol. 1990 Mar;9(2):103-10. [PubMed Link Image]
  2. Myohanen S, Kauppinen L, Wahlfors J, Alhonen L, Janne J: Human spermidine synthase gene: structure and chromosomal localization. DNA Cell Biol. 1991 Jul-Aug;10(6):467-74. [PubMed Link Image]
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 13000
Enzyme 3 Name Spermidine synthase (Spermidine synthase, isoform CRA_a)
Enzyme 3 Synonyms Not Available
Enzyme 3 Gene Name SRM
Enzyme 3 Protein Sequence >Spermidine synthase (Spermidine synthase, isoform CRA_a) 
MEPGPDGPAASGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYG
NVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESV
VQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGP
AESLFKESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQSLFPVVAYAYCTIPT
YPSGQIGFMLCSKNPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALND
VS
Enzyme 3 Number of Residues 302
Enzyme 3 Molecular Weight 33825
Enzyme 3 Theoretical pI Not Available
Enzyme 3 GO Classification Not Available
Enzyme 3 General Function Not Available
Enzyme 3 Specific Function Not Available
Enzyme 3 Pathways Not Available
Enzyme 3 Reactions Not Available
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • None
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein Not Available
Enzyme 3 UniProtKB/Swiss-Prot ID B1AKP9 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name B1AKP9_HUMAN Link Image
Enzyme 3 PDB ID Not Available
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence Not Available
Enzyme 3 GenBank Gene ID Not Available
Enzyme 3 GeneCard ID B1AKP9 Link Image
Enzyme 3 GenAtlas ID Not Available
Enzyme 3 HGNC ID Not Available
Enzyme 3 Chromosome Location Not Available
Enzyme 3 Locus Not Available
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References Not Available
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 13069
Enzyme 4 Name Adenosylmethionine decarboxylase 1
Enzyme 4 Synonyms
  1. Adenosylmethionine decarboxylase 1, isoform CRA_b
  2. Putative uncharacterized protein DKFZp313L1234
Enzyme 4 Gene Name AMD1
Enzyme 4 Protein Sequence >Adenosylmethionine decarboxylase 1 
MGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESG
IRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLI
RKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKK
QQQQQS
Enzyme 4 Number of Residues 186
Enzyme 4 Molecular Weight 21301
Enzyme 4 Theoretical pI 4.67
Enzyme 4 GO Classification
Function
  • adenosylmethionine decarboxylase activity
  • carbon-carbon lyase activity
  • carboxy-lyase activity
  • catalytic activity
  • lyase activity
Process
  • amino acid and derivative metabolism
  • amino acid derivative metabolism
  • biogenic amine metabolism
  • cellular metabolism
  • metabolism
  • physiological process
  • polyamine biosynthesis
  • polyamine metabolism
  • spermidine biosynthesis
  • spermine biosynthesis
Component
—
Enzyme 4 General Function Not Available
Enzyme 4 Specific Function Not Available
Enzyme 4 Pathways Not Available
Enzyme 4 Reactions Not Available
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein Not Available
Enzyme 4 UniProtKB/Swiss-Prot ID Q5VXN4 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name Q5VXN4_HUMAN Link Image
Enzyme 4 PDB ID 1MSV Link Image
Enzyme 4 PDB File Show
Enzyme 4 3D Structure
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence Not Available
Enzyme 4 GenBank Gene ID AL357515 Link Image
Enzyme 4 GeneCard ID Q5VXN4 Link Image
Enzyme 4 GenAtlas ID AMD1 Link Image
Enzyme 4 HGNC ID HGNC:457 Link Image
Enzyme 4 Chromosome Location Not Available
Enzyme 4 Locus Not Available
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References Not Available
Enzyme 4 Metabolite References Not Available