• Home
• Browse »
  • Metabolite Browse
  • Diseases
  • Pathways
  • Biofluids
  • Classes
  • Proteins
  • Reactions
  • Metabolite Library
• Search »
  • Chem Query
  • Text Query
  • Sequence Search
  • Advanced Search
  • MS Search
  • MS/MS Search
  • GC/MS Search
  • 1D NMR Search
  • 2D NMR Search
• About »
  • About the HMDB
  • Release Notes
  • Citing the HMDB
  • What's New
  • Statistics
  • Data Sources
  • Other Databases
• Downloads
• Contact Us

Human Metabolome Database Version 3.5

Showing metabocard for Iodate (HMDB01061)

• Identification
• Taxonomy
• Ontology
• Physical properties
• Spectra
• Biological properties
• Concentrations
• Links
• References

• Blood
• Urine

Record Information
Version	3.5
Creation Date	2005-11-16 08:48:42 -0700
Update Date	2013-05-29 13:30:14 -0600
HMDB ID	HMDB01061
Secondary Accession Numbers	None
Metabolite Identification
Common Name	Iodate
Description	Iodate is an iodate is a salt of iodic acid. Because it is more stable than iodide, most health authorities preferentially recommend iodate as an additive to salt for correcting iodine deficiency. Even in a low exposure, doubts have been raised whether the safety of iodate. In humans and rats, oral bioavailability of iodine from iodate is virtually equivalent to that from iodide. When given intravenously to rats, or when added to whole blood or tissue homogenates in vitro or to foodstuff, iodate is quantitatively reduced to iodide by nonenzymatic reactions, and thus becomes available to the body as iodide. Therefore, except perhaps for the gastrointestinal mucosa, exposure of tissues to iodate might be minimal. At much higher doses given intravenously (i.e., above 10 mg/kg), iodate is highly toxic to the retina. Ocular toxicity in humans has occurred only after exposure to doses of 600 to 1,200 mg per individual. Oral exposures of several animal species to high doses, exceeding the human intake from fortified salt by orders of magnitude, pointed to corrosive effects in the gastrointestinal tract, hemolysis, nephrotoxicity, and hepatic injury. Genotoxicity and carcinogenicity data for iodate are scarce or nonexistent. (PMID: 11396703 ).
Structure	Download: MOL | SDF | SMILES | InChI Display: 2D Structure | 3D Structure
Synonyms	Iodate (I2O62-) Iodate (IO3(1-)) Iodate anion Iodate ion Iodate ion (IO31-) Iodate(1-) Iodic acid (HIO3) ion(1-) Trioxidoiodate(1-)
Chemical Formula	IO3
Average Molecular Weight	174.9027
Monoisotopic Molecular Weight	174.889212286
IUPAC Name	iodate
Traditional IUPAC Name	iodate
CAS Registry Number	15454-31-6
SMILES	[O-][I](=O)=O
InChI Identifier	InChI=1S/HIO3/c2-1(3)4/h(H,2,3,4)/p-1
InChI Key	ICIWUVCWSCSTAQ-UHFFFAOYSA-M
Chemical Taxonomy
Kingdom	Inorganic Compounds
Super Class	Homogeneous Non-metal Compounds
Class	Non-metal Oxoanionic Compounds
Sub Class	Non-metal Iodates
Other Descriptors	a small molecule(Cyc) iodine oxoanion(ChEBI)
Substituents	N/A
Direct Parent	Non-metal Iodates
Ontology
Status	Expected and Not Quantified
Origin	Endogenous
Biofunction	Osmolyte, enzyme cofactor, signalling
Application	Not Available
Cellular locations	Not Available
Physical Properties
State	Solid
Experimental Properties	Property Value Reference Melting Point Not Available Not Available Boiling Point Not Available Not Available Water Solubility Not Available Not Available LogP Not Available Not Available
Predicted Properties	Property Value Source Water Solubility ALOGPS LogP 0.18 ChemAxon pKa (strongest acidic) -33 ChemAxon Hydrogen Acceptor Count 3 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 57.2 A2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 17.67 ChemAxon Polarizability 7.85 ChemAxon Formal Charge -1 ChemAxon Physiological Charge -1 ChemAxon
Spectra
	Not Available
Biological Properties
Cellular Locations	Not Available
Biofluid Locations	Not Available
Tissue Location	Not Available
Pathways	Not Available
Normal Concentrations
	Not Available
Abnormal Concentrations
	Not Available
Associated Disorders and Diseases
Disease References	None
Associated OMIM IDs	None
External Links
DrugBank ID	Not Available
DrugBank Metabolite ID	Not Available
Phenol Explorer Compound ID	Not Available
Phenol Explorer Metabolite ID	Not Available
FoodDB ID	FDB022400
KNApSAcK ID	Not Available
Chemspider ID	76615
KEGG Compound ID	Not Available
BioCyc ID	Not Available
BiGG ID	Not Available
Wikipedia Link	Iodate
NuGOwiki Link	HMDB01061
Metagene Link	HMDB01061
METLIN ID	Not Available
PubChem Compound	84927
PDB ID	Not Available
ChEBI ID	29226
References
Synthesis Reference	Scrabal, A.; Gruber, Josef. Halogenoxy compounds. XII. Kinetics of the formation of iodate from iodine in presence of triiodide ion. Monatshefte fuer Chemie (1917), 37 535-48.
Material Safety Data Sheet (MSDS)	Download (PDF)
General References	Czepita D: [The possibilities of using the newest experimental results in the progressive myopia treatment] Klin Oczna. 1999;101(2):145-7. Pubmed: 10418242 Burgi H, Schaffner TH, Seiler JP: The toxicology of iodate: a review of the literature. Thyroid. 2001 May;11(5):449-56. Pubmed: 11396703 Wu T, Liu GJ, Li P, Clar C: Iodised salt for preventing iodine deficiency disorders. Cochrane Database Syst Rev. 2002;(3):CD003204. Pubmed: 12137681 von Gunten U: Ozonation of drinking water: part II. Disinfection and by-product formation in presence of bromide, iodide or chlorine. Water Res. 2003 Apr;37(7):1469-87. Pubmed: 12600375 Kalk WJ: Iodine deficiency disorders in South Africa. S Afr Med J. 1998 Mar;88(3 Endocrinology):352-4. Pubmed: 12886694 Angermayr L, Clar C: Iodine supplementation for preventing iodine deficiency disorders in children. Cochrane Database Syst Rev. 2004;(2):CD003819. Pubmed: 15106221 Genc Y, Humphries JM, Lyons GH, Graham RD: Exploiting genotypic variation in plant nutrient accumulation to alleviate micronutrient deficiency in populations. J Trace Elem Med Biol. 2005;18(4):319-24. Pubmed: 16028493 Scrimshaw NS: Fifty-five-year personal experience with human nutrition worldwide. Annu Rev Nutr. 2007;27:1-18. Pubmed: 17506667 Ulbricht W: The inactivation of sodium channels in the node of Ranvier and its chemical modification. Ion Channels. 1990;2:123-68. Pubmed: 1983285 Khubaveshki S, Lozanov B: [Current problems in the pathogenesis and treatment of endemic goiter] Vutr Boles. 1990;29(5):7-13. Pubmed: 2080616 Burgos FJ, Teruel JL, Mayayo T, Lovaco F, Berenguer A, Orte L, Tallada M, Ortuno J: Diagnosis and management of lymphoceles after renal transplantation. Br J Urol. 1988 Apr;61(4):289-93. Pubmed: 3289674 Korte GE, Perlman JI, Pollack A: Regeneration of mammalian retinal pigment epithelium. Int Rev Cytol. 1994;152:223-63. Pubmed: 8206705 Cinotti A, Guandalini A, Besutti A, Mannella P: [A volumetric increase in the submandibular glands due to an organic iodate contrast medium. A case report] Radiol Med (Torino). 1993 Jan-Feb;85(1-2):138-40. Pubmed: 8480042

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government.