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Human Metabolome Database Version 2.5

 

Showing metabocard for N-Acetyl-D-Glucosamine 6-Phosphate (HMDB01062)

Legend: metabolite field enzyme field

Version 2.5
Creation Date 2005-11-16 15:48:42
Update Date 2009-05-05 20:58:31
Accession Number HMDB01062
Secondary Accession Numbers Not Available
Common Name N-Acetyl-D-Glucosamine 6-Phosphate
Description N-Acetyl-D-Glucosamine 6-Phosphate is an intermediate in the metabolism of Aminosugars. It is a substrate for Glucosamine 6-phosphate N-acetyltransferase.
Synonyms
  1. N-Acetyl-D-Glucosamine 6-Phosphate
  2. N-Acetyl-D-Glucosamine 6-Phosphic acid
  3. N-acetyl-D-glucosamine-6-phosphate
  4. n-acetyl-d-glucosamine-6-p
  5. n-acetyl-glucosamine-6-p
  6. n-acetyl-glucosamine-6-phosphate
  7. n-acetylglucosamine-6-p
Chemical IUPAC Name [(2S,3R,4R,5R)-5-acetamido-3,4,6-trihydroxy-oxan-2-yl]methoxyphosphonic acid
Chemical Formula C8H16NO9P
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Carbohydrates and Carbohydrate conjugates
Class
  • Sugar Phosphates
Sub Class
  • Monosaccharide phosphates
Family
  • Mammalian Metabolite
Species
  • hemiacetal
  • secondary alcohol
  • 1,2-diol
  • secondary carboxylic acid amide
  • phosphoric acid ester
  • heterocyclic compound
Biofunction
  • Component of Aminosugars metabolism
  • Component of Glutamate metabolism
Application
—
Source
  • Endogenous
Average Molecular Weight 301.188
Monoisotopic Molecular Weight 301.056274
Isomeric SMILES CC(=O)N[C@H]1C(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O
Canonical SMILES CC(=O)NC1C(O)OC(COP(O)(O)=O)C(O)C1O
KEGG Compound ID C00357 Link Image
BioCyc ID N-ACETYL-D-GLUCOSAMINE-6-P Link Image
BiGG ID 34733 Link Image
Wikipedia Link Not Available
NuGOwiki Link HMDB01062 Link Image
Metagene Link HMDB01062 Link Image
METLIN ID 5975 Link Image
PubChem Compound 440996 Link Image
PubChem Substance 8145789 Link Image
ChEBI ID 15784 Link Image
CAS Registry Number 102029-88-9
InChI Identifier InChI=1/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1
Synthesis Reference Not Available
Melting Point (Experimental) Not Available
Experimental Water Solubility Not Available Source: PhysProp
Predicted Water Solubility 17.6 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge -2
State Solid
Experimental LogP/Hydrophobicity Not Available Source: PhysProp
Predicted LogP/Hydrophobicity -2.02 [Predicted by ALOGPS]; -3.6 [Predicted by PubChem via XLOGP] Calculated using ALOGPS
Material Safety Data Sheet (MSDS) Not Available
MOL File Show
SDF File Show
PDB File Show
2D Structure
3D Structure
Experimental PDB ID 1FRZ Link Image
Experimental PDB File Show
Experimental PDB Structure
Experimental 1H NMR Spectrum Not Available
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum Not Available
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location
  • Cytoplasm (Predicted from LogP)
Biofluid Location Not Available
Tissue Location Not Available
Concentrations (Normal) Not Available
Concentrations (Abnormal) Not Available
Associated Disorders Not Available
OMIM ID Not Available
Pathways
Name SMPDB Link KEGG Link
Amino Sugar Metabolism SMP00045 Link Image map00520 Link Image
Glutamate Metabolism SMP00072 Link Image map00250 Link Image
General References
  1. Komatsuzawa H, Fujiwara T, Nishi H, Yamada S, Ohara M, McCallum N, Berger-Bachi B, Sugai M: The gate controlling cell wall synthesis in Staphylococcus aureus. Mol Microbiol. 2004 Aug;53(4):1221-31. [PubMed Link Image]
Metabolic Enzymes
  1. Glucosamine 6-phosphate N-acetyltransferase
  2. Glucosamine-6-phosphate isomerase
  3. N-acetylglucosamine kinase
  4. CGI-14 protein
  5. Glucosamine-6-phosphate isomerase 2
Enzyme 1 [top]
Enzyme 1 ID 5281
Enzyme 1 Name Glucosamine 6-phosphate N-acetyltransferase
Enzyme 1 Synonyms
  1. Phosphoglucosamine transacetylase
  2. Phosphoglucosamine acetylase
Enzyme 1 Gene Name GNPNAT1
Enzyme 1 Protein Sequence >Glucosamine 6-phosphate N-acetyltransferase 
MKPDETPMFDPSLLKEVDWSQNTATFSPAISPTHPGEGLVLRPLCTADLNRGFFKVLGQL
TETGVVSPEQFMKSFEHMKKSGDYYVTVVEDVTLGQIVATATLIIEHKFIHSCAKRGRVE
DVVVSDECRGKQLGKLLLSTLTLLSKKLNCYKITLECLPQNVGFYKKFGYTVSEENYMCR
RFLK
Enzyme 1 Number of Residues 184
Enzyme 1 Molecular Weight 20749
Enzyme 1 Theoretical pI 8.12
Enzyme 1 GO Classification
Function
  • N-acetyltransferase activity
  • acetyltransferase activity
  • acyltransferase activity
  • catalytic activity
  • transferase activity
  • transferase activity, transferring acyl groups
  • transferase activity, transferring groups other than amino-acyl groups
Process
—
Component
—
Enzyme 1 General Function Transcription
Enzyme 1 Specific Function Acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate
Enzyme 1 Pathways
Enzyme 1 Reactions
  • acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 21748766 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID Q96EK6 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name GNA1_HUMAN Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >555 bp 
ATGAAACCTGATGAAACTCCTATGTTTGACCCAAGTCTACTCAAAGAAGTGGACTGGAGT
CAGAATACAGCTACATTTTCTCCAGCCATTTCCCCAACACATCCTGGAGAAGGCTTGGTT
TTGAGGCCTCTTTGTACTGCTGACTTAAATAGAGGTTTTTTTAAGGTATTGGGTCAGCTA
ACAGAGACTGGAGTTGTCAGCCCTGAACAATTTATGAAATCTTTTGAGCATATGAAGAAA
TCTGGGGATTATTATGTTACAGTTGTAGAAGATGTGACTCTAGGACAGATTGTTGCTACG
GCAACTCTGATTATAGAACATAAATTCATCCATTCCTGTGCTAAGAGAGGAAGAGTAGAA
GATGTTGTTGTTAGTGATGAATGCAGAGGAAAGCAGCTTGGCAAATTGTTATTATCAACC
CTTACTTTGCTAAGCAAGAAACTGAACTGTTACAAGATTACCCTTGAATGTCTACCACAA
AATGTTGGTTTCTATAAAAAGTTTGGATATACTGTATCTGAAGAAAACTACATGTGTCGG
AGGTTTCTAAAGTAA
Enzyme 1 GenBank Gene ID AK090577 Link Image
Enzyme 1 GeneCard ID GNPNAT1 Link Image
Enzyme 1 GenAtlas ID GNPNAT1 Link Image
Enzyme 1 HGNC ID HGNC:19980 Link Image
Enzyme 1 Chromosome Location 14
Enzyme 1 Locus 14q22.2
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References Not Available
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 5443
Enzyme 2 Name Glucosamine-6-phosphate isomerase
Enzyme 2 Synonyms
  1. Glucosamine-6- phosphate deaminase
  2. GNPDA
  3. GlcN6P deaminase
  4. Oscillin
Enzyme 2 Gene Name GNPDA1
Enzyme 2 Protein Sequence >Glucosamine-6-phosphate isomerase 
MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGD
LSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDA
FEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTK
VPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCD
EDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKETEKSQSSKKPYSD
Enzyme 2 Number of Residues 289
Enzyme 2 Molecular Weight 32669
Enzyme 2 Theoretical pI 6.91
Enzyme 2 GO Classification
Function
  • catalytic activity
  • glucosamine-6-phosphate deaminase activity
  • intramolecular oxidoreductase activity
  • intramolecular oxidoreductase activity, interconverting aldoses and ketoses
  • isomerase activity
Process
  • N-acetylglucosamine metabolism
  • amine metabolism
  • amino sugar metabolism
  • carbohydrate metabolism
  • glucosamine metabolism
  • macromolecule metabolism
  • metabolism
  • nitrogen compound metabolism
  • physiological process
Component
—
Enzyme 2 General Function Carbohydrate transport and metabolism
Enzyme 2 Specific Function D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3)
Enzyme 2 Pathways
Enzyme 2 Reactions
  • D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + ammonia
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • None
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 2935438 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID P46926 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name GNPI_HUMAN Link Image
Enzyme 2 PDB ID 1NE7 Link Image
Enzyme 2 PDB File Show
Enzyme 2 3D Structure
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >870 bp 
ATGAAGCTCATCATCCTGGAGCACTATTCTCAGGCGAGCGAGTGGGCGGCTAAATACATC
AGGAACCGTATCATCCAGTTTAACCCAGGGCCAGAGAAGTACTTCACCCTGGGGCTCCCC
ACTGGGAGTACCCCACTTGGCTGCTACAAGAAGCTGATTGAATACTATAAGAATGGGGAC
CTGTCCTTTAAATATGTGAAGACCTTCAACATGGATGAGTACGTGGGCCTTCCTCGAGAC
CACCCGGAGAGTTACCACTCCTTCATGTGGAACAACTTCTTCAAGCACATTGACATCCAC
CCAGAAAACACCCACATTCTGGATGGGAATGCAGTCGACCTACAGGCAGAATGTGATGCC
TTTGAAGAGAAGATCAAGGCTGCAGGTGGGATCGAGCTATTTGTTGGAGGCATCGGCCCT
GATGGACACATTGCCTTCAACGAGCCAGGCTCCAGTCTGGTGTCCAGGACCCGTGTGAAG
ACGCTGGCCATGGATACCATCCTGGCCAATGCTAGGTTCTTCGATGGAGAACTCACCAAG
GTGCCCACCATGGCCTTGACGGTGGGGGTGGGCACTGTCATGGATGCTAGAGAGGTGATG
ATCCTTATCACAGGTGCTCACAAGGCATTTGCTCTGTACAAGGCCATCGAGGAGGGAGTG
AACCACATGTGGACCGTGTCTGCCTTCCAGCAGCATCCCCGCACCGTGTTTGTGTGTGAC
GAGGATGCCACCTTGGAGCTGAAAGTGAAGACTGTCAAGTATTTCAAAGGTTTAATGCTT
GTTCATAACAAGTTGGTGGACCCCTTGTACAGTATCAAAGAGAAAGAAACTGAGAAAAGC
CAATCTTCGAAGAAACCATACAGCGATTAG
Enzyme 2 GenBank Gene ID AF048826 Link Image
Enzyme 2 GeneCard ID GNPDA1 Link Image
Enzyme 2 GenAtlas ID GNPDA1 Link Image
Enzyme 2 HGNC ID HGNC:4417 Link Image
Enzyme 2 Chromosome Location 5
Enzyme 2 Locus 5q21
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References
  1. Wolosker H, Kline D, Bian Y, Blackshaw S, Cameron AM, Fralich TJ, Schnaar RL, Snyder SH: Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity. FASEB J. 1998 Jan;12(1):91-9. [PubMed Link Image]
  2. Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 1994;1(5):223-9. [PubMed Link Image]
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 6316
Enzyme 3 Name N-acetylglucosamine kinase
Enzyme 3 Synonyms
  1. GlcNAc kinase
Enzyme 3 Gene Name NAGK
Enzyme 3 Protein Sequence >N-acetylglucosamine kinase 
MAAIYGGVEGGGTRSEVLLVSEDGKILAEADGLSTNHWLIGTDKCVERINEMVNRAKRKA
GVDPLVPLRSLGLSLSGGDQEDAGRILIEELRDRFPYLSESYLITTDAAGSIATATPDGG
VVLISGTGSNCRLINPDGSESGCGGWGHMMGDEGSAYWIAHQAVKIVFDSIDNLEAAPHD
IGYVKQAMFHYFQVPDRLGILTHLYRDFDKCRFAGFCRKIAEGAQQGDPLSRYIFRKAGE
MLGRHIVAVLPEIDPVLFQGKIGLPILCVGSVWKSWELLKEGFLLALTQGREIQAQNFFS
SFTLMKLRHSSALGGASLGARHIGHLLPMDYSANAIAFYSYTFS
Enzyme 3 Number of Residues 344
Enzyme 3 Molecular Weight 37376
Enzyme 3 Theoretical pI 6.18
Enzyme 3 GO Classification Not Available
Enzyme 3 General Function Carbohydrate transport and metabolism
Enzyme 3 Specific Function Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Also has ManNAc kinase activity
Enzyme 3 Pathways
Enzyme 3 Reactions
  • ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • None
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 6491737 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID Q9UJ70 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name NAGK_HUMAN Link Image
Enzyme 3 PDB ID Not Available
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >1035 bp 
ATGGCCGCGATCTATGGGGGTGTAGAGGGGGGAGGCACACGATCCGAGGTCCTTTTAGTC
TCAGAGGATGGGAAGATCCTGGCAGAAGCAGATGGACTGAGCACAAACCACTGGCTGATC
GGGACAGACAAGTGTGTGGAGAGGATCAATGAGATGGTGAACAGGGCCAAACGGAAAGCA
GGGGTGGATCCTCTGGTACCGCTGCGAATTTTGGGCCTATCTCTGAGCGGTGGGGACCAG
GAGGACGCGGGGAGGATCCTGATCGAGGAGCTGAGGGACCGATTTCCCTACCTGAGTGAA
AGCTACTTAATCACCACCGATGCCGCCGGCTCCATCGCCACAGCTACACCGGATGGTGGG
ATTGTGCTCATATCTGGAACAGGCTCCAACTGCAGGCTCATCAACCCTGATGGCTCCGAG
AGTGGCTGCGGCGGCTGGGGCCATATGATGGGTGATGAGGGTTCAGCCTACTGGATCGCA
CACCAAGCAGTGAAAATAGTGTTTGACTCCATTGACAACCTAGAGGCGGCTCCTCATGAT
ATCGGCTACGTCAAACAGGCCATGTTCCACTATTTCCAGGTGCCAGATCGGCTAGGGATA
CTCACTCACCTGTATAGGGACTTTGATAAATGCAGGTTTGCTGGGTTTTGCCGGAAAATT
GCAGAAGGTGCTCAGCAGGGAGACCCCCTTTCCCGCTATATCTTCAGGAAGGCTGGGGAG
ATGCTGGGCAGACACATCGTAGCAGTGTTGCCCGAGATTGACCCGGTCTTGTTCCAGGGC
AAGATTGGACTCCCCATCCTGTGCGTGGGCTCTGTGTGGAAGAGCTGGGAGCTGCTGAAG
GAAGGTTTTCTTTTGGCGCTGACCCAGGGCAGAGAGATCCAGGCTCAGAACTTCTTCTCC
AGCTTCACCCTGATGAAGCTGAGGCACTCCTCCGCTCTGGGTGGGGCCAGCCTAGGGGCC
AGGCACATCGGGCACCTCCTCCCCATGGACTATAGCGCCAATGCCATTGCCTTCTATTCC
TACACCTTTTCCTAG
Enzyme 3 GenBank Gene ID AJ242910 Link Image
Enzyme 3 GeneCard ID NAGK Link Image
Enzyme 3 GenAtlas ID NAGK Link Image
Enzyme 3 HGNC ID HGNC:17174 Link Image
Enzyme 3 Chromosome Location 2
Enzyme 3 Locus 2p13.3
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References
  1. Hinderlich S, Berger M, Schwarzkopf M, Effertz K, Reutter W: Molecular cloning and characterization of murine and human N-acetylglucosamine kinase. Eur J Biochem. 2000 Jun;267(11):3301-8. [PubMed Link Image]
  2. Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol. 2003 May;21(5):566-9. Epub 2003 Mar 31. [PubMed Link Image]
  3. Maguire PB, Wynne KJ, Harney DF, O'Donoghue NM, Stephens G, Fitzgerald DJ: Identification of the phosphotyrosine proteome from thrombin activated platelets. Proteomics. 2002 Jun;2(6):642-8. [PubMed Link Image]
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 9280
Enzyme 4 Name CGI-14 protein
Enzyme 4 Synonyms Not Available
Enzyme 4 Gene Name Not Available
Enzyme 4 Protein Sequence >CGI-14 protein 
MRGDRAGGGPVLQFTNCRILRGGKLLREDLWVRGGRILDPEKLFFEERRVADERRDCGGR
ILAPGFIDVQINGGFGVDFSQATEDVGSGVALVAREILSHGSPPSAPPWSLPTGVYHKVV
PQIPVKSGGPHGQGVLGLHLEGPFISREKRGTHPEAHLRSFEADAFQDLLATYGPLDNVR
IVTLAPELGVARVLRALTAWICVSLGHSVADLRAAEDAVWSGTFITHLFNAMLPFHHRDP
GIVGLLTSDRLPAGRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALGLGNGR
HTLGQQEVEVDGLTAYVAGTKTLSGSIAPMDVCVRHFLQATGCSMESALEAASLHPAQLL
GLEKSKGTLDFGADADFVVLDDSLHVQATYISGELVWQADAARQ
Enzyme 4 Number of Residues 404
Enzyme 4 Molecular Weight 43213
Enzyme 4 Theoretical pI Not Available
Enzyme 4 GO Classification
Function
  • N-acetylglucosamine-6-phosphate deacetylase activity
  • catalytic activity
  • hydrolase activity
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
  • peptidase activity
  • serine-type peptidase activity
Process
  • N-acetylglucosamine metabolism
  • amine metabolism
  • amino sugar metabolism
  • cellular protein metabolism
  • glucosamine metabolism
  • macromolecule metabolism
  • metabolism
  • nitrogen compound metabolism
  • physiological process
  • protein metabolism
  • proteolysis
Component
  • cell
  • membrane
Enzyme 4 General Function Carbohydrate transport and metabolism
Enzyme 4 Specific Function Not Available
Enzyme 4 Pathways Not Available
Enzyme 4 Reactions
  • N-Acetyl-D-glucosamine 6-phosphate + H2O --> Acetate + D-Glucosamine 6-phosphate
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein 4680667 Link Image
Enzyme 4 UniProtKB/Swiss-Prot ID Q9Y303 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name Q9Y303_HUMAN Link Image
Enzyme 4 PDB ID Not Available
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence Not Available
Enzyme 4 GenBank Gene ID AF132948 Link Image
Enzyme 4 GeneCard ID Not Available
Enzyme 4 GenAtlas ID AMDHD2 Link Image
Enzyme 4 HGNC ID HGNC:24262 Link Image
Enzyme 4 Chromosome Location Not Available
Enzyme 4 Locus Not Available
Enzyme 4 SNPs Not Available
Enzyme 4 General References
  1. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res. 2000 May;10(5):703-13. [PubMed Link Image]
Enzyme 4 Metabolite References Not Available
Enzyme 5 [top]
Enzyme 5 ID 15173
Enzyme 5 Name Glucosamine-6-phosphate isomerase 2
Enzyme 5 Synonyms
  1. Glucosamine-6-phosphate deaminase 2
  2. GlcN6P deaminase 2
  3. GNPDA 2
  4. Glucosamine-6-phosphate isomerase SB52
Enzyme 5 Gene Name GNPDA2
Enzyme 5 Protein Sequence >Glucosamine-6-phosphate isomerase 2 
MRLVILDNYDLASEWAAKYICNRIIQFKPGQDRYFTLGLPTGSTPLGCYKKLIEYHKNGH
LSFKYVKTFNMDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDA
FENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANAKYFDGDLSK
VPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD
EDATLELRVKTVKYFKGLMHVHNKLVDPLFSMKDGN
Enzyme 5 Number of Residues 276
Enzyme 5 Molecular Weight 31085
Enzyme 5 Theoretical pI 6.96
Enzyme 5 GO Classification
Function
  • catalytic activity
  • glucosamine-6-phosphate deaminase activity
  • intramolecular oxidoreductase activity
  • intramolecular oxidoreductase activity, interconverting aldoses and ketoses
  • isomerase activity
Process
  • N-acetylglucosamine metabolism
  • amine metabolism
  • amino sugar metabolism
  • carbohydrate metabolism
  • glucosamine metabolism
  • macromolecule metabolism
  • metabolism
  • nitrogen compound metabolism
  • physiological process
Component
—
Enzyme 5 General Function Carbohydrate transport and metabolism
Enzyme 5 Specific Function D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3)
Enzyme 5 Pathways Not Available
Enzyme 5 Reactions Not Available
Enzyme 5 Pfam Domain Function
Enzyme 5 Signals
  • None
Enzyme 5 Transmembrane Regions
  • None
Enzyme 5 Essentiality Not Available
Enzyme 5 GenBank ID Protein 19716157 Link Image
Enzyme 5 UniProtKB/Swiss-Prot ID Q8TDQ7 Link Image
Enzyme 5 UniProtKB/Swiss-Prot Entry Name GNPI2_HUMAN Link Image
Enzyme 5 PDB ID 1NE7 Link Image
Enzyme 5 PDB File Show
Enzyme 5 3D Structure
Enzyme 5 Cellular Location Not Available
Enzyme 5 Gene Sequence >831 bp 
ATGAGGCTTGTAATTCTTGATAACTATGACTTGGCTAGTGAATGGGCAGCCAAATACATC
TGTAATCGCATCATTCAGTTCAAACCTGGACAGGACAGATATTTTACACTGGGTTTACCA
ACAGGGAGTACACCTTTAGGATGCTATAAAAAACTAATAGAATATCATAAGAATGGACAC
CTTTCTTTTAAATATGTGAAGACCTTTAATATGGATGAATATGTAGGACTTCCAAGAAAT
CATCCTGAAAGCTACCATTCTTATATGTGGAATAATTTTTTTAAGCATATCGATATAGAT
CCTAATAATGCACATATCCTTGACGGGAATGCTGCAGATTTACAAGCAGAATGTGATGCT
TTTGAAAACAAAATAAAAGAAGCTGGAGGAATAGATCTTTTTGTTGGAGGAATTGGTCCA
GATGGTCATATCGCTTTCAATGAGCCTGGATCCAGTTTAGTGTCAAGGACAAGATTAAAG
ACTCTAGCAATGGATACCATCTTGGCAAATGCCAAATATTTTGATGGAGATTTATCAAAA
GTGCCAACTATGGCTCTAACTGTTGGTGTGGGGACAGTGATGGATGCTAGAGAAGTAATG
ATCCTTATAACAGGGGCACACAAGGCATTTGCCCTGTACAAAGCAATAGAAGAAGGAGTC
AATCACATGTGGACTGTTTCCGCTTTCCAGCAGCATCCCCGGACTATTTTTGTATGCGAT
GAAGATGCTACTTTAGAATTAAGAGTTAAAACTGTGAAATACTTTAAAGGTCTAATGCAT
GTGCACAATAAACTTGTGGATCCACTATTCAGTATGAAAGATGGAAACTGA
Enzyme 5 GenBank Gene ID AF247786 Link Image
Enzyme 5 GeneCard ID Q8TDQ7 Link Image
Enzyme 5 GenAtlas ID GNPDA2 Link Image
Enzyme 5 HGNC ID HGNC:21526 Link Image
Enzyme 5 Chromosome Location Not Available
Enzyme 5 Locus Not Available
Enzyme 5 SNPs SNPJam Report Link Image
Enzyme 5 General References Not Available
Enzyme 5 Metabolite References Not Available