Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2013-05-15 21:01:45 UTC
HMDB IDHMDB01185
Secondary Accession NumbersNone
Metabolite Identification
Common NameS-Adenosylmethionine
DescriptionPhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed). S-Adenosylmethionine is only found in individuals that have used or taken this drug. It is a physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation. SAMe, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine and other molecules.
Structure
Thumb
Synonyms
  1. (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  2. 2-S-Adenosyl-L-methionine
  3. 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  4. 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  5. Active methionine
  6. Ademetionine
  7. Adenosylmethionine
  8. AdoMet
  9. Donamet
  10. L-S-Adenosylmethionine
  11. S-(5'-Adenosyl)-L-methionine
  12. S-(5'-Deoxyadenosin-5'-yl)-L-methionine
  13. S-Adenosyl methionine
  14. S-Adenosyl-L-methionine
  15. S-Adenosyl-L-Methionine Disulfate Tosylate
  16. S-Adenosyl-L-Methionine Disulphate Tosylate
  17. S-Adenosyl-methionine
  18. S-Adenosylmethionine
Chemical FormulaC15H23N6O5S
Average Molecular Weight399.445
Monoisotopic Molecular Weight399.145063566
IUPAC Name[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium
Traditional IUPAC NameSAMe
CAS Registry Number29908-03-0
SMILES
C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12
InChI Identifier
InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1
InChI KeyMEFKEPWMEQBLKI-AIRLBKTGSA-O
Chemical Taxonomy
KingdomOrganic Compounds
Super ClassAmino Acids, Peptides, and Analogues
ClassAmino Acids and Derivatives
Sub ClassGlycoamino Acids and Derivatives
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
  • Purine Nucleosides and Analogues
Substituents
  • 1,2 Diol
  • Alpha Amino Acid Or Derivative
  • Aminopyrimidine
  • Carboxylic Acid
  • Glycosyl Compound
  • Imidazole
  • Imidazopyrimidine
  • N Glycosyl Compound
  • Oxolane
  • Pentose Monosaccharide
  • Polyamine
  • Primary Aliphatic Amine (Alkylamine)
  • Purine
  • Pyrimidine
  • Saccharide
  • Secondary Alcohol
Direct ParentGlycoamino Acids and Derivatives
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Aminosugars metabolism
  • Component of Arginine and proline metabolism
  • Component of Glycerophospholipid metabolism
  • Component of Glycine, serine and threonine metabolism
  • Component of Histidine metabolism
  • Component of Methionine metabolism
  • Component of Nicotinate and nicotinamide metabolism
  • Component of Selenoamino acid metabolism
  • Component of Tryptophan metabolism
  • Component of Tyrosine metabolism
  • Component of Ubiquinone biosynthesis
ApplicationNot Available
Cellular locations
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling Point78 °CNot Available
Water Solubility1.19e+00 g/lALOGPS
LogP-5.3ChemAxon
Predicted Properties
PropertyValueSource
water solubility1.19 g/LALOGPS
logP-2ALOGPS
logP-5.3ChemAxon
logS-2.6ALOGPS
pKa (strongest acidic)1.71ChemAxon
pKa (strongest basic)9.41ChemAxon
physiological charge1ChemAxon
hydrogen acceptor count10ChemAxon
hydrogen donor count5ChemAxon
polar surface area182.63ChemAxon
rotatable bond count7ChemAxon
refractivity96.23ChemAxon
polarizability40.37ChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular Locations
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Location
  • Epidermis
  • Eye Lens
  • Fibroblasts
  • Gonads
  • Intestine
  • Kidney
  • Muscle
  • Myelin
  • Placenta
  • Prostate
  • Skeletal Muscle
  • Testes
Pathways
NameSMPDB LinkKEGG Link
Betaine MetabolismSMP00123map00260
Carnitine SynthesisSMP00465Not Available
Catecholamine BiosynthesisSMP00012map00350
Glycine and Serine MetabolismSMP00004map00260
Methionine MetabolismSMP00033map00270
Spermidine and Spermine BiosynthesisSMP00445Not Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReference
Cerebrospinal Fluid (CSF)Detected and Quantified0.25 (0.14 - 0.38) uMAdult (>18 years old)BothNormal
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodDetected and Quantified0.11 (0.087-0.17) uMAdult (>18 years old)BothNeurodegenerative diseases
UrineDetected and Quantified28.4 (25.3-31.6) umol/mmol creatinineAdult (>18 years old)BothCommentDiabetes
Associated Disorders and Diseases
Disease References
Diabetes mellitus type 2
  • Hoppel CL, Genuth SM: Urinary excretion of acetylcarnitine during human diabetic and fasting ketosis. Am J Physiol. 1982 Aug;243(2):E168-72. Pubmed: 6810706
Neurodegenerative disease
  • Obeid R, Kostopoulos P, Knapp JP, Kasoha M, Becker G, Fassbender K, Herrmann W: Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid. Clin Chem. 2007 Feb;53(2):326-33. Epub 2007 Jan 2. Pubmed: 17200133
Associated OMIM IDs
DrugBank IDDB00118
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB022473
KNApSAcK IDNot Available
Chemspider ID21169292
KEGG Compound IDC00019
BioCyc IDS-ADENOSYLMETHIONINE
BiGG ID33530
Wikipedia LinkS-Adenosylmethionine
NuGOwiki LinkHMDB01185
Metagene LinkHMDB01185
METLIN ID6064
PubChem Compound16757548
PDB ID1CMC
ChEBI ID15414
References
Synthesis ReferenceLin, Jian-Ping; Tian, Jun; You, Jian-Feng; Jin, Zhi-Hua; Xu, Zhi-Nan; Cen, Pei-Lin. An effective strategy for the co-production of S-adenosyl-L-methionine and glutathione by fed-batch fermentation. Biochemical Engineering Journal (2004), 21(1), 19-25.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Chamberlin ME, Ubagai T, Mudd SH, Wilson WG, Leonard JV, Chou JY: Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency. J Clin Invest. 1996 Aug 15;98(4):1021-7. Pubmed: 8770875
  2. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411
  3. Hoppel CL, Genuth SM: Urinary excretion of acetylcarnitine during human diabetic and fasting ketosis. Am J Physiol. 1982 Aug;243(2):E168-72. Pubmed: 6810706
  4. Koeberl DD, Young SP, Gregersen NS, Vockley J, Smith WE, Benjamin DK Jr, An Y, Weavil SD, Chaing SH, Bali D, McDonald MT, Kishnani PS, Chen YT, Millington DS: Rare disorders of metabolism with elevated butyryl- and isobutyryl-carnitine detected by tandem mass spectrometry newborn screening. Pediatr Res. 2003 Aug;54(2):219-23. Epub 2003 May 7. Pubmed: 12736383
  5. Struys EA, Jansen EE, de Meer K, Jakobs C: Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry. Clin Chem. 2000 Oct;46(10):1650-6. Pubmed: 11017945
  6. Scalabrino G, Pigatto P, Ferioli ME, Modena D, Puerari M, Caru A: Levels of activity of the polyamine biosynthetic decarboxylases as indicators of degree of malignancy of human cutaneous epitheliomas. J Invest Dermatol. 1980 Mar;74(3):122-4. Pubmed: 7359002
  7. Kaneoka H, Uesugi N, Moriguchi A, Hirose S, Takayanagi M, Yamaguchi S, Shigematsu Y, Yasuno T, Sasatomi Y, Saito T: Carnitine palmitoyltransferase II deficiency due to a novel gene variant in a patient with rhabdomyolysis and ARF. Am J Kidney Dis. 2005 Mar;45(3):596-602. Pubmed: 15754283
  8. Rosen RT, Hiserodt RD, Fukuda EK, Ruiz RJ, Zhou Z, Lech J, Rosen SL, Hartman TG: The determination of metabolites of garlic preparations in breath and human plasma. Biofactors. 2000;13(1-4):241-9. Pubmed: 11237188
  9. McFadden PN, Horwitz J, Clarke S: Protein carboxyl methyltransferase from cow eye lens. Biochem Biophys Res Commun. 1983 Jun 15;113(2):418-24. Pubmed: 6870865
  10. Garibotto G, Sofia A, Valli A, Tarroni A, Di Martino M, Cappelli V, Aloisi F, Procopio V: Causes of hyperhomocysteinemia in patients with chronic kidney diseases. Semin Nephrol. 2006 Jan;26(1):3-7. Pubmed: 16412817
  11. Spiekerkoetter U, Tokunaga C, Wendel U, Mayatepek E, Ijlst L, Vaz FM, van Vlies N, Overmars H, Duran M, Wijburg FA, Wanders RJ, Strauss AW: Tissue carnitine homeostasis in very-long-chain acyl-CoA dehydrogenase-deficient mice. Pediatr Res. 2005 Jun;57(6):760-4. Epub 2005 Mar 17. Pubmed: 15774826
  12. Jones MG, Goodwin CS, Amjad S, Chalmers RA: Plasma and urinary carnitine and acylcarnitines in chronic fatigue syndrome. Clin Chim Acta. 2005 Oct;360(1-2):173-7. Pubmed: 15967423
  13. Kelm A, Shaw L, Schauer R, Reuter G: The biosynthesis of 8-O-methylated sialic acids in the starfish Asterias rubens--isolation and characterisation of S-adenosyl-L-methionine:sialate-8-O-methyltransferase. Eur J Biochem. 1998 Feb 1;251(3):874-84. Pubmed: 9490063
  14. Solano AR, Sanchez ML, Podesta EJ, Turyn D, Dellacha JM: Membrane methylation in isolated rat testis interstitial cells unmasks functional luteinizing hormone receptors. Biochim Biophys Acta. 1987 Apr 2;928(1):107-13. Pubmed: 3828399
  15. D'Erme M, Santoro R, Allegra P, Reale A, Marenzi S, Strom R, Caiafa P: Inhibition of CpG methylation in linker DNA by H1 histone. Biochim Biophys Acta. 1993 May 28;1173(2):209-16. Pubmed: 8504169
  16. Scott JM, Weir DG: The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia. Lancet. 1981 Aug 15;2(8242):337-40. Pubmed: 6115113

Only showing the first 50 proteins. There are 129 proteins in total.

Enzymes

Gene Name:
PEMT
Uniprot ID:
Q9UBM1
Reactions
S-Adenosylmethionine + phosphatidyl-N-methylethanolamine unknown S-Adenosylhomocysteine + phosphatidyl-N-dimethylethanolaminedetails
S-Adenosylmethionine + phosphatidyl-N-dimethylethanolamine unknown S-Adenosylhomocysteine + phosphatidylcholinedetails
S-Adenosylmethionine + Phosphatidylethanolamine unknown S-Adenosylhomocysteine + phosphatidyl-N-methylethanolaminedetails
S-Adenosylmethionine + Phosphatidyl-N-dimethylethanolamine unknown S-Adenosylhomocysteine + Phosphatidylcholinedetails
S-Adenosylmethionine + Phosphatidylethanolamine unknown S-Adenosylhomocysteine + Phosphatidyl-N-methylethanolaminedetails
Gene Name:
ASMT
Uniprot ID:
P46597
Reactions
S-Adenosylmethionine + N-Acetylserotonin unknown S-Adenosylhomocysteine + Melatonindetails
S-Adenosylmethionine + 5-Hydroxyindoleacetic acid unknown S-Adenosylhomocysteine + 5-Methoxyindoleacetatedetails
Gene Name:
MTR
Uniprot ID:
Q99707
Gene Name:
COMT
Uniprot ID:
P21964
Reactions
S-Adenosylmethionine + a catechol unknown S-Adenosylhomocysteine + a guaiacoldetails
S-Adenosylmethionine + Norepinephrine unknown S-Adenosylhomocysteine + Normetanephrinedetails
S-Adenosylmethionine + Epinephrine unknown S-Adenosylhomocysteine + Metanephrinedetails
S-Adenosylmethionine + 3,4-Dihydroxybenzeneacetic acid unknown S-Adenosylhomocysteine + Homovanillic aciddetails
S-Adenosylmethionine + Dopamine unknown S-Adenosylhomocysteine + 3-Methoxytyraminedetails
2-Hydroxyestrone + S-Adenosylmethionine unknown 2-Methoxyestrone + S-Adenosylhomocysteinedetails
2-Hydroxyestradiol + S-Adenosylmethionine unknown 2-Methoxyestradiol + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + 3,4-Dihydroxyphenylglycol unknown S-Adenosylhomocysteine + Vanylglycoldetails
S-Adenosylmethionine + 3,4-Dihydroxymandelic acid unknown S-Adenosylhomocysteine + Vanillylmandelic aciddetails
Gene Name:
DOT1L
Uniprot ID:
Q8TEK3
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
GNMT
Uniprot ID:
Q14749
Reactions
S-Adenosylmethionine + Glycine unknown S-Adenosylhomocysteine + Sarcosinedetails
Gene Name:
SETD7
Uniprot ID:
Q8WTS6
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
MAT2A
Uniprot ID:
P31153
Reactions
Adenosine triphosphate + L-Methionine + Water unknown Phosphoric acid + Pyrophosphate + S-Adenosylmethioninedetails
Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Waterdetails
Gene Name:
PNMT
Uniprot ID:
P11086
Reactions
S-Adenosylmethionine + 2-Hydroxyphenethylamine unknown S-Adenosylhomocysteine + N-Methylphenylethanolaminedetails
S-Adenosylmethionine + Norepinephrine unknown S-Adenosylhomocysteine + Epinephrinedetails
Gene Name:
DPH5
Uniprot ID:
Q9H2P9
Reactions
S-Adenosylmethionine + 2-(3-Carboxy-3-aminopropyl)-L-histidine unknown S-Adenosylhomocysteine + 2-(3-carboxy-3-(trimethylammonio)propyl)-L-histidinedetails
Gene Name:
AS3MT
Uniprot ID:
Q9HBK9
Reactions
S-Adenosylmethionine + Arsenite unknown S-Adenosylhomocysteine + Methylarsonatedetails
S-Adenosylmethionine + Methylarsonite unknown S-Adenosylhomocysteine + Dimethylarsinatedetails
Gene Name:
NSD1
Uniprot ID:
Q96L73
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
SETDB1
Uniprot ID:
Q15047
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
PCMT1
Uniprot ID:
P22061
Reactions
S-Adenosylmethionine + protein L-isoaspartate unknown S-Adenosylhomocysteine + protein L-isoaspartate alpha-methyl esterdetails
Gene Name:
ICMT
Uniprot ID:
O60725
Reactions
S-Adenosylmethionine + protein C-terminal S-farnesyl-L-cysteine unknown S-Adenosylhomocysteine + protein C-terminal S-farnesyl-L-cysteine methyl esterdetails
Gene Name:
INMT
Uniprot ID:
O95050
Reactions
S-Adenosylmethionine + an amine unknown S-Adenosylhomocysteine + a methylated aminedetails
S-Adenosylmethionine + Dimethylsulfide unknown S-Adenosylhomocysteine + Trimethyl sulfoniumdetails
S-Adenosylmethionine + Tryptamine unknown S-Adenosylhomocysteine + N-Methyltryptaminedetails
S-Adenosylmethionine + Serotonin unknown S-Adenosylhomocysteine + N-Methylserotonindetails
S-Adenosylmethionine + Dimethyl selenide unknown S-Adenosylhomocysteine + Trimethylselenoniumdetails
Gene Name:
DNMT3A
Uniprot ID:
Q9Y6K1
Reactions
S-Adenosylmethionine + DNA unknown S-Adenosylhomocysteine + DNA containing 5-methylcytosinedetails
S-Adenosylmethionine + DNA cytosine unknown S-Adenosylhomocysteine + DNA 5-methylcytosinedetails
Gene Name:
COQ3
Uniprot ID:
Q9NZJ6
Reactions
S-Adenosylmethionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate unknown S-Adenosylhomocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoatedetails
S-Adenosylmethionine + 3-demethylubiquinone-n unknown S-Adenosylhomocysteine + ubiquinone-ndetails
S-Adenosylmethionine + 3-(all-trans-polyprenyl)benzene-1,2-diol unknown S-Adenosylhomocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenoldetails
2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine unknown Ubiquinone 6 + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + 3-Hexaprenyl-4,5-Dihydroxybenzoic acid unknown S-Adenosylhomocysteine + 3-Hexaprenyl-4-hydroxy-5-methoxybenzoic acid + Hydrogen Iondetails
S-Adenosylmethionine + 3-Demethylubiquinone-9 unknown S-Adenosylhomocysteine + Coenzyme Q9details
3-Polyprenyl-4,5-dihydroxybenzoate + S-Adenosylmethionine unknown 3-Polyprenyl-4-hydroxy-5-methoxybenzoate + S-Adenosylhomocysteinedetails
2-Polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine unknown Ubiquinone-2 + S-Adenosylhomocysteinedetails
Gene Name:
MAT1A
Uniprot ID:
Q00266
Reactions
Adenosine triphosphate + L-Methionine + Water unknown Phosphoric acid + Pyrophosphate + S-Adenosylmethioninedetails
Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Waterdetails
Gene Name:
EHMT2
Uniprot ID:
Q96KQ7
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
AMD1
Uniprot ID:
P17707
Reactions
S-Adenosylmethionine unknown (5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO(2)details
S-Adenosylmethionine + Hydrogen Ion unknown S-Adenosylmethioninamine + Carbon dioxidedetails
Gene Name:
MTRR
Uniprot ID:
Q9UBK8
Reactions
[methionine synthase]-methylcob(I)alamin + S-Adenosylhomocysteine + NADP unknown [methionine synthase]-cob(II)alamin + NADPH + S-Adenosylmethioninedetails
Gene Name:
SUV39H1
Uniprot ID:
O43463
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
NNMT
Uniprot ID:
P40261
Reactions
S-Adenosylmethionine + Niacinamide unknown S-Adenosylhomocysteine + 1-Methylnicotinamidedetails
S-Adenosylmethionine + Niacinamide + Hydrogen Ion unknown S-Adenosylhomocysteine + 1-Methylnicotinamidedetails
Gene Name:
SUV39H2
Uniprot ID:
Q9H5I1
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
EHMT1
Uniprot ID:
Q9H9B1
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
GAMT
Uniprot ID:
Q14353
Reactions
S-Adenosylmethionine + Guanidoacetic acid unknown S-Adenosylhomocysteine + Creatinedetails
Gene Name:
HNMT
Uniprot ID:
P50135
Reactions
S-Adenosylmethionine + Histamine unknown S-Adenosylhomocysteine + 1-Methylhistaminedetails
Gene Name:
TPMT
Uniprot ID:
P51580
Reactions
S-Adenosylmethionine + a thiopurine unknown S-Adenosylhomocysteine + a thiopurine S-methyletherdetails
Mercaptopurine + S-Adenosylmethionine unknown 6-Methylmercaptopurine + S-Adenosylhomocysteinedetails
6-Thioinosine-5'-monophosphate + S-Adenosylmethionine unknown 6-Methylthiopurine 5'-monophosphate ribonucleotide + S-Adenosylhomocysteinedetails
6-Thioguanosine monophosphate + S-Adenosylmethionine unknown 6-Methylthioguanosine monophosphate + S-Adenosylhomocysteinedetails
Gene Name:
METTL3
Uniprot ID:
Q86U44
Reactions
S-Adenosylmethionine + m(7)G(5')pppAm unknown S-Adenosylhomocysteine + m(7)G(5')pppm(6)Amdetails
Gene Name:
AHCYL2
Uniprot ID:
Q96HN2
Gene Name:
AHCY
Uniprot ID:
P23526
Gene Name:
AHCYL1
Uniprot ID:
O43865
Gene Name:
CBS
Uniprot ID:
P35520
Gene Name:
LIAS
Uniprot ID:
O43766
Reactions
Protein N(6)-(octanoyl)lysine + Hydrogen sulfide + S-Adenosylmethionine unknown protein N(6)-(lipoyl)lysine + L-Methionine + 5'-Deoxyadenosinedetails
Protein N6-(octanoyl)lysine + Sulfur donor + S-Adenosylmethionine unknown Protein N6-(lipoyl)lysine + L-Methionine + 5'-Deoxyadenosinedetails
Octanoyl-[acp] + Sulfur donor + S-Adenosylmethionine unknown Lipoyl-[acp] + L-Methionine + 5'-Deoxyadenosinedetails
Gene Name:
PRMT5
Uniprot ID:
O14744
Reactions
S-Adenosylmethionine + arginine-[histone] unknown S-Adenosylhomocysteine + N(omega)-methyl-arginine-[histone]details
Gene Name:
SETD1A
Uniprot ID:
O15047
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
PRDM2
Uniprot ID:
Q13029
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Gene Name:
MLL
Uniprot ID:
Q03164
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
DNMT3B
Uniprot ID:
Q9UBC3
Reactions
S-Adenosylmethionine + DNA unknown S-Adenosylhomocysteine + DNA containing 5-methylcytosinedetails
S-Adenosylmethionine + DNA cytosine unknown S-Adenosylhomocysteine + DNA 5-methylcytosinedetails
Gene Name:
TRDMT1
Uniprot ID:
O14717
Reactions
S-Adenosylmethionine + cytosine(38) in tRNA unknown S-Adenosylhomocysteine + 5-methylcytosine(38) in tRNAdetails
Gene Name:
SETD8
Uniprot ID:
Q9NQR1
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
MLL3
Uniprot ID:
Q8NEZ4
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
MAT2B
Uniprot ID:
Q9NZL9
Reactions
Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Waterdetails
Gene Name:
DNMT1
Uniprot ID:
P26358
Reactions
S-Adenosylmethionine + DNA unknown S-Adenosylhomocysteine + DNA containing 5-methylcytosinedetails
S-Adenosylmethionine + DNA cytosine unknown S-Adenosylhomocysteine + DNA 5-methylcytosinedetails
Gene Name:
SETDB2
Uniprot ID:
Q96T68
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails

Only showing the first 50 proteins. There are 129 proteins in total.