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Human Metabolome Database Version 3.5

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Showing metabocard for S-Adenosylmethionine (HMDB01185)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-05-15 15:01:45 -0600
HMDB ID HMDB01185
Secondary Accession Numbers None
Metabolite Identification
Common Name S-Adenosylmethionine
Description Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed). S-Adenosylmethionine is only found in individuals that have used or taken this drug. It is a physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation. SAMe, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine and other molecules.
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  2. 2-S-Adenosyl-L-methionine
  3. 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  4. 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  5. Active methionine
  6. Ademetionine
  7. Adenosylmethionine
  8. AdoMet
  9. Donamet
  10. L-S-Adenosylmethionine
  11. S-(5'-Adenosyl)-L-methionine
  12. S-(5'-Deoxyadenosin-5'-yl)-L-methionine
  13. S-Adenosyl methionine
  14. S-Adenosyl-L-methionine
  15. S-Adenosyl-L-Methionine Disulfate Tosylate
  16. S-Adenosyl-L-Methionine Disulphate Tosylate
  17. S-Adenosyl-methionine
  18. S-Adenosylmethionine
Chemical Formula C15H23N6O5S
Average Molecular Weight 399.445
Monoisotopic Molecular Weight 399.145063566
IUPAC Name [(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium
Traditional IUPAC Name SAMe
CAS Registry Number 29908-03-0
SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12
InChI Identifier InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1
InChI Key MEFKEPWMEQBLKI-AIRLBKTGSA-O
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Amino Acids, Peptides, and Analogues
Class Amino Acids and Derivatives
Sub Class Glycoamino Acids and Derivatives
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
  • Purine Nucleosides and Analogues
Substituents
  • 1,2 Diol
  • Alpha Amino Acid Or Derivative
  • Aminopyrimidine
  • Carboxylic Acid
  • Glycosyl Compound
  • Imidazole
  • Imidazopyrimidine
  • N Glycosyl Compound
  • Oxolane
  • Pentose Monosaccharide
  • Polyamine
  • Primary Aliphatic Amine (Alkylamine)
  • Purine
  • Pyrimidine
  • Saccharide
  • Secondary Alcohol
Direct Parent Glycoamino Acids and Derivatives
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Aminosugars metabolism
  • Component of Arginine and proline metabolism
  • Component of Glycerophospholipid metabolism
  • Component of Glycine, serine and threonine metabolism
  • Component of Histidine metabolism
  • Component of Methionine metabolism
  • Component of Nicotinate and nicotinamide metabolism
  • Component of Selenoamino acid metabolism
  • Component of Tryptophan metabolism
  • Component of Tyrosine metabolism
  • Component of Ubiquinone biosynthesis
Application Not Available
Cellular locations
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point 78 °C Not Available
Water Solubility 1.19e+00 g/l ALOGPS
LogP -5.3 ChemAxon
Predicted Properties
Property Value Source
Water Solubility 1.19 g/L ALOGPS
LogP -1.99 ALOGPS
LogP -5.3 ChemAxon
LogS -2.56 ALOGPS
pKa (strongest acidic) 1.71 ChemAxon
pKa (strongest basic) 9.41 ChemAxon
Hydrogen Acceptor Count 10 ChemAxon
Hydrogen Donor Count 5 ChemAxon
Polar Surface Area 182.63 A2 ChemAxon
Rotatable Bond Count 7 ChemAxon
Refractivity 96.23 ChemAxon
Polarizability 40.37 ChemAxon
Formal Charge 1 ChemAxon
Physiological Charge 1 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Location
  • Muscle
  • Skeletal Muscle
  • Fibroblasts
  • Intestine
  • Placenta
  • Testes
  • Kidney
  • Epidermis
  • Myelin
  • Prostate
  • Gonads
  • Eye Lens
Pathways
Name SMPDB Link KEGG Link
Betaine Metabolism SMP00123 map00260 Link_out
Methionine Metabolism SMP00033 map00270 Link_out
Spermidine and Spermine Biosynthesis SMP00445 Not Available
Carnitine Synthesis SMP00465 Not Available
Catecholamine Biosynthesis SMP00012 map00350 Link_out
Glycine and Serine Metabolism SMP00004 map00260 Link_out
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Cerebrospinal Fluid (CSF) Detected and Quantified
0.25 (0.14 - 0.38) uM Adult (>18 years old) Both Normal
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified 0.11 (0.087-0.17) uM Adult (>18 years old) Both Neurodegenerative diseases
Urine Detected and Quantified 28.4 (25.3-31.6) umol/mmol creatinine Adult (>18 years old) Both Comment Diabetes
Associated Disorders and Diseases
Disease References
Diabetes mellitus type 2
  • Hoppel CL, Genuth SM: Urinary excretion of acetylcarnitine during human diabetic and fasting ketosis. Am J Physiol. 1982 Aug;243(2):E168-72. Pubmed: 6810706 Link_out
    Neurodegenerative disease
    • Obeid R, Kostopoulos P, Knapp JP, Kasoha M, Becker G, Fassbender K, Herrmann W: Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid. Clin Chem. 2007 Feb;53(2):326-33. Epub 2007 Jan 2. Pubmed: 17200133 Link_out
      Associated OMIM IDs
      • 125853 Link_out (Diabetes mellitus type 2)
      DrugBank ID DB00118 Link_out
      DrugBank Metabolite ID Not Available
      Phenol Explorer Compound ID Not Available
      Phenol Explorer Metabolite ID Not Available
      FoodDB ID FDB022473
      KNApSAcK ID Not Available
      Chemspider ID 21169292 Link_out
      KEGG Compound ID C00019 Link_out
      BioCyc ID S-ADENOSYLMETHIONINE Link_out
      BiGG ID 33530 Link_out
      Wikipedia Link S-Adenosylmethionine Link_out
      NuGOwiki Link HMDB01185 Link_out
      Metagene Link HMDB01185 Link_out
      METLIN ID 6064 Link_out
      PubChem Compound 16757548 Link_out
      PDB ID 1CMC Link_out
      ChEBI ID 15414 Link_out
      References
      Synthesis Reference Lin, Jian-Ping; Tian, Jun; You, Jian-Feng; Jin, Zhi-Hua; Xu, Zhi-Nan; Cen, Pei-Lin. An effective strategy for the co-production of S-adenosyl-L-methionine and glutathione by fed-batch fermentation. Biochemical Engineering Journal (2004), 21(1), 19-25.
      Material Safety Data Sheet (MSDS) Download (PDF)
      General References
      1. Chamberlin ME, Ubagai T, Mudd SH, Wilson WG, Leonard JV, Chou JY: Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency. J Clin Invest. 1996 Aug 15;98(4):1021-7. Pubmed: 8770875 Link_out
      2. Koeberl DD, Young SP, Gregersen NS, Vockley J, Smith WE, Benjamin DK Jr, An Y, Weavil SD, Chaing SH, Bali D, McDonald MT, Kishnani PS, Chen YT, Millington DS: Rare disorders of metabolism with elevated butyryl- and isobutyryl-carnitine detected by tandem mass spectrometry newborn screening. Pediatr Res. 2003 Aug;54(2):219-23. Epub 2003 May 7. Pubmed: 12736383 Link_out
      3. Scalabrino G, Pigatto P, Ferioli ME, Modena D, Puerari M, Caru A: Levels of activity of the polyamine biosynthetic decarboxylases as indicators of degree of malignancy of human cutaneous epitheliomas. J Invest Dermatol. 1980 Mar;74(3):122-4. Pubmed: 7359002 Link_out
      4. Struys EA, Jansen EE, de Meer K, Jakobs C: Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry. Clin Chem. 2000 Oct;46(10):1650-6. Pubmed: 11017945 Link_out
      5. Kaneoka H, Uesugi N, Moriguchi A, Hirose S, Takayanagi M, Yamaguchi S, Shigematsu Y, Yasuno T, Sasatomi Y, Saito T: Carnitine palmitoyltransferase II deficiency due to a novel gene variant in a patient with rhabdomyolysis and ARF. Am J Kidney Dis. 2005 Mar;45(3):596-602. Pubmed: 15754283 Link_out
      6. Rosen RT, Hiserodt RD, Fukuda EK, Ruiz RJ, Zhou Z, Lech J, Rosen SL, Hartman TG: The determination of metabolites of garlic preparations in breath and human plasma. Biofactors. 2000;13(1-4):241-9. Pubmed: 11237188 Link_out
      7. McFadden PN, Horwitz J, Clarke S: Protein carboxyl methyltransferase from cow eye lens. Biochem Biophys Res Commun. 1983 Jun 15;113(2):418-24. Pubmed: 6870865 Link_out
      8. Garibotto G, Sofia A, Valli A, Tarroni A, Di Martino M, Cappelli V, Aloisi F, Procopio V: Causes of hyperhomocysteinemia in patients with chronic kidney diseases. Semin Nephrol. 2006 Jan;26(1):3-7. Pubmed: 16412817 Link_out
      9. Spiekerkoetter U, Tokunaga C, Wendel U, Mayatepek E, Ijlst L, Vaz FM, van Vlies N, Overmars H, Duran M, Wijburg FA, Wanders RJ, Strauss AW: Tissue carnitine homeostasis in very-long-chain acyl-CoA dehydrogenase-deficient mice. Pediatr Res. 2005 Jun;57(6):760-4. Epub 2005 Mar 17. Pubmed: 15774826 Link_out
      10. Jones MG, Goodwin CS, Amjad S, Chalmers RA: Plasma and urinary carnitine and acylcarnitines in chronic fatigue syndrome. Clin Chim Acta. 2005 Oct;360(1-2):173-7. Pubmed: 15967423 Link_out
      11. Kelm A, Shaw L, Schauer R, Reuter G: The biosynthesis of 8-O-methylated sialic acids in the starfish Asterias rubens--isolation and characterisation of S-adenosyl-L-methionine:sialate-8-O-methyltransferase. Eur J Biochem. 1998 Feb 1;251(3):874-84. Pubmed: 9490063 Link_out
      12. Solano AR, Sanchez ML, Podesta EJ, Turyn D, Dellacha JM: Membrane methylation in isolated rat testis interstitial cells unmasks functional luteinizing hormone receptors. Biochim Biophys Acta. 1987 Apr 2;928(1):107-13. Pubmed: 3828399 Link_out
      13. D'Erme M, Santoro R, Allegra P, Reale A, Marenzi S, Strom R, Caiafa P: Inhibition of CpG methylation in linker DNA by H1 histone. Biochim Biophys Acta. 1993 May 28;1173(2):209-16. Pubmed: 8504169 Link_out
      14. Hoppel CL, Genuth SM: Urinary excretion of acetylcarnitine during human diabetic and fasting ketosis. Am J Physiol. 1982 Aug;243(2):E168-72. Pubmed: 6810706 Link_out
      15. Scott JM, Weir DG: The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia. Lancet. 1981 Aug 15;2(8242):337-40. Pubmed: 6115113 Link_out
      16. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411 Link_out
      Enzymes
      Name: Phosphatidylethanolamine N-methyltransferase
      Reactions:
      S-Adenosylmethionine + phosphatidyl-N-methylethanolamine unknown S-Adenosylhomocysteine + phosphatidyl-N-dimethylethanolamine details
      S-Adenosylmethionine + phosphatidyl-N-dimethylethanolamine unknown S-Adenosylhomocysteine + phosphatidylcholine details
      S-Adenosylmethionine + Phosphatidylethanolamine unknown S-Adenosylhomocysteine + phosphatidyl-N-methylethanolamine details
      S-Adenosylmethionine + Phosphatidyl-N-dimethylethanolamine unknown S-Adenosylhomocysteine + Phosphatidylcholine details
      S-Adenosylmethionine + Phosphatidylethanolamine unknown S-Adenosylhomocysteine + Phosphatidyl-N-methylethanolamine details
      Gene Name: PEMT
      Uniprot ID: Q9UBM1 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Acetylserotonin O-methyltransferase
      Reactions:
      S-Adenosylmethionine + N-Acetylserotonin unknown S-Adenosylhomocysteine + Melatonin details
      S-Adenosylmethionine + 5-Hydroxyindoleacetic acid unknown S-Adenosylhomocysteine + 5-Methoxyindoleacetate details
      Gene Name: ASMT
      Uniprot ID: P46597 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Methionine synthase
      Reactions: Not Available
      Gene Name: MTR
      Uniprot ID: Q99707 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Catechol O-methyltransferase
      Reactions:
      S-Adenosylmethionine + a catechol unknown S-Adenosylhomocysteine + a guaiacol details
      S-Adenosylmethionine + Norepinephrine unknown S-Adenosylhomocysteine + Normetanephrine details
      S-Adenosylmethionine + Epinephrine unknown S-Adenosylhomocysteine + Metanephrine details
      S-Adenosylmethionine + 3,4-Dihydroxybenzeneacetic acid unknown S-Adenosylhomocysteine + Homovanillic acid details
      S-Adenosylmethionine + Dopamine unknown S-Adenosylhomocysteine + 3-Methoxytyramine details
      2-Hydroxyestrone + S-Adenosylmethionine unknown 2-Methoxyestrone + S-Adenosylhomocysteine details
      2-Hydroxyestradiol + S-Adenosylmethionine unknown 2-Methoxyestradiol + S-Adenosylhomocysteine details
      S-Adenosylmethionine + 3,4-Dihydroxyphenylglycol unknown S-Adenosylhomocysteine + Vanylglycol details
      S-Adenosylmethionine + 3,4-Dihydroxymandelic acid unknown S-Adenosylhomocysteine + Vanillylmandelic acid details
      Gene Name: COMT
      Uniprot ID: P21964 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase, H3 lysine-79 specific
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: DOT1L
      Uniprot ID: Q8TEK3 Link_out
      Protein Sequence: FASTA
      Name: Glycine N-methyltransferase
      Reactions:
      S-Adenosylmethionine + Glycine unknown S-Adenosylhomocysteine + Sarcosine details
      Gene Name: GNMT
      Uniprot ID: Q14749 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase SETD7
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: SETD7
      Uniprot ID: Q8WTS6 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: S-adenosylmethionine synthase isoform type-2
      Reactions:
      Adenosine triphosphate + L-Methionine + Water unknown Phosphoric acid + Pyrophosphate + S-Adenosylmethionine details
      Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Water details
      Gene Name: MAT2A
      Uniprot ID: P31153 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Phenylethanolamine N-methyltransferase
      Reactions:
      S-Adenosylmethionine + 2-Hydroxyphenethylamine unknown S-Adenosylhomocysteine + N-Methylphenylethanolamine details
      S-Adenosylmethionine + Norepinephrine unknown S-Adenosylhomocysteine + Epinephrine details
      Gene Name: PNMT
      Uniprot ID: P11086 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Diphthine synthase
      Reactions:
      S-Adenosylmethionine + 2-(3-Carboxy-3-aminopropyl)-L-histidine unknown S-Adenosylhomocysteine + 2-(3-carboxy-3-(trimethylammonio)propyl)-L-histidine details
      Gene Name: DPH5
      Uniprot ID: Q9H2P9 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Arsenite methyltransferase
      Reactions:
      S-Adenosylmethionine + Arsenite unknown S-Adenosylhomocysteine + Methylarsonate details
      S-Adenosylmethionine + Methylarsonite unknown S-Adenosylhomocysteine + Dimethylarsinate details
      Gene Name: AS3MT
      Uniprot ID: Q9HBK9 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Mitochondrial tRNA-specific 2-thiouridylase 1
      Reactions: Not Available
      Gene Name: TRMU
      Uniprot ID: O75648 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: NSD1
      Uniprot ID: Q96L73 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase SETDB1
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: SETDB1
      Uniprot ID: Q15047 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Protein-L-isoaspartate(D-aspartate) O-methyltransferase
      Reactions:
      S-Adenosylmethionine + protein L-isoaspartate unknown S-Adenosylhomocysteine + protein L-isoaspartate alpha-methyl ester details
      Gene Name: PCMT1
      Uniprot ID: P22061 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Protein-S-isoprenylcysteine O-methyltransferase
      Reactions:
      S-Adenosylmethionine + protein C-terminal S-farnesyl-L-cysteine unknown S-Adenosylhomocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester details
      Gene Name: ICMT
      Uniprot ID: O60725 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Indolethylamine N-methyltransferase
      Reactions:
      S-Adenosylmethionine + an amine unknown S-Adenosylhomocysteine + a methylated amine details
      S-Adenosylmethionine + Dimethylsulfide unknown S-Adenosylhomocysteine + Trimethyl sulfonium details
      S-Adenosylmethionine + Tryptamine unknown S-Adenosylhomocysteine + N-Methyltryptamine details
      S-Adenosylmethionine + Serotonin unknown S-Adenosylhomocysteine + N-Methylserotonin details
      S-Adenosylmethionine + Dimethyl selenide unknown S-Adenosylhomocysteine + Trimethylselenonium details
      Gene Name: INMT
      Uniprot ID: O95050 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: DNA (cytosine-5)-methyltransferase 3A
      Reactions:
      S-Adenosylmethionine + DNA unknown S-Adenosylhomocysteine + DNA containing 5-methylcytosine details
      S-Adenosylmethionine + DNA cytosine unknown S-Adenosylhomocysteine + DNA 5-methylcytosine details
      Gene Name: DNMT3A
      Uniprot ID: Q9Y6K1 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial
      Reactions:
      S-Adenosylmethionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate unknown S-Adenosylhomocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate details
      S-Adenosylmethionine + 3-demethylubiquinone-n unknown S-Adenosylhomocysteine + ubiquinone-n details
      S-Adenosylmethionine + 3-(all-trans-polyprenyl)benzene-1,2-diol unknown S-Adenosylhomocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol details
      2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine unknown Ubiquinone 6 + S-Adenosylhomocysteine details
      S-Adenosylmethionine + 3-Hexaprenyl-4,5-Dihydroxybenzoic acid unknown S-Adenosylhomocysteine + 3-Hexaprenyl-4-hydroxy-5-methoxybenzoic acid + Hydrogen Ion details
      S-Adenosylmethionine + 3-Demethylubiquinone-9 unknown S-Adenosylhomocysteine + Coenzyme Q9 details
      3-Polyprenyl-4,5-dihydroxybenzoate + S-Adenosylmethionine unknown 3-Polyprenyl-4-hydroxy-5-methoxybenzoate + S-Adenosylhomocysteine details
      2-Polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine unknown Ubiquinone-2 + S-Adenosylhomocysteine details
      Gene Name: COQ3
      Uniprot ID: Q9NZJ6 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: S-adenosylmethionine synthase isoform type-1
      Reactions:
      Adenosine triphosphate + L-Methionine + Water unknown Phosphoric acid + Pyrophosphate + S-Adenosylmethionine details
      Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Water details
      Gene Name: MAT1A
      Uniprot ID: Q00266 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase EHMT2
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: EHMT2
      Uniprot ID: Q96KQ7 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: S-adenosylmethionine decarboxylase proenzyme
      Reactions:
      S-Adenosylmethionine unknown (5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO(2) details
      S-Adenosylmethionine + Hydrogen Ion unknown S-Adenosylmethioninamine + Carbon dioxide details
      Gene Name: AMD1
      Uniprot ID: P17707 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Methionine synthase reductase
      Reactions:
      [methionine synthase]-methylcob(I)alamin + S-Adenosylhomocysteine + NADP unknown [methionine synthase]-cob(II)alamin + NADPH + S-Adenosylmethionine details
      Gene Name: MTRR
      Uniprot ID: Q9UBK8 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase SUV39H1
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: SUV39H1
      Uniprot ID: O43463 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Nicotinamide N-methyltransferase
      Reactions:
      S-Adenosylmethionine + Niacinamide unknown S-Adenosylhomocysteine + 1-Methylnicotinamide details
      S-Adenosylmethionine + Niacinamide + Hydrogen Ion unknown S-Adenosylhomocysteine + 1-Methylnicotinamide details
      Gene Name: NNMT
      Uniprot ID: P40261 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase SUV39H2
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: SUV39H2
      Uniprot ID: Q9H5I1 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase EHMT1
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: EHMT1
      Uniprot ID: Q9H9B1 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Guanidinoacetate N-methyltransferase
      Reactions:
      S-Adenosylmethionine + Guanidoacetic acid unknown S-Adenosylhomocysteine + Creatine details
      Gene Name: GAMT
      Uniprot ID: Q14353 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histamine N-methyltransferase
      Reactions:
      S-Adenosylmethionine + Histamine unknown S-Adenosylhomocysteine + 1-Methylhistamine details
      Gene Name: HNMT
      Uniprot ID: P50135 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Thiopurine S-methyltransferase
      Reactions:
      S-Adenosylmethionine + a thiopurine unknown S-Adenosylhomocysteine + a thiopurine S-methylether details
      Mercaptopurine + S-Adenosylmethionine unknown 6-Methylmercaptopurine + S-Adenosylhomocysteine details
      6-Thioinosine-5'-monophosphate + S-Adenosylmethionine unknown 6-Methylthiopurine 5'-monophosphate ribonucleotide + S-Adenosylhomocysteine details
      6-Thioguanosine monophosphate + S-Adenosylmethionine unknown 6-Methylthioguanosine monophosphate + S-Adenosylhomocysteine details
      Gene Name: TPMT
      Uniprot ID: P51580 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: N6-adenosine-methyltransferase 70 kDa subunit
      Reactions:
      S-Adenosylmethionine + m(7)G(5')pppAm unknown S-Adenosylhomocysteine + m(7)G(5')pppm(6)Am details
      Gene Name: METTL3
      Uniprot ID: Q86U44 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Putative adenosylhomocysteinase 3
      Reactions: Not Available
      Gene Name: AHCYL2
      Uniprot ID: Q96HN2 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Adenosylhomocysteinase
      Reactions: Not Available
      Gene Name: AHCY
      Uniprot ID: P23526 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Putative adenosylhomocysteinase 2
      Reactions: Not Available
      Gene Name: AHCYL1
      Uniprot ID: O43865 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Cystathionine beta-synthase
      Reactions: Not Available
      Gene Name: CBS
      Uniprot ID: P35520 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Lipoyl synthase, mitochondrial
      Reactions:
      Protein N(6)-(octanoyl)lysine + Hydrogen sulfide + S-Adenosylmethionine unknown protein N(6)-(lipoyl)lysine + L-Methionine + 5'-Deoxyadenosine details
      Protein N6-(octanoyl)lysine + Sulfur donor + S-Adenosylmethionine unknown Protein N6-(lipoyl)lysine + L-Methionine + 5'-Deoxyadenosine details
      Octanoyl-[acp] + Sulfur donor + S-Adenosylmethionine unknown Lipoyl-[acp] + L-Methionine + 5'-Deoxyadenosine details
      Gene Name: LIAS
      Uniprot ID: O43766 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Protein arginine N-methyltransferase 5
      Reactions:
      S-Adenosylmethionine + arginine-[histone] unknown S-Adenosylhomocysteine + N(omega)-methyl-arginine-[histone] details
      Gene Name: PRMT5
      Uniprot ID: O14744 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase SETD1A
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: SETD1A
      Uniprot ID: O15047 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: rRNA 2'-O-methyltransferase fibrillarin
      Reactions: Not Available
      Gene Name: FBL
      Uniprot ID: P22087 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: PR domain zinc finger protein 2
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Gene Name: PRDM2
      Uniprot ID: Q13029 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase MLL
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: MLL
      Uniprot ID: Q03164 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Molybdenum cofactor biosynthesis protein 1
      Reactions: Not Available
      Gene Name: MOCS1
      Uniprot ID: Q9NZB8 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: DNA (cytosine-5)-methyltransferase 3B
      Reactions:
      S-Adenosylmethionine + DNA unknown S-Adenosylhomocysteine + DNA containing 5-methylcytosine details
      S-Adenosylmethionine + DNA cytosine unknown S-Adenosylhomocysteine + DNA 5-methylcytosine details
      Gene Name: DNMT3B
      Uniprot ID: Q9UBC3 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: tRNA (cytosine(38)-C(5))-methyltransferase
      Reactions:
      S-Adenosylmethionine + cytosine(38) in tRNA unknown S-Adenosylhomocysteine + 5-methylcytosine(38) in tRNA details
      Gene Name: TRDMT1
      Uniprot ID: O14717 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: N-lysine methyltransferase SETD8
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: SETD8
      Uniprot ID: Q9NQR1 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase MLL3
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: MLL3
      Uniprot ID: Q8NEZ4 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Methionine adenosyltransferase 2 subunit beta
      Reactions:
      Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Water details
      Gene Name: MAT2B
      Uniprot ID: Q9NZL9 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: DNA (cytosine-5)-methyltransferase 1
      Reactions:
      S-Adenosylmethionine + DNA unknown S-Adenosylhomocysteine + DNA containing 5-methylcytosine details
      S-Adenosylmethionine + DNA cytosine unknown S-Adenosylhomocysteine + DNA 5-methylcytosine details
      Gene Name: DNMT1
      Uniprot ID: P26358 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase SETDB2
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: SETDB2
      Uniprot ID: Q96T68 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: S-adenosylmethionine mitochondrial carrier protein
      Reactions: Not Available
      Gene Name: SLC25A26
      Uniprot ID: Q70HW3 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: tRNA (cytosine(34)-C(5))-methyltransferase
      Reactions:
      S-Adenosylmethionine + cytosine(34) in tRNA precursor unknown S-Adenosylhomocysteine + 5-methylcytosine(34) in tRNA precursor details
      Gene Name: NSUN2
      Uniprot ID: Q08J23 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
      Reactions:
      S-Adenosylmethionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol unknown S-Adenosylhomocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol details
      2-Hexaprenyl-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine unknown 2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone + S-Adenosylhomocysteine details
      2-Polyprenyl-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine unknown 2-Polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-Adenosylhomocysteine details
      Gene Name: COQ5
      Uniprot ID: Q5HYK3 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: tRNA wybutosine-synthesizing protein 1 homolog
      Reactions: Not Available
      Gene Name: TYW1
      Uniprot ID: Q9NV66 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: tRNA wybutosine-synthesizing protein 1 homolog B
      Reactions: Not Available
      Gene Name: TYW1B
      Uniprot ID: Q6NUM6 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Radical S-adenosyl methionine domain-containing protein 2
      Reactions: Not Available
      Gene Name: RSAD2
      Uniprot ID: Q8WXG1 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase ASH1L
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: ASH1L
      Uniprot ID: Q9NR48 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: N-acetylserotonin O-methyltransferase-like protein
      Reactions: Not Available
      Gene Name: ASMTL
      Uniprot ID: O95671 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-arginine methyltransferase CARM1
      Reactions:
      S-Adenosylmethionine + arginine-[histone] unknown S-Adenosylhomocysteine + N(omega)-methyl-arginine-[histone] details
      Gene Name: CARM1
      Uniprot ID: Q86X55 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: CDK5 regulatory subunit-associated protein 1-like 1
      Reactions: Not Available
      Gene Name: CDKAL1
      Uniprot ID: Q5VV42 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: CDK5 regulatory subunit-associated protein 1
      Reactions: Not Available
      Gene Name: CDK5RAP1
      Uniprot ID: Q96SZ6 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Elongator complex protein 3
      Reactions: Not Available
      Gene Name: ELP3
      Uniprot ID: Q9H9T3 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase EZH2
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Gene Name: EZH2
      Uniprot ID: Q15910 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1
      Reactions: Not Available
      Gene Name: FBLL1
      Uniprot ID: A6NHQ2 Link_out
      Protein Sequence: FASTA
      Name: Leucine carboxyl methyltransferase 2
      Reactions: Not Available
      Gene Name: LCMT2
      Uniprot ID: O60294 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: mRNA cap guanine-N7 methyltransferase
      Reactions:
      S-Adenosylmethionine + G(5')pppR-RNA unknown S-Adenosylhomocysteine + m(7)G(5')pppR-RNA details
      Gene Name: RNMT
      Uniprot ID: O43148 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1
      Reactions: Not Available
      Gene Name: METT5D1
      Uniprot ID: A6NJ78 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: 7SK snRNA methylphosphate capping enzyme
      Reactions: Not Available
      Gene Name: MEPCE
      Uniprot ID: Q7L2J0 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase MLL2
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: MLL2
      Uniprot ID: O14686 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase MLL4
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: WBP7
      Uniprot ID: Q9UMN6 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase MLL5
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: MLL5
      Uniprot ID: Q8IZD2 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase NSD2
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: WHSC1
      Uniprot ID: O96028 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase NSD3
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: WHSC1L1
      Uniprot ID: Q9BZ95 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Putative methyltransferase NSUN5C
      Reactions: Not Available
      Gene Name: NSUN5P2
      Uniprot ID: Q63ZY6 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Putative methyltransferase NSUN3
      Reactions: Not Available
      Gene Name: NSUN3
      Uniprot ID: Q9H649 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Putative methyltransferase NSUN4
      Reactions: Not Available
      Gene Name: NSUN4
      Uniprot ID: Q96CB9 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Putative methyltransferase NSUN5
      Reactions: Not Available
      Gene Name: NSUN5
      Uniprot ID: Q96P11 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Putative methyltransferase NSUN6
      Reactions: Not Available
      Gene Name: NSUN6
      Uniprot ID: Q8TEA1 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Putative methyltransferase NSUN7
      Reactions: Not Available
      Gene Name: NSUN7
      Uniprot ID: Q8NE18 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
      Reactions:
      S-Adenosylmethionine + cytidine(32)/guanosine(34) in tRNA unknown S-Adenosylhomocysteine + 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA details
      Gene Name: FTSJ1
      Uniprot ID: Q9UET6 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Putative ribosomal RNA methyltransferase 2
      Reactions:
      S-Adenosylmethionine + rRNA unknown S-Adenosylhomocysteine + rRNA containing 2'-O-methyluridine details
      Gene Name: FTSJ2
      Uniprot ID: Q9UI43 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: pre-rRNA processing protein FTSJ3
      Reactions:
      S-Adenosylmethionine + rRNA unknown S-Adenosylhomocysteine + rRNA containing 2'-O-methylnucleoside details
      Gene Name: FTSJ3
      Uniprot ID: Q8IY81 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Radical S-adenosyl methionine domain-containing protein 1, mitochondrial
      Reactions: Not Available
      Gene Name: RSAD1
      Uniprot ID: Q9HA92 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase SETD1B
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: SETD1B
      Uniprot ID: Q9UPS6 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase SETD2
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: SETD2
      Uniprot ID: Q9BYW2 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase SETMAR
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: SETMAR
      Uniprot ID: Q53H47 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase SMYD3
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Gene Name: SMYD3
      Uniprot ID: Q9H7B4 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase SUV420H1
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: SUV420H1
      Uniprot ID: Q4FZB7 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase SUV420H2
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
      S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
      S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
      Gene Name: SUV420H2
      Uniprot ID: Q86Y97 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Probable methyltransferase TARBP1
      Reactions: Not Available
      Gene Name: TARBP1
      Uniprot ID: Q13395 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Dimethyladenosine transferase 1, mitochondrial
      Reactions: Not Available
      Gene Name: TFB1M
      Uniprot ID: Q8WVM0 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Dimethyladenosine transferase 2, mitochondrial
      Reactions: Not Available
      Gene Name: TFB2M
      Uniprot ID: Q9H5Q4 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: tRNA guanosine-2'-O-methyltransferase TRM11 homolog
      Reactions: Not Available
      Gene Name: TRMT11
      Uniprot ID: Q7Z4G4 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: tRNA:m(4)X modification enzyme TRM13 homolog
      Reactions:
      S-Adenosylmethionine + rRNA unknown S-Adenosylhomocysteine + rRNA containing 2'-O-methyluridine details
      S-Adenosylmethionine + cytidine(4) in tRNA(Pro) unknown S-Adenosylhomocysteine + 2'-O-methylcytidine(4) in tRNA(Pro) details
      S-Adenosylmethionine + cytidine(4) in tRNA(Gly)(GCC) unknown S-Adenosylhomocysteine + 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) details
      S-Adenosylmethionine + adenosine(4) in tRNA(His) unknown S-Adenosylhomocysteine + 2'-O-methyladenosine(4) in tRNA(His) details
      Gene Name: TRMT13
      Uniprot ID: Q9NUP7 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: tRNA (guanine(26)-N(2))-dimethyltransferase
      Reactions:
      S-Adenosylmethionine + guanine(26) in tRNA unknown S-Adenosylhomocysteine + N(2)-dimethylguanine(26) in tRNA details
      Gene Name: TRMT1
      Uniprot ID: Q9NXH9 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
      Reactions:
      S-Adenosylmethionine + adenine(58) in tRNA unknown S-Adenosylhomocysteine + N(1)-methyladenine(58) in tRNA details
      Gene Name: TRMT61A
      Uniprot ID: Q96FX7 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: tRNA (guanine-N(7)-)-methyltransferase
      Reactions:
      S-Adenosylmethionine + guanine(46) in tRNA unknown S-Adenosylhomocysteine + N(7)-methylguanine(46) in tRNA details
      Gene Name: METTL1
      Uniprot ID: Q9UBP6 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial
      Reactions:
      S-Adenosylmethionine + adenine(58) in tRNA unknown S-Adenosylhomocysteine + N(1)-methyladenine(58) in tRNA details
      Gene Name: TRMT61B
      Uniprot ID: Q9BVS5 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: tRNA (guanine(37)-N1)-methyltransferase
      Reactions:
      S-Adenosylmethionine + guanine(37) in tRNA unknown S-Adenosylhomocysteine + N(1)-methylguanine(37) in tRNA details
      Gene Name: TRMT5
      Uniprot ID: Q32P41 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: tRNA wybutosine-synthesizing protein 2 homolog
      Reactions: Not Available
      Gene Name: TRMT12
      Uniprot ID: Q53H54 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: tRNA wybutosine-synthesizing protein 3 homolog
      Reactions: Not Available
      Gene Name: TYW3
      Uniprot ID: Q6IPR3 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Probable S-adenosyl-L-methionine-dependent methyltransferase METT5D2
      Reactions: Not Available
      Gene Name: METT5D2
      Uniprot ID: P0C7V9 Link_out
      Protein Sequence: FASTA
      Name: Transmembrane O-methyltransferase
      Reactions:
      S-Adenosylmethionine + a catechol unknown S-Adenosylhomocysteine + a guaiacol details
      Gene Name: LRTOMT
      Uniprot ID: Q8WZ04 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: DNA (cytosine-5)-methyltransferase 3-like
      Reactions:
      S-Adenosylmethionine + DNA cytosine unknown S-Adenosylhomocysteine + DNA 5-methylcytosine details
      Gene Name: DNMT3L
      Uniprot ID: Q9UJW3 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Histone-lysine N-methyltransferase EZH1
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Gene Name: EZH1
      Uniprot ID: Q92800 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Leucine carboxyl methyltransferase 1
      Reactions:
      S-Adenosylmethionine + [phosphatase 2A protein]-leucine unknown S-Adenosylhomocysteine + [phosphatase 2A protein]-leucine methyl ester details
      Gene Name: LCMT1
      Uniprot ID: Q9UIC8 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: tRNA (uracil(54)-C(5))-methyltransferase homolog
      Reactions:
      S-Adenosylmethionine + uridine(54) in tRNA unknown S-Adenosylhomocysteine + 5-methyluridine(54) in tRNA details
      Gene Name: TRMT2B
      Uniprot ID: Q96GJ1 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Alkylated DNA repair protein alkB homolog 8
      Reactions:
      S-Adenosylmethionine + carboxymethyluridine(34) in tRNA unknown S-Adenosylhomocysteine + 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA details
      Gene Name: ALKBH8
      Uniprot ID: Q96BT7 Link_out
      Protein Sequence: FASTA
      Name: Protein arginine N-methyltransferase 1
      Reactions:
      S-Adenosylmethionine + arginine-[histone] unknown S-Adenosylhomocysteine + N(omega)-methyl-arginine-[histone] details
      Gene Name: PRMT1
      Uniprot ID: Q99873 Link_out
      Protein Sequence: FASTA
      Name: Protein arginine N-methyltransferase 2
      Reactions:
      S-Adenosylmethionine + arginine-[histone] unknown S-Adenosylhomocysteine + N(omega)-methyl-arginine-[histone] details
      Gene Name: PRMT2
      Uniprot ID: P55345 Link_out
      Protein Sequence: FASTA
      Name: Protein arginine N-methyltransferase 6
      Reactions:
      S-Adenosylmethionine + arginine-[histone] unknown S-Adenosylhomocysteine + N(omega)-methyl-arginine-[histone] details
      Gene Name: PRMT6
      Uniprot ID: Q96LA8 Link_out
      Protein Sequence: FASTA
      Name: Protein arginine N-methyltransferase 7
      Reactions:
      S-Adenosylmethionine + arginine-[histone] unknown S-Adenosylhomocysteine + N(omega)-methyl-arginine-[histone] details
      S-Adenosylmethionine + [myelin basic protein]-arginine unknown S-Adenosylhomocysteine + [myelin basic protein]-N(omega)-methyl-arginine details
      Gene Name: PRMT7
      Uniprot ID: Q9NVM4 Link_out
      Protein Sequence: FASTA
      Name: Calmodulin-lysine N-methyltransferase
      Reactions:
      S-Adenosylmethionine + calmodulin L-lysine unknown S-Adenosylhomocysteine + calmodulin N(6)-methyl-L-lysine details
      Gene Name: CAMKMT
      Uniprot ID: Q7Z624 Link_out
      Protein Sequence: FASTA
      Name: Probable dimethyladenosine transferase
      Reactions:
      S-Adenosylmethionine + adenine(1779)/adenine(1780) in 18S rRNA unknown S-Adenosylhomocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA details
      Gene Name: DIMT1
      Uniprot ID: Q9UNQ2 Link_out
      Protein Sequence: FASTA
      Name: HemK methyltransferase family member 1
      Reactions:
      L-Histidine + S-Adenosylmethionine unknown 3-Methylhistidine + S-Adenosylhomocysteine details
      3-Hydroxyanthranilic acid + S-Adenosylmethionine unknown 3-Methoxyanthranilate + S-Adenosylhomocysteine details
      N-Methyltyramine + S-Adenosylmethionine unknown Hordenine + S-Adenosylhomocysteine details
      Xanthurenic acid + S-Adenosylmethionine unknown 8-Methoxykynurenate + S-Adenosylhomocysteine details
      1-Hydroxypyrene + S-Adenosylmethionine unknown 1-Methoxypyrene + S-Adenosylhomocysteine details
      Gene Name: HEMK1
      Uniprot ID: Q9Y5R4 Link_out
      Name: Small RNA 2'-O-methyltransferase
      Reactions:
      S-Adenosylmethionine + small RNA unknown S-Adenosylhomocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide details
      Gene Name: HENMT1
      Uniprot ID: Q5T8I9 Link_out
      Protein Sequence: FASTA
      Name: Methyltransferase-like protein 2B
      Reactions:
      L-Histidine + S-Adenosylmethionine unknown 3-Methylhistidine + S-Adenosylhomocysteine details
      3-Hydroxyanthranilic acid + S-Adenosylmethionine unknown 3-Methoxyanthranilate + S-Adenosylhomocysteine details
      N-Methyltyramine + S-Adenosylmethionine unknown Hordenine + S-Adenosylhomocysteine details
      Xanthurenic acid + S-Adenosylmethionine unknown 8-Methoxykynurenate + S-Adenosylhomocysteine details
      1-Hydroxypyrene + S-Adenosylmethionine unknown 1-Methoxypyrene + S-Adenosylhomocysteine details
      Gene Name: METTL2B
      Uniprot ID: Q6P1Q9 Link_out
      Name: Methyltransferase-like protein 6
      Reactions:
      L-Histidine + S-Adenosylmethionine unknown 3-Methylhistidine + S-Adenosylhomocysteine details
      3-Hydroxyanthranilic acid + S-Adenosylmethionine unknown 3-Methoxyanthranilate + S-Adenosylhomocysteine details
      N-Methyltyramine + S-Adenosylmethionine unknown Hordenine + S-Adenosylhomocysteine details
      Xanthurenic acid + S-Adenosylmethionine unknown 8-Methoxykynurenate + S-Adenosylhomocysteine details
      1-Hydroxypyrene + S-Adenosylmethionine unknown 1-Methoxypyrene + S-Adenosylhomocysteine details
      Gene Name: METTL6
      Uniprot ID: Q8TCB7 Link_out
      Name: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
      Reactions:
      S-Adenosylmethionine + m(7)G(5')pppR-RNA unknown S-Adenosylhomocysteine + m(7)G(5')pppRm-RNA details
      Gene Name: FTSJD2
      Uniprot ID: Q8N1G2 Link_out
      Protein Sequence: FASTA
      Name: Ribosomal RNA small subunit methyltransferase NEP1
      Reactions:
      S-Adenosylmethionine + pseudouridine(1248) in 18S rRNA unknown S-Adenosylhomocysteine + N(1)-methylpseudouridine(1248) in 18S rRNA details
      Gene Name: EMG1
      Uniprot ID: Q92979 Link_out
      Protein Sequence: FASTA
      Name: N-terminal Xaa-Pro-Lys N-methyltransferase 1
      Reactions:
      S-Adenosylmethionine + N-terminal-(A,S)PK-[protein] unknown S-Adenosylhomocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein] details
      S-Adenosylmethionine + N-terminal-PPK-[protein] unknown S-Adenosylhomocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein] details
      Gene Name: NTMT1
      Uniprot ID: Q9BV86 Link_out
      Protein Sequence: FASTA
      Name: Alpha N-terminal protein methyltransferase 1B
      Reactions:
      S-Adenosylmethionine + N-terminal-(A,S)PK-[protein] unknown S-Adenosylhomocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein] details
      S-Adenosylmethionine + N-terminal-PPK-[protein] unknown S-Adenosylhomocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein] details
      Gene Name: METTL11B
      Uniprot ID: Q5VVY1 Link_out
      Protein Sequence: FASTA
      Name: Putative histone-lysine N-methyltransferase PRDM6
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Gene Name: PRDM6
      Uniprot ID: Q9NQX0 Link_out
      Protein Sequence: FASTA
      Name: Probable histone-lysine N-methyltransferase PRDM7
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Gene Name: PRDM7
      Uniprot ID: Q9NQW5 Link_out
      Protein Sequence: FASTA
      Name: Histone-lysine N-methyltransferase PRDM9
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Gene Name: PRDM9
      Uniprot ID: Q9NQV7 Link_out
      Protein Sequence: FASTA
      Name: Histone-lysine N-methyltransferase setd3
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Gene Name: SETD3
      Uniprot ID: Q86TU7 Link_out
      Protein Sequence: FASTA
      Name: N-lysine methyltransferase SMYD2
      Reactions:
      S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
      Gene Name: SMYD2
      Uniprot ID: Q9NRG4 Link_out
      Protein Sequence: FASTA
      Name: Trimethylguanosine synthase
      Reactions:
      S-Adenosylmethionine + m(7)G(5')pppR-RNA unknown S-Adenosylhomocysteine + m(2,7)G(5')pppR-RNA details
      S-Adenosylmethionine + m(2,7)G(5')pppR-RNA unknown S-Adenosylhomocysteine + m(2,2,7)G(5')pppR-RNA details
      Gene Name: TGS1
      Uniprot ID: Q96RS0 Link_out
      Protein Sequence: FASTA
      Name: Probable tRNA (uracil-O(2)-)-methyltransferase
      Reactions:
      S-Adenosylmethionine + uridine(44) in tRNA(Ser) unknown S-Adenosylhomocysteine + 2'-O-methyluridine(44) in tRNA(Ser) details
      Gene Name: TRMT44
      Uniprot ID: Q8IYL2 Link_out
      Protein Sequence: FASTA
      Name: Uncharacterized methyltransferase WBSCR22
      Reactions:
      L-Histidine + S-Adenosylmethionine unknown 3-Methylhistidine + S-Adenosylhomocysteine details
      3-Hydroxyanthranilic acid + S-Adenosylmethionine unknown 3-Methoxyanthranilate + S-Adenosylhomocysteine details
      N-Methyltyramine + S-Adenosylmethionine unknown Hordenine + S-Adenosylhomocysteine details
      Xanthurenic acid + S-Adenosylmethionine unknown 8-Methoxykynurenate + S-Adenosylhomocysteine details
      1-Hydroxypyrene + S-Adenosylmethionine unknown 1-Methoxypyrene + S-Adenosylhomocysteine details
      Gene Name: WBSCR22
      Uniprot ID: O43709 Link_out