Human Metabolome Database Version 3.5

Showing metabocard for S-Adenosylmethionine (HMDB01185)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-05-15 15:01:45 -0600
HMDB ID HMDB01185
Secondary Accession Numbers None
Metabolite Identification
Common Name S-Adenosylmethionine
Description Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed). S-Adenosylmethionine is only found in individuals that have used or taken this drug. It is a physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation. SAMe, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine and other molecules.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  2. 2-S-Adenosyl-L-methionine
  3. 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  4. 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  5. Active methionine
  6. Ademetionine
  7. Adenosylmethionine
  8. AdoMet
  9. Donamet
  10. L-S-Adenosylmethionine
  11. S-(5'-Adenosyl)-L-methionine
  12. S-(5'-Deoxyadenosin-5'-yl)-L-methionine
  13. S-Adenosyl methionine
  14. S-Adenosyl-L-methionine
  15. S-Adenosyl-L-Methionine Disulfate Tosylate
  16. S-Adenosyl-L-Methionine Disulphate Tosylate
  17. S-Adenosyl-methionine
  18. S-Adenosylmethionine
Chemical Formula C15H23N6O5S
Average Molecular Weight 399.445
Monoisotopic Molecular Weight 399.145063566
IUPAC Name [(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium
Traditional IUPAC Name SAMe
CAS Registry Number 29908-03-0
SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12
InChI Identifier InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1
InChI Key MEFKEPWMEQBLKI-AIRLBKTGSA-O
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Amino Acids, Peptides, and Analogues
Class Amino Acids and Derivatives
Sub Class Glycoamino Acids and Derivatives
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
  • Purine Nucleosides and Analogues
Substituents
  • 1,2 Diol
  • Alpha Amino Acid Or Derivative
  • Aminopyrimidine
  • Carboxylic Acid
  • Glycosyl Compound
  • Imidazole
  • Imidazopyrimidine
  • N Glycosyl Compound
  • Oxolane
  • Pentose Monosaccharide
  • Polyamine
  • Primary Aliphatic Amine (Alkylamine)
  • Purine
  • Pyrimidine
  • Saccharide
  • Secondary Alcohol
Direct Parent Glycoamino Acids and Derivatives
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Aminosugars metabolism
  • Component of Arginine and proline metabolism
  • Component of Glycerophospholipid metabolism
  • Component of Glycine, serine and threonine metabolism
  • Component of Histidine metabolism
  • Component of Methionine metabolism
  • Component of Nicotinate and nicotinamide metabolism
  • Component of Selenoamino acid metabolism
  • Component of Tryptophan metabolism
  • Component of Tyrosine metabolism
  • Component of Ubiquinone biosynthesis
Application Not Available
Cellular locations
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point 78 °C Not Available
Water Solubility 1.19e+00 g/l ALOGPS
LogP -5.3 ChemAxon
Predicted Properties
Property Value Source
Water Solubility 1.19 g/L ALOGPS
LogP -1.99 ALOGPS
LogP -5.3 ChemAxon
LogS -2.56 ALOGPS
pKa (strongest acidic) 1.71 ChemAxon
pKa (strongest basic) 9.41 ChemAxon
Hydrogen Acceptor Count 10 ChemAxon
Hydrogen Donor Count 5 ChemAxon
Polar Surface Area 182.63 A2 ChemAxon
Rotatable Bond Count 7 ChemAxon
Refractivity 96.23 ChemAxon
Polarizability 40.37 ChemAxon
Formal Charge 1 ChemAxon
Physiological Charge 1 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Location
  • Muscle
  • Skeletal Muscle
  • Fibroblasts
  • Intestine
  • Placenta
  • Testes
  • Kidney
  • Epidermis
  • Myelin
  • Prostate
  • Gonads
  • Eye Lens
Pathways
Name SMPDB Link KEGG Link
Betaine Metabolism SMP00123 map00260 Link_out
Methionine Metabolism SMP00033 map00270 Link_out
Spermidine and Spermine Biosynthesis SMP00445 Not Available
Carnitine Synthesis SMP00465 Not Available
Catecholamine Biosynthesis SMP00012 map00350 Link_out
Glycine and Serine Metabolism SMP00004 map00260 Link_out
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Cerebrospinal Fluid (CSF) Detected and Quantified
0.25 (0.14 - 0.38) uM Adult (>18 years old) Both Normal
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified 0.11 (0.087-0.17) uM Adult (>18 years old) Both Neurodegenerative diseases
Urine Detected and Quantified 28.4 (25.3-31.6) umol/mmol creatinine Adult (>18 years old) Both Comment Diabetes
Associated Disorders and Diseases
Disease References
Diabetes mellitus type 2
  • Hoppel CL, Genuth SM: Urinary excretion of acetylcarnitine during human diabetic and fasting ketosis. Am J Physiol. 1982 Aug;243(2):E168-72. Pubmed: 6810706 Link_out
      Neurodegenerative disease
      • Obeid R, Kostopoulos P, Knapp JP, Kasoha M, Becker G, Fassbender K, Herrmann W: Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid. Clin Chem. 2007 Feb;53(2):326-33. Epub 2007 Jan 2. Pubmed: 17200133 Link_out
          Associated OMIM IDs
          • 125853 Link_out (Diabetes mellitus type 2)
          DrugBank ID DB00118 Link_out
          DrugBank Metabolite ID Not Available
          Phenol Explorer Compound ID Not Available
          Phenol Explorer Metabolite ID Not Available
          FoodDB ID FDB022473
          KNApSAcK ID Not Available
          Chemspider ID 21169292 Link_out
          KEGG Compound ID C00019 Link_out
          BioCyc ID S-ADENOSYLMETHIONINE Link_out
          BiGG ID 33530 Link_out
          Wikipedia Link S-Adenosylmethionine Link_out
          NuGOwiki Link HMDB01185 Link_out
          Metagene Link HMDB01185 Link_out
          METLIN ID 6064 Link_out
          PubChem Compound 16757548 Link_out
          PDB ID 1CMC Link_out
          ChEBI ID 15414 Link_out
          References
          Synthesis Reference Lin, Jian-Ping; Tian, Jun; You, Jian-Feng; Jin, Zhi-Hua; Xu, Zhi-Nan; Cen, Pei-Lin. An effective strategy for the co-production of S-adenosyl-L-methionine and glutathione by fed-batch fermentation. Biochemical Engineering Journal (2004), 21(1), 19-25.
          Material Safety Data Sheet (MSDS) Download (PDF)
          General References
          1. Chamberlin ME, Ubagai T, Mudd SH, Wilson WG, Leonard JV, Chou JY: Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency. J Clin Invest. 1996 Aug 15;98(4):1021-7. Pubmed: 8770875 Link_out
          2. Koeberl DD, Young SP, Gregersen NS, Vockley J, Smith WE, Benjamin DK Jr, An Y, Weavil SD, Chaing SH, Bali D, McDonald MT, Kishnani PS, Chen YT, Millington DS: Rare disorders of metabolism with elevated butyryl- and isobutyryl-carnitine detected by tandem mass spectrometry newborn screening. Pediatr Res. 2003 Aug;54(2):219-23. Epub 2003 May 7. Pubmed: 12736383 Link_out
          3. Scalabrino G, Pigatto P, Ferioli ME, Modena D, Puerari M, Caru A: Levels of activity of the polyamine biosynthetic decarboxylases as indicators of degree of malignancy of human cutaneous epitheliomas. J Invest Dermatol. 1980 Mar;74(3):122-4. Pubmed: 7359002 Link_out
          4. Struys EA, Jansen EE, de Meer K, Jakobs C: Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry. Clin Chem. 2000 Oct;46(10):1650-6. Pubmed: 11017945 Link_out
          5. Kaneoka H, Uesugi N, Moriguchi A, Hirose S, Takayanagi M, Yamaguchi S, Shigematsu Y, Yasuno T, Sasatomi Y, Saito T: Carnitine palmitoyltransferase II deficiency due to a novel gene variant in a patient with rhabdomyolysis and ARF. Am J Kidney Dis. 2005 Mar;45(3):596-602. Pubmed: 15754283 Link_out
          6. Rosen RT, Hiserodt RD, Fukuda EK, Ruiz RJ, Zhou Z, Lech J, Rosen SL, Hartman TG: The determination of metabolites of garlic preparations in breath and human plasma. Biofactors. 2000;13(1-4):241-9. Pubmed: 11237188 Link_out
          7. McFadden PN, Horwitz J, Clarke S: Protein carboxyl methyltransferase from cow eye lens. Biochem Biophys Res Commun. 1983 Jun 15;113(2):418-24. Pubmed: 6870865 Link_out
          8. Garibotto G, Sofia A, Valli A, Tarroni A, Di Martino M, Cappelli V, Aloisi F, Procopio V: Causes of hyperhomocysteinemia in patients with chronic kidney diseases. Semin Nephrol. 2006 Jan;26(1):3-7. Pubmed: 16412817 Link_out
          9. Spiekerkoetter U, Tokunaga C, Wendel U, Mayatepek E, Ijlst L, Vaz FM, van Vlies N, Overmars H, Duran M, Wijburg FA, Wanders RJ, Strauss AW: Tissue carnitine homeostasis in very-long-chain acyl-CoA dehydrogenase-deficient mice. Pediatr Res. 2005 Jun;57(6):760-4. Epub 2005 Mar 17. Pubmed: 15774826 Link_out
          10. Jones MG, Goodwin CS, Amjad S, Chalmers RA: Plasma and urinary carnitine and acylcarnitines in chronic fatigue syndrome. Clin Chim Acta. 2005 Oct;360(1-2):173-7. Pubmed: 15967423 Link_out
          11. Kelm A, Shaw L, Schauer R, Reuter G: The biosynthesis of 8-O-methylated sialic acids in the starfish Asterias rubens--isolation and characterisation of S-adenosyl-L-methionine:sialate-8-O-methyltransferase. Eur J Biochem. 1998 Feb 1;251(3):874-84. Pubmed: 9490063 Link_out
          12. Solano AR, Sanchez ML, Podesta EJ, Turyn D, Dellacha JM: Membrane methylation in isolated rat testis interstitial cells unmasks functional luteinizing hormone receptors. Biochim Biophys Acta. 1987 Apr 2;928(1):107-13. Pubmed: 3828399 Link_out
          13. D'Erme M, Santoro R, Allegra P, Reale A, Marenzi S, Strom R, Caiafa P: Inhibition of CpG methylation in linker DNA by H1 histone. Biochim Biophys Acta. 1993 May 28;1173(2):209-16. Pubmed: 8504169 Link_out
          14. Hoppel CL, Genuth SM: Urinary excretion of acetylcarnitine during human diabetic and fasting ketosis. Am J Physiol. 1982 Aug;243(2):E168-72. Pubmed: 6810706 Link_out
          15. Scott JM, Weir DG: The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia. Lancet. 1981 Aug 15;2(8242):337-40. Pubmed: 6115113 Link_out
          16. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411 Link_out

          Enzymes

          Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 129 enzymes in total.

          Name: Phosphatidylethanolamine N-methyltransferase
          Reactions:
          S-Adenosylmethionine + phosphatidyl-N-methylethanolamine unknown S-Adenosylhomocysteine + phosphatidyl-N-dimethylethanolamine details
          S-Adenosylmethionine + phosphatidyl-N-dimethylethanolamine unknown S-Adenosylhomocysteine + phosphatidylcholine details
          S-Adenosylmethionine + Phosphatidylethanolamine unknown S-Adenosylhomocysteine + phosphatidyl-N-methylethanolamine details
          S-Adenosylmethionine + Phosphatidyl-N-dimethylethanolamine unknown S-Adenosylhomocysteine + Phosphatidylcholine details
          S-Adenosylmethionine + Phosphatidylethanolamine unknown S-Adenosylhomocysteine + Phosphatidyl-N-methylethanolamine details
          Gene Name: PEMT
          Uniprot ID: Q9UBM1 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Acetylserotonin O-methyltransferase
          Reactions:
          S-Adenosylmethionine + N-Acetylserotonin unknown S-Adenosylhomocysteine + Melatonin details
          S-Adenosylmethionine + 5-Hydroxyindoleacetic acid unknown S-Adenosylhomocysteine + 5-Methoxyindoleacetate details
          Gene Name: ASMT
          Uniprot ID: P46597 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Methionine synthase
          Reactions: Not Available
          Gene Name: MTR
          Uniprot ID: Q99707 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Catechol O-methyltransferase
          Reactions:
          S-Adenosylmethionine + a catechol unknown S-Adenosylhomocysteine + a guaiacol details
          S-Adenosylmethionine + Norepinephrine unknown S-Adenosylhomocysteine + Normetanephrine details
          S-Adenosylmethionine + Epinephrine unknown S-Adenosylhomocysteine + Metanephrine details
          S-Adenosylmethionine + 3,4-Dihydroxybenzeneacetic acid unknown S-Adenosylhomocysteine + Homovanillic acid details
          S-Adenosylmethionine + Dopamine unknown S-Adenosylhomocysteine + 3-Methoxytyramine details
          2-Hydroxyestrone + S-Adenosylmethionine unknown 2-Methoxyestrone + S-Adenosylhomocysteine details
          2-Hydroxyestradiol + S-Adenosylmethionine unknown 2-Methoxyestradiol + S-Adenosylhomocysteine details
          S-Adenosylmethionine + 3,4-Dihydroxyphenylglycol unknown S-Adenosylhomocysteine + Vanylglycol details
          S-Adenosylmethionine + 3,4-Dihydroxymandelic acid unknown S-Adenosylhomocysteine + Vanillylmandelic acid details
          Gene Name: COMT
          Uniprot ID: P21964 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Histone-lysine N-methyltransferase, H3 lysine-79 specific
          Reactions:
          S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
          Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
          S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
          S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
          Gene Name: DOT1L
          Uniprot ID: Q8TEK3 Link_out
          Protein Sequence: FASTA
          Name: Glycine N-methyltransferase
          Reactions:
          S-Adenosylmethionine + Glycine unknown S-Adenosylhomocysteine + Sarcosine details
          Gene Name: GNMT
          Uniprot ID: Q14749 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Histone-lysine N-methyltransferase SETD7
          Reactions:
          S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
          Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
          S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
          S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
          Gene Name: SETD7
          Uniprot ID: Q8WTS6 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: S-adenosylmethionine synthase isoform type-2
          Reactions:
          Adenosine triphosphate + L-Methionine + Water unknown Phosphoric acid + Pyrophosphate + S-Adenosylmethionine details
          Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Water details
          Gene Name: MAT2A
          Uniprot ID: P31153 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Phenylethanolamine N-methyltransferase
          Reactions:
          S-Adenosylmethionine + 2-Hydroxyphenethylamine unknown S-Adenosylhomocysteine + N-Methylphenylethanolamine details
          S-Adenosylmethionine + Norepinephrine unknown S-Adenosylhomocysteine + Epinephrine details
          Gene Name: PNMT
          Uniprot ID: P11086 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Diphthine synthase
          Reactions:
          S-Adenosylmethionine + 2-(3-Carboxy-3-aminopropyl)-L-histidine unknown S-Adenosylhomocysteine + 2-(3-carboxy-3-(trimethylammonio)propyl)-L-histidine details
          Gene Name: DPH5
          Uniprot ID: Q9H2P9 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Arsenite methyltransferase
          Reactions:
          S-Adenosylmethionine + Arsenite unknown S-Adenosylhomocysteine + Methylarsonate details
          S-Adenosylmethionine + Methylarsonite unknown S-Adenosylhomocysteine + Dimethylarsinate details
          Gene Name: AS3MT
          Uniprot ID: Q9HBK9 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Mitochondrial tRNA-specific 2-thiouridylase 1
          Reactions: Not Available
          Gene Name: TRMU
          Uniprot ID: O75648 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
          Reactions:
          S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
          Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
          S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
          S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
          Gene Name: NSD1
          Uniprot ID: Q96L73 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Histone-lysine N-methyltransferase SETDB1
          Reactions:
          S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
          Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
          S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
          S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
          Gene Name: SETDB1
          Uniprot ID: Q15047 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Protein-L-isoaspartate(D-aspartate) O-methyltransferase
          Reactions:
          S-Adenosylmethionine + protein L-isoaspartate unknown S-Adenosylhomocysteine + protein L-isoaspartate alpha-methyl ester details
          Gene Name: PCMT1
          Uniprot ID: P22061 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Protein-S-isoprenylcysteine O-methyltransferase
          Reactions:
          S-Adenosylmethionine + protein C-terminal S-farnesyl-L-cysteine unknown S-Adenosylhomocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester details
          Gene Name: ICMT
          Uniprot ID: O60725 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Indolethylamine N-methyltransferase
          Reactions:
          S-Adenosylmethionine + an amine unknown S-Adenosylhomocysteine + a methylated amine details
          S-Adenosylmethionine + Dimethylsulfide unknown S-Adenosylhomocysteine + Trimethyl sulfonium details
          S-Adenosylmethionine + Tryptamine unknown S-Adenosylhomocysteine + N-Methyltryptamine details
          S-Adenosylmethionine + Serotonin unknown S-Adenosylhomocysteine + N-Methylserotonin details
          S-Adenosylmethionine + Dimethyl selenide unknown S-Adenosylhomocysteine + Trimethylselenonium details
          Gene Name: INMT
          Uniprot ID: O95050 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: DNA (cytosine-5)-methyltransferase 3A
          Reactions:
          S-Adenosylmethionine + DNA unknown S-Adenosylhomocysteine + DNA containing 5-methylcytosine details
          S-Adenosylmethionine + DNA cytosine unknown S-Adenosylhomocysteine + DNA 5-methylcytosine details
          Gene Name: DNMT3A
          Uniprot ID: Q9Y6K1 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial
          Reactions:
          S-Adenosylmethionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate unknown S-Adenosylhomocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate details
          S-Adenosylmethionine + 3-demethylubiquinone-n unknown S-Adenosylhomocysteine + ubiquinone-n details
          S-Adenosylmethionine + 3-(all-trans-polyprenyl)benzene-1,2-diol unknown S-Adenosylhomocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol details
          2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine unknown Ubiquinone 6 + S-Adenosylhomocysteine details
          S-Adenosylmethionine + 3-Hexaprenyl-4,5-Dihydroxybenzoic acid unknown S-Adenosylhomocysteine + 3-Hexaprenyl-4-hydroxy-5-methoxybenzoic acid + Hydrogen Ion details
          S-Adenosylmethionine + 3-Demethylubiquinone-9 unknown S-Adenosylhomocysteine + Coenzyme Q9 details
          3-Polyprenyl-4,5-dihydroxybenzoate + S-Adenosylmethionine unknown 3-Polyprenyl-4-hydroxy-5-methoxybenzoate + S-Adenosylhomocysteine details
          2-Polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine unknown Ubiquinone-2 + S-Adenosylhomocysteine details
          Gene Name: COQ3
          Uniprot ID: Q9NZJ6 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: S-adenosylmethionine synthase isoform type-1
          Reactions:
          Adenosine triphosphate + L-Methionine + Water unknown Phosphoric acid + Pyrophosphate + S-Adenosylmethionine details
          Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Water details
          Gene Name: MAT1A
          Uniprot ID: Q00266 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Histone-lysine N-methyltransferase EHMT2
          Reactions:
          S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
          Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
          S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
          S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
          Gene Name: EHMT2
          Uniprot ID: Q96KQ7 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: S-adenosylmethionine decarboxylase proenzyme
          Reactions:
          S-Adenosylmethionine unknown (5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO(2) details
          S-Adenosylmethionine + Hydrogen Ion unknown S-Adenosylmethioninamine + Carbon dioxide details
          Gene Name: AMD1
          Uniprot ID: P17707 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Methionine synthase reductase
          Reactions:
          [methionine synthase]-methylcob(I)alamin + S-Adenosylhomocysteine + NADP unknown [methionine synthase]-cob(II)alamin + NADPH + S-Adenosylmethionine details
          Gene Name: MTRR
          Uniprot ID: Q9UBK8 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Histone-lysine N-methyltransferase SUV39H1
          Reactions:
          S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
          Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
          S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
          S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
          Gene Name: SUV39H1
          Uniprot ID: O43463 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Nicotinamide N-methyltransferase
          Reactions:
          S-Adenosylmethionine + Niacinamide unknown S-Adenosylhomocysteine + 1-Methylnicotinamide details
          S-Adenosylmethionine + Niacinamide + Hydrogen Ion unknown S-Adenosylhomocysteine + 1-Methylnicotinamide details
          Gene Name: NNMT
          Uniprot ID: P40261 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Histone-lysine N-methyltransferase SUV39H2
          Reactions:
          S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
          Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
          S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
          S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
          Gene Name: SUV39H2
          Uniprot ID: Q9H5I1 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Histone-lysine N-methyltransferase EHMT1
          Reactions:
          S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
          Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
          S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
          S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
          Gene Name: EHMT1
          Uniprot ID: Q9H9B1 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Guanidinoacetate N-methyltransferase
          Reactions:
          S-Adenosylmethionine + Guanidoacetic acid unknown S-Adenosylhomocysteine + Creatine details
          Gene Name: GAMT
          Uniprot ID: Q14353 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Histamine N-methyltransferase
          Reactions:
          S-Adenosylmethionine + Histamine unknown S-Adenosylhomocysteine + 1-Methylhistamine details
          Gene Name: HNMT
          Uniprot ID: P50135 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Thiopurine S-methyltransferase
          Reactions:
          S-Adenosylmethionine + a thiopurine unknown S-Adenosylhomocysteine + a thiopurine S-methylether details
          Mercaptopurine + S-Adenosylmethionine unknown 6-Methylmercaptopurine + S-Adenosylhomocysteine details
          6-Thioinosine-5'-monophosphate + S-Adenosylmethionine unknown 6-Methylthiopurine 5'-monophosphate ribonucleotide + S-Adenosylhomocysteine details
          6-Thioguanosine monophosphate + S-Adenosylmethionine unknown 6-Methylthioguanosine monophosphate + S-Adenosylhomocysteine details
          Gene Name: TPMT
          Uniprot ID: P51580 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: N6-adenosine-methyltransferase 70 kDa subunit
          Reactions:
          S-Adenosylmethionine + m(7)G(5')pppAm unknown S-Adenosylhomocysteine + m(7)G(5')pppm(6)Am details
          Gene Name: METTL3
          Uniprot ID: Q86U44 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Putative adenosylhomocysteinase 3
          Reactions: Not Available
          Gene Name: AHCYL2
          Uniprot ID: Q96HN2 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Adenosylhomocysteinase
          Reactions: Not Available
          Gene Name: AHCY
          Uniprot ID: P23526 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Putative adenosylhomocysteinase 2
          Reactions: Not Available
          Gene Name: AHCYL1
          Uniprot ID: O43865 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cystathionine beta-synthase
          Reactions: Not Available
          Gene Name: CBS
          Uniprot ID: P35520 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Lipoyl synthase, mitochondrial
          Reactions:
          Protein N(6)-(octanoyl)lysine + Hydrogen sulfide + S-Adenosylmethionine unknown protein N(6)-(lipoyl)lysine + L-Methionine + 5'-Deoxyadenosine details
          Protein N6-(octanoyl)lysine + Sulfur donor + S-Adenosylmethionine unknown Protein N6-(lipoyl)lysine + L-Methionine + 5'-Deoxyadenosine details
          Octanoyl-[acp] + Sulfur donor + S-Adenosylmethionine unknown Lipoyl-[acp] + L-Methionine + 5'-Deoxyadenosine details
          Gene Name: LIAS
          Uniprot ID: O43766 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Protein arginine N-methyltransferase 5
          Reactions:
          S-Adenosylmethionine + arginine-[histone] unknown S-Adenosylhomocysteine + N(omega)-methyl-arginine-[histone] details
          Gene Name: PRMT5
          Uniprot ID: O14744 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Histone-lysine N-methyltransferase SETD1A
          Reactions:
          S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
          Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
          S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
          S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
          Gene Name: SETD1A
          Uniprot ID: O15047 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: rRNA 2'-O-methyltransferase fibrillarin
          Reactions: Not Available
          Gene Name: FBL
          Uniprot ID: P22087 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: PR domain zinc finger protein 2
          Reactions:
          S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
          Gene Name: PRDM2
          Uniprot ID: Q13029 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Histone-lysine N-methyltransferase MLL
          Reactions:
          S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
          Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
          S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
          S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
          Gene Name: MLL
          Uniprot ID: Q03164 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Molybdenum cofactor biosynthesis protein 1
          Reactions: Not Available
          Gene Name: MOCS1
          Uniprot ID: Q9NZB8 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: DNA (cytosine-5)-methyltransferase 3B
          Reactions:
          S-Adenosylmethionine + DNA unknown S-Adenosylhomocysteine + DNA containing 5-methylcytosine details
          S-Adenosylmethionine + DNA cytosine unknown S-Adenosylhomocysteine + DNA 5-methylcytosine details
          Gene Name: DNMT3B
          Uniprot ID: Q9UBC3 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: tRNA (cytosine(38)-C(5))-methyltransferase
          Reactions:
          S-Adenosylmethionine + cytosine(38) in tRNA unknown S-Adenosylhomocysteine + 5-methylcytosine(38) in tRNA details
          Gene Name: TRDMT1
          Uniprot ID: O14717 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: N-lysine methyltransferase SETD8
          Reactions:
          S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
          Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
          S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
          S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
          Gene Name: SETD8
          Uniprot ID: Q9NQR1 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Histone-lysine N-methyltransferase MLL3
          Reactions:
          S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
          Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
          S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
          S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
          Gene Name: MLL3
          Uniprot ID: Q8NEZ4 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Methionine adenosyltransferase 2 subunit beta
          Reactions:
          Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Water details
          Gene Name: MAT2B
          Uniprot ID: Q9NZL9 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: DNA (cytosine-5)-methyltransferase 1
          Reactions:
          S-Adenosylmethionine + DNA unknown S-Adenosylhomocysteine + DNA containing 5-methylcytosine details
          S-Adenosylmethionine + DNA cytosine unknown S-Adenosylhomocysteine + DNA 5-methylcytosine details
          Gene Name: DNMT1
          Uniprot ID: P26358 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Histone-lysine N-methyltransferase SETDB2
          Reactions:
          S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone] details
          Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteine details
          S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine details
          S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine details
          Gene Name: SETDB2
          Uniprot ID: Q96T68 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: S-adenosylmethionine mitochondrial carrier protein
          Reactions: Not Available
          Gene Name: SLC25A26
          Uniprot ID: Q70HW3 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA