You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.
Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2016-02-11 01:04:06 UTC
HMDB IDHMDB01250
Secondary Accession NumbersNone
Metabolite Identification
Common NameN-Acetylarylamine
DescriptionN-Acetylarylamine is an odourless solid chemical of leaf or flake-like appearance. It is also known as acetanilide, N-phenylacetamide, acetanil, or acetanilid, and was formerly known by the trade name Antifebrin. N-Acetylarylamine has analgesic and fever-reducing properties; it is in the same class of drugs as acetaminophen (paracetamol). Under the name acetanilid it formerly figured in the formula of a number of patent medicines and over the counter drugs. In 1948, Julius Axelrod and Bernard Brodie discovered that acetanilide is much more toxic in these applications than other drugs, causing methemoglobinemia and ultimately doing damage to the liver and kidneys. As such, acetanilide has largely been replaced by less toxic drugs, in particular acetaminophen, which is a metabolite of acetanilide and whose use Axelrod and Brodie suggested in the same study.
Structure
Thumb
Synonyms
ValueSource
AcetamidobenzeneChEBI
AcetanilChEBI
AcetanilidChEBI
AcetanilideChEBI
Acetic acid anilideChEBI
N-AcetylaminobenzeneChEBI
N-AcetylarylamineChEBI
Acetate anilideGenerator
AntifebrinHMDB
Chemical FormulaC8H9NO
Average Molecular Weight135.1632
Monoisotopic Molecular Weight135.068413915
IUPAC NameN-phenylacetamide
Traditional Nameacetanilide
CAS Registry Number55576-55-1
SMILES
CC(=O)NC1=CC=CC=C1
InChI Identifier
InChI=1S/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)
InChI KeyInChIKey=FZERHIULMFGESH-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as acetanilides. These are organic compounds containing an acetamide group conjugated to a phenyl group.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassAnilides
Direct ParentAcetanilides
Alternative Parents
Substituents
  • N-arylamide
  • Acetanilide
  • Acetamide
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
StatusExpected but not Quantified
Origin
  • Endogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Membrane
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility6.39 mg/mL at 25 °CNot Available
LogP1.16HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility4.03 mg/mLALOGPS
logP1.05ALOGPS
logP1.21ChemAxon
logS-1.5ALOGPS
pKa (Strongest Acidic)14.38ChemAxon
pKa (Strongest Basic)-4.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area29.1 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity40.92 m3·mol-1ChemAxon
Polarizability14.52 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular Locations
  • Membrane
Biofluid LocationsNot Available
Tissue LocationNot Available
PathwaysNot Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB022512
KNApSAcK IDNot Available
Chemspider ID880
KEGG Compound IDC07565
BioCyc IDN-ACETYLARYLAMINE
BiGG IDNot Available
Wikipedia LinkNot Available
NuGOwiki LinkHMDB01250
Metagene LinkHMDB01250
METLIN ID6107
PubChem Compound904
PDB IDNot Available
ChEBI ID28884
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Ogino M, Nakada Y, Negoro N, Itokawa S, Nishimura S, Sanada T, Satomi T, Kita S, Kubo K, Marui S: Discovery of a novel acyl-CoA: cholesterol acyltransferase inhibitor: the synthesis, biological evaluation, and reduced adrenal toxicity of (4-phenylcoumarin)acetanilide derivatives with a carboxylic acid moiety. Chem Pharm Bull (Tokyo). 2011;59(11):1369-75. [22041073 ]
  2. Poraj-Kobielska M, Kinne M, Ullrich R, Scheibner K, Kayser G, Hammel KE, Hofrichter M: Preparation of human drug metabolites using fungal peroxygenases. Biochem Pharmacol. 2011 Oct 1;82(7):789-96. doi: 10.1016/j.bcp.2011.06.020. Epub 2011 Jun 23. [21723855 ]
  3. Wu Y, Choy PY, Mao F, Kwong FY: Toluene derivatives as simple coupling precursors for cascade palladium-catalyzed oxidative C-H bond acylation of acetanilides. Chem Commun (Camb). 2013 Jan 25;49(7):689-91. doi: 10.1039/c2cc37352a. [23230572 ]
  4. Yan GF, Wang Q, Wei BL, Sun XC, Chen GQ, Gao SM: [Photophysical properties of novel organic europium (III) complexes]. Guang Pu Xue Yu Guang Pu Fen Xi. 2010 Oct;30(10):2606-10. [21137382 ]
  5. Chen CZ, Yan CT, Kumar PV, Huang JW, Jen JF: Determination of alachlor and its metabolite 2,6-diethylaniline in microbial culture medium using online microdialysis enriched-sampling coupled to high-performance liquid chromatography. J Agric Food Chem. 2011 Aug 10;59(15):8078-85. doi: 10.1021/jf201129j. Epub 2011 Jul 11. [21707080 ]
  6. Liang HQ, Tao YP, Han LG, Han YX, Mo YJ: [Raman, FTIR spectra and normal mode analysis of acetanilide]. Guang Pu Xue Yu Guang Pu Fen Xi. 2012 Oct;32(10):2706-9. [23285870 ]
  7. Sun L, Zhang S, Song Q: (4-Chloro-acetanilido-kappa(2)N,O)bis-[2-(pyridin-2-yl)phenyl-kappa(2)C(1),N]irid ium(III). Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 1;69(Pt 2):m98. doi: 10.1107/S1600536813000433. Epub 2013 Jan 12. [23424440 ]
  8. Bouchonnet S, Bourcier S, Souissi Y, Genty C, Sablier M, Roche P, Boireau V, Ingrand V: GC-MS(n) and LC-MS/MS couplings for the identification of degradation products resulting from the ozonation treatment of Acetochlor. J Mass Spectrom. 2012 Apr;47(4):439-52. doi: 10.1002/jms.2056. [22689619 ]
  9. Kalkhoff SJ, Vecchia AV, Capel PD, Meyer MT: Eleven-year trend in acetanilide pesticide degradates in the Iowa River, Iowa. J Environ Qual. 2012 Sep-Oct;41(5):1566-79. doi: 10.2134/jeq2011.0426. [23099949 ]
  10. Weiler M, Nakamura T, Sekiya H, Dopfer O, Miyazaki M, Fujii M: Ionization-induced solvent migration in acetanilide-methanol clusters inferred from isomer-selective infrared spectroscopy. Chemphyschem. 2012 Dec 7;13(17):3875-81. doi: 10.1002/cphc.201200704. Epub 2012 Oct 30. [23112069 ]
  11. Fu YY, Yang CX, Yan XP: Metal-organic framework MIL-100(Fe) as the stationary phase for both normal-phase and reverse-phase high performance liquid chromatography. J Chromatogr A. 2013 Jan 25;1274:137-44. doi: 10.1016/j.chroma.2012.12.015. Epub 2012 Dec 17. [23290359 ]
  12. Ogino M, Fukui S, Nakada Y, Tokunoh R, Itokawa S, Kakoi Y, Nishimura S, Sanada T, Fuse H, Kubo K, Wada T, Marui S: Discovery of a potent and orally available acyl-CoA: cholesterol acyltransferase inhibitor as an anti-atherosclerotic agent: (4-phenylcoumarin)acetanilide derivatives. Chem Pharm Bull (Tokyo). 2011;59(10):1268-73. [21963637 ]
  13. Lu C, Markina NA, Larock RC: Synthesis of N-acylcarbazoles through palladium-catalyzed aryne annulation of 2-haloacetanilides. J Org Chem. 2012 Dec 21;77(24):11153-60. doi: 10.1021/jo3021727. Epub 2012 Dec 5. [23214463 ]

Enzymes

General function:
Involved in acetyltransferase activity
Specific function:
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Gene Name:
NAT1
Uniprot ID:
P18440
Molecular weight:
33898.445
General function:
Involved in acetyltransferase activity
Specific function:
Not Available
Gene Name:
NAT2
Uniprot ID:
A4Z6T7
Molecular weight:
33570.2