Human Metabolome Database Version 3.5

Showing metabocard for Guanosine triphosphate (HMDB01273)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:10:13 -0700
HMDB ID HMDB01273
Secondary Accession Numbers None
Metabolite Identification
Common Name Guanosine triphosphate
Description Guanosine triphosphate (GTP) is a guanine nucleotide containing three phosphate groups esterified to the sugar moiety. GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. 5'-GTP
  2. GTG
  3. GTP
  4. Guanosine 5'-(tetrahydrogen triphosphate)
  5. Guanosine 5'-triphosphate
  6. Guanosine 5'-triphosphorate
  7. Guanosine 5'-triphosphoric acid
  8. Guanosine mono(tetrahydrogen triphosphate) (ester)
  9. Guanosine Triphosphate
  10. H4gtp
Chemical Formula C10H16N5O14P3
Average Molecular Weight 523.1804
Monoisotopic Molecular Weight 522.990659781
IUPAC Name ({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
Traditional IUPAC Name ({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxyphosphonic acid
CAS Registry Number 86-01-1
SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
InChI Identifier InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChI Key XKMLYUALXHKNFT-UUOKFMHZSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Nucleosides, Nucleotides, and Analogues
Class Purine Nucleotides
Sub Class Purine Ribonucleotides
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
  • Ribonucleotides(KEGG)
  • guanosine 5'-phosphate(ChEBI)
  • purine ribonucleoside 5'-triphosphate(ChEBI)
Substituents
  • 1,2 Diol
  • 1 Phosphoribosyl Imidazole
  • Aminopyrimidine
  • Glycosyl Compound
  • Hypoxanthine
  • Imidazole
  • Imidazopyrimidine
  • Monosaccharide Phosphate
  • N Glycosyl Compound
  • Organic Hypophosphite
  • Organic Phosphite
  • Organic Pyrophosphate
  • Oxolane
  • Pentose Monosaccharide
  • Phosphoric Acid Ester
  • Purine
  • Purinone
  • Pyrimidine
  • Pyrimidone
  • Saccharide
  • Secondary Alcohol
Direct Parent Purine Ribonucleoside Triphosphates
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Folate biosynthesis
  • Component of Pyruvate metabolism
Application Not Available
Cellular locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility 10.4 g/L ALOGPS
LogP -0.63 ALOGPS
LogP -3.6 ChemAxon
LogS -1.70 ALOGPS
pKa (strongest acidic) 0.8 ChemAxon
pKa (strongest basic) 1.57 ChemAxon
Hydrogen Acceptor Count 14 ChemAxon
Hydrogen Donor Count 8 ChemAxon
Polar Surface Area 294.81 A2 ChemAxon
Rotatable Bond Count 8 ChemAxon
Refractivity 97.24 ChemAxon
Polarizability 39.81 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -3 ChemAxon
Spectra
1H NMR Spectrum
MS/MS Spectrum Quattro_QQQ 10
MS/MS Spectrum Quattro_QQQ 25
MS/MS Spectrum Quattro_QQQ 40
[1H,13C] 2D NMR Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
Tissue Location
  • Neuron
  • Placenta
  • Testes
  • Platelet
Pathways
Name SMPDB Link KEGG Link
Citric Acid Cycle SMP00057 map00020 Link_out
Gluconeogenesis SMP00128 map00010 Link_out
Pterine Biosynthesis SMP00005 map00790 Link_out
Transcription/Translation SMP00019 Not Available
Purine Metabolism SMP00050 map00230 Link_out
DNA Replication Fork SMP00477 Not Available
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
56.0 +/- 7.0 uM Adult (>18 years old) Male Normal
  • Geigy Scient...
Cerebrospinal Fluid (CSF) Detected and Quantified
1.83 +/- 0.032 uM Adult (>18 years old) Both Normal
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Cerebrospinal Fluid (CSF) Detected and Quantified 1.59 +/- 1.42 uM Adult (>18 years old) Both Rachialgia
Cerebrospinal Fluid (CSF) Detected and Quantified 2.80 +/- 1.80 uM Adult (>18 years old) Both Subarachnoid hemorrhage
Cerebrospinal Fluid (CSF) Detected and Quantified 2.08 +/- 1.91 uM Adult (>18 years old) Both Epilepsy
Cerebrospinal Fluid (CSF) Detected and Quantified 1.30 +/- 1.23 uM Adult (>18 years old) Both Comment Stroke
Cerebrospinal Fluid (CSF) Detected and Quantified 1.92 +/- 1.53 uM Adult (>18 years old) Both Neuroinfection
Associated Disorders and Diseases
Disease References
Rachialgia
  • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
      Subarachnoid hemorrhage
      • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
          Epilepsy
          • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
              Stroke
              • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
                  Neuroinfection
                  • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
                      Associated OMIM IDs
                      DrugBank ID Not Available
                      DrugBank Metabolite ID Not Available
                      Phenol Explorer Compound ID Not Available
                      Phenol Explorer Metabolite ID Not Available
                      FoodDB ID FDB022527
                      KNApSAcK ID Not Available
                      Chemspider ID 6569 Link_out
                      KEGG Compound ID C00044 Link_out
                      BioCyc ID GTP Link_out
                      BiGG ID 33641 Link_out
                      Wikipedia Link Guanosine triphosphate Link_out
                      NuGOwiki Link HMDB01273 Link_out
                      Metagene Link HMDB01273 Link_out
                      METLIN ID 6128 Link_out
                      PubChem Compound 6830 Link_out
                      PDB ID GTP Link_out
                      ChEBI ID 15996 Link_out
                      References
                      Synthesis Reference Stiller, Regine; Thiem, Joachim. Preparative enzymatic conversion of guanosine-5'-monophosphate to guanosine-5'-triphosphate. Synlett (1990), (11), 709-10.
                      Material Safety Data Sheet (MSDS) Download (PDF)
                      General References
                      1. Lester HA, Steer ML, Levitzki A: Prostaglandin-stimulated GTP hydrolysis associated with activation of adenylate cyclase in human platelet membranes. Proc Natl Acad Sci U S A. 1982 Feb;79(3):719-23. Pubmed: 6121325 Link_out
                      2. Naylor EW, Ennis D, Davidson AG, Wong LT, Applegarth DA, Niederwieser A: Guanosine triphosphate cyclohydrolase I deficiency: early diagnosis by routine urine pteridine screening. Pediatrics. 1987 Mar;79(3):374-8. Pubmed: 3822637 Link_out
                      3. Iwanaga N, Yamamasu S, Tachibana D, Nishio J, Nakai Y, Shintaku H, Ishiko O: Activity of synthetic enzymes of tetrahydrobiopterin in the human placenta. Int J Mol Med. 2004 Jan;13(1):117-20. Pubmed: 14654981 Link_out
                      4. Chantin C, Bonin B, Boulieu R, Bory C: Liquid-chromatographic study of purine metabolism abnormalities in purine nucleoside phosphorylase deficiency. Clin Chem. 1996 Feb;42(2):326-8. Pubmed: 8595732 Link_out
                      5. Reichert LE Jr, Dattatreyamurty B: The follicle-stimulating hormone (FSH) receptor in testis: interaction with FSH, mechanism of signal transduction, and properties of the purified receptor. Biol Reprod. 1989 Jan;40(1):13-26. Pubmed: 2493820 Link_out
                      6. Schmidt VA, Scudder L, Devoe CE, Bernards A, Cupit LD, Bahou WF: IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization. Blood. 2003 Apr 15;101(8):3021-8. Epub 2002 Dec 19. Pubmed: 12515716 Link_out
                      7. Chen Q, He Y, Yang K: Gene therapy for Parkinson's disease: progress and challenges. Curr Gene Ther. 2005 Feb;5(1):71-80. Pubmed: 15638712 Link_out

                      Enzymes

                      Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 569 enzymes in total.

                      Name: Phospholipase D1
                      Reactions: Not Available
                      Gene Name: PLD1
                      Uniprot ID: Q13393 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Ectonucleoside triphosphate diphosphohydrolase 1
                      Reactions:
                      Guanosine triphosphate + Water unknown Guanosine diphosphate + Phosphoric acid details
                      Gene Name: ENTPD1
                      Uniprot ID: P49961 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Soluble calcium-activated nucleotidase 1
                      Reactions: Not Available
                      Gene Name: CANT1
                      Uniprot ID: Q8WVQ1 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Ectonucleoside triphosphate diphosphohydrolase 3
                      Reactions:
                      Guanosine triphosphate + Water unknown Guanosine diphosphate + Phosphoric acid details
                      Gene Name: ENTPD3
                      Uniprot ID: O75355 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Uridine-cytidine kinase 1
                      Reactions:
                      Guanosine triphosphate + Cytidine unknown Guanosine diphosphate + Cytidine monophosphate details
                      Guanosine triphosphate + Uridine unknown Guanosine diphosphate + Uridine 5'-monophosphate details
                      Gene Name: UCK1
                      Uniprot ID: Q9HA47 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase, mitochondrial
                      Reactions:
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Gene Name: NME4
                      Uniprot ID: O00746 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase A
                      Reactions:
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Gene Name: NME1
                      Uniprot ID: P15531 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase 7
                      Reactions:
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Gene Name: NME7
                      Uniprot ID: Q9Y5B8 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase B
                      Reactions:
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Gene Name: NME2
                      Uniprot ID: P22392 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase 3
                      Reactions:
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Gene Name: NME3
                      Uniprot ID: Q13232 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase 6
                      Reactions:
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Gene Name: NME6
                      Uniprot ID: O75414 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
                      Reactions: Not Available
                      Gene Name: ENPP1
                      Uniprot ID: P22413 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Fucose-1-phosphate guanylyltransferase
                      Reactions:
                      Guanosine triphosphate + Fucose 1-phosphate unknown Pyrophosphate + GDP-L-fucose details
                      Gene Name: FPGT
                      Uniprot ID: O14772 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Inosine triphosphate pyrophosphatase
                      Reactions:
                      Guanosine triphosphate + Water unknown Guanosine monophosphate + Pyrophosphate details
                      Gene Name: ITPA
                      Uniprot ID: Q9BY32 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: GMP synthase [glutamine-hydrolyzing]
                      Reactions: Not Available
                      Gene Name: GMPS
                      Uniprot ID: P49915 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
                      Reactions:
                      P(1),P(4)-bis(5'-guanosyl) tetraphosphate + Water unknown Guanosine triphosphate + Guanosine monophosphate details
                      Diguanosine tetraphosphate + Water unknown Guanosine triphosphate + Guanosine monophosphate details
                      Gene Name: NUDT2
                      Uniprot ID: P50583 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylate kinase isoenzyme 5
                      Reactions: Not Available
                      Gene Name: AK5
                      Uniprot ID: Q9Y6K8 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: CTP synthase 1
                      Reactions: Not Available
                      Gene Name: CTPS1
                      Uniprot ID: P17812 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Glutamate dehydrogenase 1, mitochondrial
                      Reactions: Not Available
                      Gene Name: GLUD1
                      Uniprot ID: P00367 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylate cyclase type 7
                      Reactions:
                      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
                      Gene Name: ADCY7
                      Uniprot ID: P51828 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylate cyclase type 4
                      Reactions:
                      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
                      Gene Name: ADCY4
                      Uniprot ID: Q8NFM4 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylate cyclase type 6
                      Reactions:
                      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
                      Gene Name: ADCY6
                      Uniprot ID: O43306 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylate cyclase type 5
                      Reactions:
                      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
                      Gene Name: ADCY5
                      Uniprot ID: O95622 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylate cyclase type 8
                      Reactions:
                      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
                      Gene Name: ADCY8
                      Uniprot ID: P40145 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylate cyclase type 9
                      Reactions:
                      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
                      Gene Name: ADCY9
                      Uniprot ID: O60503 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylate cyclase type 3
                      Reactions:
                      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
                      Gene Name: ADCY3
                      Uniprot ID: O60266 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylate cyclase type 1
                      Reactions:
                      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
                      Gene Name: ADCY1
                      Uniprot ID: Q08828 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: DNA-directed RNA polymerase III subunit RPC4
                      Reactions:
                      Guanosine triphosphate + RNA unknown Pyrophosphate + RNA details
                      Gene Name: POLR3D
                      Uniprot ID: P05423 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: DNA-directed RNA polymerase II subunit RPB2
                      Reactions:
                      Guanosine triphosphate + RNA unknown Pyrophosphate + RNA details
                      Gene Name: POLR2B
                      Uniprot ID: P30876 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: DNA-directed RNA polymerase II subunit RPB1
                      Reactions:
                      Guanosine triphosphate + RNA unknown Pyrophosphate + RNA details
                      Gene Name: POLR2A
                      Uniprot ID: P24928 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: DNA-directed RNA polymerase, mitochondrial
                      Reactions: Not Available
                      Gene Name: POLRMT
                      Uniprot ID: O00411 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: DNA-directed RNA polymerase I subunit RPA2
                      Reactions:
                      Guanosine triphosphate + RNA unknown Pyrophosphate + RNA details
                      Gene Name: POLR1B
                      Uniprot ID: Q9H9Y6 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: DNA-directed RNA polymerase III subunit RPC7
                      Reactions:
                      Guanosine triphosphate + RNA unknown Pyrophosphate + RNA details
                      Gene Name: POLR3G
                      Uniprot ID: O15318 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: DNA-directed RNA polymerase III subunit RPC2
                      Reactions:
                      Guanosine triphosphate + RNA unknown Pyrophosphate + RNA details
                      Gene Name: POLR3B
                      Uniprot ID: Q9NW08 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: DNA-directed RNA polymerase I subunit RPA49
                      Reactions:
                      Guanosine triphosphate + RNA unknown Pyrophosphate + RNA details
                      Gene Name: POLR1E
                      Uniprot ID: Q9GZS1 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: DNA-directed RNA polymerase III subunit RPC8
                      Reactions:
                      Guanosine triphosphate + RNA unknown Pyrophosphate + RNA details
                      Gene Name: POLR3H
                      Uniprot ID: Q9Y535 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: DNA-directed RNA polymerase III subunit RPC10
                      Reactions:
                      Guanosine triphosphate + RNA unknown Pyrophosphate + RNA details
                      Gene Name: POLR3K
                      Uniprot ID: Q9Y2Y1 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Pyruvate kinase isozymes M1/M2
                      Reactions:
                      Guanosine triphosphate + Pyruvic acid unknown Guanosine diphosphate + Phosphoenolpyruvic acid details
                      Gene Name: PKM
                      Uniprot ID: P14618 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Pyruvate kinase isozymes R/L
                      Reactions:
                      Guanosine triphosphate + Pyruvic acid unknown Guanosine diphosphate + Phosphoenolpyruvic acid details
                      Gene Name: PKLR
                      Uniprot ID: P30613 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Ectonucleoside triphosphate diphosphohydrolase 4
                      Reactions: Not Available
                      Gene Name: ENTPD4
                      Uniprot ID: Q9Y227 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylosuccinate synthetase isozyme 2
                      Reactions:
                      Guanosine triphosphate + Inosinic acid + L-Aspartic acid unknown Guanosine diphosphate + Phosphoric acid + Adenylsuccinic acid details
                      Guanosine triphosphate + Inosinic acid + L-Aspartic acid unknown Guanosine diphosphate + Phosphoric acid + N(6)-(1,2-dicarboxyethyl)AMP details
                      Gene Name: ADSS
                      Uniprot ID: P30520 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylosuccinate synthetase isozyme 1
                      Reactions:
                      Guanosine triphosphate + Inosinic acid + L-Aspartic acid unknown Guanosine diphosphate + Phosphoric acid + Adenylsuccinic acid details
                      Guanosine triphosphate + Inosinic acid + L-Aspartic acid unknown Guanosine diphosphate + Phosphoric acid + N(6)-(1,2-dicarboxyethyl)AMP details
                      Gene Name: ADSSL1
                      Uniprot ID: Q8N142 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
                      Reactions:
                      Guanosine triphosphate + Succinic acid + Coenzyme A unknown Guanosine diphosphate + Phosphoric acid + Succinyl-CoA details
                      Gene Name: SUCLG1
                      Uniprot ID: P53597 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
                      Reactions:
                      Guanosine triphosphate + Oxalacetic acid unknown Guanosine diphosphate + Phosphoenolpyruvic acid + CO(2) details
                      Guanosine triphosphate + Oxalacetic acid unknown Guanosine diphosphate + Phosphoenolpyruvic acid + Carbon dioxide details
                      Gene Name: PCK2
                      Uniprot ID: Q16822 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
                      Reactions:
                      Guanosine triphosphate + Succinic acid + Coenzyme A unknown Guanosine diphosphate + Phosphoric acid + Succinyl-CoA details
                      Gene Name: SUCLG2
                      Uniprot ID: Q96I99 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
                      Reactions:
                      Guanosine triphosphate + Oxalacetic acid unknown Guanosine diphosphate + Phosphoenolpyruvic acid + CO(2) details
                      Guanosine triphosphate + Oxalacetic acid unknown Guanosine diphosphate + Phosphoenolpyruvic acid + Carbon dioxide details
                      Gene Name: PCK1
                      Uniprot ID: P35558 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Adenylate cyclase type 2
                      Reactions:
                      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
                      Gene Name: ADCY2
                      Uniprot ID: Q08462 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: GTP cyclohydrolase 1
                      Reactions:
                      Guanosine triphosphate + Water unknown Formic acid + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate details
                      Guanosine triphosphate + Water unknown Formamidopyrimidine nucleoside triphosphate details
                      Gene Name: GCH1
                      Uniprot ID: P30793 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
                      Reactions:
                      Guanosine triphosphate + Succinic acid + Coenzyme A unknown Guanosine diphosphate + Phosphoric acid + Succinyl-CoA details
                      Gene Name: SUCLA2
                      Uniprot ID: Q9P2R7 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Atrial natriuretic peptide receptor 2
                      Reactions:
                      Guanosine triphosphate unknown Cyclic GMP + Pyrophosphate details
                      Gene Name: NPR2
                      Uniprot ID: P20594 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA